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  • Burster, Timo; Gärtner, Fabian; Bulach, Christiane; Zhanapiya, Anuar; Gihring, Adrian; Knippschild, Uwe (Pharmaceuticals, 2021-03-08)
    Immunotherapy has been established as an important area in the therapy of malignant diseases. Immunogenicity sufficient for immune recognition and subsequent elimination can be bypassed by tumors through altered and/or ...
  • Shevtsov, Alexandr; Vergnaud, Gilles; Amirgazin, Asylulan; Lukhnova, Larissa; Izbanova, Uinkul; Shevtsov, Vladislav (American Society for Microbiology, 2020-12-10)
    We present a retrospective analysis of strains from two anthrax outbreaks in western Kazakhstan in 2009. The outbreaks occurred during the same period and in the same area located close to main roads, favoring a single ...
  • Filchakova, Olena; Dossym, Dina; Ilyas, Aisha; Kuanysheva, Tamila; Abdizhamil, Altynay; Bukasov, Rostislav (Talanta, 2022)
    More than six billion tests for COVID-19 has been already performed in the world. The testing for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and corresponding human antibodies is essential not ...
  • Baiken, Yeldar; Kanayeva, Damira; Taipakova, Sabira; Groisman, Regina; Ishchenko, Alexander A.; Begimbetova, Dinara; Matkarimov, Bakhyt; Saparbaev, Murat (Frontiers in Cell and Developmental Biology, 2021-01-22)
    Chemical alterations in DNA induced by genotoxic factors can have a complex nature such as bulky DNA adducts, interstrand DNA cross-links (ICLs), and clustered DNA lesions (including double-strand breaks, DSB). Complex ...
  • Myngbay, Askhat; Manarbek, Limara; Ludbrook, Steve; Kunz, Jeannette (International Journal o f Molecular Sciences, 2021-02-28)
    Rheumatoid arthritis (RA) is a chronic autoimmune disease causing inflammation of joints, cartilage destruction and bone erosion. Biomarkers and new drug targets are actively sought and progressed to improve available ...
  • Mirasbekov, Yersultan; Zhumakhanova, Adina; Zhantuyakova, Almira; Sarkytbayev, Kuanysh; Malashenkov, Dmitry V.; Baishulakova, Assel; Dashkova, Veronika; Davidson, Thomas A.; Vorobjev, Ivan A.; Jeppesen, Erik; Barteneva, Natasha S. (Scientific reports, 2021-04-30)
    A machine learning approach was employed to detect and quantify Microcystis colonial morphospecies using FlowCAM-based imaging flow cytometry. The system was trained and tested using samples from a long-term mesocosm ...
  • Saidova, Aleena A.; Potashnikova, Daria M.; Tvorogova, Anna V.; Maly, Ivan V.; Hofmann, Wilma A.; Vorobjev, Ivan A. (PeerJ Chemistry Journals, 2018-11-20)
    Prostate cancer (PC) diagnostics and treatment often present a challenging task due to cancer subtype heterogeneity and differential disease progression in patient subgroups. Hence, the critical issue is finding a reliable ...
  • Kanayeva, Damira; Bekmurzayeva, Aliya; Duncanson, Wynter J.; Azevedo, Helena S. (ELSEVIER, 2018-08-24)
    Stainless steel (SS) is widely used in many biomedical applications including bone implants and cardiovascular stents due to its good mechanical properties, biocompatibility and low price. Surface modification allows ...
  • Xie, Yingqiu; Nurkesh, Ayan; Ibragimova, Nazgul; Zhanzak, Zhuldyz; Meyerbekova, Aizhan; Alexeyeva, Zhanna; Yesbolatova, Aiya; Satayeva, Madina; Mustafa, Aidana; Manarbek, L.; Maipas, Aisulu; Altaikyzy, Akerke; Keneskhanova, Zhibek; Akbay, Burkitkan; Chen, Zhenbang (Nazarbayev University School of Sciences and Humanities, 2019-01-30)
    BackgroundSome membrane proteins can translocate into the nucleus, defined as nuclear localized membrane proteins (NLMPs), including receptor tyrosine kinases (RTKs). We previously showed that nuclear MET (nMET), a member ...
  • Xie, Yingqiu; Liu, Gaomin; Yang, Fan; Li, Fangfang; Li, Zhongjie; Lang, Yange; Shen, Bingzheng; Wu, Yingliang; Li, Wenxin; Harrison, Patrick L.; Strong, Peter N.; Miller, Keith; Cao, Zhijian (Nazarbayev University School of Sciences and Humanities, 2018-05-28)
    The alarming rise in the prevalence of antibiotic resistance among pathogenic bacteria poses a unique challenge for the development of effective therapeutic agents. Antimicrobial peptides (AMPs) have attracted a great deal ...
  • Barteneva, Natasha S.; Meirkhanova, Ayagoz; Malashenkov, Dmitry; Vorobjev, Ivan A. (Microorganisms, 2022)
    Regulated cell death (RCD) is central to the development, integrity, and functionality of multicellular organisms. In the last decade, evidence has accumulated that RCD is a universal phenomenon in all life domains. ...
  • Aibekova, Lazzat; Bexeitova, Aizada; Aldabergenova, Arailym; Hortelano, Gonzalo; Ge, Zhangwen; Yi, Feng; Shao, Yiming; DeHovitz, Jack; Vermund, Sten H.; Ali, Syed (Hindawi, 2020-07-15)
    Background. Following the collapse of the Union of Soviet Socialist Republic (USSR) in 1991, trans-border mobility increased within the former Soviet Union (FSU) countries. In addition, drug-trafficking and injection drug ...
  • Sharip, Aigul; Kunz, Jeannette (Biomolecules, 2020-10)
    Spondyloarthritis comprises a group of inflammatory diseases of the joints and spine, with various clinical manifestations. The group includes ankylosing spondylitis, reactive arthritis, psoriatic arthritis, arthritis ...
  • Kazybay, Bexultan; Ahmad, Ashfaq; Xie, Yingqiu (Travel Medicine and Infectious Disease, 2022)
    Given that international and domestic flights now require only adults to be vaccinated or have negative PCR test results, adolescents’ vacci nation of COVID-19 for safe travel needs urgent consideration. As adults benefit ...
  • Arbuz, Alexandr; Kawalek, Anna; Ozhmegov, Kirill; Dyja, Henryk; Panin, Evgeniy; Lepsibayev, Anuar; Sultanbekov, Sanzhar; Shamenova, Rakhima (MDPI, 2020-09-27)
    An overview of the prospects for the development of nuclear technologies and the conclusion of the relevant requirements for advanced structural materials, their classification and features were performed. In order to ...
  • Bekbossynova, Ayaulym; Zharylgap, Albina; Filchakova, Olena (MDPI AG, 2021-06-03)
    Acetylcholine was the first neurotransmitter described. The receptors targeted by acetylcholine are found within organisms spanning different phyla and position themselves as very attractive targets for predation, as well ...
  • Miguel A., Maestro; Ferdinand, Molnar; Carsten, Carlberg (Journal of Medicinal Chemistry, 2019-03-27)
    For many individuals, in particular during winter, supplementation with the secosteroid vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune diseases, and possibly also different types ...
  • Kattner, Patricia; Zeiler, Katharina; Herbener, Verena J.; Ferla-Brühl, Katia La; Kassubek, Rebecca; Grunert, Michael; Burster, Timo; Brühl, Oliver; Weber, Anna Sarah; Strobel, Hannah; Karpel-Massler, Georg; Ott, Sibylle; Hagedorn, Alexa; Tews, Daniel; Schulz, Ansgar; Prasad, Vikas; Siegelin, Markus D.; Nonnenmacher, Lisa; Fischer-Posovszky, Pamela; Halatsch, Marc-Eric; Debatin, Klaus-Michael; Westhoff, Mike-Andrew (Theranostics, 2021)
    Cancers in animals present a large, underutilized reservoir of biomedical information with critical implication for human oncology and medicine in general. Discussing two distinct areas of tumour biology in non-human hosts, ...
  • Smailov, Bauyrzhan; Alybayev, Sanzhar; Smekenov, Izat; Mursalimov, Aibek; Saparbaev, Murat; Sarbassov, Dos; Bissenbaev, Amangeldy (Frontiers Media, 2020-11-23)
    Germination is a process of seed sprouting that facilitates embryo growth. The breakdown of reserved starch in the endosperm into simple sugars is essential for seed germination and subsequent seedling growth. At the early ...
  • Rudolf, Mark A.; Andreeva, Anna; Kozlowski, Mikolaj M.; Kim, Christina E.; Moskowitz, Bailey A.; Anaya-Rocha, Alejandro; Kelley, Matthew W.; Corwin, Jeffrey T. (Society for Neuroscience, 2020-05-13)
    Loss of sensory hair cells causes permanent hearing and balance deficits in humans and other mammals, but for nonmammals such deficits are temporary. Nonmammals recover hearing and balance sensitivity after supporting cells ...

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