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NU Research Week - II
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Browsing NU Research Week - II by Issue Date

Browsing NU Research Week - II by Issue Date

Now showing items 21-40 of 203

Construction of large scale boolean logic based pathways of colorectal cancer stem cells

Abetov, D.A.; Mustapova, Z.N.; Begimbetova, D.A.; Bulanin, D. (Nazarbayev University, 2014)

Despite advances in the post-genomic era, which allowed for generation of an impressive amount of biological data, representing the whole network of biological interactions, gene regulating networks and signaling pathways ...
Role of HSC70 protein in maintenance of endoplasmic reticulum CA2+ homeostasis

Khamzina, Y.; Nauryzbayeva, A.; Gilman, C. (Nazarbayev University, 2014)

Intracellular calcium homeostasis is disrupted in many neuronal diseases and traumatic brain injuries resulting in endoplasmic reticulum (ER) stress [1]. ER stress and intracellular calcium homeostasis is a hub of signaling ...
Genetic homongeneity and major histocompatibility complex haplotyping of white mice

Sydykova, K.; Sadykov, M.; Zhailauova, A.; Adilbayeva, A.; Myngbay, A.; Adarichev, V. A. (Nazarbayev University, 2014)

Inbred murine strains are generated to insure genetic homogeneity and uniqueness and define immune characteristics, like major histocompatibility complex (MHC) haplotype, of the experimental model. Maintaining of the ...
High sensitivity detection of NBT on novel SERS substrate

Khamkhash, L.; Ralchenko, Y.; Bukasov, R. (Nazarbayev University, 2014)

Surface-enhanced Raman scattering (SERS) is rapidly evolving as a useful analytical tool in chemical and biological analysis. The most critical aspect of SERS is the research of efficient SERSactive substrates, such as ...
Quantum dynamics in molecules and nanostructures in strong fields

Bubin, S. (Nazarbayev University, 2014)

With the advance of time-dependent probes the investigation of the dynamical behavior of matter at the nanoscale has become a very important research direction. Laser-assisted steering of the electron motion in molecules ...
Evaluation of extracorporeal gas exchange device hemolung for potential application in pediatric practice

Mussin, Y.; Bulanin, D.; Jeffries, R.; Zhumadilov, Zh.; Olzhayev, F.; Federspiel, W. (Nazarbayev University, 2014)

The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using the catheters of smaller diameter and blood flow rates applied in pediatrics.
Developing an asset management framework for water resource management in Kazakhstan

Bradshaw, R. A.; Mashtayeva, S.; Khairaliyev, S; James, A.; Kho, Y. H.; Rojas-Solorzano, L. (Nazarbayev University, 2014)

The project's main objective is the development and application of an asset management framework that institutionalizes and operationalizes infrastructure management and decision making (investment, operation, maintenance) ...
Thermal management of LI-ION battery packs

Adair, D.; Ismailov, K.; Bakenov, Zhumabay (Nazarbayev University, 2014)

A design for the thermal management of Lithium-ion battery packing as used in hybrid and electric vehicles has been developed. The design satisfies all thermal and physical issues relating to the battery packs used in ...
Correlation between ocular elasticity and intraocular pressure on optic nerve damages

Ko, M. W. L.; Ali, Md. H.; Lam, D. C. C. (Nazarbayev University, 2014)

Optic neuropathy in glaucoma causes visual field loss and blindness [1]. The optic nerve damage in the lamina cribrosa (LC) of the sclera, the primary site of glaucoma, is correlated with the intraocular pressure (IOP) ...
SNX 9 interacts with dynamin 2 and N-wasp to regulate focal adhesion disassembly and cell migration

Zhubanchaliyev, A.; Chao, W. T.; Kunz, J. (Nazarbayev University, 2014)

The turnover of focal adhesions is essential for normal cell migration and tumor invasion, but the underlying mechanisms are poorly understood. We have previously shown that the disassembly of focal adhesions occurs by ...
Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats

Tokay, T.; Rehberg, M.; Kirschstein, T.; Rohde, M.; Mueller, L.; Askarova, Sholpan; Kohling, R.; Zhumadilov, Z. (Nazarbayev University, 2014)

The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission in the hippocampus, and cognitive ...
The future of translational biomedical research at Nazarbayev University

Saparov, A.; Alibek, K.; Brusic, V.; Pignatelli, M. (Nazarbayev University, 2014)

The ultimate goal of fundamental biomedical research is to decipher mechanisms underlying the impairment of molecules, cells, tissues, and organs and subsequent dysfunction of the whole human body. Knowledge of these ...
Genetic dissection of the biochemical activities of human DNA repair protein, APE1

Redrejo-Rodriguez, M.; Mursalimov, A.; Koshenov, Z.; Zhakupova, K.; Saparbaev, M. K.; Ishchenko, A. A.; Matkarimov, B. (Nazarbayev University, 2014)

Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways. In the BER pathway, APE1 cleaves DNA at AP sites and ...
Estimation of carrier life time from intrinsic photoluminescence of ZnO

Bhowmick, M.; Ullrich, B.; X i, H.; Flores, D.A. (Nazarbayev University, 2014)

Comprehensive knowledge of the optical properties, particularly of the room temperature (RT) photoluminescence (PL), of ZnO is essential for the future employment of this wideband gap (~3.3 eV at 300 K) II-VI compound ...
Age-realted dementia in Kazahstan: adaptation of the 10/66 dementia research group population -based study protocol

Kaiyrlykyzy, A.; Adambekov, Sh.; Alimbetov, D.; Askarova, Sholpan (Nazarbayev University, 2014)

Background. The prevalence of dementia is increasing worldwide as the population ages and affects 10 % of the population over 65 years old and 40 % of people over the age of 80.[1] In Kazakhstan, as well as in other ...
E.Coli derived camelid antibodies as a sensor for P53 in saliva

Niyazmetova, L.; Zhailauova, A.; Sadykov, M.; Muradova, Z.; Ospanova, B.; Pak, A.; Abdirakhmanova, Altynay; Stambekova, D.; Bayakhmetov, S.; Tsyba, N. (Nazarbayev University, 2014)

Oral squamous cell carcinoma (OSCC) is a malignant tumor with 640,000 new cases annually in the world [1]. Saliva testing is non-invasive procedure that is capable to detect potential biomarkers for OSCC. It was shown ...
Optimal current quality of a single-phase multilevel inverter with a staircase modulation

Aldabergenov, M.; Familiant, Y. L.; Ruderman, A. (Nazarbayev University, 2014)

The authors address the problem of optimal current quality for a single-phase multilevel inverter with a staircase modulation (Fig.1). The current quality is characterized by current ripple Normalized Mean Square (NMSc). ...
Design and synthesis of organic nonlinear optical materials

Zhanabergenova, M.; Baptayev, B.; Tauanov, Z.; Zhakiyeva, Z.; Yergeshbayeva, S.; Berillo, D.; Adilov, S. (Nazarbayev University, 2014)

Following the development of the idea of octupolar molecules as nonlinear optical materials a variety of compounds have been reported. Trans-porphyrins have a great potential to selforder into octupolar symmetry. Nonlinear ...
Stability of small positronic atoms in ground and excited states

Bubin, S. (Nazarbayev University, 2014)

Studying the dynamical stability of positron-atom and positron-molecule complexes provides an insight into the physics and chemistry of low energy positrons and their interaction with matter. Beams of low energy positrons ...
Human movement learning with dynamic movement primitives combined with mixture models

Alizadeh, T.; Calinon, S. (Nazarbayev University, 2014)

The proposed research is to provide a probabilistic approach to learn human movements. Dynamical Movement Primitives (DMP) have been extensively used in robotics in order to learn human motions [1]. The DMP modulates a ...