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Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?

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dc.contributor.author Aituov, Bauyrzhan
dc.contributor.author Duisembekova, Assem
dc.contributor.author Bulenova, Assel
dc.contributor.author Alibek, Kenneth
dc.date.accessioned 2017-11-08T04:43:59Z
dc.date.available 2017-11-08T04:43:59Z
dc.date.issued 2012
dc.identifier.citation Aituov et al.(>3), 2012, Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm?,Infectious Agents and Cancer ru_RU
dc.identifier.issn 1750-9378
dc.identifier.uri doi:10.1186/1750-9378-7-18
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/2748
dc.description.abstract The regulation of cancerous tumor development is converged upon by multiple pathways and factors. Besides environmental factors, gastrointestinal (GI) tract cancer can be caused by chronic inflammation, which is generally induced by bacteria, viruses, and parasites. The role of these inducers in cancer development, cell differentiation and transformation, cell cycle deregulation, and in the expression of tumor-associated genes cannot be ignored. Although Helicobacter pylori activates many oncogenic pathways, particularly those in gastric and colorectal cancers, the role of viruses in tumor development is also significant. Viruses possess significant oncogenic potential to interfere with normal cell cycle control and genome stability, stimulating the growth of deregulated cells. An increasing amount of recent data also implies the association of GI cancers with bacterial colonization and viruses.This review focuses on host-cell interactions that facilitate primary mechanisms of tumorigenesis and provides new insights into novel GI cancer treatments. ru_RU
dc.language.iso en ru_RU
dc.publisher Infectious Agents and Cancer ru_RU
dc.rights Open Access - the content is available to the general public ru_RU
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject gastric cancer ru_RU
dc.subject Colorectal cancer ru_RU
dc.subject Liver cancer ru_RU
dc.subject Helicobacter pylori ru_RU
dc.subject Cytomegalovirus ru_RU
dc.subject Epstein-Barr virus ru_RU
dc.subject John Cunningham virus ru_RU
dc.subject Streptococcus bovis ru_RU
dc.subject Hepatitis C virus ru_RU
dc.subject Helminthes ru_RU
dc.title Pathogen-driven gastrointestinal cancers: Time for a change in treatment paradigm? ru_RU
dc.type Article ru_RU


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Open Access - the content is available to the general public Except where otherwise noted, this item's license is described as Open Access - the content is available to the general public