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Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases

Talhaoui, Ibtissam; Matkarimov, Bakhyt T.; Tchenio, Thierry; Zharkov, Dmitry O.; Saparbaev, Murat K. (Free Radical Biology and Medicine, 2017-06-01)

Abstract In cellular organisms composition of DNA is constrained to only four nucleobases A, G, T and C, except for minor DNA base modifications such as methylation which serves for defence against foreign DNA or gene ...
Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli

Zutterling, Caroline; Mursalimov, Aibek; alhaoui, Ibtissam; Koshenov, Zhanat; Akishev, Zhiger; Bissenbaev, Amangeldy K.; Mazon, Gerard; Geacintov, Nicolas E.; Gasparutto, Didier; Groisman, Regina; Zharkov, Dmitry O.; Matkarimov, Bakhyt T.; Saparbaev, Murat (BIOCHEMISTRY, BIOPHYSICS AND MOLECULAR BIOLOGY, 2018-12-15)

DNA repair is essential to counteract damage to DNA induced by endo- and exogenous factors, to maintain genome stability. However, challenges to the faithful discrimination between damaged and non-damaged DNA strands ...
Acoustoelectric properties of graphene under the influence of saw and external electric field

Insepov, Z.; Tynyshtykbayev, Kurbangali B.; Kononenko, Oleg V.; Roshchupkin, Dmitry V. (Nazarbayev University, NURIS, Institute of Microelectronics Technology and High Purity Materials, 2015)

The effect of SAW on the electrical properties of the few-layer (2-3 layers) graphene is studied. Under the influence of SAW the appearence of acoustoelectric current IAEC in graphene is observed. The sign and magnitude ...
ACTIVATED CARBON/PECTIN COMPOSITE ENTEROSORBENT FOR HUMAN PROTECTION FROM INTOXICATION WITH XENOBIOTICS PB(II) AND SODIUM DICLOFENAC

Jandosov, Jakpar; Alavijeh, Mo; Sultakhan, Shynggyskhan; Baimenov, Alzhan; Bernardo, Maria; Sakipova, Zuriyadda; Azat, Seytkhan; Lyubchyk, Svitlana; Zhylybayeva, Nurzhamal; Naurzbayeva, Gulmira; Mansurov, Zulkhair; Mikhalovsky, Sergey; Berillo, Dmitriy (Molecules, 2022)

The use of enterosorbents—materials which can be administered orally and eliminate toxic substances from the gastrointestinal tract (GIT) by sorption—offers an attractive complementary protection of humans against acute ...
Adipose-derived perivascular stem cells promote sensorimotor recovery after ischemic stroke in rats

Ogay, Vyacheslav; Kumasheva, Venera; Baidosova, Sholpan; Li, Yelena; Shpekov, Azat; Makhambetov, Yerbol; Kaliyev, Assylbek; Zhetpisbayev, Berik; Olzhayev, Farkhad; Ramankulov, Yerlan (Journal of Biotechnology, 2017-08-30)

In this study, we test a novel hypothesis that treatment of stroke with adipose-derived perivascular stem cells (PSCs) promote sensorimotor recovery after stroke in rats. Rat PSCs were isolated from subcutaneous adipose ...
A Low-Cost Open-Source 3-D-Printed Three-Finger Gripper Platform for Research and Educational Purposes

Telegenov, Kuat; Tlegenov, Yedige; Shintemirov, Almas (IEEE Access, 2015-06-02)

Robotics research and education have gained significant attention in recent years due to increased development and commercial deployment of industrial and service robots. A majority of researchers working on robot grasping ...
A model of rf breakdown arcs

Insepov, Z.; Bross, A.; Qian, Z.; Norem, J.; Huang, D.; Veitzer, S.; Torun, Y. (Fermilab, 2008)

This paper presents a rst iteration of a model that attempts to describe all aspects of breakdown in rf cavities and provides some estimates of the parameters and parameter ranges involved, as an aid to producing more ...
A New Multiscale Approach to Nuclear Fuel Simulations: Atomistic Validation of Kinetic Method

Insepov, Z.; Rest, J.; Hofman, G. L.; Yacout, A.; Norman, G. E.; Starikov, S. A.; Stegailov, V. V. (Transactions of the American Nuclear Society, 2010)

A key issue for fuel behavior codes is their sensitivity to values of various materials properties, many of which have large uncertainties or have not been measured. Kinetic mesoscale models, such as those developed at ...
Anticancer Effects and uses of Melatonin A Review

Mektepbayeva, Damel; Alibek, Kenneth; Atinbayeva, N.; Irving, S; Zhaisanbayeva, B; Mussurova, S; Mussakhan, S (Austin Journal of Cancer and Clinical Research, 2015-08)

Melatonin (N-acetyl-5-methoxytryptamine, MLT) is a naturally occurring hormone secreted by the pineal gland. Clinical evidence suggests that MLT may have a possible role in the treatment of cancer, where MLT presents many ...
ANTIPROLIFERATIVE AND CYTOTOXIC ACTIVITY OF GERANIACEAE PLANT EXTRACTS AGAINST FIVE TUMOR CELL LINES

Sergazy, Shynggys; Vetrova, Anastassiya; Orhan, Ilkay Erdogan; Deniz, Fatma Sezer Senol; Kahraman, Ahmet; Zhang, Jian-Ye; Aljofan, Mohamad (Future science, 2021)

Several plant species of the genera Geranium and Erodium were extracted and screened against five tumor cell lines for their potential antitumor activities. Out of the tested species, four showed potential antitumor ...
ANTIRADICAL AND CYTOPROTECTIVE PROPERTIES OF ALLIUM NUTANS L. HONEY AGAINST CCL4-INDUCED LIVER DAMAGE IN RATS

Sergazy, Shynggys; Gulyayev, Alexander; Amangeldiyeva, Aidana; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Shulgau, Zarina; Chulenbayeva, Laura; Khassenbekova, Zhanagul; Kushugulova, Almagul; Aljofan, Mohamad (Frontiers in Pharmacology, 2021-09-20)

The aim of this study is determine the in vitro and in vivo antiradical properties and the cytoprotective activity of Allium nutans L. honey extract. The antiradical properties of the extracts were investigated in rabbit ...
An Assessment of Universal Dependency Annotation Guidelines for Turkic Languages

Tyers, Francis; Washington, Jonathan; Çöltekin, Çağrı; Makazhanov, Aibek (Tatarstan Academy of Sciences, 2017-10-21)

Annotated corpora of three Turkic languages – Turkish, Kazakh, and Uyghur – were released as part of version 2 of the Free/Open-Source Universal Dependencies (UD) syntactic and morphological annotation guidelines. The ...
ASSOCIATION OF GENETIC POLYMORPHISMS WITH COMPLICATIONS OF IMPLANTED LVAD DEVICES IN PATIENTS WITH CONGESTIVE HEART FAILURE: A KAZAKHSTANI STUDY

Zhalbinova, Madina R.; Rakhimova, Saule E.; Kozhamkulov, Ulan A.; Akilzhanova, Gulbanu A.; Kaussova, Galina K.; Akilzhanov, Kenes R.; Pya, Yuriy V.; Lee, Joseph H.; Bekbossynova, Makhabbat S.; Akilzhanova, Ainur R. (Journal of Personalized Medicine, 2022-05-04)

The left ventricular assist device (LVAD) is one of the alternative treatments for heart failure (HF) patients. However, LVAD support is followed by thrombosis, and bleeding complications which are caused by high ...
Atomic layer deposition for TiO2 and TiN nanometer films

Ainabayev, Ardak; Bozheyev, Farabi; Zhuldassov, Abat; Lukasheva, Maria; Tynyshtykbaev, Kurbangali B.; Insepov, Z. (Materials Today: Proceedings, 2017-01-01)

Abstract In this work processes of atomic layer deposition (ALD) of TiO2 and TiN using ALD method and impact of thickness and composition of grown film on stoichiometry and morphology of deposited layer are investigated. ...
BIODICA: A COMPUTATIONAL ENVIRONMENT FOR INDEPENDENT COMPONENT ANALYSIS OF OMICS DATA

Captier, Nicolas; Merlevede, Jane; Molkenov, Askhat; Seisenova, Ainur; Zhubanchaliyev, Altynbek; Nazarov, Petr V; Barillot, Emmanuel; Kairov, Ulykbek; Zinovyev, Andrei (Bioinformatics, 2022)

We developed BIODICA, an integrated computational environment for application of independent component analysis (ICA) to bulk and single-cell molecular profiles, interpretation of the results in terms of biological functions ...
Bioinspired study of energy and electron transfer in photovoltaic system

Moniruddin, Md; Ilyassov, Baurzhan; Seliverstova, Evgeniya; Shabdan, Yerkin; Bakranov, Nurlan; Ibrayev, Niyazbek; Nuraje, Nurxat (Journal of Experimental Nanoscience, 2017)

This study focuses on understanding the fundamentals of energy transfer and electron transport in photovoltaic devices with uniquely designed nanostructures by analysing energy transfer in purple photosynthetic bacteria ...
Biological effects of non-ionizing electromagnetic fields: Two sides of a coin

Saliev, Timur; Begimbetova, Dinara; Masoud, Abdul-Razak; Matkarimov, Bakhyt (PERGAMON-ELSEVIER SCIENCE, 2019-01)

Controversial, sensational and often contradictory scientific reports have triggered active debates over the biological effects of electromagnetic fields (EMFs) in literature and mass media the last few decades. This could ...
Biomarkers, interventions and healthy ageing

Kenessary, Almas; Zhumadilov, Zhaxybay; Nurgozhin, Talgat; Kipling, David; Yeoman, Mark; Cox, Lynne; Ostler, Elizabeth; Faragher, Richard (New Biotechnology, 2013-05-25)

Population ageing is probably the single most important healthcare challenge the developed and developing world will face in the 21st century. This is because the later part of the human life course is marked by the emergence ...
Can surface cracks and unipolar arcs explain breakdown and gradient limits?

Insepov, Z.; Norem, J. (J. Vac. Sci. Technol, 2013)

We argue that the physics of unipolar arcs and surface cracks can help understand rf breakdown, and vacuum arc data. We outline a model of the basic mechanisms involved in breakdown and explore how the physics of unipolar ...
Character-based Deep Learning Models for Token and Sentence Segmentation

Toleu, Alymzhan; Tolegen, Gulmira; Makazhanov, Aibek (Tatarstan Academy of Sciences, 2017-10-21)

In this work we address the problems of sentence segmentation and tokenization. Informally the task of sentence segmentation involves splitting a given text into units that satisfy a certain definition (or a number of ...