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Cutting edge: IgE plays an active role in tumor immunosurveillance in mice

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dc.contributor.author Nigro, Elisa A.
dc.contributor.author Brini, Anna T.
dc.contributor.author Yenagi, Vijay A.
dc.contributor.author Ferreira, Lorena M.
dc.contributor.author Achatz-Straussberger, Gertrude
dc.contributor.author Ambrosi, Alessandro
dc.contributor.author Sanvito, Francesca
dc.contributor.author Soprana, Elisa
dc.contributor.author Van Anken, Eelco
dc.contributor.author Achatz, Gernot
dc.contributor.author Siccardi, Antonio G.
dc.contributor.author Vangelista, Luca
dc.date.accessioned 2017-01-12T06:26:47Z
dc.date.available 2017-01-12T06:26:47Z
dc.date.issued 2016-10-01
dc.identifier.citation Nigro, E. A., Brini, A. T., Yenagi, V. A., Ferreira, L. M., Achatz-Straussberger, G., Ambrosi, A., ... Vangelista, L. (2016). Cutting edge: IgE plays an active role in tumor immunosurveillance in mice. Journal of Immunology, 197(7), 2583-2588. DOI: 10.4049/jimmunol.1601026 ru_RU
dc.identifier.uri http://nur.nu.edu.kz/handle/123456789/2244
dc.description.abstract Exogenous IgE acts as an adjuvant in tumor vaccination in mice, and therefore a direct role of endogenous IgE in tumor immunosurveillance was investigated. By using genetically engineered mice, we found that IgE ablation rendered mice more susceptible to the growth of transplantable tumors. Conversely, a strengthened IgE response provided mice with partial or complete resistance to tumor growth, depending on the tumor type. By genetic crosses, we showed that IgE-mediated tumor protection was mostly lost in mice lacking FceRI. Tumor protection was also lost after depletion of CD8+ T cells, highlighting a cross-Talk between IgE and T cell- mediated tumor immunosurveillance. Our findings provide the rationale for clinical observations that relate atopy with a lower risk for developing cancer and open new avenues for the design of immunotherapeutics relevant for clinical oncology. The Journal of Immunology, 2016, 197: 2583-2588. ru_RU
dc.language.iso en ru_RU
dc.publisher Journal of Immunology ru_RU
dc.rights Attribution-NonCommercial-ShareAlike 3.0 United States *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0/us/ *
dc.subject neoplasms ru_RU
dc.subject immunoglobulin E ru_RU
dc.subject immunologic monitoring ru_RU
dc.title Cutting edge: IgE plays an active role in tumor immunosurveillance in mice ru_RU
dc.type Article ru_RU

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