Browsing Abstracts by Title

Now showing items 34-53 of 89

Migration characteristics of cell grown in embryonic microenvironment and under antiviral agents

Karapina, O.; Shaimerdenova, M.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Cancer metastasis is a crucial process of spread of cancer cells from the origin of tumor lesion to the tissues and other organs beyond, where new tumor lesions are formed which might be a single kick of event that may ...
Molecular-genetical tumor parameters at patients with lung cancer taking into account smoking factor

Smagulova, G.; Zhylkaydarova, A.; Tuleuhanov, S.; Esentayeva, S.; Baimukhametov, E.; Goncharova, T.; Sokolenko, E.; Kerimov, A. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

In Kazakhstan lung cancer takes the first place in the cancer morbidity and cancer mortality structure. Tobacco smoking (TS) remains the most established cause of lung carcinogenesis and other disease processes. ...
Morphometric characteristics of cancer cells grown in embryonic microenvironment and under antiviral treatment

Shaimerdenova, M.; Karapina, O.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Aggressive cancer cells express markers of multipotent stem cells and tightly interconnect with its surrounding microenvironment, by which the differential plasticity of cancer cells and also its carcinogenicity is ...
MSCS functionalized with osteophilis polymer enhance compact bone regeneration in osteoporotics rat model in vivo

Safarova (Yantsen), Y.; OIzhayev, F.; ldrissova, D.; Umbayev, B.; Murata, H.; Koepsel, R.; Russell, A.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Undeniable increase in osteoporotic fractures is associated mainly with the global population aging. Age-related alterations shift bone metabolism to induced osteoclastic activity and reduction of osteoblasts that ...
Oрганизационные аспекты развития кардиологической помощи населению на базе АО «ННЦОТ»

Искакова, Б.К.; Молдабеков, Т.К.; Аймакова, Г.О.; Бияхметова, Э.А.; Лепесова, Г.У. (National Laboratory Astana, Назарбаев Университет 2016, 2016-05-11)

По данным официальной статистики, основная причина смертности населения Казахстана обусловлена болезнями системы кровообращения (БСК). К сожалению, в последние годы в стране отмечается рост заболеваемости БСК с 13391,1 ...
Population ageing and quality of life of retiree

Menlibayeva, K.; Karp, L.; Dauletova, G. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Population ageing is taking place in nearly all the countries of the world. The global share of older people (aged 60 years or over) increased from 9.2 percent in 1990 to 11.7 per cent in 2013 and will continue to grow ...
Protocol optimization for abtaining lyophilized human amniotic membrane extract

Shramko, A.; Umbayev, В.; Olzhayev, R.; Idrissova, D.; Masoud, A.; Sadyrbekov, D.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

The amniotic membrane (AM) is the inner amniotic fluid-filled membrane which forms a cavity around the embryo. AM has long been used in the treatment of venous ulcers and burns. Freshly extracted AM has been shown to ...
Rapid evaluation of DNA damage with comet assay in combination of high throughput microscopy

Baiskhanova, D.; Bobrova, X.; Kauanova, S.; Begimbetova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Comet assay is well known method for DNA damage evaluation. However, it also possesses some limitations related to the problem with manual entry of each comet for analysis that decreases the performance and measurement ...
Recent progress in understanding of hypertension

Mutig, K. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Uncontrolled hypertension is associated with increased risk of cardiovascular morbidity and mortality in general population. Renal salt handling is essential for volume regulation and blood pressure control. The ...
Removal of low and middle molecular weight toxins by activated carbon materials

Akhmetova, A.; Howell, C.; Jandosov, J.; Baimenov, A.; Mansurov, Z.; Nurgozhin, T.; Mikhalovsky, S. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Haemoperfusion (HP), or blood purification via adsorption, has been introduced almost at the same time as haemodialysis in 1960s. HP compared to dialysis does not introduce any substances into the body and only removes ...
Restoration of mesenchymal stem cell function using pharmacological agents

Masoud, A.; Umbayev, B.; Shramko, A.; Idrissova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

The extensive characteristics of mesenchymal stem cells (MSCs), especially their capacity to replicate and differentiate into any type of fully developed cell make these cells suitable for use in cell therapy. These cells ...
Results of the study of biological subtypes of breast cancer

Tailakov, B.B.; Tuleutaev, M.E.; Pirozhenko, O.P.; Gubskaya, E.B.; Orazbekov, B.S.; Balhozhaeva, A.A.; Zhukov, Y.; Rutzhanuly, I.R.; Omarov, M.H.; Makis, R.T.; Tusupbekov, E.H.; Ermagambetova, A.T. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Identification of biological subtypes of breast cancer using immunohistochemical tumor markers: ER and RP receptor, Ki67, Her-2 / neu is a modern criterion for the development of optimal therapies for the breast cancer.
Role of astrocyte aging in the pathogenesis of alzheimer`s disease

Imangali, N.; Alimbetov, D.; Tsoy, A.; Saparbayev, S.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Alzheimer's disease (AD) is the most abundant severe and irreversible neurodegenerative disease in the world that affects people over 65 years old. The major hallmarks of AD pathology are the senile p-amyloid plaques, ...
Serum collagen triple helix repeat-containing (CTHRC1) levels is associated with circulating stem cell factor and pro-inflammatory cytokines in rheumatoid arthritis

Bexeitov, Y; Myngbay, A; Adilbayeva, A; Yevstratenko, B.P.; Aitzhanova, R.M.; Otarbayev, N.K.; Adarichev, V.A. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Everyday monitoring disease activity of chronic inflammatory diseases such as Rheumatoid Arthritis (RA) is a tempting approach for every patient for attaining personalized treatment strategies. Still underdeveloped area ...
Serum levels of apoptosis - related markers (P53, BCL-2, SFAS-L, CASPASE-9) in copd patients

Saduakassova, A.B.; Akparova, A.Yu.; Abdrahmanova, В. M.; Bersimbay, R.I. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Apoptosis is a complex process of regulated and programmed cell death. In this process, the activation of many genes and signaling pathways is involved. Apoptosis provides a protective function due to the elimination of ...
Stem cells in inflammatory diseases

Kang, Kyung-Sun (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

The systemic application of MSCs derived from various origins including bone marrow, adipose tissue, gingiva, and umbilical cord has been tested for its efficacy to suppress chemically induced colitis in animals. Most ...
Study the effect of gene polymorphism contribution of statin biotransformation and lipid metabolism for parameters of statin efficacy. Recruiting

Kozhakhmetov, S.S.; Kushugulova, A.R.; Kakimova, A.B.; Saduakhassova, S.A.; Urasova, M.S.; Khassenbekova, Zh.R.; Kozhakhmetova, S.S.; Kazhybayev, A.K.; Urazbayeva, G.S.; Tuleutayeva, G.K.; Ongarbayeva, A.E.; Beysembayeva, S.Ch.; Nurgozhin, T.S.; Zhumadilov, Zh. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Rosuvastatin is high-performance hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which commonly used in the treatment of hyperlipidemia. It significantly reduces levels of LDL, which accompanied by a moderate increase ...
The study of the therapeutic effects of hyaluronic acid, chondroinductive factors and mesenchymal stem cells on regeneration of articular cartilage defects in rabbits

Sarsenova, M.; Karzhauov, M.; Kaliev, Ye.; Raimagambetov, E.; Ogay, V. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Regeneration of injured articular cartilage is one of the most difficult problems in traumatology and orthopedics. Applied nowadays surgical methods that are aimed at stimulation of cartilage regeneration in damaged joint ...
Transcriptome profiling by next - generation sequencing and pathway analysis of esophageal squamous cell carcinoma in Kazakhstan

Rakhimova, S.; Kairov, U.; Molkenov, A.; Zhukov, Y.; Omarov, M.; Popova, M.; Zhumadilov, Zh.; Akilzhanova, A. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

Esophageal cancer is the eighth most common cancer in the world and the highest in Eastern Asia. The incidence rate in Kazakhstan is 10.1: 100 000. Esophageal squamous cell carcinoma (ESCC) is the dominant histological ...
Treatment of end - stage liver disease in the jsc national scientific center for oncology and transplantology, Astana: views and perspectives

Yesmembetov, K.; Kaliaskarova, K.; Muratova, Zh.; Borovskiy, S.; Sultanaliyev, T.; Mukazhanov, A.; Zharkimbekov, B.; Zhexembayev, A.; Kuttymuratov, G.; Amanzholov, B. (National Laboratory Astana, Nazarbayev University 2016, 2016-05-11)

End-stage liver disease represents a major healthcare problem worldwide and in Kazakhstan, carrying a high risk for mortality. Around 1000 patients with end-stage liver disease need liver transplantation in Kazakhstan, ...