Browsing Abstracts by Title

Now showing items 18-37 of 89

Deep brain stimulation for neurodegenerative diseases

Shashkinl, Ch.; Akshulakovl, S.; Makhambetovl, Y.; Shpekovl, A.; Dzhamantaeval, B.; Akhmetzhanovl, V. (2016-05)

Neurodegenerative diseases (ND) with movement and cognitive disorders are very complicated diseases to treat. Sometimes medical treatment is not successful or results in unpleasant complications. Nowadays neurosurgical ...
Development of a new method of surgical treatment of patellofemoral pain syndrome

Akilzhanov, K. (2016-05)

Patellofemoral pain syndrome (PFBS) - one of the most frequent symptom in orthopedic practice. According to available statistics, from 18% to 33% of all calls to the Orthopaedic Trauma and sports doctors about the pathology ...
D-serine improves learning and memory in epileptic animals

Tokay, T.; Mueller, L.; Xie, Y.; Kirschstein, T.; Beck, H.; Koehling, R. (2016-05)

The N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of synaptic plasticity and is essential for many forms of learning and memory. Activation of NMDAR by glutamate requires the presence of D-Serine, ...
Effectiveness of pulic screening for glaucoma in republic of Kazakhstan

Tashtitova, L.B.; Botabekova, Т.К.; Aldasheva, N.A.; Uteuliyev, E.S. (2016-05)

In the Republic of Kazakhstan (RK) glaucoma is the second place ranking in the structure of primary disability on eyesight. In 80.2% of cases-these are invalids of the first or second group (Islamova S.E., 2009). In 2010 ...
Elevated levels of plasma collagen priple helix repeat-containing (CTHRC1) protein correlates with increased granul ocytopoiesis and higher rheumatoid arthritis disease severity score

Myngbay, A.; Bexeitov, Y.; Adilbayeva, A.; Yevstratenko, B. P.; Aitzhanova, R. M.; Otarbayev, N. K.; Adarichev, V.A. (2016-05)

Monitoring and suppressing activity of the pathological granulating pannus tissue is essential for Rheumatoid Arthritis (RA) management. Synovial joints pain and tissue destruction is a derivative of the pannus activity. ...
Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage

Khassenbekova, Zh.; Berikkhanova, K.; Gulyayev, A.; Sergazy, Sh.; Yermekbayeva, В.; Kushugulova, A.R.; Omarova, D.; Akhmetova, A.; Nurgozhin, T.; Zhumadilov, Zh. (2016-05)

Correction of phenotypic plasticity of macrophages for reprogramming inflammatory response is of great interest to modern medicine. To date, there are lots of factors, which can alter macrophages' phenotype to M1 or M2. ...
Establishment of small cell lung cancer cell lines and validation of their growth characteristics

Alimbetov, D.; Idrissova, D.; Davis, T.; Kipling, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Rapidly metastasizing lung cancer is the top killer in the United States and many other countries. In 2014, there were nearly 224 210 new cases of lung cancer and 159 260 predicted mortality from the disease in the US ...
Generation of hepatocyte-like cells from human pluripotent stem cells

Sekenova, A.; Kumasheva, V.; Li, Ye.; Baidosova, Sh.; Ogay, V. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

The demand for donor livers in transplantation medicine continues to increase every year with the difficulties in finding compatible human hepatocytes. Therefore, generation of patient specific human hepatocytes from ...
Glial cells and their molecules in nerve regeneration

Riethmacher, D. (2016-05)

Peripheral nerve injury has many causes ranging from traumatic damage to metabolic disturbances (e.g.in diabetes mellitus). The primary pathology can affect axons (nerve transection) or Schwann cells, and their interdependence ...
HLA-B27 subtypes distribution among the healthy population in Kazakhstan

Shuinshkalieva, Zh.; Turganbekova, A.; Akparova, A. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Human leukocyte antigen B27 (HLA-B27) is a molecule of class I major histocompatibility complex. Numerous studies showed an association of the antigen with various types of spondyloarthropathies. The strength of this ...
Honey and papaya extract loaded polyurethane based bio-nanofibrous scafford for skin regeneration

Jaganathan, S. K. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Skin regeneration is vital for chronic or acute wounds healing. Honey and Carica papaya fruit extract are rich source of various proteins, amino acids, vitamins and essential minerals. These naturally available biomolecules ...
Identification of therapeutic targets for chemotherapy-resistant colon cancer stem cells

Francipane, M. G.; Bulanin, D.; Lagasse, E. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Current first-line chemotherapy generally consists of cytotoxic agents. While these agents may initially control disease by effectively debulking tumors, the tumors invariably recur due to the ability of cancer stem cells ...
IL-10-1082 A/G pomoter polimorphism is associated with copd

Imanbay, A.; Turbekova, Sh.; Akparova, A.Yu.; Abishev, M.T.; Bersimbaev, R. I. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Interleukin-10 is an important immunoregulatory cytokine produced by many cell populations. It inhibits the production of proinflammatory cytokines by macrophages and thus has immunosuppressive effects on T cells, monocytes ...
Influence of Gamma-glutamyl carboxylage (GGCX) on warfarin dose

Zhalbinova, M.; Rakhimova, S.; Bekbosynova, M.; Myrzakhmetova, Sh.; Akilzhanova, A. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Warfarin is an oral anticoagulant which is popular in cardiology for the prevention and treatment of thromboembolic events in patients with deep vein thrombosis. Patients usually treated according to the clinical data. ...
Isolation and characterization of rabbit periosteum-derived mesenchymal stem cells

Surumbayeva, A.; Ogay, Vyacheslav (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Periosteum represents a good source for mesenchymal stem cells (MSCs). They have been regarded as a promising therapeutic tool for muscoskeletal regeneration. Periosteum-derived MSCs have higher osteogenic potential in ...
Isolation and enrichment of rat bone marrow mesenchymal stem cells

Baidosova, S.; Kumasheva, V.; Kerimbayev, T.; Aleynikov, V.; Aldiyarova, N.; Ogay, Vyacheslav (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Mesenchymal stem cells (MSCs) are a promising tool for cell therapy, because of their specific characteristics, which mimic partially those of embryonic stem cells, but with some advantages in terms of availability, ...
Migration characteristics of cell grown in embryonic microenvironment and under antiviral agents

Karapina, O.; Shaimerdenova, M.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Cancer metastasis is a crucial process of spread of cancer cells from the origin of tumor lesion to the tissues and other organs beyond, where new tumor lesions are formed which might be a single kick of event that may ...
Molecular-genetical tumor parameters at patients with lung cancer taking into account smoking factor

Smagulova, G.; Zhylkaydarova, A.; Tuleuhanov, S.; Esentayeva, S.; Baimukhametov, E.; Goncharova, T.; Sokolenko, E.; Kerimov, A. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

In Kazakhstan lung cancer takes the first place in the cancer morbidity and cancer mortality structure. Tobacco smoking (TS) remains the most established cause of lung carcinogenesis and other disease processes. ...
Morphometric characteristics of cancer cells grown in embryonic microenvironment and under antiviral treatment

Shaimerdenova, M.; Karapina, O.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Aggressive cancer cells express markers of multipotent stem cells and tightly interconnect with its surrounding microenvironment, by which the differential plasticity of cancer cells and also its carcinogenicity is ...
MSCS functionalized with osteophilis polymer enhance compact bone regeneration in osteoporotics rat model in vivo

Safarova (Yantsen), Y.; OIzhayev, F.; ldrissova, D.; Umbayev, B.; Murata, H.; Koepsel, R.; Russell, A.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Undeniable increase in osteoporotic fractures is associated mainly with the global population aging. Age-related alterations shift bone metabolism to induced osteoclastic activity and reduction of osteoblasts that ...