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Browsing Abstracts by Issue Date

Browsing Abstracts by Issue Date

Now showing items 21-40 of 89

Effectiveness of pulic screening for glaucoma in republic of Kazakhstan

Tashtitova, L.B.; Botabekova, Т.К.; Aldasheva, N.A.; Uteuliyev, E.S. (2016-05)

In the Republic of Kazakhstan (RK) glaucoma is the second place ranking in the structure of primary disability on eyesight. In 80.2% of cases-these are invalids of the first or second group (Islamova S.E., 2009). In 2010 ...
MSCS functionalized with osteophilis polymer enhance compact bone regeneration in osteoporotics rat model in vivo

Safarova (Yantsen), Y.; OIzhayev, F.; ldrissova, D.; Umbayev, B.; Murata, H.; Koepsel, R.; Russell, A.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Undeniable increase in osteoporotic fractures is associated mainly with the global population aging. Age-related alterations shift bone metabolism to induced osteoclastic activity and reduction of osteoblasts that ...
Apolipoprotein E genetic variation and statin therapy appointment

Kassenova, A.; Kossumov, A.; Nurgozhin, T.; Supiyev, A. (2016-05)

Dyslipidemia is an important risk factor for cardiovascular disease due to the significant influence of cholesterol on atherosclerosis. Several genetic variants in genes related with triglyceride (TG) metabolism has been ...
Identification of therapeutic targets for chemotherapy-resistant colon cancer stem cells

Francipane, M. G.; Bulanin, D.; Lagasse, E. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Current first-line chemotherapy generally consists of cytotoxic agents. While these agents may initially control disease by effectively debulking tumors, the tumors invariably recur due to the ability of cancer stem cells ...
Generation of hepatocyte-like cells from human pluripotent stem cells

Sekenova, A.; Kumasheva, V.; Li, Ye.; Baidosova, Sh.; Ogay, V. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

The demand for donor livers in transplantation medicine continues to increase every year with the difficulties in finding compatible human hepatocytes. Therefore, generation of patient specific human hepatocytes from ...
Establishment of small cell lung cancer cell lines and validation of their growth characteristics

Alimbetov, D.; Idrissova, D.; Davis, T.; Kipling, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Rapidly metastasizing lung cancer is the top killer in the United States and many other countries. In 2014, there were nearly 224 210 new cases of lung cancer and 159 260 predicted mortality from the disease in the US ...
Isolation and enrichment of rat bone marrow mesenchymal stem cells

Baidosova, S.; Kumasheva, V.; Kerimbayev, T.; Aleynikov, V.; Aldiyarova, N.; Ogay, Vyacheslav (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Mesenchymal stem cells (MSCs) are a promising tool for cell therapy, because of their specific characteristics, which mimic partially those of embryonic stem cells, but with some advantages in terms of availability, ...
Astroprotective potential of extract from limonium gmelinii for stroke therapy

Shayakhmetov, Y.; Tsoy, A.; Zhussupova, G.; Askarova, Sh. (2016-05)

It's known that proinflammatory cytokines, such asTNF-a, produced by injured neurons and infiltrated leukocytes, involved in every aspect of stroke. Cytokines promote activation of astroglia, induce oxidative stress ...
Morphometric characteristics of cancer cells grown in embryonic microenvironment and under antiviral treatment

Shaimerdenova, M.; Karapina, O.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Aggressive cancer cells express markers of multipotent stem cells and tightly interconnect with its surrounding microenvironment, by which the differential plasticity of cancer cells and also its carcinogenicity is ...
Rapid evaluation of DNA damage with comet assay in combination of high throughput microscopy

Baiskhanova, D.; Bobrova, X.; Kauanova, S.; Begimbetova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Comet assay is well known method for DNA damage evaluation. However, it also possesses some limitations related to the problem with manual entry of each comet for analysis that decreases the performance and measurement ...
A targeted sequencing reveal overlapping pattern of genetic variants in patients with cardiomyopathy with cardiac arrhythmias in Kazakhstan

Akilzhanova, A.; Guelly, Ch.; Abilova, Zh.; Rakhimova, S.; Akhmetova, A.; Kairov, U.; Nuralinov, O.; Rashbayeva, G.; Trajanoski, S.; Zhumadilov, Zh.; Bebosynova, M. (2016-05)

Ventricular tachycardia (VT) is a common symptom in cardiac disorders of different etiology. Abnormalities of ion channels are attributed to mutations in the genes encoding the channel protein and cause altered function ...
Anticancer effects of leech extract on breast cancer cells

Murzakhmetova, S.; Janzakova, D.; Mektepbayeva, D. (2016-05)

Throughout the history of humanity, leech therapy appeared as a procedure in medicine all over the world. The very first use of leech in human treatment was mentioned in Eqypt 3500 years ago. In 2004, Food and Drug ...
Glial cells and their molecules in nerve regeneration

Riethmacher, D. (2016-05)

Peripheral nerve injury has many causes ranging from traumatic damage to metabolic disturbances (e.g.in diabetes mellitus). The primary pathology can affect axons (nerve transection) or Schwann cells, and their interdependence ...
Bio-medical applications of ultrasound

Saliev, T. (2016-05)

Despite of the classical perception of an ultrasound as a diagnostic modality, it possesses a great potential for therapeutic applications. In the range of experimental studies it has been shown that the ultrasound is ...
c-Met signaling as a promise of targeted therapy in glioblastoma tumor

Xie, Y.; Istayeva, Sh.; Tokay, T.; Zhumadilov, Zh.; Chen, Zh. (2016-05)
Cancer cells response on the microtubuler-inhibiting drugs

Balabiyev, A.; Kakpenova, A.; Kauanova, S.; Vorobjev, I.A. (2016-05)

Cancer is one of the age-related diseases with detrimental impact on people survival. Improvement of cancer therapies is a major focus of many scientists around the world. Anticancer drugs based on the microtubules ...
Assessment of nutritional status of elderly and senile age people

Doszhanova, G.N.; Abduldayeva, A.A.; Dalenov, E.D. (2016-05)

Introduction: A healthy nutrition is a predictor of active longevity, contributing to improve the life span and quality of life. Objective: To evaluate the nutritional status of elderly people living in Astana, depending ...
Adiponectin plasma levels in patients with age-related dementia

Kaiyrlykyzy, A.; Umbayev, B.; Masoud, A.; Shramko, A.; Idrissova, D.; Zhussupova, A.; Alzhanova, D.; Alimbetov, D.; Askarova, S. (2016-05)

Adiponectin play a significant role in the regulation of type 2 diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease and neurodegenerative disorders. Evidence suggests that adiponectin may be an independent ...
Biomechanical properties of collagens studied by brillouin light scattering spectroscopy and atomic force microscopy

Akilbekova, D.; Alimzhanov, D.; Utegulov, Zh. (2016-05)

Collagen is the most abundant protein in the human body and the main component of highly organized tissue structures. Its fibrillar structure is responsible for biomechanical anisotropies in the tissues and their exceptional ...
Results of the study of biological subtypes of breast cancer

Tailakov, B.B.; Tuleutaev, M.E.; Pirozhenko, O.P.; Gubskaya, E.B.; Orazbekov, B.S.; Balhozhaeva, A.A.; Zhukov, Y.; Rutzhanuly, I.R.; Omarov, M.H.; Makis, R.T.; Tusupbekov, E.H.; Ermagambetova, A.T. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Identification of biological subtypes of breast cancer using immunohistochemical tumor markers: ER and RP receptor, Ki67, Her-2 / neu is a modern criterion for the development of optimal therapies for the breast cancer.