• MESENCHYMAL STEM CELLS COATED WITH SYNTHETIC BONE-TARGETING POLYMERS ENHANCE OSTEOPOROTIC BONE FRACTURE REGENERATION 

  Safarova, Yuliya; Olzhayev, Farkhad; Umbayev, Bauyrzhan; Tsoy, Andrey; Hortelano, Gonzalo; Tokay, Tursonjan; Murata, Hironobu; Russell, Alan; Askarova, Sholpan (MDPI AG, 2020-10-12)

  Osteoporosis is a progressive skeletal disease characterized by reduced bone density leading to bone fragility and an elevated risk of bone fractures. In osteoporotic conditions, decrease in bone density happens due to the ...
• PLANT EXTRACT OF LIMONIUM GMELINII ATTENUATES OXIDATIVE RESPONSES IN NEURONS, ASTROCYTES, AND CEREBRAL ENDOTHELIAL CELLS IN VITRO AND IMPROVES MOTOR FUNCTIONS OF RATS AFTER MIDDLE CEREBRAL ARTERY OCCLUSION 

  Nurkenov, Tulendy; Tsoy, Andrey; Olzhayev, Farkhad; Abzhanova, Elvira; Turgambayeva, Anel; Zhussupova, Aizhan; Avula, Bharathi; Ross, Samir; Aituarova, Aigerim; Kassymova, Dariya; Zhusupova, Galiya; Shalakhmetova, Tamara; Tokay, Tursonjan; Lee, James C.; Askarova, Sholpan (MDPI, 2021-11-15)

  There are numerous publications demonstrating that plant polyphenols can reduce oxidative stress and inflammatory processes in the brain. In the present study we have investigated the neuroprotective effect of plant extract ...
• GALACTOSE-INDUCED SKIN AGING: THE ROLE OF OXIDATIVE STRESS 

  Umbayev, Bauyrzhan; Askarova, Sholpan; Almabayeva, Aigul; Saliev, Timur; Masoud, Abdul-Razak; Bulanin, Denis (Hindawi, 2020-06-17)

  Skin aging has been associated with a higher dietary intake of carbohydrates, particularly glucose and galactose. In fact, the carbohydrates are capable of damaging the skin’s vital components through nonenzymatic glycation, ...
• IMPROVEMENT OF NEUROLOGICAL FUNCTION IN RATS WITH ISCHEMIC STROKE BY ADIPOSEDERIVED PERICYTES 

  Ogay, Vyacheslav; Kumasheva, Venera; Li, Yelena; Mukhlis, Sholpan; Sekenova, Aliya; Olzhayev, Farkhad; Tsoy, Andrey; Umbayev, Baurzhan; Askarova, Sholpan; Shpekov, Azat; Kaliyev, Assylbek; Zhetpisbayev, Berik; Makhambetov, Yerbol; Akshulakov, Serik; Saparov, Arman; Ramankulov, Yerlan (SAGE Publications, 2020-09-04)

  Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation ...
• Mesenchymal stem cells modifications for enhanced bone targeting and bone regeneration 

  Safarova, Yuliya; Umbayev, Bauyrzhan; Hortelano, Gonzalo; Askarova, Sholpan (Future Medicine, 2020-04-16)

  In pathological bone conditions (e.g., osteoporotic fractures or critical size bone defects), increasing the pool of osteoblast progenitor cells is a promising therapeutic approach to facilitate bone healing. Since mesenchymal ...
• ИЗУЧЕНИЕ ФЕНОЛЬНЫХ СОЕДИНЕНИЙ ЯГОД ТРЕХ ВИДОВ РАСТЕНИЙ РОДА VACCINIUM, ПРОИЗРАСТАЮЩИХ В ХАНТЫМАНСИЙСКОМ АВТОНОМНОМ ОКРУГЕ 

  Gulyayev, Alexandr; Гуляев, Александр; Белова, Екатерина; Тритэк, Владислав; Шульгау, Зарина; Кривых, Елена; Коваленко, Людмила; Дренин, Алексей; Ботиров, Эркин (Алтайский государственный университет, 2020-03-05)

  Впервые проведено исследование химического состава полифенольных соединений плодов клюквы (Vaccinium oxycoccus L.), черники (Vaccinium myrtillus L.) и брусники (Vaccinium vitis-idaea L.), произрастающих на территории ...
• The Links Between the Gut Microbiome, Aging, Modern Lifestyle and Alzheimer's Disease 

  Askarova, Sholpan; Umbayev, Bauyrzhan; Masoud, Abdul-Razak; Kaiyrlykyzy, Aiym; Safarova, Yuliya; Tsoy, Andrey; Olzhayev, Farkhad; Kushugulova, Almagul R. (Frontiers Media, 2020-03-18)

  Gut microbiome is a community of microorganisms in the gastrointestinal tract. These bacteria have a tremendous impact on the human physiology in healthy individuals and during an illness. Intestinal microbiome can influence ...
• Статины: потенциал в лечении болезни альцгеймера 

  Askarova, S.; Adambekov, S.; Tsoy, A.; Isayeva, R.; Shalakhmetova, T. (Al-Farabi Kazakh National University, 2015-04)

  Болезнь Альцгеймера (БА) является широко распространённым хроническим нейродегенеративным заболеванием, поражающим людей в возрасте 65 лет и старше, против которого до сих пор не разработано эффективных методов лечения. ...
• Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting 

  D'Souza, Sonia; Murata, Hironobu; Jose, Moncy V.; Askarova, Sholpan; Yantsen, Yuliya; Andersen, Jill D.; Edington, Collin D.J.; Clafshenkel, William P.; Koepsel, Richard R.; Russell, Alan J. (Biomaterials, 2014-11-01)

  Abstract The field of polymer-based membrane engineering has expanded since we first demonstrated the reaction of N-hydroxysuccinimide ester-terminated polymers with cells and tissues almost two decades ago. One remaining ...
• Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System 

  Han, Bo; Tokay, Tursonjan; Zhang, Guangming; Sun, Peng; Hou, Shangwei (Oxidative Medicine and Cellular Longevity, 2017-03-06)

  Ether-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the ...
• Клеточные технологии в трансплантации почки / Cell technologies in renal transplantation 

  Momynaliev (Момыналиев), K.T. (К.Т.); Ogay (Огай), Vyacheslav (Вячеслав); Khoroshun (Хорошун), E.V. (Е.В.); Babenko (Бабенко), N.N. (Н.Н.); Kaabak (Каабак), М.М. (M.M.) (Нефрология и диализ, 2014-04)

  местительной терапии при хронической почечной недостаточности в терминальной стадии. Благодаря современным иммунодепрессантам, резко повысилась краткосрочная выживаемость пациентов и трансплантата. Однако долгосрочная ...
• Саморегуляция раковых стволовых клеток толстой кишки / Colon cancer stem cells self regulation 

  Ogay (Огай), Vyacheslav (Вячеслав) (Вестник КазНУ. Серия биологическая. №1/1 (60). 2014, 2014)

  Colon cancer high death rate and low percentage of recovery depend on tumor initiating cancer stem cells (CSCs). CSCs have ability such as survival in stress condition, absence of sensitivity to apoptose. These properties ...
• Паракринные регуляторы раковых стволовых клеток толстой кишки / Paracrine regulators of colon cancer stem cells 

  Ogay (Огай), Vyacheslav (Вячеслав); Issabekova (Исабекова), A.S. (А.С.) (Вестник КазНУ. Серия биологическая, 2014)

  Раковые стволовые клетки основная причина возобновления болезни после лечения. Для эффективной борьбы с этими клетками необходимо понимание механизмов выживание этих клеток и их стимуляторов. В данной работе оценено влияние ...
• Bonghan Ducts as Possible Pathways for Cancer Metastasis 

  Yoo, Jung Sun; Kim, Hong Bae; Ogay, Vyacheslav; Lee, Byung-Cheon; Ahn, Saeyoung; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-04-01)

  Objective: The present study has been designed to find a possible new route for the metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique of trypan blue staining. Materials and Methods: ...
• Visualization of Bonghan Microcells by Electron and Atomic Force Microscopy 

  Baik, Ku Youn; Ogay, Vyacheslav; Jeoung, Sae Chae; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-04-13)

  Objectives: The origin of adult stem cells remains an open question. If they derive from embryos, it is difficult to determine the mechanism which interrupts their differentiation during tissue formation. In the 1960s, ...
• Comparison of the characteristic features of bonghan ducts, blood and lymphatic capillaries 

  Ogay, Vyacheslav; Bae, Kyung Hee; Kim, Ki Woo; Soh, Kwang-sup (Journal of Acupuncture and Meridian Studies, 2009-03-31)

  Objective: To show that the characteristic morphological and ultrastructural features of a Bonghan corpuscle and duct presented here are consistent with the description given in the early reports of Bonghan Kim. Materials ...
• Electrical сharacterization of proposed transpositional acupoints on the Urinary Bladder Meridian in a Rat Model 

  Han, Hyun-Jung; Park, Sang-Jun; Soh, Kwang-sup; Myoung, Hyoun-Seok; Lee, Kyoung-Joung; Ogay, Vyacheslav; Lee, Yong-Heum (Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine., 2011)

  Specific electrical characteristicsof acupointswere investigated on the urinary bladder (BL) meridian in 14 rats. BL acupointsand non-acupoints on the back were selected and their electrical voltages were measured by using ...
• First experience of using biological prosthesis "UniLine" for correction of heart valve diseases 

  Zhurko, S.; Olzhayev, F.; Chiginev, V.; Fedorov, S. (Personalized medicine and Global Health, 2015)

  To conduct a clinical study of immediate results, assessment of hemodynamic characteristics of developed a new biological stented prosthesis «UniLine» (Russia, Kemerovo) designed for correction of heart valve lesions of ...
• Perinatal outcomes in preterm premature rupture of membranes 

  Chuvakova, T.; Bapayeva, G.; Issayeva, R.; Begimbetova, D.; Olzhayev, F.; Dzhamanaeva, K.; Kenbaeva, K. (Personalized medicine and Global Health, 2015)

  Preterm premature rupture of membranes (PPROM) is one of the leading causes of perinatal morbidity and mortality. Intrauterine continuous amnioinfusion via a subcutaneously implanted port system for PPROM is an attempt ...
• Evaluation of amino acid level in the blood of fetuses and newborns with intrauterine growth restriction 

  Chuvakova, T.; Bapayeva, G.; Issayeva, R.; Olzhayev, F.; Dzhamanaeva, K.; Kenbaeva, K. (Personalized medicine and Global Health, 2015)

  The processes of growth of the fetus are provided by a constant supply of amino acids from mother, which provides the production of proteins and muscle tissue of the fetus. The purpose of this research was to study the ...

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