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Browsing 02.National Laboratory Astana by Author "7b8baf46-e022-4381-85b6-b7b262dac10d"

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Assessing reproducibility of matrix factorization methods in independent transcriptomes

Cantini, Laura; Kairov, Ulykbek; de Reynies, Aurelien; Barillot, Emmanuel; Radvanyi, Francois; Zinovyev, Andrei (OXFORD UNIV PRESS, 2019)

Motivation Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on ...
GENETIC VARIANTS, METABOLOME, AND GUT MICROBIOME BIOMARKERS FOR OBESITY AND AGING IN RANDOMLY SELECTED KAZAKH INDIVIDUALS

Akilzhanova, Ainur; Rakhimova, Saule; Kozhamkulov, Ulan; Kairov, Ulykbek; Kushugulova, Almagul R.; Terwilliger, Joseph; Lee, Joseph (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Objective: Metabolic syndrome (MS) is a cluster of inter-related and heritable metabolic traits, which collectively impart unsurpassed risk for atherosclerotic cardiovascular disease and type 2diabetes. Considerable work ...
Independent Component Analysis for Unraveling the Complexity of Cancer Omics Datasets

Sompairac, Nicolas; Nazarov, Petr V.; Czerwinska, Urszula; Cantini, Laura; Biton, Anne; Molkenov, Askhat; Zhumadilov, Zhaxybay; Barillot, Emmanuel; Radvanyi, Francois; Gorban, Alexander; Kairov, Ulykbek; Zinovyev, Andrei (MDPI, 2019-09-02)

Independent component analysis (ICA) is a matrix factorization approach where the signals captured by each individual matrix factors are optimized to become as mutually independent as possible. Initially suggested for ...
PATIENTS WITH CORONARY HEART DISEASE, DILATED CARDIOMYOPATHY AND IDIOPATHIC VENTRICULAR TACHYCARDIA SHARE OVERLAPPING PATTERNS OF PATHOGENIC VARIATION IN CARDIAC RISK GENES

Guelly, Christian; Abilova, Zhannur; Nuralinov, Omirbek; Panzitt, Katrin; Akhmetova, Ainur; Rakhimova, Saule; Kozhamkulov, Ulan; Kairov, Ulykbek; Molkenov, Askhat; Seisenova, Ainur; Trajanoski, Slave; Abildinova, Gulzhaina; Kaussova, Galina; Windpassinger, Christian; Lee, Joseph H.; Zhumadilov, Zhaxybay; Bekbossynova, Makhabbat; Akilzhanova, Ainur (PeerJ, 2021-01)

Background Ventricular tachycardia (VT) is a major cause of sudden cardiac death (SCD). Clinical investigations can sometimes fail to identify the underlying cause of VT and the event is classified as idiopathic (iVT). ...
RE-SEARCHER: GUI-BASED BIOINFORMATICS TOOL FOR SIMPLIFIED GENOMICS DATA MINING OF VCF FILES

Karabayev, Daniyar; Molkenov, Askhat; Yerulanuly, Kaiyrgali; Kabimoldayev, Ilyas; Daniyarov, Asset; Sharip, Aigul; Seisenova, Ainur; Zhumadilov, Zhaxybay; Kairov, Ulykbek (PeerJ Inc., 2021-05-03)

Background. High-throughput sequencing platforms generate a massive amount of high-dimensional genomic datasets that are available for analysis. Modern and user-friendly bioinformatics tools for analysis and interpretation ...
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution

Kairov, Ulykbek; Aynaud, Marie-Ming; Mirabeau, Olivier; Gruel, Nadege; Grossetête, Sandrine; Boeva, Valentina; Durand, Simon; Surdez, Didier; Zaïdi, Sakina; Gribkova, Svetlana; Fouché, Aziz; Raynal, Virginie; Tirode, Franck; Grünewald, Thomas G P; Bohec, Mylene; Baulande, Sylvain; Janoueix-Lerosey, Isabelle; Vert, Jean-Philippe; Barillot, Emmanuel (Cell Press, 2020-02-11)

EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the ...
A USER-FRIENDLY TOOL FOR SIMPLIFIED GENOMICS DATA MINING FROM LARGE VCF FILES

Karabayev, Daniyar; Molkenov, Askhat; Yerulanuly, Kaiyrgali; Daniyarov, Asset; Sharip, Aigul; Seisenova, Ainur; Zhumadilov, Zhaxybay; Kairov, Ulykbek (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: High-throughput sequencing platforms generate a massive amount of high-dimensional genomic datasets that are available for analysis. Modern and user-friendly bioinformatics tools for analysis and interpretation ...
WHOLE GENOME SEQUENCE DATA OF MYCOBACTERIUM TUBERCULOSIS XDR STRAIN, ISOLATED FROM PATIENT IN KAZAKHSTAN

Daniyarov, Asset; Molkenov, Askhat; Rakhimova, Saule; Akhmetova, Ainur; Nurkina, Zhannur; Yerezhepov, Dauren; Chingissova, Lyailya; Bismilda, Venera; Toxanbaeva, Bekzat; Akilzhanova, Ainur; Kozhamkulov, Ulan; Kairov, Ulykbek (Elsevier, 2020-12)

Drug-resistant tuberculosis (TB) is a major public health problem. Clinical Mycobacterium tuberculosis (MTB) isolate with Extensively drug-resistant tuberculosis (MTB-XDR) profile was subjected to whole-genome sequencing ...
WHOLE-GENOME SEQUENCING AND GENOMIC VARIANT ANALYSIS OF KAZAKH INDIVIDUALS

Kairov, Ulykbek; Molkenov, Askhat; Rhie, Arang; Rakhimova, Saule; Yoo, Seong-Keun; Kozhamkulov, Ulan; Sharip, Aigul; Akhmetova, Ainur; Abilmazhinova, Aliya; Zhalbinova, Madina; Yerezhepov, Dauren; Zhabagin, Maxat; Shin, Jeongeon; Kharchenko, Peter; Kim, Jong-Il; Lee, Joseph; Seo, Jeong-Sun; Akilzhanova, Ainur; Zhumadilov, Zhaxybay (International conference "MODERN PERSPECTIVES FOR BIOMEDICAL SCIENCES: FROM BENCH TO BEDSIDE”; National Laboratory Astana, 2020)

Introduction: Kazakhstan is the multi-ethnic country with the dominant Kazakh ethnic group in the middle of the Eurasian continent. All existing human genetic diversity datasets are only partial representations of worldwide ...
WHOLE-GENOME SEQUENCING DATA OF KAZAKH INDIVIDUALS

Kairov, Ulykbek; Molkenov, Askhat; Rakhimova, Saule; Kozhamkulov, Ulan; Sharip, Aigul; Karabayev, Daniyar; Daniyarov, Asset; Lee, Joseph H.; Terwilliger, Joseph D.; Akilzhanova, Ainur; Zhumadilov, Zhaxybay (BioMed Central Ltd, 2021-02-04)

Objectives: Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today ...