• TARGETED DELIVERY OF CYTOKINES, GROWTH FACTORS AND PRE-DIFFERENTIATED CELLS FOR MI TREATMENT 

  Raziyeva, Kamila (Nazarbayev University School of Medicine, 2023-12)

  Following myocardial infarction (MI), cardiac tissue undergoes irreversible cellular alterations, with cardiomyocytes being replaced by fibrotic tissue. To combat this our lab synthesized a novel chitosan-based cryogel ...
• THE AXL INHIBITOR TP-0903 AND ARTESUNATE SYNERGISE TO INDUCE REACTIVE OXYGEN SPECIES, DNA DAMAGE AND APOPTOSIS IN TRIPLE NEGATIVE BREAST CANCER CELLS 

  Terragno, Mirko (Nazarbayev University School of Medicine, 2024-01)

  Triple Negative Breast Cancer (TNBC) is an aggressive, often rapidly growing form of breast cancer. TNBC usually displays a basal molecular phenotype that associates with epithelial mesenchymal transition (EMT), a cellular ...
• PERIOSTIN IN INFLAMMATORY BOWEL DISEASE (IBD) DEVELOPMENT AND SYNERGISTIC EFFECTS MEDIATED VIA CCL5 

  Mukanova, Saida (School of Medicine, 2023)

  Inflammatory bowel disease (IBD) is characterized by chronic inflammation in any part of the gastrointestinal tract (Ulcerative colitis and Crohn’s disease) and leads to severe damage mostly of small and/or large intestines. ...
• EVALUATING TREND ANALYSIS IN THE PERFORMANCE OF ALMATY MARATHON RUNNERS FROM 2016 TO 2021 

  Abilkhassenov, Adil (School of Medicine, 2023)

  The aim of the present study was to investigate trends in performance and participation of Almaty Marathon since 2016 to 2021. We analyzed 48 885 runners from different region, including Kazakhstan as individual region, ...
• BARRIERS AND FACILITATORS OF MARATHON TRAINING IN KAZAKHSTAN 

  Mirali, Altynay (School of Medicine, 2023)

  Purpose: To examine the barriers and facilitators of marathon training among non-elite athletes in Kazakhstan. Methods: A cross-sectional survey was conducted using a validated questionnaire on a purposely selected ...
• THE COMPARATIVE TRANSCRIPTOME ANALYSIS OF SHORT- AND LONG-TERM EFFECTS OF ENDURANCE EXERCISE 

  Alpyssova, Shakhara (School of Medicine, 2023)

  Transcriptomics studies the complete set of RNA and expression levels of mRNAs in a genome, which is widely used in expression profiling. [1] Transcriptomics used for observing the variation in gene expression through ...
• PROGNOSIS OF THE DIABETES TYPE II USING MACHINE LEARNING TECHNOLOGY 

  Shungeyev, Amanzhol (School of Medicine, 2023)

  The annual statistics of the incidence of diabetes mellitus shows a stable growth. Most diabetics are not aware of their diagnosis and the risks that this disease carries. Also, an important problem is playing sports in ...
• OPTIMIZATION OF ANALYSIS OF POPULAR DOPING SUBSTANCES USING ULTRA HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) AND GAS CHROMATOGRAPHY - MASS SPECTROMETRY (GC-MS) METHODS 

  Bissarinov, Zhandos (School of Medicine, 2023)

  Use of the prohibited and potentially dangerous substances in sports has become an actual problem for sports world. According to the list of sanctioned athletes, provided by Kazakhstan National Anti-Doping Centre. [1][3] ...
• THE COMPARATIVE METHYLOME ANALYSIS AFTER ACUTE ENDURANCE EXERCISE 

  Toktarbay, Bauyrzhan (School of Medicine, 2023)

  One of the processes of epigenetic modifications is DNA methylation. It is an epigenetic mechanism in which a methyl group is added to a cytosine's C5 position to produce 5-methylcytosine [1]. The most prevalent sites for ...
• A QUALITATIVE EXPLORATION OF THE IMPACT OF ACTIVITIES UNDERTAKEN USING IMMERSIVE VIRTUAL REALITY ON MENTAL WELL-BEING. 

  Ardakuly, Issa Emir (School of Medicine, 2023)

  Research question/objective and design: This is a phenomenological study. Aim of the study is to make a qualitative exploration of the impact of activities undertaken using Immersive Virtual Reality set on mental well-being. ...
• A QUALITATIVE EXPLORATION OF GYM USERS EXPERIENCE OF USING A VIRTUAL REALITY WARM-UP ROUTINE BEFORE TRAINING 

  Abdibayeva, Amina (School of Medicine, 2023)

  Research objective: The main objective of this research is in-depth exploration of people's experience of using Virtual Reality technology on warm-up routine before training in the gym. Virtual Reality is widely used in ...
• PARENT-MEDIATED PHYSICAL ACTIVITY INTERVENTION FOR CHILDREN WITH AUTISM SPECTRUM DISORDER 

  Bissarinova, Aiym (School of Medicine, 2023-03)

  Autism spectrum disorders (ASD) are a diverse set of neurodevelopmental problems with restricted patterns of behavior, interests, and activities as well as difficulties in social interaction and communication (Calderoni, ...
• THE EFFECT OF RADIATION ON THE INCIDENCE AND MORTALITY FROM SOLID CANCER IN EAST KAZAKHSTAN AND PAVLODAR REGIONS, KAZAKHSTAN 

  Akhanov, Ualsher (School of Medicine, 2023-04)

  Semey (Semipalatinsk) Nuclear Test Site (SNTS) presents a substantive importance for interdisciplinary research in fields of radiology, radiation protection and environmental health. The potential effect of nuclear testing ...
• COMBINED SUPPLEMENTATION OF COENZYME Q10 AND OTHER NUTRIENTS IN SPECIFIC MEDICAL CONDITIONS 

  Tippairote, Torsak; Bjørklund, Geir; Gasmi, Amin; Semenova, Yuliya; Peana, Massimiliano; Chirumbolo, Salvatore; Hangan, Tony (Nutrients, 2022)

  Coenzyme Q10 (CoQ10) is a compound with a crucial role in mitochondrial bioenergetics and membrane antioxidant protection. Despite the ubiquitous endogenous biosynthesis, specific medical conditions are associated with ...
• CELIAC DISEASE AND GALLBLADDER: PATHOPHYSIOLOGICAL ASPECTS AND CLINICAL ISSUES 

  Poddighe, Dimitri; Dossybayeva, Kuanysh; Abdukhakimova, Diyora; Akhmaltdinova, Lyudmila; Ibrayeva, Aigul (Nutrients, 2022)

  Celiac Disease (CD) is an immune-mediated disorder which primarily affects the small intestine; however, extra-intestinal organs are often affected by the pathological process, too. As regards the digestive system, liver ...
• IN SITU TRANSFORMATION OF ELECTROSPUN NANOFIBERS INTO NANOFIBER-REINFORCED HYDROGELS 

  Martin, Alma; Nyman, Jenny Natalie; Reinholdt, Rikke; Cai, Jun; Schaedel, Anna-Lena; J. A. van der Plas, Mariena; Malmsten, Martin; Rades, Thomas; Heinz, Andrea (Nanomaterials, 2022)

  Nanofiber-reinforced hydrogels have recently gained attention in biomedical engineering. Such three-dimensional scaffolds show the mechanical strength and toughness of fibers while benefiting from the cooling and absorbing ...
• INTERACTIONS OF APIGENIN AND SAFRANAL WITH THE 5HT1A AND 5HT2A RECEPTORS AND BEHAVIORAL EFFECTS IN DEPRESSION AND ANXIETY: A MOLECULAR DOCKING, LIPID-MEDIATED MOLECULAR DYNAMICS, AND IN VIVO ANALYSIS 

  Amin, Faiq; Ibrahim, Mahmoud A. A.; Rizwan-ul-Hasan, Syed; Khaliq, Saima; Gabr, Gamal A.; Khan, Asra; Sidhom, Peter A.; Tikmani, Prashant; Shawky, Ahmed M.; Ahmad, Saara; Abidi, Syed Hani (Molecules, 2022)

  The current study utilizes in silico molecular docking/molecular dynamics to evaluate the binding affinity of apigenin and safranal with 5HT1AR/5HT2AR, followed by assessment of in vivo effects of these compounds on ...
• ANALYSIS OF THE ANTIMICROBIAL AND ANTI-BIOFILM ACTIVITY OF NATURAL COMPOUNDS AND THEIR ANALOGUES AGAINST STAPHYLOCOCCUS AUREUS ISOLATES 

  Mastoor, Sobia; Nazim, Fizza; Rizwan-ul-Hasan, Syed; Ahmed, Khalid; Khan, Shabnam; Nawazish Ali, Syed; Abidi, Syed Hani (Molecules, 2022)

  Staphylococcus aureus (S. aureus) is one of the most frequent causes of biofilm-associated infections. With the emergence of antibiotic-resistant, especially methicillinresistant S. aureus (MRSA), there is an urgent need ...
• NURSES’ PERCEPTION OF SAFETY CULTURE IN MEDICAL SURGICAL UNITS IN HOSPITALS IN SAUDI ARABIA 

  Alrasheadi, Bader A.; Alamri, Majed S.; Aljohani, Khalid A.; AL-Dossary, Reem; Albaqawi, Hamdan; Alharbi, Jalal; Al Hosis, Khaled; Aljohani, Mohammed S.; Almadani, Noura; Falatah, Rawaih; Alotaibi, Jazi S.; Almazan, Joseph U. (Medicina, 2022)

  Introduction: Patient safety captures the essence of the primary principle of medical ethics, primum non nocere, first do no harm; this is an important concern in the health care system. Nurses are indispensable members ...
• ANTI-INFLAMMATORY, ANTIOXIDANT, AND ANTI-ATHEROSCLEROTIC EFFECTS OF NATURAL SUPPLEMENTS ON PATIENTS WITH FMF-RELATED AA AMYLOIDOSIS: A NON-RANDOMIZED 24-WEEK OPEN-LABEL INTERVENTIONAL STUDY 

  Romano, Micol; Garcia-Bournissen, Facundo; Piskin, David; Rodoplu, Ulkumen; Piskin, Lizzy; Elzagallaai, Abdelbaset A.; Tuncer, Tunc; Sezer, Siren; Ucuncuoglu, Didar; Honca, Tevfik; Poddighe, Dimitri; Yavuz, Izzet; Stenvinkel, Peter; Yilmaz, Mahmut Ilker; Demirkaya, Erkan (life, 2022)

  We aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with ...

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