Research Institute of Experimental and Clinical Pharmacology and Pharmacy
http://nur.nu.edu.kz:80/handle/123456789/1124
2024-03-29T06:49:04ZPCN99 Cost-Effectiveness Evaluation of Sunitinib as First-Line Targeted Therapy for Metastatic Renal Cell Carcinoma in Kazakhstan
http://nur.nu.edu.kz:80/handle/123456789/2888
PCN99 Cost-Effectiveness Evaluation of Sunitinib as First-Line Targeted Therapy for Metastatic Renal Cell Carcinoma in Kazakhstan
Kostyuk, A.; Nurgozhin, T.; Mazhitov, T.; Almadiyeva, A.
2014-05-01T00:00:00ZCardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy
http://nur.nu.edu.kz:80/handle/123456789/2880
Cardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy
Shulgau, Z.; Gulyayev, A.; Yermekbayeva, B.; Adilgozhina, G.; Tritek, V.; Nurgozhin, T.
Present study aimed to investigate possible cardioprotective properties of polyphenol concentrates obtained from Cabernet Sauvignon type of Kazakhstani grapes using rat model doxorubicin-induced cardiomyopathy.
2015-08-01T00:00:00ZCytisin Amidophosphate – Promising Role for The Liver Treatment
http://nur.nu.edu.kz:80/handle/123456789/2878
Cytisin Amidophosphate – Promising Role for The Liver Treatment
Gulyayev, A.; Shulgau, Z.; Yermekbayeva, B.; Sergazy, S.; Nurgozhin, T.
2015-08-01T00:00:00ZPCN14 A Pharmacoeconomic Appraisal of Cabazitaxel Versus Abiraterone for the Second-Line Treatment of Patients with Metastatic Hormone-Refractory Prostate Cancer (MHRPC) Progressing After the Treatment with Docetaxel: a Systematic Review
http://nur.nu.edu.kz:80/handle/123456789/2871
PCN14 A Pharmacoeconomic Appraisal of Cabazitaxel Versus Abiraterone for the Second-Line Treatment of Patients with Metastatic Hormone-Refractory Prostate Cancer (MHRPC) Progressing After the Treatment with Docetaxel: a Systematic Review
Bektur, C.; Nurgozhin, T.
2014-05-01T00:00:00ZLong-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy
http://nur.nu.edu.kz:80/handle/123456789/2764
Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy
Mao, Xiao-Yuan; Tokay, Tursonjan; Zhou, Hong-Hao; Jin, Wei-Lin
Epileptic seizures are frequently caused by brain tumors. Traditional anti-epileptic treatments do not acquire satisfactory responses. Preoperative and postoperative seizures seriously influence the quality of life of patients. Thus, tumor-associated
epilepsy (TAE) is an important subject of the current research. The delineation of the
etiology of epileptogenesis in patients with primary brain tumor may help to find the
novel and effective drug targets for treating this disease. In this review, we describe
the current status of treatment of TAE. More importantly, we focus on the factors
that are involved in the functional connectivity between tumors and stromal cells.
We propose that there exist two modes, namely, long-range and short-range modes,
which likely trigger neuronal hyperexcitation and subsequent epileptic seizures. The
long-range mode is referred to as factors released by tumors including glutamate
and GABA, binding to the corresponding receptor on the cellular membrane and
causing neuronal hyperactivity, while the short-range mode is considered to involve
direct intracellular communication between tumor cells and stromas. Gap junctions
and tunneling nanotube network are involved in cellular interconnections. Future
investigations focused on those two modes may find a potential novel therapeutic
target for treating TAE.
2016-03-07T00:00:00Z