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Browsing by Author "Umbayev, B."

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Activation of cell ageing pathways with novel small molecules for cancer treatment

Masoud, A.; Brook, A.; Davis, T.; Umbayev, B.; Tsoy, A.; Askarova, Sh.; Kipling, D.; Alimbetov, D. (National Laboratory Astana, Nazarbayev University, 2017-09-15)
Adiponectin plasma levels in patients with age-related dementia

Kaiyrlykyzy, A.; Umbayev, B.; Masoud, A.; Shramko, A.; Idrissova, D.; Zhussupova, A.; Alzhanova, D.; Alimbetov, D.; Askarova, S. (2016-05)

Adiponectin play a significant role in the regulation of type 2 diabetes, obesity, atherosclerosis, non-alcoholic fatty liver disease and neurodegenerative disorders. Evidence suggests that adiponectin may be an independent ...
Assesing the cytokine content of human platelet-rich plasma

Masoud, A.; Umbayev, B.; Olzhayev, F.; Idrissova, D.; Shramko, A.; Kaiyrlykyzy, A.; Askarova, Sh. (2016-05)

Human platelet-rich plasma (PRP) is plasma that is enriched with thrombocytes at a concentration of 1000 * 109 per litre, higher than normal (150 - 350 * 109 per litre). Thrombocytes are known to contain growth factors ...
Biocompatibility of new thermoreversible poloxamer 407-based hydrogels

Masoud, A.; Olzhayev, F.; Askarova, Sh.; Shramko, A.; Sadyrbekov, D.; Safarova, Y.; Tsoy, A.; Umbayev, B. (National Laboratory Astana, Nazarbayev University, 2017-09-15)
Cell therapeutic approaches for the treatment of experimentally induced liver fibrosis

Askarova, Sholpan; Umbayev, B.; Tsoy, A.; Bulanin, D.; Ongarbayeva, N.; Shalakhmetova, T. (Nazarbayev University, 2013)

The results of our study provide evidence that HT improved animal survival and liver functions by generating an ectopic hepatic mass inside the Peyer’s patches. These observations point to the conclusion that hepatocyte ...
Differentiation of mesenchymal stem cells into hepatocytes

Ualiyeva, S.; Umbayev, B.; Masoud, A.; Askarova, Sholpan (Nazarbayev University, 2014)

Acute and chronic liver diseases are common in Kazakhstan and other countries. These diseases are known to cause significant disability and death. In many cases, liver transplantation is the last resort for patients with ...
Isolation of primary human hepatocytes from cirrhotic liver

Ualiyeva, S.; Umbayev, B.; Donbay, A.; Askarova, Sholpan (Nazarbayev University, 2014)

Chronic degenerative liver diseases are among most complex social, clinical and epidemiological health problems worldwide. This is due to the steady increase in the incidence and mortality of patients with this pathology. ...
Mesenchymal stem cells and osteophilic polymer as promising agents in bone regeneration

Yantsen, Y.; Idrissova, D.; Olzhayev, F.; Umbayev, B.; Murata, H.; Russell, A.; Askarova, Sh. (Center for Life Sciences, Nazarbayev University, 2014)

Mesenchymal stem cells (MSCs) are an attractive stem cell source for transplantation. MSCs can easily differentiate into osteoblasts and increase in osteoblast number will have positive effect on the bone regeneration in ...
MSCS functionalized with osteophilis polymer enhance compact bone regeneration in osteoporotics rat model in vivo

Safarova (Yantsen), Y.; OIzhayev, F.; ldrissova, D.; Umbayev, B.; Murata, H.; Koepsel, R.; Russell, A.; Askarova, Sh. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Undeniable increase in osteoporotic fractures is associated mainly with the global population aging. Age-related alterations shift bone metabolism to induced osteoclastic activity and reduction of osteoblasts that ...
Osteophilic polymer and mesenchymal stem cells in bone regeneration

Safarova (Yantsen), Y.; Olzhayev, F.; Umbayev, B.; Murata, H.; Russell, A.; Askarova, Sh. (National Laboratory Astana, Nazarbayev University, 2017-09-15)
Research on the bio-distribution of interferon gamma-containing pharmacocytes

Ibrasheva, D.; Idrissova, D.; Umbayev, B.; Masoud, A.; Askarova, Sholpan (Nazarbayev University, 2014)

Viral hepatitis B and C- is a widespread infectious disease of the liver and is a potential threat to human life. Treatment of HCV and HBV requires prolonged (parenteral or oral) administration of antiviral and ...
Restoration of mesenchymal stem cell function using pharmacological agents

Masoud, A.; Umbayev, B.; Shramko, A.; Idrissova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

The extensive characteristics of mesenchymal stem cells (MSCs), especially their capacity to replicate and differentiate into any type of fully developed cell make these cells suitable for use in cell therapy. These cells ...
Role of ROS in AB42 mediated cell surface P-selectin expression and actin polymerization

Tsoy, A.; Askarova, Sholpan; Shalakhmetova, T.; Umbayev, B.; Adambekov, S.; Zhumadilov, Z. (Nazarbayev University, 2014)

Blood-brain barrier dysfunction plays an important role in the onset and progression of Alzheimer's disease (AD). In the AD brains an increased deposition of A(3 in the cerebral vasculature has been found to correlate ...
Role of ROS in AB42 mediated cell surface p-selectin expression and actin polymerization

Tsoy, A.; Askarova, Sholpan; Shalakhmetova, T.; Umbayev, B.; Adambekov, S.; Zhumadilov, Z. (Nazarbayev University, 2013)

The results of our study have indicated that Aβ42 induces expression of P-selectin on the surface of bEnd3 cells and promotes actin polymerization in a time dependent manner, and all these events correlate with ROS generation. ...