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Browsing by Subject "Cancer"

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Cancer cells response on the microtubuler-inhibiting drugs

Balabiyev, A.; Kakpenova, A.; Kauanova, S.; Vorobjev, I.A. (2016-05)

Cancer is one of the age-related diseases with detrimental impact on people survival. Improvement of cancer therapies is a major focus of many scientists around the world. Anticancer drugs based on the microtubules ...
Determining the optimal number of independent components for reproducible transcriptomic data analysis

Kairov, Ulykbek; Cantini, Laura; Greco, Alessandro; Molkenov, Askhat; Czerwinska, Urszula; Barillot, Emmanuel; Zinovyev, Andrei (BioMed Central, 2017)

Background: Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the ...
Disruption of Bcl-2 and Bcl-xL by viral proteins as a possible cause of cancer

Alibek, Kenneth; Irving, Stephanie; Sautbayeva, Zarina; Kakpenova, Ainur; Bekmurzayeva, Aliya; Baiken, Yeldar; Imangali, Nurgul; Shaimerdenova, Madina; Mektepbayeva, Damel; Balabiyev, Arnat; Chinybayeva, Aizada (Infectious Agents and Cancer, 2014)

The Bcl proteins play a critical role in apoptosis, as mutations in family members interfere with normal programmed cell death. Such events can cause cell transformation, potentially leading to cancer. Recent discoveries ...
ENDOMETRIOSIS AND GYNAECOLOGICAL CANCERS: MOLECULAR INSIGHTS BEHIND A COMPLEX MACHINERY

Vetvicka, Vaclav; Fiala, Ludek; Garzon, Simone; Buzzaccarini, Giovanni; Terzic, Milan; Laganà, Antonio Simone (Menopause Review/Przegląd Menopauzalny, 2021)

Endometriosis is described as the presence of both endometrial glandular and stromal cells outside the uterine cavity. A major characterization of this disease is ectopic implantation of endometrial cells with increased ...
Migration characteristics of cell grown in embryonic microenvironment and under antiviral agents

Karapina, O.; Shaimerdenova, M.; Mektepbayeva, D.; Akilbekova, D. (National Laboratory Astana, NAZARBAYEV UNIVERSITY, 2016-05)

Cancer metastasis is a crucial process of spread of cancer cells from the origin of tumor lesion to the tissues and other organs beyond, where new tumor lesions are formed which might be a single kick of event that may ...