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A CARBON DOT-BASED CO-NANOZYME WITH ALKALINE PHOSPHATASE – MECHANISM AND APPLICATION

Fan, Haiyan; Dukenbayev, Kanat; Sun, Qinglei; Khamijan, Medina; Turdaliyev, Akhrorbek; Ysmaiyl, Alibek; Tassanbiyeva, Aigerim; Ma, Cuiping; Xie, Yingqiu (RSC Advances, 2021-10-21)

Elevated levels of alkaline phosphatase (ALP) are associated with bone metastasis, liver cancer, prostate cancer, breast cancer, and many other diseases or stem cell marker. It is therefore of great significance to ...
Dysregulation of YAP by ARF Stimulated with Tea-derived Carbon Nanodots

Xie, Yingqiu; Kauanova, Sholpan; Fan, Haiyan; Sun, Qinglei; Nurkesh, Ayan; Lu, Jiang; Tursynkhan, Darkhan; Yang, Qing; Kassymbek, Aishabibi; Karibayev, Mirat; Duisenova, Korlan; Wang, Xiao; Manarbek, Limara; Maipas, Aisulu; Chen, Zhenbang; Balanay, Mannix P. (Nazarbayev University School of Sciences and Humanities, 2017-11-29)

YAP is a downstream nuclear transcription factor of Hippo pathway which plays an essential role in development, cell growth, organ size and homeostasis. It was previously identified that elevation of YAP in genomics of ...
GENERATION OF PARTICLE ASSEMBLIES MIMICKING ENZYMATIC ACTIVITY BY PROCESSING OF HERBAL FOOD: THE CASE OF RHIZOMA POLYGONATI AND OTHER NATURAL INGREDIENTS IN TRADITIONAL CHINESE MEDICINE

Benassi, Enrico; Fan, Haiyan; Sun, Qinglei; Dukenbayev, Kanat; Wang, Qian; Shaimoldina, Ainur; Tassanbiyeva, Aigerim; Nurtay, Lazzat; Nurkesh, Ayan; Kutzhanova, Aidana; Mu, Chenglin; Dautov, Adilet; RAZBEKOVA, MADINA; Kabylda, Anar; Yang, Qing; Li, Ziye; Amin, Amr; Li, Xugang; Xie, Yingqiu (Royal Society of Chemistry, 2021-01-13)

Processed herbs have been widely used in eastern and western medicine; however, the mechanism of their medicinal effects has not yet been revealed. It is commonly believed that a central role is played by chemically active ...
Nuclear MET requires ARF and is inhibited by carbon nanodots through binding to phospho-tyrosine in prostate cancer

Xie, Yingqiu; Fan, Haiyan; Wenfu, Lu; Yang, Qing; Nurkesh, Ayan; Yeleussizov, Tleubek; Maipas, Aisulu; Lu, Jiang; Manarbek, L.; Chen, Zh.; Benassi, E. (Nazarbayev University School of Sciences and Humanities, 2019-04-18)

Nuclear receptor tyrosine kinases (nRTKs) are aberrantly upregulated in many types of cancers, but the regulation of nRTK remains unclear. We previously showed androgen deprivation therapy (ADT) induces nMET in ...
Synthesis of nitrogen-doped zinc oxide nanostructures and their application in antibacterial activity against e.coli, lactis, aerogenes, s.marcescens

Issayeva, Saule; Kabylda, Anar; Xie, Yingqiu; Fan, Haiyan (The 8th International Conference on Nanomaterials and Advanced Energy Storage Systems; Nazarbayev University; National Laboratory Astana; Institute of Batteries, 2020-08)

The nanoparticles made of zinc oxide are well known because of their broader applications in various optoelectronic devices. The current work was dedicated to the synthesis, characterization, antibacterial testing and ...