2024-03-29T13:17:45Zhttp://nur.nu.edu.kz/oai/requestoai:nur.nu.edu.kz:123456789/4122018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Abetov, D.A.
Mustapova, Z.N.
Begimbetova, D.A.
Bulanin, D.
2015-10-21T05:33:31Z
2015-10-21T05:33:31Z
2014
http://nur.nu.edu.kz/handle/123456789/412
Despite advances in the post-genomic era, which allowed for generation of an impressive
amount of biological data, representing the whole network of biological interactions, gene regulating
networks and signaling pathways in a unified temple and coherent way is still a challenging task. Here
we performed analysis of upregulated molecular networks found in colorectal cancer stem cells (CCSC).
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-21T05:33:31Z
No. of bitstreams: 1
construction of large scale1.pdf: 73516 bytes, checksum: 856c03e7ca6802f0f10efa22a757e023 (MD5)
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construction of large scale1.pdf: 73516 bytes, checksum: 856c03e7ca6802f0f10efa22a757e023 (MD5)
Previous issue date: 2014
en
Nazarbayev University
biological interactions
colorectal cancer stem cells
pathway diagram
CCSC biology
Construction of large scale boolean logic based pathways of colorectal cancer stem cells
Abstract
oai:nur.nu.edu.kz:123456789/4132018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Abilmazhinova, A.
Zhabagin, M.
Rakhimova, S.
Bakhtin, M.
Kazymbet, P.
Akilzhanova, A.
Zhumadilov, Z.
2015-10-21T06:30:19Z
2015-10-21T06:30:19Z
2014
http://nur.nu.edu.kz/handle/123456789/413
Taking into account the fact that Kazakhstan is one of the world's leaders in uranium mining, and given the extent of the damage suffered as a result of the work on the Semipalatinsk nuclear test site, the general background radiation in some regions came under the influence of additional effects of chronic exposure to low doses of radiation, the study and search for new methods of dosimetry, as an integral part of the radiological protection of the population, is a priority for the state. The purpose of this study is the search for and development of potential biomarkers by assessing the impact if ionising radiation on gene expression and quantification of global methylation and hydroxymethylation of uranium industry workers.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-21T06:30:19Z
No. of bitstreams: 1
gene expression1.pdf: 109117 bytes, checksum: a1936602dad87b2378cd56a5fcd0997d (MD5)
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gene expression1.pdf: 109117 bytes, checksum: a1936602dad87b2378cd56a5fcd0997d (MD5)
Previous issue date: 2014
en
Nazarbayev University
gene expression
global methylation
hydroxymethylation
human radiation
biomarker
Gene expression and methylation profiles as a biomarker for human radiation exposure
Abstract
oai:nur.nu.edu.kz:123456789/4142018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Sydykova, K.
Sadykov, M.
Zhailauova, A.
Adilbayeva, A.
Myngbay, A.
Adarichev, V. A.
2015-10-21T09:08:58Z
2015-10-21T09:08:58Z
2014
http://nur.nu.edu.kz/handle/123456789/414
Inbred murine strains are generated to insure genetic homogeneity and uniqueness
and define immune characteristics, like major histocompatibility complex (MHC) haplotype, of the
experimental model. Maintaining of the perfect inbred stock leads to increased level of homozygosity
and sometimes encounters a problem of inbreeding depression and consequently deviation from
strict inbreeding protocol. Our goals are (i) study genetic homogeneity of mice in the colony, and (ii)
haplotyping of H-2 complex (MHC in mice) in this strain.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-21T09:08:58Z
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GENETIC HOMOGENEITY.pdf: 85695 bytes, checksum: 836f7029557d583fb7187d8c22312c04 (MD5)
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GENETIC HOMOGENEITY.pdf: 85695 bytes, checksum: 836f7029557d583fb7187d8c22312c04 (MD5)
Previous issue date: 2014
en
Nazarbayev University
genetic homogeneity
histocompatibility complex
haplotype
DNA product
Genetic homongeneity and major histocompatibility complex haplotyping of white mice
Abstract
oai:nur.nu.edu.kz:123456789/4152018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Bexeitov, Y. K.
Ramez, M
Forde, T. S.
Adarichev, V. A.
2015-10-21T09:26:49Z
2015-10-21T09:26:49Z
2014
http://nur.nu.edu.kz/handle/123456789/415
Brucellosis is one of the most frequent zoonosis worldwide. Infection is transferable
to humans, where brucellosis is associated with high incidence of osteoarticular disease including
osteomyelitis, arthritis and spondyloarthritis. Peripheral arthritis and sacroiliitis often develop in patients
with no or low count of live Brucella. Recently, we demonstrated that mice develop spontaneous arthritis
several weeks after acute infection when bacteria are already eradicated. We aim to decipher immune
mechanism of the brucellosis-associated delayed arthritis that has not been elucidated so far.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-21T09:26:49Z
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MOLECULAR MIMICRY.pdf: 102100 bytes, checksum: b87bbe1d6858b268777a8a5d89d0cc77 (MD5)
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MOLECULAR MIMICRY.pdf: 102100 bytes, checksum: b87bbe1d6858b268777a8a5d89d0cc77 (MD5)
Previous issue date: 2014
en
Nazarbayev University
brucellosis
osteomyelitis
arthritis
spondyloarthritis
cytotoxic T cells
Molecular mimicry of brucella melitensis epitopes in mouse and human arthritis
Abstract
oai:nur.nu.edu.kz:123456789/4162018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Adilbayeva, A.
Myngbay, A.
Adarichev, V. A.
2015-10-21T09:42:29Z
2015-10-21T09:42:29Z
2014
http://nur.nu.edu.kz/handle/123456789/416
Rheumatoid arthritis (RA) is chronic inflammatory disease characterized by the
development of hypercellular pannus tissue in the affected joints of patients. Pannus invasiveness and
activation correlates with stronger tissue destruction and worse clinical prognosis. Using murine arthritis
model, we recently discovered that synovial concentration of Collagen Triple Helix Repeat-containing
1 (CTHRC1) message and protein is directly correlated with arthritis severity. In carcinogenesis,
overexpression of CTHRC1 is associated with enhanced metastatic potential of solid tumors and increased
cell motility. Our goal is to investigate the mechanism of synovial cell motility and invasiveness and the
role of non-canonical WNT signaling in pannus development.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-21T09:42:29Z
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NEW ARTHRITIC.pdf: 89406 bytes, checksum: d33ea6a445bf44b49290668a3ea1f778 (MD5)
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NEW ARTHRITIC.pdf: 89406 bytes, checksum: d33ea6a445bf44b49290668a3ea1f778 (MD5)
Previous issue date: 2014
en
Nazarbayev University
fibroblast motility
protein
cell morphology
cell movement velocity
cell polarization
New arthritic pannus-specific protein promotes fibroblast motility and polarization
Abstract
oai:nur.nu.edu.kz:123456789/4172018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Myngbay, A.
Adilbayeva, A.
Adarichev, V. A.
2015-10-22T10:05:37Z
2015-10-22T10:05:37Z
2014
http://nur.nu.edu.kz/handle/123456789/417
Development of hypercellular invasive pannus tissue within synovial joints is a hallmark
of Rheumatoid Arthritis (RA). Pannus produces proteases that damage bone and cartilage. Non-invasive
monitoring of pannus activity is important for clinical assessment of patients as well as for control of
the efficacy of therapeutic interventions. Available biomarkers are not satisfactory in terms of pannus
specificity and sensitivity for monitoring local inflammation and bone erosion. Our goal is collecting
clinical samples of synovial fluid and plasma from patients with RA and/or osteoarthritis (OA) to study
the role of WNT signaling in pannus formation and developing set of serum biomarkers to monitor
pannus activity.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T10:05:37Z
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NEW SERUM.pdf: 84684 bytes, checksum: ee765074014b6a0e0402014ae84b888f (MD5)
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NEW SERUM.pdf: 84684 bytes, checksum: ee765074014b6a0e0402014ae84b888f (MD5)
Previous issue date: 2014
en
Nazarbayev University
serum
biomarker
rheumatoid arthritis
protein
blood plasma
New serum biomarker for rheumatoid arthritis
Abstract
oai:nur.nu.edu.kz:123456789/4182018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Myngbay, A.
Adilbayeva, A.
Sadykov, M.
Zhailauova, A.
Adarichev, V. A.
Alibek, K.
2015-10-22T10:23:30Z
2015-10-22T10:23:30Z
2014
http://nur.nu.edu.kz/handle/123456789/418
Vaccination is a major tool to protect people from seasonal infections of different
strains of influenza virus that presently infects millions of individuals worldwide. Virus genome is
highly polymorphic, and universal vaccine that protects against permanently changing virus is still
under development. Despite notable differences between humans and rodents in the disease course,
immunobiology and clinical evaluations, murine infectious models remain one of the major tools to test
approaches for influenza vaccine development.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T10:23:30Z
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PROTECTIVE EFFECT.pdf: 85980 bytes, checksum: 1b69db8b66a8ab9d83ab0cbe0fa757be (MD5)
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PROTECTIVE EFFECT.pdf: 85980 bytes, checksum: 1b69db8b66a8ab9d83ab0cbe0fa757be (MD5)
Previous issue date: 2014
en
Nazarbayev University
vaccination
immunobiology
clinical evaluations
influenza vaccine
Protective effect of peptide vaccination in murine infection with influenza virus
Abstract
oai:nur.nu.edu.kz:123456789/4192018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Akhmetova, А.
Kozhamkulov, U.
Bismilda, V.
Chingissova, L.
Akilzhanova, A.
2015-10-22T10:45:11Z
2015-10-22T10:45:11Z
2014
http://nur.nu.edu.kz/handle/123456789/419
Methods of genotyping of M. tuberculosis play important role in tuberculosis (TB)
infection control. These techniques are used to detect or exclude laboratory errors, control recurrent
cases and determine ways of TB transmission. Today, there are more than 10 methods of genotyping,
MIRU-VNTR being one of the most widely used methods in the world.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T10:45:11Z
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BEIJING GENOTYPE.pdf: 101009 bytes, checksum: 61fffbded2c677273e13ba150ac9ceda (MD5)
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BEIJING GENOTYPE.pdf: 101009 bytes, checksum: 61fffbded2c677273e13ba150ac9ceda (MD5)
Previous issue date: 2014
en
Nazarbayev University
genotype
Beijing genotype
isolates of M. tuberculosis
MIRU-VNTR analysis
Beijing genotype is the most dominant genotype among clinical isolates of m.tuberculosis in Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/4202018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Akilzhanova, A.
Guelly, C.
Abilova, Z. M.
Rakhimova, S.
Nuralinov, O. M.
Abdrakhmanov, A. C.
Bekbosynova, M. S.
2015-10-22T10:57:00Z
2015-10-22T10:57:00Z
2014
http://nur.nu.edu.kz/handle/123456789/420
The human ryanodine receptor 2 (RYR2) is one of the key players tightly regulating
calcium efflux from the sarcoplasmic reticulum to the cytosol and found frequently mutated (<60%) in
context of catecholaminergic polymorphic ventricular tachycardia (CPVT1) [1].
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T10:57:00Z
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SCREENING MUTATIONS.pdf: 98053 bytes, checksum: fe62f2d8e986f05d0083b3a6a9c48342 (MD5)
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SCREENING MUTATIONS.pdf: 98053 bytes, checksum: fe62f2d8e986f05d0083b3a6a9c48342 (MD5)
Previous issue date: 2014
en
Nazarbayev University
ventricular tachycardia
ventricular arrhythmia
RYR2 gene
Screening mutation in RYR2 gene in a Kazakhstani idiopathic ventricular tachycardia study cohort: two novel mutations
Abstract
oai:nur.nu.edu.kz:123456789/4212018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Aldabergenova, A.
Poole, R.
2015-10-22T11:21:04Z
2015-10-22T11:21:04Z
2014
http://nur.nu.edu.kz/handle/123456789/421
Neural specification is further complicated when we consider that it needs to be
coordinated across the left-right (L/R) axis. Disruptions in the bilaterally symmetric organization of
the human brain are frequently observed in patients with neurological disorders. Furthermore, certain
neurological disorders such as schizophrenia and Parkinson's disease present or progress asymmetrically,
suggesting the possibility of underlying asymmetric genetic causes. The question of how early neural
specification is regulated to produce both bilaterally symmetric and L/R asymmetric structures has been
largely unexplored.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T11:21:04Z
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REGULATION OF ASYMMETRIC.pdf: 97927 bytes, checksum: 9cf4dc24029969efbdbb921a818fc82e (MD5)
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REGULATION OF ASYMMETRIC.pdf: 97927 bytes, checksum: 9cf4dc24029969efbdbb921a818fc82e (MD5)
Previous issue date: 2014
en
Nazarbayev University
asymmetric
neuronal
non-neuronal
C. elegans
proneural gene
embryos
Regulation of asymmetric neurogenesis in c. elegans
Abstract
oai:nur.nu.edu.kz:123456789/4222018-08-15T03:49:33Zcom_123456789_409com_123456789_129col_123456789_411
Alizadeh, T.
Calinon, S.
2015-10-22T11:30:36Z
2015-10-22T11:30:36Z
2014
http://nur.nu.edu.kz/handle/123456789/422
The proposed research is to provide a probabilistic approach to learn human movements.
Dynamical Movement Primitives (DMP) have been extensively used in robotics in order to learn human
motions [1]. The DMP modulates a virtual spring with a learned non-linear force profile /(x), perturbing
the system to make it follow a desired trajectory.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T11:30:36Z
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HUMAN MOVEMENT.pdf: 164568 bytes, checksum: 280a0217821413f665183542fc04cf15 (MD5)
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HUMAN MOVEMENT.pdf: 164568 bytes, checksum: 280a0217821413f665183542fc04cf15 (MD5)
Previous issue date: 2014
en
Nazarbayev University
dynamical movement primitives
human motions
mixture models
Human movement learning with dynamic movement primitives combined with mixture models
Abstract
oai:nur.nu.edu.kz:123456789/4232018-08-15T03:49:33Zcom_123456789_409com_123456789_129col_123456789_411
Balabaev, N. K.
Finkelstein, A. V.
Galzitskaya, O. V.
Garbuzynskiy, S. O.
Glyakina, A. V.
Lobanov, M. Yu.
Matkarimov, B.
2015-10-22T11:40:33Z
2015-10-22T11:40:33Z
2014
http://nur.nu.edu.kz/handle/123456789/423
Recent progress in modeling of protein folding in Dr. Shaw laboratory has been
achieved only after some improvements of potentials of covalent forces, taken from the standard AMBER
force field; and still, the force field used is not quite satisfactory to reproduce folded structures of some
larger proteins, having significant, about 5A, RMS deviation between the computed and experimentally
determined 3D structures. The objective of this research is to develop and test new polarizable atomic
force fields (FFs) for "in-vacuum" and "in-water" non-bonded interactions based on AMBER ff99SBILDN
force fields, improved by inclusion of new terms. FFs parameter optimization will be done using
our set of molecular crystals with crystallographic data from the Cambridge Structural Database and
sublimation/solvation thermodynamics characteristics from various sources.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T11:40:33Z
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DEVELOPMENT.pdf: 88540 bytes, checksum: 23ef8ec5def2b07ab076d88f497c5b29 (MD5)
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DEVELOPMENT.pdf: 88540 bytes, checksum: 23ef8ec5def2b07ab076d88f497c5b29 (MD5)
Previous issue date: 2014
en
Nazarbayev University
molecular dynamics
3D structures
molecular crystals
thermodynamics characteristics
Development and testing of new force fields for molecular dynamics simulations
Abstract
oai:nur.nu.edu.kz:123456789/4242018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Baltabekova, A. Zh.
Shagyrova, Zh. S.
Voykov, M.
Ramanculov, E. M.
Shustov, A. V.
2015-10-22T11:53:03Z
2015-10-22T11:53:03Z
2014
http://nur.nu.edu.kz/handle/123456789/424
Immunoglobulin E (IgE) plays a central role in type I hypersensitivity including allergy
and asthma. Novel treatment strategy envisages development of a therapeutic vaccine designed to elicit
autologous blocking antibodies against the IgE. We sought to develop an IgE-epitope antigen that induces
antibodies against a receptor-contacting epitope on human IgE molecule.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T11:53:03Z
No. of bitstreams: 1
SPLIT CORE.pdf: 85271 bytes, checksum: 4ebf34783447421d412d98c4e4b35a1b (MD5)
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SPLIT CORE.pdf: 85271 bytes, checksum: 4ebf34783447421d412d98c4e4b35a1b (MD5)
Previous issue date: 2014
en
Nazarbayev University
immunoglobulin E
human IgE
immunodominant region
split core technology
Split core technology allows efficient production of virus-like particles presenting a receptor-contacting epitope of human IgE
Abstract
oai:nur.nu.edu.kz:123456789/4252018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Zhanshayeva, L.
Zhussupbekov, M.
Rojas-Solorzano, L.
2015-10-22T12:03:29Z
2015-10-22T12:03:29Z
2014
http://nur.nu.edu.kz/handle/123456789/425
The goal of this project is to develop a CFD model of blood to predict hemolysis due to
mechanical action in biomedical blood-wetted devices. Most of the current models approximate blood as
a Newtonian fluid at high shear rates. Our work is based on numerical model developed in [1] that
modeled blood as a multiphase fluid with constant viscosity. Although successful in capturing phase
segregation (Fahraeus-Lindqvist effect), it still did not reach acceptable agreement with experimental
data in terms of damage. Gijsen et al. [2] reported significant differences between flow fields obtained by
Newtonian and non-Newtonian models of blood. The goal of this study is to introduce non-Newtonian
blood rheology to the base model and validate it with existing experimental data.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T12:03:29Z
No. of bitstreams: 1
PREDICTION OF BLOOD.pdf: 104419 bytes, checksum: 60d7428147f9545a2517848d1465f105 (MD5)
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PREDICTION OF BLOOD.pdf: 104419 bytes, checksum: 60d7428147f9545a2517848d1465f105 (MD5)
Previous issue date: 2014
en
Nazarbayev University
CFD model
biomedical blood-wetted
blood rheology
Prediction of blood damage within biomedical blood-wetted devices due to mechanical action
Abstract
oai:nur.nu.edu.kz:123456789/4262018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Brusic, V.
2015-10-22T12:13:34Z
2015-10-22T12:13:34Z
2014
http://nur.nu.edu.kz/handle/123456789/426
The World's total data is doubling every two years. Data expansion includes growth in quantity,
complexity, and types of data. The enormous rate of generation and on-line access to data is profoundly
changing the way how business is conducted. Biomedical data include research and development data,
clinical data, activity and cost data, patient behavior data, basic science data, and standards and ontologies,
among others. Furthermore, Big Data approaches are increasingly needed for utilization of results
from various Omics studies. Specific applications include predictive and content analytics that support
drug discovery and optimization, the development of new diagnostic methods, and personalization of
medicine. Biomedical data vary in granularity, quality, and complexity. There is a variety of sources and
data formats - web pages, publications, technical reports, and databases. The challenge is to make the
transition from data to actionable knowledge.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T12:13:34Z
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MATHEMATICAL MODELING.pdf: 96958 bytes, checksum: c27f19c2186de6cc49c00675910d0886 (MD5)
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MATHEMATICAL MODELING.pdf: 96958 bytes, checksum: c27f19c2186de6cc49c00675910d0886 (MD5)
Previous issue date: 2014
en
Nazarbayev University
biomedical data
mathematical modeling
data formats
T-cell immunome
big data analysis
Mathematical modeling and big data analytics in biomedicine
Abstract
oai:nur.nu.edu.kz:123456789/4272018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Ralchenko, Y.
Khamkhash, L.
Bukasov, R.
2015-10-22T12:24:26Z
2015-10-22T12:24:26Z
2014
http://nur.nu.edu.kz/handle/123456789/427
The use of SERS for detection, analysis and imaging has attracted great interest in the
past decade owing to its high sensitivity and molecular fingerprint specificity. There is an increasing
interest in scientific community to SERS as it becomes a versatile method for early medical diagnostics
and reliable detection of major health threats to humans (e.g. cancer, tuberculosis, etc) and animals [1].
The key component of our SERS-based immunoassay include:1) a capture substrate to specifically adsorb
antigens from solution; (2) Extrinsic Raman Labels (ERLs): surface functionalized gold nanoparticles
(AuNPs) to bind to captured antigens selectively and generate intense SERS signals, which contain both
capture antigen and SERS active readout molecule (4-nitrobenzenethiol (4-NBT)).
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T12:24:26Z
No. of bitstreams: 1
SUBNANOMOLAR DETECTION.pdf: 109696 bytes, checksum: 8c7c59552a0a9fde8cbabe1384a4fa0c (MD5)
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SUBNANOMOLAR DETECTION.pdf: 109696 bytes, checksum: 8c7c59552a0a9fde8cbabe1384a4fa0c (MD5)
Previous issue date: 2014
en
Nazarbayev University
subnanomolar detection
tuberculosis biomarker
antibodies
molecule
Subnanomolar detection of tuberculosis biomarker MPT64 in sandwich sers immunoassay on novel low -cost substrate
Abstract
oai:nur.nu.edu.kz:123456789/4282018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Craig, B. J.
Karabayeva, A.
2015-10-22T12:34:03Z
2015-10-22T12:34:03Z
2014
http://nur.nu.edu.kz/handle/123456789/428
One of the greatest challenges to public health in Kazakhstan is the increasing prevalence
of cardiovascular diseases (CVDs). Perceptions of responsibility in health vary across populations [1],
and research in Kazakhstan has revealed that patients tend to place the responsibility for their health
on doctors rather than on their own individual health choices [2]. Due to the relationship between
lifestyle and many CVDs, this presents a problem for the future health of Kazakhstan's public. This study
examined the perspectives of patients being treated for CVDs regarding their care and lifestyles in order
to be able to inform patient education and behavior change efforts as well as improve larger public health
promotion.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T12:34:03Z
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CARDIOVASCULAR DISEASES.pdf: 85242 bytes, checksum: 9ea541ffc4c2a96afdd71ffff0f4446b (MD5)
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CARDIOVASCULAR DISEASES.pdf: 85242 bytes, checksum: 9ea541ffc4c2a96afdd71ffff0f4446b (MD5)
Previous issue date: 2014
en
Nazarbayev University
cardiovascular diseases
health
patient perspectives
Cardiovascular diseases and health:patient perspectives
Abstract
oai:nur.nu.edu.kz:123456789/4292018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Dashkova, V.
Segev, E.
Khromov, V.
Kolter, R.
Vorobjev, I.
Barteneva, N. S.
2015-10-22T12:43:20Z
2015-10-22T12:43:20Z
2014
http://nur.nu.edu.kz/handle/123456789/429
Flow cytometry (FCM) is a promising tool in the field of aquatic phytoplankton
ecology because it allows for multi-parameter assessment of the physiological state of individual cells in
an algal population. It can help to elucidate major questions such as phytoplankton taxa identification,
the evaluation of cell quantity and viability, and the measuring of phytoplankton and general microbial
metabolic activities. Traditionally, microalgal characterization is performed by microscopic analysis using
UV-excited nuclear dyes (e.g. Hoechst and DAPI) or dyes that are excited in the blue-green part of the
spectrum such as propidium iodide and eosin. The development of multi-laser cytometric systems has
widened the possibilities for multi-parametric analysis and cell sorting of phytoplankton populations.
Notwithstanding, significant algae autofluorescence originating from different types of chlorophyll and
accessory pigments may overlap with propidium iodide and/or eosin staining and affect the resolution
of algae clusters and cell sorting.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-22T12:43:20Z
No. of bitstreams: 1
NEW NUCLEIC.pdf: 105916 bytes, checksum: 4698e5753ea180e5356298d7f168ab56 (MD5)
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NEW NUCLEIC.pdf: 105916 bytes, checksum: 4698e5753ea180e5356298d7f168ab56 (MD5)
Previous issue date: 2014
en
Nazarbayev University
nuclear dyes
propidium iodide
eosin
cytometric systems
phytoplankton populations
New nucleic dyes for pico-and nanoplankton cytometric analysis
Abstract
oai:nur.nu.edu.kz:123456789/4302018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Dauyey, K.
Morgan, F. J.
Bohndiek, S. E.
2015-10-23T04:35:32Z
2015-10-23T04:35:32Z
2014
http://nur.nu.edu.kz/handle/123456789/430
Optical imaging as non-invasive modality has tremendous research applications in the
area of biomedical sciences such as characterization of cancerous cells. However, this imaging modality
is limited by depth of light penetration of around 1 mm in living tissues obscuring visualization in vivo.
Optoacoustic imaging is a potential solution of this problem based on detection of ultrasound produced
by light-absorbing molecules exposed to laser radiation resulting in a tissue contrast. The image contrast
relies on absorption of laser emission, however providing ultrasound resolution in living tissues. This
study characterized properties of colorectal adenocarcinoma cells expressing Near-infrared Fluorescent
proteins (iRFPs) for detection and visualization in Multispectral Optoacoustic Tomography (MSOT)
settings in both tissue-mimicking phantoms and mice. We estimated variables affecting MSOT imaging of
3D multicellular tissue spheroids such as size, expression of iRFP in vitro. We tested MSOT for detection
of subcutaneously implanted tumours expressing iRFPs in BALB/C nude mice in vivo.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-23T04:35:32Z
No. of bitstreams: 1
LISTENING TO REPORTER.pdf: 100455 bytes, checksum: 53a7fcca4d0644601099f822e57ae13b (MD5)
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LISTENING TO REPORTER.pdf: 100455 bytes, checksum: 53a7fcca4d0644601099f822e57ae13b (MD5)
Previous issue date: 2014
en
Nazarbayev University
colorectal adenocarcinoma
fluorescent spectral
spheroids
molecules
tissue
ultrasound
Listening to reporter proteins: how loud does the message need to be?
Abstract
oai:nur.nu.edu.kz:123456789/4312018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Evtyhova, E. B.
Voykov, M.
Ramanculov, E. M.
Shustov, A. V.
2015-10-23T04:52:02Z
2015-10-23T04:52:02Z
2014
http://nur.nu.edu.kz/handle/123456789/431
Currently there are no industrial eukaryotic expression systems other than transient
expression from plasmids or expression from genes integrated into host genome. Both approaches (use
of eukaryotic plasmids or chromosomal integration) suffer from poor scalability and often from poor
yields. Although, in laboratory settings, effective means for transducing of cultured cells to express
foreign proteins and for high-level transient expression were developed based on viral genomes. We
thought to develop a scalable and suitable for industrial application technology for the production of
recombinant human erythropoietin (EPO) in mammalian cell cultures using an expression vector based
on the genome of RNA virus.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-23T04:52:02Z
No. of bitstreams: 1
DEVELOPMENT OF A TECHNOLOGY.pdf: 86251 bytes, checksum: 72999be92d6250d828533248bcbe9bb3 (MD5)
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DEVELOPMENT OF A TECHNOLOGY.pdf: 86251 bytes, checksum: 72999be92d6250d828533248bcbe9bb3 (MD5)
Previous issue date: 2014
en
Nazarbayev University
recombinant
human erythropoietin
mammalian cells
synthetic gene
oligonucleotides
polyprotein
protein
Development of a technology for expression of recombinant human erythropoietin in cultured mammalian cells using alphavirus expression system
Abstract
oai:nur.nu.edu.kz:123456789/4322018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Folgheraiter, M.
2015-10-23T05:11:31Z
2015-10-23T05:11:31Z
2014
http://nur.nu.edu.kz/handle/123456789/432
Designing the actuation system for a robot is a crucial step during the machine
development. This phase is even more critical if the robotic system is represented by a haptic interface
or a rehabilitation system that are meant to operate in near contact with the human body. Generally, the
design process takes into account a realistic model of the limb interacting with the interface [1,2] and
includes as set of simulations intended to study the coupled interface-limb system. The result of these
simulations allows fixing important requirements necessary to design the interface. Among them the
number of Degrees of Freedom (DOF), the joints type and configuration, and the links dimensions.
When the kinematic of the interface is ready a proper dynamic model [3] needs to be formalized and
computed. This is demanded to find out other important design elements like the optimal actuators
displacement and dimensioning.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-23T05:11:31Z
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DESIGN METHODOLOGY.pdf: 105648 bytes, checksum: 4dc2b23e6e06712ae96a4493546bb764 (MD5)
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DESIGN METHODOLOGY.pdf: 105648 bytes, checksum: 4dc2b23e6e06712ae96a4493546bb764 (MD5)
Previous issue date: 2014
en
Nazarbayev University
robot
haptic interface
rehabilitation system
design
dynamic model
Design methodology for haptic interfaces and rehabilitation systems
Abstract
oai:nur.nu.edu.kz:123456789/4332018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Khamzina, Y.
Nauryzbayeva, A.
Gilman, C.
2015-10-23T05:29:00Z
2015-10-23T05:29:00Z
2014
http://nur.nu.edu.kz/handle/123456789/433
Intracellular calcium homeostasis is disrupted in many neuronal diseases and traumatic
brain injuries resulting in endoplasmic reticulum (ER) stress [1]. ER stress and intracellular calcium
homeostasis is a hub of signaling mechanisms that determine whether injured neurons will live or die.
With survivable injuries neurons seek to restore normal function by several mechanisms including the
upregulation of chaperones [2]. Hsc70 (aka Hsp73 and HSPA8) is one of such proteins, which is found
to be highly concentrated in neurons. Unlike other chaperones in the HSP family Hsc70 is constitutively
expressed and interacts with both cell cycle and apoptosis regulating proteins [3]. Therefore, we tested
the hypothesis that Hsc70 regulates neural stem cell fate in response to changes intracellular calcium
homeostasis. Currently little is known about the function of this novel chaperone or about the role of ER
calcium homeostasis in neural stem cell fate determination and this work is the first to investigate this
topic.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-23T05:29:00Z
No. of bitstreams: 1
ROLE OF HSC70.pdf: 98624 bytes, checksum: 3b825a1a35f7f1daf2400740a15ee47e (MD5)
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ROLE OF HSC70.pdf: 98624 bytes, checksum: 3b825a1a35f7f1daf2400740a15ee47e (MD5)
Previous issue date: 2014
en
Nazarbayev University
intracellular
calcium
homeostasis
neuronal
brain
endoplasmic
reticulum
injuries
apoptosis
Role of HSC70 protein in maintenance of endoplasmic reticulum CA2+ homeostasis
Abstract
oai:nur.nu.edu.kz:123456789/4362018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Ibrasheva, D.
Idrissova, D.
Umbayev, B.
Masoud, A.
Askarova, Sholpan
2015-10-23T08:38:04Z
2015-10-23T08:38:04Z
2014
http://nur.nu.edu.kz/handle/123456789/436
Viral hepatitis B and C- is a widespread infectious disease of the liver and is a potential
threat to human life. Treatment of HCV and HBV requires prolonged (parenteral or oral) administration
of antiviral and immune-stimulating agents, which often have serious side effects that lead to abrupt
termination of the therapy and the development of viral resistance. Targeted delivery of drugs directly
to the affected organ is one of the most promising areas that seek to improve the outcome of treatment
of patients with chronic diseases. Among the various drug delivery systems, erythrocytic pharmacocytes
are of special interest. They are a shade of red blood cells, that could be loaded with antiviral drugs and
drugs that boost the immune system. Owing to the fact that erythrocytes are destroyed by mononuclear
phagocytes in the liver, it is assumable that the EP serve as a promising and direct means of delivering
antiviral drugs and immune-modulators into the liver parenchyma to treat viral hepatitis.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-23T08:38:04Z
No. of bitstreams: 1
RESEARCH ON THE BIO-DISTRIBUTION.pdf: 82285 bytes, checksum: d710b284241472a0146edb85dc3744f3 (MD5)
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RESEARCH ON THE BIO-DISTRIBUTION.pdf: 82285 bytes, checksum: d710b284241472a0146edb85dc3744f3 (MD5)
Previous issue date: 2014
en
Nazarbayev University
treatment
erythrocytic pharmacocytes
blood
immune system
phagocytes
bio-distribution
plasma
Research on the bio-distribution of interferon gamma-containing pharmacocytes
Abstract
oai:nur.nu.edu.kz:123456789/4372018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Kaiyrlykyzy, A.
Adambekov, Sh.
Alimbetov, D.
Askarova, Sholpan
2015-10-23T09:16:19Z
2015-10-23T09:16:19Z
2014
http://nur.nu.edu.kz/handle/123456789/437
Background. The prevalence of dementia is increasing worldwide as the population ages and affects
10 % of the population over 65 years old and 40 % of people over the age of 80.[1] In Kazakhstan, as well
as in other countries around the world, the population of aged people has been increasing over the past
decades. According to available statistics, by the end of 2013, the percentage of people aged 65 and older
in Kazakhstan was 6.7% [2]. Given the fact that Kazakhstan's current population is about 17,221 million
people [2], and based on data from the global statistics, it can be assumed that at least 115,000 elderly
people could be suffering from age-related dementia. Nevertheless, such pathology is currently may not
being diagnosed in Kazakhstan; consequently giving no accurate statistical data on the number of people
suffering from this age-related pathology. Thus, the aim of this study is to estimate true prevalence of
dementia and assess the risk factors associated with the disease.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-23T09:16:19Z
No. of bitstreams: 1
AGE-REALTED DEMENTIA.pdf: 114075 bytes, checksum: d52a713f763dd7b1d3d4b18e6e2ace04 (MD5)
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AGE-REALTED DEMENTIA.pdf: 114075 bytes, checksum: d52a713f763dd7b1d3d4b18e6e2ace04 (MD5)
Previous issue date: 2014
en
Nazarbayev University
dementia diagnosis
subtypes
mental disorders
physical health
anthropometry
demographics
care arrangements
Age-realted dementia in Kazahstan: adaptation of the 10/66 dementia research group population -based study protocol
Abstract
oai:nur.nu.edu.kz:123456789/4382018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Kalieva, M. Zh.
Shagyrova, Zh. S.
Voykov, M.
Ramanculov, E. M.
Shustov, A. V.
2015-10-23T09:28:18Z
2015-10-23T09:28:18Z
2014
http://nur.nu.edu.kz/handle/123456789/438
Foot-and-mouth disease (FMD) is important disease of cloven-foot animals including
cows and swine. Although annual vaccination against the FMD is mandated in regions of South
Kazakhstan, outbreaks of the disease are registered every year. These outbreaks result in huge economic
losses because international rules require culling of all the diseased and contacted animals and all
products from these animals must be destroyed. Currently available anti-FMD vaccines are all produced
using the original technology of inactivation of virus (foot-and-mouth disease virus, FMDV) grown in
cell cultures. Recombinant anti-FMD vaccine is a long anticipated development in the industry because
the recombinant vaccine is safe and compatible with diagnostic tests for discrimination of diseased and
vaccinated animals (DIVA).
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-23T09:28:18Z
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DEVELOPMENT OF A RECOMBINANT.pdf: 83130 bytes, checksum: 923e1e23e283ed5e04b8d0df88316389 (MD5)
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DEVELOPMENT OF A RECOMBINANT.pdf: 83130 bytes, checksum: 923e1e23e283ed5e04b8d0df88316389 (MD5)
Previous issue date: 2014
en
Nazarbayev University
foot-and-mouth disease
vaccine
recombinant vaccine
inactivation of virus
animals
immunogenicity
Development of a recombinant foot -and-mouth disease vaccine
Abstract
oai:nur.nu.edu.kz:123456789/4502018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Kauanova, S.
Kakpenova, A.
Balabiyev, A.
Vorobjev, I.
2015-10-26T05:32:05Z
2015-10-26T05:32:05Z
2014
http://nur.nu.edu.kz/handle/123456789/450
The cell motility assays became an important step for trial of new developed anti-tumor
drugs and compounds [1, 2]. Set of experiments was performed with microtubule affecting drugs on a
model population of 3T3 cells. This study is focused on the complex analysis of cell population behavior
that can be further used to develop method for evaluation of drugs in preclinical trials.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T05:32:04Z
No. of bitstreams: 1
THE MULTIDIMENSIONAL ANALYSIS.pdf: 85467 bytes, checksum: 7cdd403016aaff85ffbb706559aa05b4 (MD5)
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THE MULTIDIMENSIONAL ANALYSIS.pdf: 85467 bytes, checksum: 7cdd403016aaff85ffbb706559aa05b4 (MD5)
Previous issue date: 2014
en
Nazarbayev University
cell
microtubule
mechanism
nocodazole
taxol
vinorelbine
The multidimensional analysis of cell behaviour
Abstract
oai:nur.nu.edu.kz:123456789/4512018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Ko, M. W. L.
Ali, Md. H.
Lam, D. C. C.
2015-10-26T05:47:15Z
2015-10-26T05:47:15Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/451
Optic neuropathy in glaucoma
causes visual field loss and blindness [1]. The optic
nerve damage in the lamina cribrosa (LC) of the
sclera, the primary site of glaucoma, is correlated
with the intraocular pressure (IOP) [2]. Literature
shows that the optic nerves are sheared at high
IOP and the scleral biomechanical properties
play an important role in the development and
progression of glaucomatous damage to the LC
and ganglion cell axons with the optic nerve head
(ONH). The aim of this study is to determine and
characterize the correlation between the corneal,
scleral and ONH elasticity, and intraocular
pressure on the optic nerve damages.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T05:47:15Z
No. of bitstreams: 1
CORRELATION BETWEEN.pdf: 119818 bytes, checksum: 7f5de036288c48b16ed7785d75999329 (MD5)
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CORRELATION BETWEEN.pdf: 119818 bytes, checksum: 7f5de036288c48b16ed7785d75999329 (MD5)
Previous issue date: 2014
en
Nazarbayev University
optic
glaucoma
ocular elasticity
lamina cribrosa
cornea
sclera
intraocular pressure
Correlation between ocular elasticity and intraocular pressure on optic nerve damages
Abstract
oai:nur.nu.edu.kz:123456789/4522018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Merzhakupova, D.
Adilgozhina, G.
Kim, A.
Chao, W. T.
Kunz, J.
2015-10-26T05:59:43Z
2015-10-26T05:59:43Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/452
Rac1 activity is concentrated at the front of migrating cells where it initiates signaling
processes necessary for cell migration in normal and pathological situations. The signaling pathways
downstream of Rac1 are well characterized. However, how Rac1 activation is regulated to confer cell
movement is incompletely understood.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T05:59:43Z
No. of bitstreams: 1
PIPKla REGULATES.pdf: 86593 bytes, checksum: df980df9c2f830dca8b32d86ea350c02 (MD5)
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PIPKla REGULATES.pdf: 86593 bytes, checksum: df980df9c2f830dca8b32d86ea350c02 (MD5)
Previous issue date: 2014
en
Nazarbayev University
rac1
cell
osteosarcoma
breast cancer
biochemical
plasma membrane
PIPK1a regulates RAC1 and akt activation to promote cell migration and proliferation
Abstract
oai:nur.nu.edu.kz:123456789/4532018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Beisekenova, S.
Ospanova, B.
Kabdullayeva, T.
Chao, W. T.
Kunz, J.
2015-10-26T06:24:31Z
2015-10-26T06:24:31Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/453
Cell migration and tissue invasion during tumor metastasis require the regulated
disassembly of focal adhesions, but the underlying mechanisms remain poorly defined. We previously
showed that the turnover of focal adhesions occurs through odpha5Peta1 integrin endocytosis from focal
adhesions (1). We further discovered that only integrins in their active conformation are internalized
during focal adhesion disassembly and we set out to define the molecular machinery responsible for
integrin transport (1,2). These studies revealed that the pathway required for the trafficking of active
integrins involves different components than the pathway required for the trafficking of inactive integrins
(1,2). Significantly, only by inhibiting the endocytosis of activated integrins was cell migration inhibited
(2). Hence, the further identification of key components of the focal adhesion disassembly pathway is
likely to expose novel avenues to inhibit tumor cell invasion and metastasis.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T06:24:31Z
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PIPKIN REGULATES.pdf: 104667 bytes, checksum: caa3e205404492a13ec1505dd9295a9f (MD5)
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PIPKIN REGULATES.pdf: 104667 bytes, checksum: caa3e205404492a13ec1505dd9295a9f (MD5)
Previous issue date: 2014
en
Nazarbayev University
PIPK1b
alpha5beta1
endocytosis
phosphatidylinositol
4-phosphate
phosphatidylinositol-4
5-kinase beta PIPK1P
via synthesis of PI4,5P2
PIPK1b regulates integrin endocytosis for focal adhesion disassembly by modulating the recruitment of the endocytic machinery to focal adhesions
Abstract
oai:nur.nu.edu.kz:123456789/4542018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_410
Kurakbayev, K.
Bridges, D.
2015-10-26T06:43:15Z
2015-10-26T06:43:15Z
2013
http://nur.nu.edu.kz/handle/123456789/454
The international research project “Coordinating Academic Programmes of Secondary Schooling and Higher Education Institutions of Kazakhstan in the Context of the International Experience” grew out of a partnership between the newly established Nazarbayev University Graduate School of Education (NUGSE) and the University of Cambridge Faculty of Education.
The funding for the study was provided by the Ministry of Education and Science of the Republic of Kazakhstan through Nazarbayev University Graduate School of Education.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T06:43:15Z
No. of bitstreams: 1
COORDINATING ACADEMIC PROGRAMMES OF SECONDARY SCHOOLING.docx.pdf: 1088424 bytes, checksum: db07ad03ee8c4d68404a103c7d0c24a6 (MD5)
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COORDINATING ACADEMIC PROGRAMMES OF SECONDARY SCHOOLING.docx.pdf: 1088424 bytes, checksum: db07ad03ee8c4d68404a103c7d0c24a6 (MD5)
Previous issue date: 2013
en
Nazarbayev University
secondary schooling
higher education
NUGSE
University of Cambridge Faculty of Education
Coordinating academic programmes of secondary schooling and higher education institutions of Kazakhstan in the context of the international experience
Abstract
oai:nur.nu.edu.kz:123456789/4552018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Zhubanchaliyev, A.
Chao, W. T.
Kunz, J.
2015-10-26T08:01:25Z
2015-10-26T08:01:25Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/455
The turnover of focal adhesions is essential for normal cell migration and tumor
invasion, but the underlying mechanisms are poorly understood. We have previously shown that the
disassembly of focal adhesions occurs by endocytosis of activated integrins from adhesion sites (1). We
have further identified new components that mediate integrin endocytosis. Here, we provide the initial
characterization of one of these components, sorting nexin 9 (Snx9), an endocytic adaptor protein not
previously implicated in cell adhesion and migration.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T08:01:25Z
No. of bitstreams: 1
SNX 9 INTERACTS.pdf: 110636 bytes, checksum: 16d333da22bfb42fdfd633c2baf5b89c (MD5)
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SNX 9 INTERACTS.pdf: 110636 bytes, checksum: 16d333da22bfb42fdfd633c2baf5b89c (MD5)
Previous issue date: 2014
en
Nazarbayev University
cell migration
Snx9 regulation
cell biological
biochemical
SNX 9 interacts with dynamin 2 and N-wasp to regulate focal adhesion disassembly and cell migration
Abstract
oai:nur.nu.edu.kz:123456789/4562018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Jaguparov, A.
Tursynbay, Y.
Kim, A.
Chao, W. T.
Kunz, J.
2015-10-26T08:18:13Z
2015-10-26T08:18:13Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/456
The polarized delivery of integrin adhesion molecules to the leading edge is required
for cell migration and has been linked to cancer cell invasion, cancer aggressiveness, and poor patient
outcome (1,2). Thus, regulators of integrin traffic may represent new molecular targets to inhibit tumor
progression. However, identifying the regulatory networks that control integrin traffic has posed a big
challenge, because, in contrast to the internalization of other cargoes, integrins take diverse routes,
depending on their specific ligand, activation state, type of adhesion structure and cell type assayed.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T08:18:13Z
No. of bitstreams: 1
PI4,5P2 REGULATES.pdf: 110193 bytes, checksum: 18d17654f23e7a43028c84a908b3c11b (MD5)
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PI4,5P2 REGULATES.pdf: 110193 bytes, checksum: 18d17654f23e7a43028c84a908b3c11b (MD5)
Previous issue date: 2014
en
Nazarbayev University
PI4,5P2
Exo70
PIPK1P protein
cell migration
cell polarity
PI4,5P2 regulates the polarized trafficking of integrins through EXO70 for directional cell migration
Abstract
oai:nur.nu.edu.kz:123456789/4572018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_410
Sagintayeva, A.
Hartley, M.
2015-10-26T08:24:18Z
2015-10-26T08:24:18Z
2013
http://nur.nu.edu.kz/handle/123456789/457
This has been a collaborative research project involving researchers at Nazarbayev University Graduate School of Education and the University of Pennsylvania’s Graduate School of Education. The principal investigators were Aida Sagintayeva (NUGSE) and Matthew Hartley (Penn GSE).
The purpose of this project was to learn how academic leaders at a set of six public and private institutions in Kazakhstan are preparing for greater institutional autonomy and encouraging innovation. The goal has been to identify both challenges as well as models of best practice that other institutions in Kazakhstan, the region, and elsewhere might learn from.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T08:24:18Z
No. of bitstreams: 1
Enhancing.pdf: 678851 bytes, checksum: 686f2affffef36637160bb12b1bc4138 (MD5)
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Enhancing.pdf: 678851 bytes, checksum: 686f2affffef36637160bb12b1bc4138 (MD5)
Previous issue date: 2013
en
Nazarbayev University
education system in Kazakhstan
academic leaders
institutional autonomy
Enhancing management systems and ensuring quality of education in the Republic of Kazakhstan in the context of the world best practicies
Abstract
oai:nur.nu.edu.kz:123456789/4582018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Azhunussova, A.
Shayakhmetov, Y.
Chao, W. T.
Kunz, J.
2015-10-26T08:30:24Z
2015-10-26T08:30:24Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/458
The endocytosis, degradation, and recycling of cadherins is crucial for the dynamic
regulation of adherens junctions and the control of cell-cell adhesion during tissue formation and in
many pathological conditions. In order to allow for dynamic changes in intercellular adhesion, adherens
junctions assemble and disassemble in a continuous fashion. A key mechanism for modulating adhesion
strength is the adjustment of the cell surface levels of E-cadherin, the major component of adherens
junctions. E-cadherin endocytosis, often accompanied by its degradation, has been observed in many
developmental and disease processes and accounts for more rapid changes in adhesion strength that can
occur independently of the transcriptional regulation of E-cadherin. However, the molecular mechanisms
underlying E-cadherin endocytosis and recycling remain incompletely understood.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T08:30:24Z
No. of bitstreams: 1
PIPKIN REGULATES E-CADHERIN.pdf: 111606 bytes, checksum: b67eebad0155ac2218206473e30d4ef0 (MD5)
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PIPKIN REGULATES E-CADHERIN.pdf: 111606 bytes, checksum: b67eebad0155ac2218206473e30d4ef0 (MD5)
Previous issue date: 2014
en
Nazarbayev University
endocytosis
degradation
cadherins
dynamic regulation
pathological conditions
migratory phenotype
PIPK1b regulates E-cadherin endocytosis in polarized breast cancer cells and promotes a switch to a migratory phenotype
Abstract
oai:nur.nu.edu.kz:123456789/4592018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Sagintayeva, A.
Perna, Laura W.
2015-10-26T08:36:06Z
2015-10-26T08:36:06Z
2013
http://nur.nu.edu.kz/handle/123456789/459
This has been a collaborative research project involving researchers at Nazarbayev University Graduate School of Education and the University of Pennsylvania’s Graduate School of Education. The principal investigators were Aida Sagintayeva (NUGSE) and Laura Perna (Penn GSE).
The goal of the research project was to explore the role of strategies for internationalizing higher education in developing a nation’s human capital. The research team identified and categorized higher education internationalization strategies adopted by nations across the globe and studied in-depth the factors influencing participation in and the benefits of the international student exchange programs sponsored by the Republic of Kazakhstan.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T08:36:06Z
No. of bitstreams: 1
Internationalization.pdf: 654668 bytes, checksum: b593a0b28e15fbfe1aabf42c65d842e9 (MD5)
Made available in DSpace on 2015-10-26T08:36:06Z (GMT). No. of bitstreams: 1
Internationalization.pdf: 654668 bytes, checksum: b593a0b28e15fbfe1aabf42c65d842e9 (MD5)
Previous issue date: 2013
en
Nazarbayev University
First research week
education and science
socio-economic globalization
international programs
Bolashak program
Internationalization as a strategic factor in the development of education and science in the Republic of Kazakhstan in the environment of socio-economic globalization
Abstract
oai:nur.nu.edu.kz:123456789/4602018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Masoud, A.
Kravtsova, O. A.
Biktagirova, E.
2015-10-26T08:50:00Z
2015-10-26T08:50:00Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/460
Currently, hypertension is recognized as one of the most common cardio-vascular
diseases. Recent studies indicate the multifactorial nature of this disease, in which much emphasis is given
to genetic factors for their role in the development of this disease. With, results based on the identification
of genetic markers associated with the risk of developing hypertension vary vastly and remain highly
controversial, primarily due to the ethno-genetic and geographical features of the populations under
study, there is an urgent need to identify a phenotypic trait that would allow analysis of associations with
the risk of developing hypertension irrespective of an individual's ethnic background or geographical
location. One such a prospective trait is the rate of Na-Li counter-transport, which remains unchanged
for most of an individual's lifetime, with rare exceptions. Hence this study is aimed at identifying the
contribution of gene polymorphisms of the renin-angiotensin system in the formation of genetic
predisposition to hypertension in individuals with different rates of erythrocyte Na-Li counter-transport.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T08:50:00Z
No. of bitstreams: 1
GENETIC FACTORS.pdf: 81396 bytes, checksum: 26649a4397f0c5eb623a9ec5cf369685 (MD5)
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GENETIC FACTORS.pdf: 81396 bytes, checksum: 26649a4397f0c5eb623a9ec5cf369685 (MD5)
Previous issue date: 2014
en
Nazarbayev University
DNA extraction
polymerase chain reaction (PCR)
restriction analysis
separation of the amplified products
analysis of statistical data
hypertension
Na-Li counter-transport
Genetic factors of hypertension in individuals with different rates of Na-Li counter -transport
Abstract
oai:nur.nu.edu.kz:123456789/4612018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_410
Sagintayeva, A.
PDP faculty and staff
students of the PDP
2015-10-26T09:13:30Z
2015-10-26T09:13:30Z
2013
http://nur.nu.edu.kz/handle/123456789/461
Kazakhstan’s education currently responds to a matrix of past, present and impending imperatives.The challenge for the new regime is to drive forward reform that takes these imperatives into account in new, coherent, and sustainable ways. Each of our interviewees talked of the confidence and steadfastness that should nourish all those who would march forward into a brave new world. But the message they leave us is clear: No matter how smooth or rocky the path might be that lies ahead, it is only through knowledge, noble action, hard work, perseverance - and the search for excellence - that we can change.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T09:13:30Z
No. of bitstreams: 1
stepping.pdf: 2297451 bytes, checksum: 864dcf5354f1843ad4b61d6c29477cdd (MD5)
Made available in DSpace on 2015-10-26T09:13:30Z (GMT). No. of bitstreams: 1
stepping.pdf: 2297451 bytes, checksum: 864dcf5354f1843ad4b61d6c29477cdd (MD5)
Previous issue date: 2013
en
Nazarbayev University
education system in Kazakhstan
preserving cultural values
oral history of Kazakhstan
Stepping stones: recording the voices of the past
Abstract
oai:nur.nu.edu.kz:123456789/4622018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Matkarimov, B.
Takhanov, R.
2015-10-26T09:16:33Z
2015-10-26T09:16:33Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/462
The prediction of protein's native structure given its amino acid sequence is one of
the central problems in modern computational biology/biophysics/biochemistry and computer science.
Today there are more than 80000 3D structures of various biomacromolecules at the open access, e.g. in
Protein Data Bank (PDB), and these databases have exponential growth rate. Project goal is to design
and implement computing experiments related to biomacromolecular folding problem. This includes the
development of high performance bioinformatics software.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T09:16:33Z
No. of bitstreams: 1
PROTEIN^ S CONFORMATIONAL.pdf: 89372 bytes, checksum: fb60419d7b0ed1ddefd87e7fb99b9aa8 (MD5)
Made available in DSpace on 2015-10-26T09:16:33Z (GMT). No. of bitstreams: 1
PROTEIN^ S CONFORMATIONAL.pdf: 89372 bytes, checksum: fb60419d7b0ed1ddefd87e7fb99b9aa8 (MD5)
Previous issue date: 2014
en
Nazarbayev University
biology
biophysics
biochemistry
biomacromolecules
bioinformatics software
computer science
Protein's conformational structure prediction via pattern recognition and constraint satisfaction methods
Abstract
oai:nur.nu.edu.kz:123456789/4632018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_410
Wheatcroft, S.G.
Garnaut, A.
O’Grada, C.
Bishop, I.
2015-10-26T09:31:19Z
2015-10-26T09:31:19Z
2013
http://nur.nu.edu.kz/handle/123456789/463
This abstract reports on an international project being carried out at Nazarbayev University that provides a more detailed picture of the geography and chronology of the largest famines of the twentieth century. Our preliminary results on the Soviet famine of 1932-33 challenge many of the conventional views. Because of international interest in this work, preliminary results concerning mapping the Soviet famine have been published in Russia and Ukraine, and are available on the website of the Russian State Archive Administration.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T09:31:19Z
No. of bitstreams: 1
mapping.pdf: 1937217 bytes, checksum: cff2a55f40f0e8c5821c898ea35faa67 (MD5)
Made available in DSpace on 2015-10-26T09:31:19Z (GMT). No. of bitstreams: 1
mapping.pdf: 1937217 bytes, checksum: cff2a55f40f0e8c5821c898ea35faa67 (MD5)
Previous issue date: 2013
en
Nazarbayev University
Soviet famine
Mapping and evaluating the major famines of modern times
Abstract
oai:nur.nu.edu.kz:123456789/4642018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Molkenov, A.
Kairov, U.
Kozhamkulov, U.
Rakhimova, S.
Askapuli, A.
Zhabagin, M.
Abilova, Zh.
Akhmetova, A.
Yerezhepov, D.
Abilmazhinova, A.
Bismilda, V.
Chingisova, L.
Zhumadilov, Zh.
Akilzhanova, A.
2015-10-26T09:44:22Z
2015-10-26T09:44:22Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/464
The project is aimed to create the prerequisites for a personalized approach to the diagnosis
and treatment of tuberculosis (TB) by identifying and comparing the whole genome sequences of
M.tuberculosis strains isolated in Kazakhstan. Analysis for whole genome sequences obtained using the
next generation sequencing technology will clarify the factors cause of the formation of highly virulent
strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T09:44:22Z
No. of bitstreams: 1
WHOLE GENOME.pdf: 97350 bytes, checksum: 996ddf5d4ee848ad6e83d2b389de49d2 (MD5)
Made available in DSpace on 2015-10-26T09:44:22Z (GMT). No. of bitstreams: 1
WHOLE GENOME.pdf: 97350 bytes, checksum: 996ddf5d4ee848ad6e83d2b389de49d2 (MD5)
Previous issue date: 2014
en
Nazarbayev University
genome sequences
tuberculosis
genetic markers
strains
Whole genome sequencing of mycobacterium tuberculosis in Kazakhstan: first sequence results of two clinical isolates
Abstract
oai:nur.nu.edu.kz:123456789/4652018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_410
Hammerbeck, D.
2015-10-26T10:00:09Z
2015-10-26T10:00:09Z
2013
http://nur.nu.edu.kz/handle/123456789/465
My thesis in this paper is that Orientalism in South and Central Asia is not and has not been a strictly homogeneous phenomenon: instead it has reflected different Western ideas and perceptions on these areas, some which display an acute understanding of the area, and some less so, although certain trends have dominated, resulting in a complex exchange of ideas, one that continues in the 21st century.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T10:00:09Z
No. of bitstreams: 1
empire.pdf: 1099915 bytes, checksum: 4dbbfaf87692aab1f6331b1437931e60 (MD5)
Made available in DSpace on 2015-10-26T10:00:09Z (GMT). No. of bitstreams: 1
empire.pdf: 1099915 bytes, checksum: 4dbbfaf87692aab1f6331b1437931e60 (MD5)
Previous issue date: 2013
en
Nazarbayev University
orientalism
french literature
The empire of custom: Indian&Central Asia in 18th&19th century french language literatures
Abstract
oai:nur.nu.edu.kz:123456789/4662018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Mu, X.
Sultankulov, B.
Agarwal, R.
Mahjoub, A.
Schott, T.
Greco, N.
Huard, J.
Weiss, K.
2015-10-26T10:03:44Z
2015-10-26T10:03:44Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/466
The idea of epigenetic reprogramming of cancer cells by an embryonic microenvironment
possesses potential interest from the prospect of both basic science and potential therapeutic strategies.
Chick embryo extract (CEE) has been used for the successful expansion of many specific stem cells
and has demonstrated the ability to facilitate DNA demethylation. The current study was conducted to
compare the status of DNA methylation in highly metastatic and less metastatic osteosarcoma cells and
to investigate whether CEE may affect the epigenetic regulation of tumor suppressor genes and thus
change the metastatic phenotypes of highly metastatic osteosarcoma cells.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T10:03:44Z
No. of bitstreams: 1
EPIGENETIC REPROGRAMMING.pdf: 82402 bytes, checksum: 34189af640b5e3cb5b42cabe2775a12d (MD5)
Made available in DSpace on 2015-10-26T10:03:44Z (GMT). No. of bitstreams: 1
EPIGENETIC REPROGRAMMING.pdf: 82402 bytes, checksum: 34189af640b5e3cb5b42cabe2775a12d (MD5)
Previous issue date: 2014
en
Nazarbayev University
epigenetic reprogramming
embryonic microenvironment
osteosarcoma cells
cell apoptosis
genes
Epigenetic reprogramming of cancer cells under embryonic microenvironment
Abstract
oai:nur.nu.edu.kz:123456789/4682018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_410
Cofran, Z.
2015-10-26T10:17:08Z
2015-10-26T10:17:08Z
2013
http://nur.nu.edu.kz/handle/123456789/468
Australopithecus robustus has a distinct mandibular anatomy, with a broad and deep corpus and a tall, relatively upright ramus. How this anatomy arose through development is unknown, as gross mandibular size and shape change across subadult growth have yet to be examined quantitatively in this species.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T10:17:08Z
No. of bitstreams: 1
mandibular.pdf: 925524 bytes, checksum: 3cd73b4c71f326d4f2ea6f052d3b3fec (MD5)
Made available in DSpace on 2015-10-26T10:17:08Z (GMT). No. of bitstreams: 1
mandibular.pdf: 925524 bytes, checksum: 3cd73b4c71f326d4f2ea6f052d3b3fec (MD5)
Previous issue date: 2013
en
Nazarbayev University
australopithecus robustus
mandibular anatomy
Mandibular growth and development in australopithecus robustus
Abstract
oai:nur.nu.edu.kz:123456789/4672018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Mussin, Y.
Jeffries, R.
Bulanin, D.
Zhumadilov, Zh.
Olzhayev, F.
Federspiel, W.
2015-10-26T10:16:00Z
2015-10-26T10:16:00Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/467
Adult extracorporeal carbon dioxide removal (ECCO2R) systems and pediatric ECMO
share the common objectives of having a low blood flow rate and low priming volume while safely
maintaining sufficient respiratory support. The Hemolung is a highly simplified adult ECCO2R system
intended for partial respiratory support in adult patients with acute hypercapnic respiratory failure.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T10:16:00Z
No. of bitstreams: 1
PRECLINICAL EVALUATION.pdf: 80909 bytes, checksum: 60f8a499ebaf1c136073b375e3368910 (MD5)
Made available in DSpace on 2015-10-26T10:16:00Z (GMT). No. of bitstreams: 1
PRECLINICAL EVALUATION.pdf: 80909 bytes, checksum: 60f8a499ebaf1c136073b375e3368910 (MD5)
Previous issue date: 2014
en
Nazarbayev University
adult extracorporeal
carbon dioxide
blood
hypercapnic respiratory
anesthesia
pulmonary artery
Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system for pediatric application
Abstract
oai:nur.nu.edu.kz:123456789/4692018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Mussin, Y.
Bulanin, D.
Jeffries, R.
Zhumadilov, Zh.
Olzhayev, F.
Federspiel, W.
2015-10-26T10:29:01Z
2015-10-26T10:29:01Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/469
The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange
effectiveness while using the catheters of smaller diameter and blood flow rates applied in pediatrics.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T10:29:01Z
No. of bitstreams: 1
EVALUATION OF EXTRACORPOREAL.pdf: 81681 bytes, checksum: 45f0d6d86eec98b8e36a1390ba84a628 (MD5)
Made available in DSpace on 2015-10-26T10:29:01Z (GMT). No. of bitstreams: 1
EVALUATION OF EXTRACORPOREAL.pdf: 81681 bytes, checksum: 45f0d6d86eec98b8e36a1390ba84a628 (MD5)
Previous issue date: 2014
en
Nazarbayev University
gas exchange
blood
hydrodynamic pressure
hemolung
Evaluation of extracorporeal gas exchange device hemolung for potential application in pediatric practice
Abstract
oai:nur.nu.edu.kz:123456789/4702018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_410
Assylbekov, Zh.
2015-10-26T11:01:47Z
2015-10-26T11:01:47Z
2013
http://nur.nu.edu.kz/handle/123456789/470
In this paper the author analyzes relationships between IELTS, CPS (foundation), GPA scores and cities where students graduated from high schools for students of Nazarbayev University (NU).
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-26T11:01:47Z
No. of bitstreams: 1
relationship.pdf: 685390 bytes, checksum: 3450812e2398051c94793d372e41ad39 (MD5)
Made available in DSpace on 2015-10-26T11:01:47Z (GMT). No. of bitstreams: 1
relationship.pdf: 685390 bytes, checksum: 3450812e2398051c94793d372e41ad39 (MD5)
Previous issue date: 2013
en
Nazarbayev University
IELTS
CPS
GPA scores
Relationship between city of graduation, english language proficiency and academic performance for Nazarbayev university students
Abstract
oai:nur.nu.edu.kz:123456789/4712018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_410
Zhumadilova, A.
Craig, B. J.
Tsoy, A.
Gabdrakhmanova, A.
Bobak, M.
2015-10-27T04:13:17Z
2015-10-27T04:13:17Z
2013
http://nur.nu.edu.kz/handle/123456789/471
The main finding of this study is the very small proportion of doctors, nurses and patients who believe that interaction should be patient-oriented. These results highlight the necessity of improvement of communication among health care providers towards patient-oriented approaches in order to decrease miscommunication with patients. The fact that most patients prefer doctor-oriented interaction may reflect cultural influences on interaction; educational interventions for patients may also be needed.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T04:13:17Z
No. of bitstreams: 1
evaluation.pdf: 787644 bytes, checksum: cf8058e2f17049fc69d4a665d37d4f82 (MD5)
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evaluation.pdf: 787644 bytes, checksum: cf8058e2f17049fc69d4a665d37d4f82 (MD5)
Previous issue date: 2013
en
Nazarbayev University
health care providers
healthcare professionals
Evaluation of communication between physicians and patients in Astana hospital # 1
Abstract
oai:nur.nu.edu.kz:123456789/4722022-02-02T09:39:14Zcom_123456789_409com_123456789_129col_123456789_411
Niyazmetova, L.
Zhailauova, A.
Sadykov, M.
Muradova, Z.
Ospanova, B.
Pak, A.
Abdirakhmanova, Altynay
Stambekova, D.
Bayakhmetov, S.
Tsyba, N.
2015-10-27T04:16:43Z
2015-10-27T04:16:43Z
2014
http://nur.nu.edu.kz/handle/123456789/472
Oral squamous cell carcinoma (OSCC) is a malignant tumor with 640,000 new cases
annually in the world [1]. Saliva testing is non-invasive procedure that is capable to detect potential
biomarkers for OSCC. It was shown that elevated level of p53 protein was identified in OSCC patients
at different stages of the disease (ibid). Camelid antibodies containing only variable regions, nanobodies
(VHH) and single-chain variable regions (scFv) with VH and VL, are becoming popular in many
biological studies including diagnostic applications. It was identified that VL region alone showed higher
affinity to p53 than VHH, and dimerization of VL region with another one increases the affinity up
to 10 folds [2]. Camelid antibodies have similar affinity to its substrate as human antibodies and can
be conjugated to other proteins without functional lose. They can be expressed and secreted in many
organisms including E.Coli in high amount, which reduces the cost of antibodies production. Thus, the
aim of this project is to design a biosensor, based on available sequence of antibodies, to detect p53 in
saliva samples for OSCC diagnosis.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T04:16:43Z
No. of bitstreams: 1
E.COLI DERIVED.pdf: 98272 bytes, checksum: 790fd419e1b8e714feae2f056470c757 (MD5)
Made available in DSpace on 2015-10-27T04:16:43Z (GMT). No. of bitstreams: 1
E.COLI DERIVED.pdf: 98272 bytes, checksum: 790fd419e1b8e714feae2f056470c757 (MD5)
Previous issue date: 2014
en
Nazarbayev University
cell carcinoma
saliva
protein
camelid antibodies
E.Coli derived camelid antibodies as a sensor for P53 in saliva
Abstract
oai:nur.nu.edu.kz:123456789/4732018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_410
Craig, B. J.
Engstrom, M.C.
2015-10-27T04:24:18Z
2015-10-27T04:24:18Z
2013
http://nur.nu.edu.kz/handle/123456789/473
This study investigates how much the citizens of Kazakhstan feel they have control over their own health. Efforts in health promotion build on the assumption that the public sees their current health choices and behaviors as related to and causes of particular health outcomes. Research shows that different populations demonstrate variance in health beliefs and attributions of health behaviors[1]. We examined the public’s perceived control over their health using the three subscales and whether these perceptions were correlated with health behaviors.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T04:24:18Z
No. of bitstreams: 1
perceptions.pdf: 770434 bytes, checksum: e33d218f3dc0a857f816bdc8bad97f12 (MD5)
Made available in DSpace on 2015-10-27T04:24:18Z (GMT). No. of bitstreams: 1
perceptions.pdf: 770434 bytes, checksum: e33d218f3dc0a857f816bdc8bad97f12 (MD5)
Previous issue date: 2013
en
Nazarbayev University
First research week
healthcare system
healthcare problems
Perceptions of control in health: cultural consideration
Abstract
oai:nur.nu.edu.kz:123456789/4862018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Redrejo-Rodriguez, M.
Mursalimov, A.
Koshenov, Z.
Zhakupova, K.
Saparbaev, M. K.
Ishchenko, A. A.
Matkarimov, B.
2015-10-27T04:40:45Z
2015-10-27T04:40:45Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/486
Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme
involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways. In the BER
pathway, APE1 cleaves DNA at AP sites and 3'-blocking moieties generated by DNA glycosylases. In the
NIR pathway, APE1 incises DNA 5' to a number of oxidatively damaged bases. Here we propose to identify
and characterize critical amino acids of APE1 involved in either BER and/or NIR functions by using
the alignment of the known three-dimensional (or tertiary) structures of Xth family AP endonucleases
including the Methanothermobacter thermautotrophicus Mth212, Bacillus subtilis ExoA (1), E. coli Xth
and human APE1 proteins (2).
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T04:40:45Z
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GENETIC DISSECTION.pdf: 103697 bytes, checksum: 15904d36d5aab0ed7e6fbc3056ab73a9 (MD5)
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GENETIC DISSECTION.pdf: 103697 bytes, checksum: 15904d36d5aab0ed7e6fbc3056ab73a9 (MD5)
Previous issue date: 2014
en
Nazarbayev University
DNA repair
APE1 protein
endonucleases
glycosylases
amino acid
biochemical
Genetic dissection of the biochemical activities of human DNA repair protein, APE1
Abstract
oai:nur.nu.edu.kz:123456789/4832018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_410
Craig, B. J.
Kabylbekova, Z.
2015-10-27T04:40:05Z
2015-10-27T04:40:05Z
2013
http://nur.nu.edu.kz/handle/123456789/483
Maternity care in Kazakhstan has been characterized as low in quality with low levels of public health knowledge. Previous research indicates childbirth preparation courses improve knowledge and encourage participation and decision making of mothers. Such courses, are rare in Kazakhstan. This study examined the benefits of childbirth preparation courses as well as the needs and expectations regarding childbirth care through the perspectives of new mothers.
The qualitative method of focus groups was chosen for this study in order to examine how people use and interpret meanings and messages in particular contexts. The criteria for participation included women who have given birth within the previous 12 months in Astana and had attended childbirth courses provided by the non-governmental organization SABI Astana.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T04:40:05Z
No. of bitstreams: 1
culture.pdf: 841999 bytes, checksum: c70331b7d70e284414d0ba80178c525a (MD5)
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culture.pdf: 841999 bytes, checksum: c70331b7d70e284414d0ba80178c525a (MD5)
Previous issue date: 2013
en
Nazarbayev University
healthcare system
maternity care
public health
childbirth preparation
childbirth preparation courses
Culture and maternity care in Kazakhstan: what new mothers expected
Abstract
oai:nur.nu.edu.kz:123456789/4932018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Rogers, P.
Niyazmetova, L.
Abdiyeva, K.
2015-10-27T04:56:02Z
2015-10-27T04:56:02Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/493
The primary objective of the present educational research program is to improve upon existing
commercially available USMLE review programs. With the clear shortage of both residency slots,
the medical student's performance (score), on the USMLE assumes a new and critical importance.
Furthermore, there is a global need for 4.3 million new doctors and nurses. This shortage is particularly
evident in Central and Southeast Asia. Many of the needed new doctors will most probably be required
to pass the USMLE.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T04:56:02Z
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AN INTEGRATED.pdf: 78799 bytes, checksum: 050310b28dd21985a31d103ffee87bd9 (MD5)
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AN INTEGRATED.pdf: 78799 bytes, checksum: 050310b28dd21985a31d103ffee87bd9 (MD5)
Previous issue date: 2014
en
Nazarbayev University
USMLE review programs
medical license
program
integration
project
educational
An integrated review program for the preparation for the United States medical license examination (USMLE)
Abstract
oai:nur.nu.edu.kz:123456789/4942018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_410
Overmyer, S.P.
Ivanov, I.
Fazylova, A.
Islam, S.
Kinayat, K.
Kussainov, K.
Sailuova, N.
Zhunisbekova, I.
2015-10-27T05:12:28Z
2015-10-27T05:12:28Z
2013
http://nur.nu.edu.kz/handle/123456789/494
The goal of this research is to unleash the creative potential of computer science students by engaging them in problem-solving activities within immersive simulations of real-world problem domains. This engagement provides the experience of learning to create solutions to ill-defined, real-world problems in a risk-free, but constrained and adaptive environment. Our long-term intention is to exploit the value of communities of practice for individual students by determining the necessary and sufficient conditions
for the formation of synthetic communities of practice (SCoP). This SCoP typically involves one “live” student, and a “community” of intelligent agents.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T05:12:28Z
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teaching.pdf: 859797 bytes, checksum: e0523c99f6d85f5573e388e15df47fcd (MD5)
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teaching.pdf: 859797 bytes, checksum: e0523c99f6d85f5573e388e15df47fcd (MD5)
Previous issue date: 2013
en
Nazarbayev University
problem-solving activities
synthetic communities of practice
NURIS
Teaching it with synthetic communities of practice
Abstract
oai:nur.nu.edu.kz:123456789/4952018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Saliev, T.
Illsley, M.
Akhmetova, A.
Nurgozhin, T.
Mikhalovsky, S. V.
2015-10-27T05:15:34Z
2015-10-27T05:15:34Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/495
The combination "cryogel + nanoparticles" allows developing a new type of wound
dressing, where antimicrobial properties of silver nanoparticles made have been utilized. Previous reports
have shown that the production of shaped nanoparticles and the incorporation onto cryogels is feasible
[1-2]. This study investigates the toxicity of these constructs to primary human dermal fibroblast cells in
context of possible clinical application.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T05:15:34Z
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TOXICITY STUDIES.pdf: 86909 bytes, checksum: 2e7d24a02b16debc364c8e7c3eee9498 (MD5)
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TOXICITY STUDIES.pdf: 86909 bytes, checksum: 2e7d24a02b16debc364c8e7c3eee9498 (MD5)
Previous issue date: 2014
en
Nazarbayev University
cryogel
nanoparticles
silver
polyacrylamide cryogel
human fibroblasts
Toxicity studies of combination of silver nanoparticles and cryogels
Abstract
oai:nur.nu.edu.kz:123456789/5012018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_410
Akhmetova, A.
Rakhimova, S.
Kairov, U.
Abilova, Zh.
Askapuli, A.
Zhabagin, M.
Yerezhepov, D.
Abilmazhinova, A.
Molkenov, A.
Akilzhanova, A.
2015-10-27T05:28:37Z
2015-10-27T05:28:37Z
2013
http://nur.nu.edu.kz/handle/123456789/501
In this study combined design was used, which included: 1) Case-control study; 2) Molecular epidemiological study; and 3) Study of human genetic susceptibility to tuberculosis.This work is the first case-control study in Kazakhstan where complex factors of TB risk and their effects are estimated. The study confirmed the role of main risk factors of tuberculosis development in Kazakhstan: young age, single relationship status, living in rent apartment, smoking, diabetes and migration.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T05:28:37Z
No. of bitstreams: 1
mapping of eco.pdf: 1076622 bytes, checksum: 50ea0fc74d6be44921eb3c5369806e57 (MD5)
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mapping of eco.pdf: 1076622 bytes, checksum: 50ea0fc74d6be44921eb3c5369806e57 (MD5)
Previous issue date: 2013
en
Nazarbayev University
health problems in Kazakhstan
case-control study
tuberculosis in Kazakhstan
Mapping of eco-social and genetic factors of susceptibility of tuberculosis among the population of the Rebuplic of Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/5022018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Saparov, A.
Alibek, K.
Brusic, V.
Pignatelli, M.
2015-10-27T05:35:29Z
2015-10-27T05:35:29Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/502
The ultimate goal of fundamental biomedical research is to decipher mechanisms underlying the
impairment of molecules, cells, tissues, and organs and subsequent dysfunction of the whole human body.
Knowledge of these mechanisms helps discover and develop new approaches in the diagnosis, prevention
and treatment of various diseases. Translational biomedical research enables the application of basic
scientific discoveries to diagnostics, patient care and clinical practice. Thus, translational biomedical
research is a link between fundamental research, clinical research and clinical practice. Transfer of
discoveries from the bench to the bedside is a very complex and time consuming process that includes
pre-clinical studies and several phases of clinical trials, along with the development of clinical guidelines
and protocols, and the eventual implementation of best clinical practices.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T05:35:29Z
No. of bitstreams: 1
THE FUTURE OF TRANSLATIONAL.pdf: 78358 bytes, checksum: 6b9decc199b100fb0f1a84f97145bd6c (MD5)
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THE FUTURE OF TRANSLATIONAL.pdf: 78358 bytes, checksum: 6b9decc199b100fb0f1a84f97145bd6c (MD5)
Previous issue date: 2014
en
Nazarbayev University
biomedical research
molecules
cells
tissues
organs
diagnosis
patient
clinical practice
health
gene
transcriptomics
proteomics
metabolomics
biomedical informatics
The future of translational biomedical research at Nazarbayev University
Abstract
oai:nur.nu.edu.kz:123456789/5042018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_410
Askarova, Sholpan
Tsoy, A.
Lee, J.C-M.
2015-10-27T05:48:07Z
2015-10-27T05:48:07Z
2013
http://nur.nu.edu.kz/handle/123456789/504
This study demonstrated that Aβ binding to RAGE at the CECs and astrocytes surface is required for NADPH oxidase complex assembling, resulting in subsequent ROS generation and phosphorylation of cPLA2α. Therefore, understanding precise molecular mechanisms underlying Aβ mediated oxidative damage may provide new insights into the development of preventive and treatment strategies for AD.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T05:48:07Z
No. of bitstreams: 1
rage.pdf: 1142402 bytes, checksum: 406f4c2e2769e927cdce6ac5faf905b7 (MD5)
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rage.pdf: 1142402 bytes, checksum: 406f4c2e2769e927cdce6ac5faf905b7 (MD5)
Previous issue date: 2013
en
Nazarbayev University
Alzheimer’s disease
healthcare system
Rage targeted strategies for Alzheimer`s Amyloid B peptide include blood brain barrier dysfunctions
Abstract
oai:nur.nu.edu.kz:123456789/5032018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Fujimoto, Y.
Schonbach, C.
2015-10-27T05:44:36Z
2015-10-27T05:44:36Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/503
Z-DNA is the left-handed helical structure of the usually right-handed B-DNA double
helix structure. Z-DNA conformations have been found to cause mutagenesis and genetic instability [1].
In this study, human genome sequences potentially forming Z-DNA regions (ZDRs) were extracted and
analysed for functional implications.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T05:44:36Z
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Z-DNA FORMING.pdf: 111171 bytes, checksum: 3919bcdd03761663b5ee8def960e4ea8 (MD5)
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Z-DNA FORMING.pdf: 111171 bytes, checksum: 3919bcdd03761663b5ee8def960e4ea8 (MD5)
Previous issue date: 2014
en
Nazarbayev University
Z-DNA
human genome
gene ontology
chromosomes
Z-DNA forming regions in the human genome
Abstract
oai:nur.nu.edu.kz:123456789/5052018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_411
Shramko, A.
Kiyan, V.
Borovikov, S. N.
2015-10-27T05:53:29Z
2015-10-27T05:53:29Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/505
The basic components of the diagnostic test systems are antigens and specific antibodies.
The main objective of developing express tests for the diagnosis of bovine leukemia virus (BLV) is to
obtain a virus antigen drug, which is very time-consuming to prepare. This problem can be solved by
producing anti-idiotype antibodies that have a chemical structure identical to that of the viral antigen
and does not require large expenditures to manufacture [1, 2].
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T05:53:29Z
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PREPARATION OF ANTI-IDIOTYPIC.pdf: 96026 bytes, checksum: d39407e1e0038e9e8aaafd05a8622e43 (MD5)
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Previous issue date: 2014
en
Nazarbayev University
antigens
antibodies
diagnosis
bovine leukemia
anti-idiotypic
Preparation of anti-idiotypic antibodies for the diagnosis of bovine leukemia
Abstract
oai:nur.nu.edu.kz:123456789/5062018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_410
Akhmetova, A. S.
Nurgozhin, T.S.
Mikhalovsky, S. V.
Saliev, T.
2015-10-27T06:02:38Z
2015-10-27T06:02:38Z
2013
http://nur.nu.edu.kz/handle/123456789/506
Cryogels are sponge-like, highly porous, interconnected hydrogels formed using a freezing process.They have a large surface area for wound contact and, in this case, with a selective barrier (agarose) that allows the passage of volatile malodorous molecules but not serum proteins. This way agarose scaffold absorbs wound exudate and incorporated activated carbon prevents odorous molecules from escaping. In this study, agarose cryogels, hydrogels and films and their composites with activated carbon (AC) were
studied as potential wound dressing materials.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T06:02:38Z
No. of bitstreams: 1
carbon.pdf: 1506251 bytes, checksum: 9d21b919eabc8954c96d225edbd75698 (MD5)
Made available in DSpace on 2015-10-27T06:02:38Z (GMT). No. of bitstreams: 1
carbon.pdf: 1506251 bytes, checksum: 9d21b919eabc8954c96d225edbd75698 (MD5)
Previous issue date: 2013
en
Nazarbayev University
science
polymer materials
treatment of chronic ulcers
Carbon-polymer dressing for the treatment of chronic ulcers
Abstract
oai:nur.nu.edu.kz:123456789/5072018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Sultankulov, B.
Mektepbayeva, D.
Zhiyenbay, Y.
Seralin, A.
Alibek, K.
2015-10-27T06:04:33Z
2015-10-27T06:04:33Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/507
Cell therapy using stem cells is a promising strategy for the treatment of ischemic
diseases, nevertheless low viability of implanted cells, is one of the main problems limiting stem cell
therapy. In addition, there is a risk of proliferation of the transformed cells in mesenchymal stem cells
carrying properties of cancer stem cells. Using conditioned media from stem cells instead of stem cell
themselves avoids the risks that may arise with the direct use of stem cells. Conditioned media from
various stem cells contains a different number of cytokines and growth factors, necessary for the natural
process of new vessel formation.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T06:04:33Z
No. of bitstreams: 1
DEVELOPMENT OF TECHNOLOGY.pdf: 83892 bytes, checksum: 1429436404f98456aaba62d3bf332860 (MD5)
Made available in DSpace on 2015-10-27T06:04:33Z (GMT). No. of bitstreams: 1
DEVELOPMENT OF TECHNOLOGY.pdf: 83892 bytes, checksum: 1429436404f98456aaba62d3bf332860 (MD5)
Previous issue date: 2014
en
Nazarbayev University
cell
implanted cells
cell therapy
cytokines
polymer
nanoparticles
angiogenesis
tissue
allogeneic transplantations
clinical application
Development of technology and study of optimized secreted products of stem cells for collaterogenesis
Abstract
oai:nur.nu.edu.kz:123456789/5172018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_410
Bulanin, D.
Mustapova, Zh.
Begimbetova, D.
Kanafina, A.
Lagasse, E.
2015-10-27T06:25:43Z
2015-10-27T06:25:43Z
2013
http://nur.nu.edu.kz/handle/123456789/517
In our experiments, we used Rat Mammary Tumor cell line as a supporting feeder cell layer and the media supplemented with several grows factors for mouse colon SC growing and expansion. The goal of our experiments was to identify potential markers that can be used for simple isolation of the SC from mouse colon using flow cytometry techniques.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T06:25:43Z
No. of bitstreams: 1
isolation.pdf: 1438408 bytes, checksum: f00a81f4fcfb2a2f4dcad9784067919c (MD5)
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isolation.pdf: 1438408 bytes, checksum: f00a81f4fcfb2a2f4dcad9784067919c (MD5)
Previous issue date: 2013
en
Nazarbayev University
Stem cell biology
modern biomedical science
Isolation and characterization of stem cells from mouse colon
Abstract
oai:nur.nu.edu.kz:123456789/5232018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Sypabekova, M. D.
Bekniyazov, I. S.
Bekmurzayeva, A. K.
Myrkhiyeva, Zh. M.
Chinybayeva, A. K.
Ashikbayeva, Zh. A.
Ayupova, T. Zh.
Mustafina, K. B.
Kanayeva, D.
2015-10-27T08:18:16Z
2015-10-27T08:18:16Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/523
Early detection of cancer is important in administering timely treatment and increasing
cancer survival rates. For early cancer detection one can use biomarkers, which are characteristics that
can be objectively measured or evaluated as indicators of normal or pathogenic processes. In our study we
study three protein biomarkers: carcinoembryonic antigen (CEA), interleukin-6 (IL-6) and extracellular
protein kinase A (ECPKA), which have been implicated in various types of human cancer. The main
objective of this project is to develop a biosensor for detection of multiple cancer biomarkers. To detect
these protein biomarkers high affinity ssDNA aptamers are being selected. Aptamers are short single
stranded DNAs with an ability to bind to various targets with high affinity and specificity which selected
by SELEX (Systemic Evolution of Ligands through Exponential enrichment) [2]. Ultimately, aptamers
against each of the biomarker will be conjugated to magnetic nanoparticles to capture biomarkers from
biological fluids. Another aptamer is proposed to be conjugated to quantum dots for quantitation of
biomarkers when analyzed on spectrometer.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T08:18:16Z
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MULTIPLEXED.pdf: 96936 bytes, checksum: 0ce1c0c51f0e433964cf8d70e21f7b2a (MD5)
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MULTIPLEXED.pdf: 96936 bytes, checksum: 0ce1c0c51f0e433964cf8d70e21f7b2a (MD5)
Previous issue date: 2014
en
Nazarbayev University
biomarkers
protein
spectrometer
analyze
magnetic nanoparticles
aptamers
biological fluids
Multiplexed detection of cancer biomarkers using an optical biosensor
Abstract
oai:nur.nu.edu.kz:123456789/5242018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_410
Freese, K.
Shubnikov, E.
LaPorte, R.
Adambekov, S.
Askarova, Sholpan
Zhumadilov, Z.
Linkov, F.
2015-10-27T08:29:15Z
2015-10-27T08:29:15Z
2013
http://nur.nu.edu.kz/handle/123456789/524
The Central Asian Journal of Global Health (CAJGH) is the first peer reviewed, open access journal in Central Asia (CA) aimed at those working in the areas of public health, medicine, and bioengineering. Specifically, it focuses on a geographic region that is oftentimes not highlighted by existing journals. While the main focus at CAJGH is placed on CA countries, submissions from other regions are encouraged as well. Many accepted publications have come from outside the CA region.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T08:29:15Z
No. of bitstreams: 1
the central.pdf: 728734 bytes, checksum: 3af7f89dff8d76e45fdc135ce3b2178f (MD5)
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the central.pdf: 728734 bytes, checksum: 3af7f89dff8d76e45fdc135ce3b2178f (MD5)
Previous issue date: 2013
en
Nazarbayev University
The Central Asian Journal of Global Health
research articles
open access journal
The Central Asian journal of global health to increase science productivity
Abstract
oai:nur.nu.edu.kz:123456789/5252017-11-01T04:33:08Zcom_123456789_409com_123456789_129col_123456789_411oai:nur.nu.edu.kz:123456789/5262018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_410
Kairov, U.
Molkenov, A.
Zhabagin, M.
Askapuli, A.
Abilmazhinova, A.
Akhmetova, A.
Yerezhepov, D.
Abilova, Zh.
Rahimova, S.
Zhumadilov, Zh.
Akilzhanova, A.
2015-10-27T08:56:05Z
2015-10-27T08:56:05Z
2013
http://nur.nu.edu.kz/handle/123456789/526
The aim of the project is to define genetic architecture of Kazakh population by sequencing and analyzing whole exomes and whole genomes of Kazakhs living in different regions of Kazakhstan
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T08:56:05Z
No. of bitstreams: 1
genetic.pdf: 854135 bytes, checksum: 76e330c89aa4b1b5a10e2062e34d0cad (MD5)
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genetic.pdf: 854135 bytes, checksum: 76e330c89aa4b1b5a10e2062e34d0cad (MD5)
Previous issue date: 2013
en
Nazarbayev University
genetic architecture
Kazakh population
Genetic architecture of Kazakh population
Abstract
oai:nur.nu.edu.kz:123456789/5352018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Tokay, T.
Rehberg, M.
Kirschstein, T.
Rohde, M.
Mueller, L.
Askarova, Sholpan
Kohling, R.
Zhumadilov, Z.
2015-10-27T09:17:29Z
2015-10-27T09:17:29Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/535
The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the
induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission
in the hippocampus, and cognitive impairments in aged animals are accompanied by reduced NMDARmediated
plasticity at Schaffer collateral—CA1 synapses. However, the specific contribution of NMDAR
subunits to NMDAR-mediated synaptic responses in aged tissue has not yet been fully understood. The
main purpose of present study was to examine whether there is an impact of aging on NMDAR subunit
expression and whether synaptic plasticity may depend on NMDAR subunit composition in the aged
hippocampus.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T09:17:29Z
No. of bitstreams: 1
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ALTERED NR2A.pdf: 87252 bytes, checksum: e02fcdafd08dd97c1875d98e975726d1 (MD5)
Previous issue date: 2014
en
Nazarbayev University
hippocampus
aged animals
NR2B/NR2A ratio
synaptic plasticity
Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats
Abstract
oai:nur.nu.edu.kz:123456789/5342018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Zhumadilov, Zh.
Issayeva, R.
Berikkhanova, K.
Terlikbayeva, A.
Darisheva, M.
Amirov, B.
Rakhimova, S.
Akilzhanova, A.
2015-10-27T09:16:52Z
2015-10-27T09:16:52Z
2013
http://nur.nu.edu.kz/handle/123456789/534
We designed a case-control study to examine demographic, clinical, social and cultural factors associated with tuberculosis in four regions of Kazakhstan. Cases included persons identified by the national tuberculosis program as having primary pulmonary tuberculosis, and controls were healthy household members and randomly selected community residents.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T09:16:52Z
No. of bitstreams: 1
genetic, social.pdf: 1926203 bytes, checksum: ce45c479a83e41250eff9fcad023c8be (MD5)
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genetic, social.pdf: 1926203 bytes, checksum: ce45c479a83e41250eff9fcad023c8be (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
Tuberculosis control
case-control studies
Genetic, social, and behavioral risk factors for tuberculosis: preliminary results from a matched case-control study in Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/5372018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Tsoy, A.
Askarova, Sholpan
Shalakhmetova, T.
Umbayev, B.
Adambekov, S.
Zhumadilov, Z.
2015-10-27T10:20:56Z
2015-10-27T10:20:56Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/537
Blood-brain barrier dysfunction plays an important role in the onset and progression
of Alzheimer's disease (AD). In the AD brains an increased deposition of A(3 in the cerebral vasculature
has been found to correlate with increased transmigration of blood-born inflammatory cells and
neurovascular inflammation [1]. Transmigration of leukocytes into brain parenchyma is a sequential
process starting with primary capture to the endothelium and rolling adhesion mediated by tethering
on selectins and selectin ligands. P-selectin is a type I transmembrane cell adhesion molecule which is
stored in cytoplasmic Weibel-Palade bodies (WPb) and can be mobilized on the endothelial cell surface
within minutes upon exposure to different pro-inflammatory agents; then it's rapidly cleared through
endocytosis in 30 min. It has become evident that A(3 activates cerebral endothelial cells (CECs) and
induces mobilization of P-selectin to the cell surface [2]. However, expression mechanisms of this receptor
on the surface of brain endothelial cells under administration with A(342 remain unclear. Since P-selectin
is stored in WPb, and there is an evidence of active role of ROS (reactive oxygen species) and actin
filaments in the different stages of WPb exocytosis, in this study we examined the dynamic of P-selectin
expression on the endothelial cell surface activated by A(342 in relation to ROS and actin polymerization.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T10:20:56Z
No. of bitstreams: 1
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ROLE OF ROS IN A042 MEDIATED.pdf: 77963 bytes, checksum: aba43642b6e3464a2dc5d09a9f57e0fc (MD5)
Previous issue date: 2014
en
Nazarbayev University
blood-brain
leukocytes
cytoplasmic
endothelial cells
physiological trigger
actin polymerization
blood
Role of ROS in AB42 mediated cell surface P-selectin expression and actin polymerization
Abstract
oai:nur.nu.edu.kz:123456789/5382018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Akhmetova, A. S.
Saliev, T.
Nurgozhin, T.S.
Mikhalovsky, S. V.
2015-10-27T10:40:01Z
2015-10-27T10:40:01Z
2013
http://nur.nu.edu.kz/handle/123456789/538
500 million persons live with various kidney diseases. Chronic illness of kidneys eventually leads to the terminal stage known as end stage renal disease (ESRD). Dialysis is a life sustaining therapy for patients who progress to ESRD and do not receive a transplant. There are over one million ESRD patients on dialysis worldwide. Despite the relatively high cost of dialysis ($55,000 per patient per year) patient survival remains poor. Current dialysis systems remove small, water soluble metabolites but fail to remove significant amounts of higher molecular weight and protein bound uraemic toxins whose retention is most damaging. In this project an alternative extracorporeal treatment using adsorption as the main clearing process, is being developed.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T10:40:01Z
No. of bitstreams: 1
nanostructured carbon.pdf: 1644680 bytes, checksum: b204f3c7a76887611e1771128cf0ad92 (MD5)
Made available in DSpace on 2015-10-27T10:40:01Z (GMT). No. of bitstreams: 1
nanostructured carbon.pdf: 1644680 bytes, checksum: b204f3c7a76887611e1771128cf0ad92 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
end stage renal disease
healthcare problems
Nanostructured carbon adsorbents for haemoperfusion
Abstract
oai:nur.nu.edu.kz:123456789/5392018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Ualiyeva, S.
Umbayev, B.
Masoud, A.
Askarova, Sholpan
2015-10-27T10:47:44Z
2015-10-27T10:47:44Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/539
Acute and chronic liver diseases are common in Kazakhstan and other countries. These
diseases are known to cause significant disability and death. In many cases, liver transplantation is the
last resort for patients with end stage liver disease, but it is an extremely expensive procedure and is
associated with many risks. The most important among them is an immune rejection. Autologous cell
transplantation is a potential therapeutic approach for liver regeneration and could become an alternative
to organ transplantation. In this regard, mesenchymal stem cells (MSCs) are a very attractive source for
differentiation into hepatocytes. These cells can be isolated from bone marrow and adipose tissue of the
patient and exponentially expanded in vitro. Transplantation of hepatocytes differentiated from MSCs
could become a new promising approach in treatment of the patients with chronic liver conditions.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T10:47:44Z
No. of bitstreams: 1
DIFFERENTIATION OF MESENCHYMAL.pdf: 81676 bytes, checksum: f08e97fffda9ade882cb7f8d4779014b (MD5)
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DIFFERENTIATION OF MESENCHYMAL.pdf: 81676 bytes, checksum: f08e97fffda9ade882cb7f8d4779014b (MD5)
Previous issue date: 2014
en
Nazarbayev University
acute
chronic
liver
cell
organ
transplantation
mesenchymal stem cells
hepatocytes
Differentiation of mesenchymal stem cells into hepatocytes
Abstract
oai:nur.nu.edu.kz:123456789/5412018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_410
Molkenov, A.
Abilmazhinova, A.
Akhmetova, A.
Chingisova, L.
Bismilda, V.
Yerezhepov, D.
Kozhamkulov, U.
Abilova, Zh.
Askapuli, A.
Zhabagin, M.
Kairov, U.
Rahimova, S.
Zhumadilov, Zh.
Akilzhanova, A.
2015-10-27T11:25:10Z
2015-10-27T11:25:10Z
2013
http://nur.nu.edu.kz/handle/123456789/541
The next generation sequencing technology provides a tool to obtain genetic data from clinically isolates M.tuberculosis. Using it we can clarify the factors cause of the formation of highly virulent strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance, which will pave the personalized approach in the diagnosis and treatment of TB.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T11:25:10Z
No. of bitstreams: 1
creating.pdf: 865556 bytes, checksum: e6a04f94142b771e4f079efa43468d5c (MD5)
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creating.pdf: 865556 bytes, checksum: e6a04f94142b771e4f079efa43468d5c (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
Tuberculosis
healthcare problems
Creating prerequisites of personalized approach in the diagnosis and treatment of tuberculosis, based on whole genome-sequencing of M.tuberculosis
Abstract
oai:nur.nu.edu.kz:123456789/5402018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Ualiyeva, S.
Umbayev, B.
Donbay, A.
Askarova, Sholpan
2015-10-27T10:58:27Z
2015-10-27T10:58:27Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/540
Chronic degenerative liver diseases are among most complex social, clinical and
epidemiological health problems worldwide. This is due to the steady increase in the incidence and
mortality of patients with this pathology. Orthotopic liver transplantation is the only way to save the
lives of patients with decompensated diffuse and focal lesions of the liver. One-year survival after liver
transplantation reaches 60-80%, but more than half of the patients on the waiting list do not survive until
operation. In this regard, hepatocyte transplantation could be an option for the patients who are on the
waiting list for organ transplantation.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-27T10:58:27Z
No. of bitstreams: 1
ISOLATION OF PRIMARY.pdf: 76431 bytes, checksum: c0f8c38f40324f474d6feeebb1095b79 (MD5)
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ISOLATION OF PRIMARY.pdf: 76431 bytes, checksum: c0f8c38f40324f474d6feeebb1095b79 (MD5)
Previous issue date: 2014
en
Nazarbayev University
chronic degenerative liver
epidemiological health
pathology
orthotopic liver
liver
hepatocyte
cirrhosis
Isolation of primary human hepatocytes from cirrhotic liver
Abstract
oai:nur.nu.edu.kz:123456789/5422018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_410
Saliev, T.
Tachibana, K.
Campbell, P.A.
2015-10-28T04:11:45Z
2015-10-28T04:11:45Z
2013
http://nur.nu.edu.kz/handle/123456789/542
The purpose for the present study is to quantify the biological effects of ultra-low intensity and its ability to induce the apoptosis in cancer cells, mainly characterized via cell viability and apoptosis assays, and including scenarios with ultrasound-contrast agent presence.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T04:11:45Z
No. of bitstreams: 1
induction.pdf: 1375389 bytes, checksum: 979234c766c612ead27c599c873f0f08 (MD5)
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induction.pdf: 1375389 bytes, checksum: 979234c766c612ead27c599c873f0f08 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
cancer treatment
cancer cells
healthcare problems
blood cancer
Induction of apoptosis by ultra-low intensity ultrasound for cancer treatment
Abstract
oai:nur.nu.edu.kz:123456789/5432018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Tsoy, A.
Askarova, Sholpan
Shalakhmetova, T.
Umbayev, B.
Adambekov, S.
Zhumadilov, Z.
2015-10-28T04:35:28Z
2015-10-28T04:35:28Z
2013
http://nur.nu.edu.kz/handle/123456789/543
The results of our study have indicated that Aβ42 induces expression of P-selectin on the surface of bEnd3 cells and promotes actin polymerization in a time dependent manner, and all these events correlate with ROS generation. The rapid, posttranslational cell signaling response mediated by ROS, may well represent an important physiological trigger of the micro vascular inflammatory response in AD and requires further investigations.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T04:35:28Z
No. of bitstreams: 1
role.pdf: 1157795 bytes, checksum: 8382c56c6a109d88a7dfb05f67c9a835 (MD5)
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role.pdf: 1157795 bytes, checksum: 8382c56c6a109d88a7dfb05f67c9a835 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
cells
ROS generation
Role of ROS in AB42 mediated cell surface p-selectin expression and actin polymerization
Abstract
oai:nur.nu.edu.kz:123456789/5442018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_410
Kulsharova, G.
Saliev, T.
Akhmetova, A.
Nurgozhin, T.
Mikhalovsky, S. V.
2015-10-28T04:46:01Z
2015-10-28T04:46:01Z
2013
http://nur.nu.edu.kz/handle/123456789/544
The purpose of this project is to develop a system capable of eliminating the bacterial infection in clinical environment, by means of new type of wound dressing based on macroporous polymer hydrogel matrix. The matrix has embedded conductive nanoparticles with antimicrobial and bactericidal activity, which can be enhanced by external application of microwaves.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T04:46:01Z
No. of bitstreams: 1
nanoparticle.pdf: 818072 bytes, checksum: 1882b929dfa90830f99de59824c52c77 (MD5)
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nanoparticle.pdf: 818072 bytes, checksum: 1882b929dfa90830f99de59824c52c77 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
bacterial infection
bactericidal activity
antimicrobial activity
Nanoparticle based wound dressings with microwave-enhanced antimicrobial function
Abstract
oai:nur.nu.edu.kz:123456789/5452018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_410
Askarova, Sholpan
Umbayev, B.
Tsoy, A.
Bulanin, D.
Ongarbayeva, N.
Shalakhmetova, T.
2015-10-28T05:15:40Z
2015-10-28T05:15:40Z
2013
http://nur.nu.edu.kz/handle/123456789/545
The results of our study provide evidence that HT improved animal survival and liver functions by generating an ectopic hepatic mass inside the Peyer’s patches. These observations point to the conclusion that hepatocyte transplantation into lymph nodes would improve efficacy of cell –based therapy of patients with liver fibrosis and cirrhosis.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T05:15:40Z
No. of bitstreams: 1
cell therapeutic.pdf: 1201678 bytes, checksum: 59de17ba1aa50a895e1c040fab36f2b3 (MD5)
Made available in DSpace on 2015-10-28T05:15:40Z (GMT). No. of bitstreams: 1
cell therapeutic.pdf: 1201678 bytes, checksum: 59de17ba1aa50a895e1c040fab36f2b3 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
healthcare
liver fibrosis
Cell therapeutic approaches for the treatment of experimentally induced liver fibrosis
Abstract
oai:nur.nu.edu.kz:123456789/5462018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_410
Yantsen, Y.
Askarova, Sholpan
Adambekov, S.
Murata, H.
Andersen, J.
D’Souza, S.
Edington, C.
Koepsel, R.
Russell, A.
2015-10-28T05:27:49Z
2015-10-28T05:27:49Z
2013
http://nur.nu.edu.kz/handle/123456789/546
The polymer coated cells were shown to be stably attached to bone fragments for at least 2 hours, confirming the bone targeting potential of the polymer. Our next step will be to test this approach in rat model of osteoporosis to determine its actual performance in vivo.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T05:27:49Z
No. of bitstreams: 1
polymer.pdf: 553915 bytes, checksum: 983c7ead8e1e26d21f36e9e18851374e (MD5)
Made available in DSpace on 2015-10-28T05:27:49Z (GMT). No. of bitstreams: 1
polymer.pdf: 553915 bytes, checksum: 983c7ead8e1e26d21f36e9e18851374e (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
polymer
science
Bone remodeling
Polymer coating enhances affinity of bone marrow-derived MSCS to bone
Abstract
oai:nur.nu.edu.kz:123456789/5472018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Wheeler, C. G.
Felten, M. K.
Yengsep, K.
2015-10-28T06:25:44Z
2015-10-28T06:25:44Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/547
The project designs and tests a multifaceted worksite intervention protocol that includes
smoking cessation, dietary instruction, and exercise regimens to lower the prevalence of CVD morbidity
and mortality in Kazakhstan. Kazakhstan has among the highest CVD morbidity and mortality rates in
the world. Development of an effective worksite intervention model that targets and improves the health
behaviors and health status of high-risk middle age working males can be extended to the Republic's
crucial and expanding workplace environment.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T06:25:44Z
No. of bitstreams: 1
COMBATING CVD.pdf: 77288 bytes, checksum: d4620352cf8a29e244ba825250edb9ff (MD5)
Made available in DSpace on 2015-10-28T06:25:44Z (GMT). No. of bitstreams: 1
COMBATING CVD.pdf: 77288 bytes, checksum: d4620352cf8a29e244ba825250edb9ff (MD5)
Previous issue date: 2014
en
Nazarbayev University
CVD
workplace
combating
social marketing
methodology
Combating CVD in Kazakhstan through workplace interventions
Abstract
oai:nur.nu.edu.kz:123456789/5482018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_410
Zhabagin, M.
Sabitov, Zh.
Tarlykov, P.
Dibirova, H.
Bogunova, A.
Tazhigulova, I.
Frolova, S.
Isakova, Zh.
Nymadawa, P.
Zakharov, I.
Balanovsky, O.
2015-10-28T08:08:32Z
2015-10-28T08:08:32Z
2013
http://nur.nu.edu.kz/handle/123456789/548
There is a strong connection between social selection and birth rate of the descendants, whose fathers had achieved high social status during the expansion of the Mongol Empire and associated historical events. We suppose this major ancestral haplotype to be the “proto-Mongolian haplotype”, inherited by Genghis Khan and his descendants. It can be assumed that the four common haplotypes also spread as a result of positive social selection, because some clans were endowed with a number of privileges and high
status during the Mongol expansion.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T08:08:32Z
No. of bitstreams: 1
the possible.pdf: 1138339 bytes, checksum: a85753c44b214cc90c58c4923f257bad (MD5)
Made available in DSpace on 2015-10-28T08:08:32Z (GMT). No. of bitstreams: 1
the possible.pdf: 1138339 bytes, checksum: a85753c44b214cc90c58c4923f257bad (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
Central Asian populations
Mongol Empire
Genghis Khan
Mongol expansion
The possible role of social selection in the distribution of major haplotypes of Y-chromosome haplogroup C3 in Central Asian populations
Abstract
oai:nur.nu.edu.kz:123456789/5502018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Yerezhepov, D.
Zhabagin, M.
Abilova, Zh.
Askapuli, A.
Abilmazhinova, A.
Rakhimova, S.
Kairov, U.
Molkenov, A.
Akhmetova, A.
Akilzhanova, A.
2015-10-28T08:28:34Z
2015-10-28T08:28:34Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/550
Almost one third of the world's population is infected with Mycobacterium tuberculosis
(MTB) and only 10% of them will develop any active form of the disease. TB is second (1s t is HIV/AIDS)
greatest killer worldwide due to a single infectious agent. In 2012, 8.6 million people developed active TB
and 1.3 million died. Over 95% of TB deaths occur in developing countries. In 2012, an estimated more
than half million children became ill with TB and 74 000 of them died. The TB cases are declining annually,
but very slowly. Multi-drug resistant TB (MDR-TB) and extensively drug-resistant tuberculosis (XDRTB)
is present in almost all surveyed countries. Kazakhstan is not highly burdened by TB. Kazakhstan is
the list of MDR-TB and XDR-TB burden countries. Our aim is to investigate an association of Vitamin D
receptor (FokI, TaqI, ApaI & BsmI) and IF-y genes" polymorphisms with risk of developing pulmonary
TB (PTB) among Kazakhstani population.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T08:28:34Z
No. of bitstreams: 1
A S S O C I A T I O N O F V I T A M I N D.pdf: 94394 bytes, checksum: 7e315182c5ad90773d814b8924a7ba83 (MD5)
Made available in DSpace on 2015-10-28T08:28:34Z (GMT). No. of bitstreams: 1
A S S O C I A T I O N O F V I T A M I N D.pdf: 94394 bytes, checksum: 7e315182c5ad90773d814b8924a7ba83 (MD5)
Previous issue date: 2014
en
Nazarbayev University
vitamin D
FokI
TaqI
ApaI
BsmI
IF-y genes
polymorphisms
pulmonary
healthy
Association of vitamin D receptor (FOKI, TAQI, APAI & BSMI) and IF-y genes' polymorphisms with risk of developing pulmonary TB (PTB) among Kazakhstani population
Abstract
oai:nur.nu.edu.kz:123456789/5492018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_410
Zhumadilov, Zh.
Mussin, Y.
Bulanin, D.
Federspiel, W.J.
Wearden, P.
Kuhn, N.
2015-10-28T08:23:00Z
2015-10-28T08:23:00Z
2013
http://nur.nu.edu.kz/handle/123456789/549
At present, severe respiratory failure is a leading cause of neonatal and pediatric mortality in Kazakhstan. Ventilator therapy is not always applicable and do not allow to manage effectively the formidable complications of the diseases. The main focus of the project is the development of one of the methods that provides direct oxygen supply to the blood and CO2 removal, bypassing the hematoalveolar barrier and avoiding the risks of currently used extracorporeal life support devices. The overall goal was to modify an existing CO2 removal device (Hemolung) to meet the required parameters for
pediatric application.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T08:23:00Z
No. of bitstreams: 1
development.pdf: 1116140 bytes, checksum: 48873aa875308d4ec664b3309871d6f9 (MD5)
Made available in DSpace on 2015-10-28T08:23:00Z (GMT). No. of bitstreams: 1
development.pdf: 1116140 bytes, checksum: 48873aa875308d4ec664b3309871d6f9 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
pediatric application
oxygen supply
Hemolung Respiratory Support system
Development of an improved extracorporeal gas exchange device for future pediatric application
Abstract
oai:nur.nu.edu.kz:123456789/5522018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Baiken, Y.
Mussabekova, A.
Aituov, B.
Kashikova, S.
Bexeitov, Y.
Alibek, K.
2015-10-28T08:39:10Z
2015-10-28T08:39:10Z
2013
http://nur.nu.edu.kz/handle/123456789/552
Current work demonstrates use of modern in silico tools for predicting peptide-based vaccine candidates. Four out of twenty one showed good HSV-2 neutralization activity. Further investigation is needed to obtain effective anti-HSV protective vaccine candidates. Future directions of this work will be further optimization of epitope selection strategy and use of other search algorithms.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T08:39:10Z
No. of bitstreams: 1
dev.pdf: 1749293 bytes, checksum: eaf6fc3bac10cfe9aec52769274c5ec4 (MD5)
Made available in DSpace on 2015-10-28T08:39:10Z (GMT). No. of bitstreams: 1
dev.pdf: 1749293 bytes, checksum: eaf6fc3bac10cfe9aec52769274c5ec4 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
multivalent vaccine
human herpesvirus
Development of a multivalent vaccine against human herpesviruses
Abstract
oai:nur.nu.edu.kz:123456789/5512018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Zhalmagambetov, B.
Orakov, A.
Gilman, C.
2015-10-28T08:38:36Z
2015-10-28T08:38:36Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/551
Cancer is responsible for millions of deaths annually1. Especially, cancer in overweight people
becoming to pose a threat as some cancers are becoming resistant to chemotherapy 2 , 3 . In addition,
most overweight people have a diabetes or hyperglycemia. Although it was shown that hyperglycemia
can trigger epigenetic changes in many cancer cells, there is no data how hyperglycemia would affects
migration through epigenetic alterations. We aim to study abovementioned by assessing the cell migration
under hyperglycemic conditions on glioblastoma cells and the specific epigenetic changes associated with
hyperglycemia. We will use immunofluorescence, bisulfate conversion sequencing to assess epigenetic
status and do scratch assay to study cell migration. Our results can shed light on the effect of epigenetic
changes to cell migration under hyperglycemic conditions.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T08:38:36Z
No. of bitstreams: 1
HYPERGLYCEMIA INDUCED.pdf: 86550 bytes, checksum: f1a951fa61ebb61a28f258a5b4bad1ba (MD5)
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HYPERGLYCEMIA INDUCED.pdf: 86550 bytes, checksum: f1a951fa61ebb61a28f258a5b4bad1ba (MD5)
Previous issue date: 2014
en
Nazarbayev University
diabetes
hyperglycemia
glioblastoma cells
epigenetic changes
immunofluorescence
cell migration
chemotherapy
cell
Hyperglycemia induced epigenetic changes and cell migration
Abstract
oai:nur.nu.edu.kz:123456789/5532018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Zhulamanova, A.
Shakhabayeva, G.
Saduakhasova, S.
Kozhakhmetov, S.
Kushugulova, A.
2015-10-28T08:50:26Z
2015-10-28T08:50:26Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/553
Ecology affects human organism by causing breaks in DNA and, therefore, induce
mutations and malignant cell formation. Comet assay is a quantitative method that allows to measure
DNA damage in eukaryotic cells (Liao, McNutt, & Zhu, 2009). This method is widely used in areas,
such as human biomonitoring, genotoxicology, and ecology. Comet assay is also called a single-cell gel
electrophoresis. Thus, the products of electrophoresis are analyzed under the fluorescent light, which
makes it similar to comets. DNA strand breaks are detected by comparing the intensity of the comet
tail relative to the head (Collins, 2004). Probiotics containing Lactobacillus rhamnosus were used, as
Lactobacilli probiotics were found to be safe and effective against urogenital diseases, food hypersensitivity,
and dental caries (Lebeer, Vanderleyden, & De Keersmaeckler, 2008). The aim of the research was to
study DNA protector mechanism for three probiotic products, containing L. rhamnosus.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T08:50:26Z
No. of bitstreams: 1
ANALYSIS OF PROTECTOR MECHANISM.pdf: 102209 bytes, checksum: 425765a52f47f5c1a4414f86d77f5c73 (MD5)
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ANALYSIS OF PROTECTOR MECHANISM.pdf: 102209 bytes, checksum: 425765a52f47f5c1a4414f86d77f5c73 (MD5)
Previous issue date: 2014
en
Nazarbayev University
ecology
human organism
DNA
comet assay
eukaryotic cells
biomonitoring
genotoxicology
gel electrophoresis
electrophoresis
fluorescent light
probiotics
Analysis of protector mechanism of probiotics using DNA comet assay
Abstract
oai:nur.nu.edu.kz:123456789/5542018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Kanayeva, D.
Bekmurzayeva, A.
Bekniyazov, I.
Rakhmetova, A.
Sypabekova, M.
Ashikbayeva, Z.
Akan, M.
Wang, R.
Lum, J.
Li, Y.
2015-10-28T08:57:50Z
2015-10-28T08:57:50Z
2013
http://nur.nu.edu.kz/handle/123456789/554
Tuberculosis (TB) is an airborne disease caused by Mycobacterium tuberculosis. TB is the leading cause of morbidity and mortality in the developing world. Early and accurate diagnosis of TB would greatly enhance the treatment and prevention of the disease. Current methods of TB detection suffer from various limitations such as low specificity and sensitivity, being too complex and expensive. In the present work, we aim to develop an optical biosensor based on DNA aptamers, quantum dot (QD) crystals and magnetic nanoparticles (MNP) for detection of MPT64 protein, specific to M.tuberculosis. Aptamer-MNP conjugate is used for separation of MPT64 from solution, while aptamer-QD is used to detect its presence afterwards using fluorometer.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T08:57:50Z
No. of bitstreams: 1
development of an optical.pdf: 840394 bytes, checksum: 34bd6b58d6daee3fdc428d31134f8a44 (MD5)
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development of an optical.pdf: 840394 bytes, checksum: 34bd6b58d6daee3fdc428d31134f8a44 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
healthcare problems
Tuberculosis control
optical biosensor
Development of an optical biosensor for diagnosis of tuberculosis
Abstract
oai:nur.nu.edu.kz:123456789/5552018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Shayakhmetov, Y.
Jaguparov, A.
Tsoy, A.
2015-10-28T09:02:16Z
2015-10-28T09:02:16Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/555
Alzheimer's disease (AD) is a chronic neurodegenerative disorder which affects
approximately 10% of the population at age 65 and 40% of people over the age 80. Clinically, AD pathology
is characterized by an increased deposition of amyloid-(3 peptide (A(3) in the brain, and a progressive
impairment of cognition and memory of affected individuals. Blood Brain Barrier (BBB) dysfunction is
observed in all of the stages of AD, and may even precede neuron degeneration in AD brains. During the
early stages of AD, microvasculature deficiencies and hypertrophy of astrocytes are commonly observed.
Numerous in vivo and in vitro studies have demonstrated that the vascular deposition of A(3 induces
oxidative stress in cerebral endothelial cells (CECs). A(3-induced oxidative stress in cells, in turn, initiates
a cascade of redox reactions leading to apoptosis and neurovascular inflammation. Consequently,
antioxidants are considered as therapeutic agents in A(3-induced CECs damage.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T09:02:16Z
No. of bitstreams: 1
EXTRACT OF LIMONIUM.pdf: 89782 bytes, checksum: 063e7f259c6ee3cb42ef1a4cdcc2d9f4 (MD5)
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EXTRACT OF LIMONIUM.pdf: 89782 bytes, checksum: 063e7f259c6ee3cb42ef1a4cdcc2d9f4 (MD5)
Previous issue date: 2014
en
Nazarbayev University
limoniun gmelinii
polyphenols
neuron
hypertrophy
astrocytes
pathology
blood brain barrier
Extract of limonium gmelinii attenuates AB-and H2O2-induced oxidative response in cerebral endothelial cells
Abstract
oai:nur.nu.edu.kz:123456789/5562018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Kakpenova, A.
Zhanbossinova, A.
Negmetzhanov, B.
Tauanov, Z.
Karginov, V.
Adilov, S.
Alibek, K.
2015-10-28T09:08:09Z
2015-10-28T09:08:09Z
2013
http://nur.nu.edu.kz/handle/123456789/556
“Rational Drug Design” method is a new principle and methodology in producing pharmaceuticals based on precise and structure-oriented approach. The proposed method is based on principle of blocking the pores caused by Staphylococccus aureus (S. aureus) toxins in the membranes of host cells [1]. Design of β-cyclodextrin derivatives with precise geometry might be used for production of antibacterial and prophylactic pharmaceuticals against S. aureus infection.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T09:08:09Z
No. of bitstreams: 1
rational.pdf: 839059 bytes, checksum: 587d7e57b3b8e761ceb9aa9055fad0e1 (MD5)
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rational.pdf: 839059 bytes, checksum: 587d7e57b3b8e761ceb9aa9055fad0e1 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
chemical drugs
pharmaceuticals
Staphylococccus aureus infection
Rational design of new chemical drugs based on compounds that block the pores in cell membranes
Abstract
oai:nur.nu.edu.kz:123456789/5572018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Alzaatreh, A.
Famoye, F.
Lee, C.
2015-10-28T09:12:58Z
2015-10-28T09:12:58Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/557
Statistical distributions are commonly applied to describe real world phenomena. Due to the usefulness
of statistical distributions, their theory is widely studied and new distributions are developed. The
interest in developing more flexible statistical distributions remains strong in statistics profession. Many
generalized classes of distributions have been developed and applied to describe various phenomena.
Recently, Alzaatreh et al. (2014) developed a new method to generate family of distributions and called it
the gamma-X family of distributions.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T09:12:58Z
No. of bitstreams: 1
A NEW GENERALIZATION.pdf: 120508 bytes, checksum: c3d9d18e770151b9261045b813e971de (MD5)
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A NEW GENERALIZATION.pdf: 120508 bytes, checksum: c3d9d18e770151b9261045b813e971de (MD5)
Previous issue date: 2014
en
Nazarbayev University
phenomena
generalization
normal distribution
statistical properties
gamma-normal distribution
A new generalization of the normal distribution: the gamma-normal distribution and its applications
Abstract
oai:nur.nu.edu.kz:123456789/5582018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_410
Zhanbossinova, A.
Yespolayeva, S.
Khamitova, G.
Negmetzhanov, B.
Alibek, K.
Adilov, S.
2015-10-28T09:19:19Z
2015-10-28T09:19:19Z
2013
http://nur.nu.edu.kz/handle/123456789/558
Incorporating indole, resorcinol, and porphyrin derivatives into ferrocene and ruthenium complexes could improve their anticancer activity. These compounds are furnished with functional groups which are expected to induce programmed cell death and show high selectivity to cancer cells. Currently, they are at the stage of in vitro testing for anticancer activity.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T09:19:19Z
No. of bitstreams: 1
novel.pdf: 760536 bytes, checksum: 7947a0b074a950deb21f28c7c72e8134 (MD5)
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novel.pdf: 760536 bytes, checksum: 7947a0b074a950deb21f28c7c72e8134 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
cancer treatment
anticancer activity
Novel organometallic compounds for cancer treatment
Abstract
oai:nur.nu.edu.kz:123456789/5592018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Akhatova, A.
Kassymov, A.
Kazmaganbetova, M.
Rojas-Solorzano, L.
2015-10-28T09:35:01Z
2015-10-28T09:35:01Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/559
Due to the steadily rising number of vehicles, atmospheric air pollution has become
one of the evident problems in main cities around the world. Astana, the capital city of Kazakhstan,
is not an exception with it current expansion and economic growth. In order to avoid the hazardous
consequences of automobile and industry pollution onto the residents' health of Astana, it is important
to analyze and monitor the conditions of atmospheric air in the city. The main objective of this research
project is to simulate and analyze the dispersion of vehicle pollutants (CO) at the crossroad of Zhenis
and Bogenbay streets using Computational Fluid Dynamics (CFD) tools based on SolidWorks-EFD
numerical platform. This particular place for the study is selected because of its relatively heavy traffic
load and its close location to many residential buildings.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T09:35:01Z
No. of bitstreams: 1
ANALYSIS OF POLLUTANT.pdf: 143277 bytes, checksum: 0cb0969b988a61d57dc4f482307146f6 (MD5)
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ANALYSIS OF POLLUTANT.pdf: 143277 bytes, checksum: 0cb0969b988a61d57dc4f482307146f6 (MD5)
Previous issue date: 2014
en
Nazarbayev University
atmospheric
air
pollution
vehicle
analyze
conditions
Analysis of pollutant dispersion in a street canyon of Astana
Abstract
oai:nur.nu.edu.kz:123456789/5602018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_410
Adarichev, V. A.
Sarkar, S.
Kalamov, N.
Brucker, J.
Forde, T. S.
Shekhani, M.T.
Lyons, B.
2015-10-28T09:55:50Z
2015-10-28T09:55:50Z
2013
http://nur.nu.edu.kz/handle/123456789/560
We found that Pgis2-congenic mice that carry genetically-deficient copy of C5(Hc) complement component were susceptible to collagen antibody-induced arthritis while inflammation was transient. Using differential gene expression analysis tools, we identified 20 genes whose down/up regulation in Pgis2-congenic mice might rescue C5 complement deficiency or, in a wider sense, rescue the function of the entire Pgis2 locus.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T09:55:50Z
No. of bitstreams: 1
transcriptome.pdf: 1101882 bytes, checksum: 6b76066a3ca7054e6f3f20d0ac6582ee (MD5)
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transcriptome.pdf: 1101882 bytes, checksum: 6b76066a3ca7054e6f3f20d0ac6582ee (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
arthritis
science
Transcriptome of congenic mice with transient inflammatory arthritis: resque of C5 complement deficiency
Abstract
oai:nur.nu.edu.kz:123456789/5612018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Aldabergenov, M.
Familiant, Y. L.
Ruderman, A.
2015-10-28T10:00:16Z
2015-10-28T10:00:16Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/561
The authors address the problem of optimal current quality for a single-phase
multilevel inverter with a staircase modulation (Fig.1). The current quality is characterized by current
ripple Normalized Mean Square (NMSc). The goal is to find theoretically optimal switching angles and
respective minimal NMSc values. The previous research didn't provide comprehensive solutions for
arbitrary modulation indices and level counts.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T10:00:15Z
No. of bitstreams: 1
OPTIMAL CURRENT QUALITY.pdf: 193288 bytes, checksum: 1a4439a0e1f73fda3faed10facbe2760 (MD5)
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OPTIMAL CURRENT QUALITY.pdf: 193288 bytes, checksum: 1a4439a0e1f73fda3faed10facbe2760 (MD5)
Previous issue date: 2014
en
Nazarbayev University
optimal
current
quality
single-phase
multilevel inverter
staircase modulation
Optimal current quality of a single-phase multilevel inverter with a staircase modulation
Abstract
oai:nur.nu.edu.kz:123456789/5622018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Arkhangelsky, E.
Zdorovets, M.
2015-10-28T10:08:25Z
2015-10-28T10:08:25Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/562
Forward osmosis (FO) process has gained vast popularity in recent years. FO has the
potential advantages of low energy demand, insignificant membrane fouling, and as result rare membrane
cleaning is required [1]. Despite that nowadays different research groups from around the world [2]
working on development of highly productive membranes for direct osmosis process, water flux of FO
membranes is far away from water flux of reverse osmosis membranes. With reference to that it can be
claimed that development of the new generation of forward osmosis membrane is of high importance.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T10:08:25Z
No. of bitstreams: 1
DEVELOPMENT OF NOVEL HIGHLY.pdf: 122572 bytes, checksum: ae34e082dd7437dc2e959c1d2ede9379 (MD5)
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DEVELOPMENT OF NOVEL HIGHLY.pdf: 122572 bytes, checksum: ae34e082dd7437dc2e959c1d2ede9379 (MD5)
Previous issue date: 2014
en
Nazarbayev University
osmosis
energy
development
membranes
generation
irradiation
polymer
physical
chemical
treatment
ions
Development of novel highly productive track etch membranes for forward osmosis process
Abstract
oai:nur.nu.edu.kz:123456789/5632018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Chinybayeva, A. K.
Kabdullina, A.
Soltabayeva, A.
Myngbay, A.
Adarichev, V. A.
Alibek, K.
2015-10-28T10:12:16Z
2015-10-28T10:12:16Z
2013
http://nur.nu.edu.kz/handle/123456789/563
Influenza virus is a major pathogen with global spread which infects birds and mammals, including humans. The virus is constantly changing, thus influenza stays in the centre of vaccine research. Effective vaccine should have a wide spectrum of protection from the most circulating and dangerous subtypes of the virus. Our goals are identifying the most immunogenic peptide epitopes among three subtypes of Influenza A virus (H1N1, H3N2 и H5N1) according to affinity to MHC class I & II molecules, and finding epitopes localized in conservative regions of the viral proteome. We propose to screen synthetic oligopeptides emulating conservative and immunogenic regions for the strongest humoral and cell
mediated responses in mice to select several epitopes/peptides as multivalent peptide vaccine candidate.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T10:12:16Z
No. of bitstreams: 1
design.pdf: 1232454 bytes, checksum: a9e283abe8a12285deaa4c4a18b3ab04 (MD5)
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design.pdf: 1232454 bytes, checksum: a9e283abe8a12285deaa4c4a18b3ab04 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
Influenza virus
vaccine research
Design and development of multivalent peptide vaccine candidate against influenza a virus
Abstract
oai:nur.nu.edu.kz:123456789/5642018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Bakdolotov, A.
Assembayeva, M.
Akhmetbekov, Y.
2015-10-28T10:21:36Z
2015-10-28T10:21:36Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/564
The project's main objective is the modeling of the electricity sector in Kazakhstan. The
demand growth in the last years could be compensated so far by reactivation and retrofit of existing old
reserve capacities from the Soviet era. Translated into choices for system development the decisions are
on technologies of new capacity, availability and costs of resources, and the transmission network. All
these aspects can be addressed with the detailed electricity sector model.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T10:21:36Z
No. of bitstreams: 1
MODELLING OF ELECTRICITY.pdf: 105050 bytes, checksum: e80d1256b8b14facdebf3c4eab5a3ade (MD5)
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MODELLING OF ELECTRICITY.pdf: 105050 bytes, checksum: e80d1256b8b14facdebf3c4eab5a3ade (MD5)
Previous issue date: 2014
en
Nazarbayev University
modeling
electricity sector
energy system
technical
economic
analysis
energy storage
power plants
Modelling of electricity sector of Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/5652018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_410
Matkarimov, B.
Takhanov, R.
2015-10-28T10:28:12Z
2015-10-28T10:28:12Z
2013
http://nur.nu.edu.kz/handle/123456789/565
The prediction of the native structure of proteins given their amino acid sequence is one of the central problems in modern computational biology/biophysics/biochemistry and computer science. Today there are more than 80000 3D structures of various biomacromolecules in the open access, e.g. in Protein Data Bank (PDB), and these databases have exponential growth rate. The project goal is to design and implement computing experiments related to biomacromolecular folding. This includes the development of high performance bioinformatics software.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T10:28:12Z
No. of bitstreams: 1
prediction.pdf: 725626 bytes, checksum: 9b4b7ecd33c4395e7cf5d6cf6c7413f0 (MD5)
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prediction.pdf: 725626 bytes, checksum: 9b4b7ecd33c4395e7cf5d6cf6c7413f0 (MD5)
Previous issue date: 2013
en
Nazarbayev University
first research week
bioinformatics software
proteins
biomacromolecules
Prediction of the protein conformation via pattern recognition and constraint satisfaction methods
Abstract
oai:nur.nu.edu.kz:123456789/5662018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Abilgaziyev, A.
Nogerbek, N.
Rojas-Solorzano, L.
2015-10-28T10:30:49Z
2015-10-28T10:30:49Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/566
Oil catch cans are devices used in some internal combustion engines to prevent oil
droplets from entering into the exhaust manifold of the engine. The main purpose of this paper is to study
the design of a typical oil catch can used in regular vehicles and analyze the effects caused by varying the
length of its inner tube and the relative position of the outlet: either radial or tangential to the can body.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T10:30:49Z
No. of bitstreams: 1
CFD STUDY.pdf: 91020 bytes, checksum: 6fed8242bf1905bb0d21352fa28fedbc (MD5)
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CFD STUDY.pdf: 91020 bytes, checksum: 6fed8242bf1905bb0d21352fa28fedbc (MD5)
Previous issue date: 2014
en
Nazarbayev University
oil
analyze
platform
mass conservation
energy conservation
model
CFD study of an oil catch can
Abstract
oai:nur.nu.edu.kz:123456789/5672018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_411
Balanay, M. P.
2015-10-28T10:53:49Z
2015-10-28T10:53:49Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/567
The use of biological organisms for removal of
heavy-metal in situ brings down the production cost due to the lesser
pre-treatment steps in the removal process. Initial assessments of
the heavy-metal binding bacteria from wastewaters, indicates that
Bacillus and Chryseomonas sp. exhibited positive growth response
behavior when exposed to lead and cadmium [1]. This incorporation
of the heavy-metal species leads to the increase in the molecular
mass of the protein as shown in the SDS-PAGE result (Figure 1).
In this research, two metal-binding proteins of B. subtilis 1C7I and
1P3J were analyzed and optimized using DFT method to look into
the possibility of replacement of heavy metals (Cd, Cr, Hg, and Pb)
in its metal active sites.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T10:53:49Z
No. of bitstreams: 1
HEAVY-METAL BINDING.pdf: 134777 bytes, checksum: 8c9dad906edb0d230c3862a2805eb9f7 (MD5)
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HEAVY-METAL BINDING.pdf: 134777 bytes, checksum: 8c9dad906edb0d230c3862a2805eb9f7 (MD5)
Previous issue date: 2014
en
Nazarbayev University
biological
organism
heavy-metal
pre-treatment
wastewaters
bacillus
chryseomonas
cadmium
protein
Heavy-metal binding affinity in metalloproteins: a computational approach
Abstract
oai:nur.nu.edu.kz:123456789/5682018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Balanay, M. P.
Lee, S. H.
Kim, D. H.
2015-10-28T11:02:09Z
2015-10-28T11:02:09Z
2014
9786018046728
http://nur.nu.edu.kz/handle/123456789/568
The conformation of the dye on the semiconductor is an important factor for the
improvement of charge injection and minimization of the back electron transfer process. In addition, the
dye should be able to suppress aggregation by introducing bulky alkyl groups, addition of co-adsorbents,
or designing a dye with a п-bridge between two chromophores forming a spiro-like configuration [1,2].
This study presents the synthesis of two compounds having double D-TT-A configurations namely, KS-11
and KS-13 and comparing their photovoltaic properties with the rod-like configuration, herein labelled
as KS-10.
Submitted by dspace nu (dspace@nu.edu.kz) on 2015-10-28T11:02:09Z
No. of bitstreams: 1
T R I P H E N Y L A M I N E.pdf: 134476 bytes, checksum: 264ea441dd0b5348082d55cfa6848466 (MD5)
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Previous issue date: 2014
en
Nazarbayev University
photovoltaic
synthesis
configuration
chromophores
electrolyte
photophysical
electrochemical
Triphenylamine dyes having symmetric double D-TI-A configuration for dye-sensitized solar cells
Abstract
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