2024-03-29T09:46:55Zhttp://nur.nu.edu.kz/oai/requestoai:nur.nu.edu.kz:123456789/28412018-08-15T03:50:18Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Oshakbayev, Kuat
author
Dukenbayeva, Bibazhar
author
Togizbayeva, Gulnar
author
Gazaliyeva, Meruyert
author
Syzdykova, Alma
author
Daurenbekov, Kanat
author
Issa, Pernekul
author
2017-05-30
Aim: To study physical and chemical structures and properties including calorific value of human adipose tissue in different anatomical location in autopsy-assigned clinical trial.
Methods: A pilot physical and chemical descriptive randomized autopsy-assigned trial. Adipose tissue 252 sampled from 36 individuals at autopsy who between 36 and 63 years old died from road accidents. Interventions: Chemical functional groups and calorific value were studied using infrared and atomic adsorptive spectrometries, elemental chemical analysis and differential scanning calorimetry. Adipose tissue was sampled from the 7 various anatomical locations. Results: The highest levels of the analysed chemical substancies were found in dense atherosclerotic plaque. Dense atherosclerotic plaque contains the most of metabolic products, organic and inorganic elements. Dense
atherosclerotic plaque has the most of calorific value. The lowest calorific capacity has a pararenal fat. Conclusions: Human body lipids serve as a harbor for various organic substances, they may absorb different metabolic products, and they have different calorific capacity depending on their location and forms. Atherosclerotic plaque contains the most of organic and inorganic elements, and brings the highest energy potential.
Oshakbayev Kuat, 2017(May 30), Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial, BBA Clinical, pp.14-19
http://dx.doi.org/10.1016/j.bbacli.2017.05.002
http://nur.nu.edu.kz/handle/123456789/2841
body lipids
atherosclerotic plaque
physical and chemical structure
calorific value
autopsy trial
Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial
oai:nur.nu.edu.kz:123456789/28422018-08-15T03:50:27Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Oshakbayev, Kuat
author
Dukenbayeva, Bibazhar
author
Togizbayeva, Gulnar
author
Durmanova, Aigul
author
Gazaliyeva, Meruyert
author
Sabir, Abdul
author
Issa, Aliya
author
Idrisov, Alisher
author
2017
Background: The prevalence of type 2 diabetes is increasing in worldwide despite the development of new treatment methods. Aim of the study was to evaluate a weight loss method on body composition, glycemic, lipid and hormone profiles, blood pressure and reactive oxygen species in people with treated type 2 diabetes. Methods: A 24-week open, prospective, randomized, controlled clinical trial including 272 adult patients with
treated type 2 diabetes was performed. The patients were divided in two groups: Main group consisted of 208 patients who followed a method including a calorie restriction diet and optimal physical activity; Control included 64 patients who received conventional drug treatment with weight loss. Main Outcome Measures were weight loss, fasting glucose and 2-hour oral glucose tolerance test (OGTT), HbA1c. Secondary endpoints were blood pressure, lipid and insulin blood levels. Results: At 24 weeks, patients in Main weight lost between 8-18 kg (10–21%); their body mass index significantly decreased (-4.2 kg/m2) as well as their waist circumference (-13 cm) compared to Control. In Main weight loss was
achieved fatty mass reduction. In Main fasting glucose and OGTT, HbA1c, blood pressure, reactive oxygen species decreased significantly, whereas hemoglobin levels and heel bone mineral density increased. In Main blood insulin levels decreased by 72.0%, cortisol levels decreased by 40.7%, while testosterone levels in men increased by 2.4 times from baseline. The application of the weight loss method led to a decrease in drug doses leading to their complete withdrawal. Conclusions: The results of this study show the beneficial role of a weight loss method in improving glycemic, lipid and hormone profiles, electrolyte and biochemical indices, blood pressure, reactive oxygen species and bone
mineral density in patients with treated type 2 diabetes.
Oshakbayev Kuat et al.(>7), 2017, Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial, Nutrition & Metabolism
DOI 10.1186/s12986-017-0163-9
http://nur.nu.edu.kz/handle/123456789/2842
type 2 diabetes
weight loss
restriction diet
glycemic/lipid and hormone profiles
lipid/protein oxidation
Weight loss technology for people with treated type 2 diabetes: a randomized controlled trial
oai:nur.nu.edu.kz:123456789/28432018-08-15T03:50:28Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Oshakbayev, Kuat
author
Dukenbayeva, Bibazhar
author
Otarbayev, Nurzhan
author
Togizbayeva, Gulnar
author
Tabynbayev, Nariman
author
Gazaliyeva, Meruyert
author
Idrisov, Alisher
author
Oshakbayev, Pernekul
author
2015-11-25
Background: The prevalence and burden of atherosclerotic (AS) diseases are increasing during the last twenty years. Some studies show a close relationship between overweight and AS, but influence on AS diseases of different weight loss methods are still studying. The purpose of the research was to study the effectiveness of a weight loss program in AS patients in randomized controlled trial, and to develop a conception of evolution of AS.
Methods: A randomized controlled prospective clinical trial including 97 people, from them 71 patients with various AS manifestations. Patients were divided in 2 subgroups for non-drug weight loss program, and conventional drug therapy. The weight loss program included calorie restriction with 100–150 kcal/day, fat-free vegetables, salt diet, and optimum physical activity. Statistical analysis was performed using SPSS for Windows
version 17.0. Results: The weight loss subgroup lost ranging between 7-20 % from an initial weight (P = 0.016). Weight loss was achieved due to fatty mass reduction only (P = 0.005). Hemoglobin levels (P < 0.001), bone mineral density (P < 0.001), percentages of water (P = 0.006) and muscle masses (P = 0.0038) were increased in weight loss subgroup. Ejection fraction (P < 0.0001), systolic output (P < 0.0001) were increased in patients with coronary artery disease. The weight loss program led to a decrease in symptomatic drugs doses up to total abolition. A conception of AS was developed.
Conclusions: The weight loss program treated the AS diseases; improved laboratory and instrumental parameters, decreased symptomatic drugs doses. AS development is a logical way of ontogenetic ageing of body fat.
Oshakbayev Kuat et al.(>7), 2015(November 25), Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial, Nutrition Journal
DOI 10.1186/s12937-015-0108-y
http://nur.nu.edu.kz/handle/123456789/2843
atherosclerosis
overweight
weight loss
endogen metabolic intoxication
ageing
Research Subject Categories::MEDICINE
Weight loss therapy for clinical management of patients with some atherosclerotic diseases: a randomized clinical trial
oai:nur.nu.edu.kz:123456789/28572018-08-15T03:50:17Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Akilbekova, Dana
author
Mektepbayeva, Damel
author
2017-01-01
Abstract In this chapter, we will focus on how 3D printer technology is transforming traditional medicine into a personalized approach, giving an overview of the technology advancement and its clinical applications. First, we will discuss why personalization in medicine is required, its benefits for the patients and how 3D printing technology can address this need for the patient specific treatment solutions. Basic capabilities of 3D printers and the three most common 3D printing technologies used in medical applications will be covered as well. The second section focuses on current and potential medical applications of 3D printing. The main medical applications can be arranged into three categories: (1) 3D bioprinting of organs and tissues; (2) patient specific medical devices: prosthetics and implants; and (3) 3D models for surgical preparation. Here, we will discuss 3D printing of living cells, in situ 3D bioprinting directly to the defect site, some successful cases of the implantation of various 3D constructs and the production of precise anatomical models for surgical trainings. Lastly, we will highlight challenges and emerging technology developments for the printing of functional organ constructs and medical devices.
Dana Akilbekova and Damel Mektepbayeva, 5 - Patient specific in situ 3D printing, In 3D Printing in Medicine, edited by Deepak M. Kalaskar,, Woodhead Publishing, 2017, Pages 91-113
9780081007174
https://www.sciencedirect.com/science/article/pii/B9780081007174000041
http://nur.nu.edu.kz/handle/123456789/2857
Personalized medicine
in situ 3D bioprinting
patient specific medical devices
5 Patient specific in situ 3D printing
oai:nur.nu.edu.kz:123456789/29712021-02-05T05:59:54Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Oshakbayev, Kuat
author
Dukenbayeva, Bibazhar
author
Togizbayeva, Gulnar
author
Gazaliyeva, Meruyert
author
Syzdykova, Alma
author
Daurenbekov, Kanat
author
Issa, Pernekul
author
2017-12-01
Abstract AimTo study physical and chemical structures and properties including calorific value of human adipose tissue in different anatomical location in autopsy-assigned clinical trial. MethodsA pilot physical and chemical descriptive randomized autopsy-assigned trial. Adipose tissue 252 sampled from 36 individuals at autopsy who between 36 and 63years old died from road accidents. Interventions: Chemical functional groups and calorific value were studied using infrared and atomic adsorptive spectrometries, elemental chemical analysis and differential scanning calorimetry. Adipose tissue was sampled from the 7 various anatomical locations. ResultsThe highest levels of the analysed chemical substancies were found in dense atherosclerotic plaque. Dense atherosclerotic plaque contains the most of metabolic products, organic and inorganic elements. Dense atherosclerotic plaque has the most of calorific value. The lowest calorific capacity has a pararenal fat. ConclusionsHuman body lipids serve as a harbor for various organic substances, they may absorb different metabolic products, and they have different calorific capacity depending on their location and forms. Atherosclerotic plaque contains the most of organic and inorganic elements, and brings the highest energy potential.
Kuat Oshakbayev, Bibazhar Dukenbayeva, Gulnar Togizbayeva, Meruyert Gazaliyeva, Alma Syzdykova, Kanat Daurenbekov, Pernekul Issa, Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial, In BBA Clinical, Volume 8, 2017, Pages 14-19
22146474
https://www.sciencedirect.com/science/article/pii/S2214647417300089
http://nur.nu.edu.kz/handle/123456789/2971
Body lipids
Atherosclerotic plaque
Physical and chemical structure
Calorific value
Autopsy trial
Accumulated substancies and calorific capacity in adipose tissue: Physical and chemical clinical trial
oai:nur.nu.edu.kz:123456789/32362018-08-15T03:50:30Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
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Чиналиев, Азат Мырзабаевич
author
Парманов, Айдар Толегенович
author
2018-05-18
В данной статье рассмотрены результаты ранних и поздних послеоперационных осложнений у пациентов с варикозной патологией большой подкожной вены, находившимся на стационарном лечении в условиях частной клиники г. Астана, с целью выявления их особенностей на основе анализа полученной информации посредством непосредственного курирования пациентов, данных из истории болезней, статистических карт, выписных эпикризов, амбулаторно-поликлинических данных.
Чиналиев, Азат Мырзабаевич; Парманов, Айдар Толегенович (2018) Результаты эндовенозной лазерной абляции при варикозной трансформации большой подкожной вены. 1st KAZAKHSTAN VENOUS FORUM, 18-19 OF MAY,2018, ALMATY, KAZAKHSTAN
http://nur.nu.edu.kz/handle/123456789/3236
варикозная трансформация
кроссэктомия
сафенэктомия
эндовенозная термическая абляция
Результаты эндовенозной лазерной абляции при варикозной трансформации большой подкожной вены.
oai:nur.nu.edu.kz:123456789/32392018-08-15T03:50:31Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Tabymbaev, N.B
author
Baizhanuly, K.B.
author
Zhumagazin, ZH.D.
author
2018
Benign prostatic hyperplasia (BPH) is one of the most common diseases in older men age. In the course of the trial treatment of such pathology is impossible due to a number of objective reasons, such as age and severe concomitant diseases impossible surgical methods of treatment.
Zhumagazin, ZH.D., Baizhanuly, K.B., Tabymbaev, N.B (2018) Embolization of the prostatic arteries in BPH patients is relatively safe and effective treatment and an alternative for surgical treatment in patients with high operating and anesthetic risk. UMC “National Scientific center for Oncology and transplantation”.
http://nur.nu.edu.kz/handle/123456789/3239
prostatic arteries
surgical treatment
anesthetic risk
Embolization of the prostatic arteries in BPH patients is relatively safe and effective treatment and an alternative for surgical treatment in patients with high operating and anesthetic risk.
oai:nur.nu.edu.kz:123456789/32412018-08-15T03:50:30Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Султаналиев,Т.А.
author
Боровский,С.П.
author
Сагандыков,И.Н.
author
Сулейменов,С.С.
author
Землянский,В.В.
author
Тукинов,Р.Я.
author
2017-06-22
ретроспективный анализ результатов эндопротезирования аневризм аорты у пациентов c высоким риском периоперационных осложнений при открытых оперативных вмешательствах
Султаналиев, Т. А., Боровский, С. П., Сагандыков, И. Н., Сулейменов, С. С., Землянский, В. В., Тукинов, Р. Я. (2018) ЭНДОПРОТЕЗИРОВАНИЕ АНЕВРИЗМ АОРТЫ. ПЯТЬ ЛЕТ ВНЕДРЕНИЮ МЕТОДА. Материалы XXXIII Международной конференции Российского общества ангиологов и сосудистых хирургов.
http://nur.nu.edu.kz/handle/123456789/3241
эндопротезирование аневризм аорты
Research Subject Categories::MEDICINE
аневризм аорты
Эндопротезирование аневризм аорты. Пять лет внедрению метода
oai:nur.nu.edu.kz:123456789/33202018-08-15T03:50:28Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Golriz, Mohammad
author
Fonouni, Hamidreza
author
Kuttymuratov, Gani
author
Esmaeilzadeh, Majid
author
Jarahian, Parvin
author
Longerich, Thomas
author
Tahmasbi, Morva
author
Faridar, Alireza
author
Abbasi, Sepehr
author
Mehrabi, Arianeb
author
Gebhard, Marta M.
author
2015
Currently, due to lack of optimal donors, more marginal organs are transplanted. Therefore, there is a high interest to ameliorate preischemic organ preservation, especially for critical donor organs. In this regard, a new histidinetryptophane
ketoglutarate (HTK-N) solution has been designed and its protective efficacy was compared with the standard preservation solutionsdUniversity of Wisconsin solution
and standard HTK or Custodiol (Bretschneider’s solution). Methods: Seventy-two landrace pigs were included into the study, as donors and recipients. The donor kidneys were perfused during explantation with cold University of Wisconsin solution (n Z 12), standard HTK (n Z 12), or HTK-N solutions (n Z 12), kept in the respective preservation solution at 4 C for 30 hours, implanted in the recipient pigs, and reperfused. The pigs survived in daily control for 7 days. The serum creatinine and blood urea nitrogen were assessed
in pre- and postreperfusion phase on the 3rd day and 7th day posttransplantation. Additionally, tissue samples were taken to analyze the histopathological degree of tubular injury and regeneration before and after reperfusion.
Golriz, Mohammad, Fonouni, Hamidreza, Kuttymuratov, Gani, Esmaeilzadeh, Majid, Jarahian, Parvin, Longerich, Thomas, Tahmasbi, Morva, Faridar, Alireza, Abbasi, Sepehr, Mehrabi, Arianeb, Gebhard, Marta M. (2015) Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model. Asian Journal of Surgery
10.1016/j.asjsur.2015.07.001
http://nur.nu.edu.kz/handle/123456789/3320
ischemia reperfusion injury
kidney transplantation
preservation solution
Influence of a modified preservation solution in kidney transplantation: A comparative experimental study in a porcine model
oai:nur.nu.edu.kz:123456789/33212018-08-15T03:50:28Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Esmaeilzadeh, Majid
author
Fonouni, Hamidreza
author
Golriz, Mohammad
author
Majlesara, Ali
author
Kuttymuratov, Gani
author
Bergmann, Frank
author
Jarahian, Parvin
author
Khazaeipour, Zahra
author
Faridar, Alireza
author
Tahmasbi, Morva
author
Longerich, Thomas
author
Gebhard, Marta M.
author
Mehrabi, Arianeb
author
2016
One of the great challenges in pancreas transplantation is the ischemia reperfusion injury. It is mentioned that free oxygen and/or nitrogen radicals play a prominent role in this phase. To minimize this problem, a modified histidineetryptophan eketoglutarate (HTK) solution that contains modified antioxidants has been developed. Our aim was to evaluate this solution in improving the viability of the pancreas in comparison with standard HTK and University of Wisconsin (UW) solutions in a porcine model of pancreas transplantation.
Majid Esmaeilzadeh, Hamidreza Fonouni, Mohammad Golriz, Ali Majlesara, Gani Kuttymuratov, Frank Bergmann, Parvin Jarahian, Zahra Khazaeipour, Alireza Faridar, Morva Tahmasbi Rad, Thomas Longerich, Martha M. Gebhard and Arianeb Mehrabi. (2016) Evaluation of the modified HTK solution in pancreas transplantationdAn experimental model. Asian Journal of Surgery. Volume 39. Issue 2. Pages 66-73
dx.doi.org/10.1016/j.asjsur.2015.03.017
http://nur.nu.edu.kz/handle/123456789/3321
histidine tryptophan ketoglutarate
ischemia reperfusion injury
pancreas transplantation
University of Wisconsin
Evaluation of the modified HTK solution in pancreas transplantationdAn experimental model
oai:nur.nu.edu.kz:123456789/33222018-08-15T03:50:18Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Важенин, А.В.
author
Шаназаров, Н.А.
author
Шунько, Е.Л.
author
2015
В настоящее время индуцированные лечением первично-множественные злокачественные новообразования являются одной из основных причин смертности онкологических больных после проведенного лучевого и химиолучевого лечения. Целью нашего исследования является сравнительный анализ особенностей развития первично-множественных метахронных опухолей после лучевой и
химиолучевой терапии первой опухоли. Мы выделили группу из 232 больных, у которых впоследствии после лучевой терапии первой опухоли возникли первично-множественные метахронные опухоли (1 группа) и группу из 42 больных, у которых впоследствии после химиолучевой терапии первой опухоли возникли первично-множественные метахронные опухоли (2 группа). Для больных, пролеченных
лучевой терапией, характерны: более старший возраст, более длительные интервалы времени от
появления первой опухоли до появления второй опухоли, от начала терапии первой опухоли до появления второй опухоли и от начала лучевой терапии первой опухоли до появления второй опухоли. Аналогичная тенденция сохраняется и при соответствующем сравнении подгрупп больных 1 и 2 группы (с мультицентрическими метахронными множественными опухолями в одном органе, с системными опухолями и опухолями парных органов, несистемными множественными опухолями различных органов).
Важенин А.В., Шаназаров Н.А., Шунько Е.Л. (2015) СРАВНИТЕЛЬНЫЙ АНАЛИЗ ОСОБЕННОСТЕЙ РАЗВИТИЯ ВТОРЫХ ОПУХОЛЕЙ ПОСЛЕ ЛУЧЕВОЙ ТЕРАПИИ И ХИМИОЛУЧЕВОЙ ТЕРАПИИ ПЕРВОЙ ОПУХОЛИ. Фундаментальные исследования.1 (часть 8)
http://nur.nu.edu.kz/handle/123456789/3322
первично-множественные злокачественные опухоли
лучевая терапия
химиолучевая терапия
Cравнительный анализ особенностей развития вторых опухолей после лучевой терапии и химиолучевой терапии первой опухоли
oai:nur.nu.edu.kz:123456789/33242018-08-15T03:50:28Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Ospanov, Oral
author
Maleckas, Almantas
author
Orekeshova, Akzhunus
author
2016
Background and aim: Established anti-reflux procedures such as fundoplications are less
efficient in obese patients. The aim of this study was to investigate clinical effectiveness of
the fundoplication combined with gastric greater curvature plication in the treatment of
gastroesophageal reflux disease (GERD) in obese patients.
Materials and methods: During the period from June 2010 to September 2014, patients
operated for GERD with BMI from 30 to 39.9 kg/m2 were included into the prospective study.
Laparoscopic Nissen fundoplication (LNF, n = 58) was performed until February 2013 and
later laparoscopic Nissen fundoplication was combined with gastric greater curvature
plication (LNFGP, n = 56). The groups were compared according to the control of GERD
and weight loss.
Results: In LNF group there were significantly more males, patients had lower BMI and longer duration of GERD symptoms. Duration of surgery was significantly longer in LNFGP group, 96.5 (17.3) min vs. 59.8 (16.1) min (P < 0.0001). Postoperative morbidity was similar, 3.6% and 3.4% in LNFGP and LNF groups, respectively (P = 0.9539). The average percentage of excess BMI loss after 12 months was 45.3 (5.8) in LNFGP group as compared to 18.4 (4.6) in LNF group (P < 0.0001). Significantly more patients experienced remission or improvement of type 2 diabetes mellitus (P = 0.03) and hypercholesterolemia (P = 0.0001) in LNFGP group. No significant differences between the groups in postoperative DeMeester score, GERD-HRQL mean score, overall satisfaction and healing of esophagitis were observed.
Ospanov, Oral, Maleckas, Almantas, Orekeshova, Akzhunus. (2016) Gastric greater curvature plication combined with Nissen fundoplication in the treatment of gastroesophageal reflux disease and obesity. Medicina. 52. 283-290 pages
http://nur.nu.edu.kz/handle/123456789/3324
Gastroesophageal reflux disease
OBESITY
Nissen fundoplication
Gastric greater curvature plication
Gastric greater curvature plication combined with Nissen fundoplication in the treatment of gastroesophageal reflux disease and obesity
oai:nur.nu.edu.kz:123456789/33252018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Tchirikov, Michael
author
Zhumadilov, Zhaxybay
author
Bapayeva, Gauri
author
Bergner, Michael
author
Entezami, Michael
author
2017
Objective: To determine if intrauterine intraumbilical supplementation with amino acids (AA) and glucose can improve neonatal outcome of severe growth restricted
human fetuses (IUGR). Methods: Prospective pilot study of intrauterine treatment
of severe IUGR fetuses [n = 14, 27 weeks of gestation (range 23–31)] with erebroplacental ratio < 1, with longterm intraumbilical AA and glucose supplementation
(10% of feto-placental blood volume/day) using a perinatal port system alone (n = 5) or combined with hyperbaric oxygenation (n = 1, HBO) vs. control group (n = 8).
Tchirikov, Michael, Zhumadilov, Zhaxybay, Bapayeva, Gauri, Bergner, Michael, Entezami, Michael. (2017) The effect of intraumbilical fetal nutrition via a subcutaneously implanted port system on amino acid concentration by severe IUGR human fetuses. J Perinat Med. 45(2). 227–236 pages
DOI 10.1515/jpm-2016-0155
http://nur.nu.edu.kz/handle/123456789/3325
Amino acids; cordocentesis; fetal growth restriction; HBO; hyperbaric oxygenation; intraumbilical infusion; intrauterine treatment; IUGR; port.
The effect of intraumbilical fetal nutrition via a subcutaneously implanted port system on amino acid concentration by severe IUGR human fetuses
oai:nur.nu.edu.kz:123456789/33262018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Abildinova, Gulshara
author
Abdrakhmanova, Zhanara
author
Tuchinsky, Helena
author
Nesher, Elimelech
author
Pinhasov, Albert
author
Raskin, Leon
author
2016
The routine detection of large and medium copy number variants (CNVs) is well established. Hemizygotic deletions or duplications in the large Duchenne muscular dystrophyDMD gene responsible for Duchenne and Becker muscular dystrophies are routinely identified using multiple ligation probe amplification and array-based comparative
genomic hybridization. These methods only map deleted or duplicated exons, without providing the exact location of breakpoints. Commonly used methods for the detection of CNV breakpoints include long-range PCR and primer walking, their success being limited by the deletion size, GC content and presence of DNA repeats. Here, we present a strategy for detecting the breakpoints of medium and large CNVs regardless of their size. The hemizygous deletion of exons 45-50 in the DMD gene and the large autosomal heterozygous PARK2 deletion were used to demonstrate the workflow that relies on real-time quantitative PCR to narrow down the deletion region and Sanger sequencing for
breakpoint confirmation. The strategy is fast, reliable and cost-efficient, making it amenable to widespread use in genetic laboratories.
Abildinova, Gulshara, Abdrakhmanova, Zhanara, Tuchinsky, Helena, Nesher, Elimelech, Pinhasov, Albert , Raskin, Leon. (2016) Fast detection of deletion breakpoints using quantitative PCR. Genetics and Molecular Biology. 39, 3, 365-369 pages
http://nur.nu.edu.kz/handle/123456789/3326
deletion boundaries
deletion breakpoints
DMD gene
Duchenne and Becker muscular dystrophies
hemizygous deletions
heterozygous deletions
Fast detection of deletion breakpoints using quantitative PCR
oai:nur.nu.edu.kz:123456789/33272018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Khvan, Marina
author
Vento, Sandro
author
2016
Khvan, Marina, Vento, Sandro. (2016) Successful Treatment with Verapamil and Oxygen for Hemodialysis-Related Headache in a 15 Year Old Girl. IMAJ.VOL 18
http://nur.nu.edu.kz/handle/123456789/3327
headache, hemodialysis, verapamil, oxygen, Kazakhstan
Successful treatment with verapamil and oxygen for hemodialysis-related headache in a 15 year old girl
oai:nur.nu.edu.kz:123456789/33282018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Cainelli, Francesca
author
Tastanbekova, Venera
author
Nurgaliev, Dair
author
Lim, Natalya
author
Vento, Sandro
author
2017
Cainelli, Francesca, Tastanbekova, Venera, Nurgaliev, Dair, Lim, Natalya, Vento, Sandro. (2017) Infantile Osteopetrosis in a Kazakh Boy. IMAJ. VOL 19
http://nur.nu.edu.kz/handle/123456789/3328
osteopetrosis, bone marrow, thrombocytopenia, rare diseases, Kazakhstan
Infantile Osteopetrosis in a Kazakh Boy
oai:nur.nu.edu.kz:123456789/33292018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Jaxybayeva, Altynshash
author
Kenzhegulova, Raushan
author
Baygazyieva, Lyazzat
author
Cainelli, Francesca
author
2017
Jaxybayeva, Altynshash, Kenzhegulova, Raushan, Baygazyieva, Lyazzat, Cainelli, Francesca . (2017) Niemann-Pick Disease Type C Initially Misdiagnosed as Gaucher Disease in a 6 Year Old Kazakh Girl. IMAJ. pages 262–264
http://nur.nu.edu.kz/handle/123456789/3329
Niemann-Pick type C, Gaucher disease, beta-glucosidase, rare diseases, Kazakhstan
Niemann-Pick disease type C initially misdiagnosed as gaucher disease in a 6 year old kazakh girl
oai:nur.nu.edu.kz:123456789/33302018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Cainelli, Francesca
author
Nurgaliev, Dair
author
Nurgaliyeva, Kadischa
author
Ivanova-Razumova, Tatyana
author
Bulanin, Denis
author
Vento, Sandro
author
2017-05
Cainelli, Francesca, Nurgaliev, Dair, Nurgaliyeva, Kadischa, Ivanova-Razumova, Tatyana, Bulanin, Denis, Vento, Sandro. (2017) Type 1 Gaucher disease with fatal outcome in a 17 year old girl from Kazakhstan. IMAJ. Vol 19. 329–330 pages
http://nur.nu.edu.kz/handle/123456789/3330
Gaucher disease, splenectomy, pulmonary hypertension, rare diseases, Kazakhstan
Type 1 Gaucher disease with fatal outcome in a 17 year old girl from Kazakhstan
oai:nur.nu.edu.kz:123456789/33312018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Suleimenova, Ardak
author
Utebaliyeva, Ruslan
author
Jenalayev, Damir
author
Bilal, Ruslan
author
Isabekova, Altynay
author
Vento, Sandro
author
2017-05
Suleimenova, Ardak. Utebaliyeva, Ruslan. Jenalayev, Damir. Bilal, Ruslan. Isabekova, Altynay. Vento, Sandro. (2017) A Rare Case of a Hydatid Cyst of the Neck in a Kazakh Boy. IMAJ. VOL 19. 584-585 pages.
DOI 10.1515/jpm-2016-0155
http://nur.nu.edu.kz/handle/123456789/3331
echinococcosis, hydatid cyst, neck cyst, Kazakhstan
A Rare Case of a Hydatid Cyst of the Neck in a Kazakh Boy
oai:nur.nu.edu.kz:123456789/33322018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Kemaikin, Vadim M.
author
Olifirovich, Anastasiya A.
author
Kolesnev, Alexandr V.
author
Nemerovchenko, Anatoliy V.
author
Vildanova, Ruzal F.
author
Gainutdinova, Olga V.
author
Tusipova, Adiya A.
author
Esimbekova, Ayauzhan E.
author
Baimursina, Aliya K.
author
Suleimenova, Ayzat S.
author
Lesechko, Olga O.
author
Ansatbaeva, Gulnaz D.
author
Alimbetova, Mariya S
author
2017
The Unit of Oncohematology and Bone Marrow Transplantation (BMT) was arranged on basis of the Republican Research Center of Hospital Emergencies SC (Astana, Republic of Kazakhstan) in August 2010. Since July 2014, a Clinical Department with 69 beds was arranged, and National Research Center for Oncology and Transplantation SC was arranged. From 2010 to 2016, the modalities of hematopoietic stem cell transplantation have been advanced, from autologous BMT to allogeneic hematopoietic stem cell transplants (HSCT) from matched donors (33%), and haploidentical HSCTs (43% in 2016), a total of 186 transpants. Bone marrow was used as a source of stem cells in 71 cases (71 donors for allo-HSCT in 69 recipients), whereas peripheral stem cells were harvested in 73 cases (15 donors for 15 recipients of allo-BMT, and 58 marrow harvests for autologous BMT).
Kemaikin, Vadim M., Olifirovich, Anastasiya A., Kolesnev, Alexandr V., Nemerovchenko, Anatoliy V., Vildanova, Ruzal F., Gainutdinova, Olga V., Tusipova, Adiya A., Esimbekova, Ayauzhan E., Baimursina, Aliya K., Suleimenova, Ayzat S., Lesechko, Olga O., Ansatbaeva, Gulnaz D., Alimbetova, Mariya S.. ( 2017) Astana experience: Department of Oncohematology and Bone Marrow Transplantation, National Research Center of Oncology and Transplantation. Cellular Therapy and Transplantation (CTT). Vol. 6, No. 1 (18)
doi: 10.18620/ctt-1866-8836-2017-6-1-30-36
http://nur.nu.edu.kz/handle/123456789/3332
Hematopoietic stem cell transplantation, clinical advancements, Astana, Republic of Kazakhstan.
Astana experience: department of oncohematology and bone marrow transplantation, National Research Center of Oncology and Transplantation
oai:nur.nu.edu.kz:123456789/33332018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Vangelista, Luca
author
Vento, Sandro
author
2018-01-12
CCR5 and its interaction with chemokine ligands have been crucial for understanding
and tackling HIV-1 entry into target cells. However, over time, CCR5 has witnessed
an impressive transition from being considered rather unimportant in physiology and
pathology to becoming central in a growing number of pathophysiological conditions.
It now turns out that the massive efforts devoted to combat HIV-1 entry by interfering
with CCR5, and the subsequent production of chemokine ligand variants, small chemical
compounds, and other molecular entities and strategies, may set the therapeutic
standards for a wealth of different pathologies. Expressed on various cell types, CCR5
plays a vital role in the inflammatory response by directing cells to sites of inflammation.
Aside HIV-1, CCR5 has been implicated in other infectious diseases and non-infectious
diseases such as cancer, atherosclerosis, and inflammatory bowel disease. Individuals
carrying the CCR5Δ32 mutation live a normal life and are warranted a natural barrier to
HIV-1 infection. Therefore, CCR5 antagonism and gene-edited knockout of the receptor
gained growing interest for the therapeutic role that CCR5 blockade may play in the
attenuation of the severity or progression of numerous diseases.
Vangelista, Luca, Vento, Sandro. (2018) The expanding Therapeutic Perspective of CCR5 Blockade. Frontiers in Immunology.
doi: 10.3389/fimmu.2017.01981
http://nur.nu.edu.kz/handle/123456789/3333
CCR5
CCL5
inflammation
HIV-1
cancer
The expanding Therapeutic Perspective of CCR5 Blockade
oai:nur.nu.edu.kz:123456789/33342018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Ivanova, Raifa
author
Goremykina, Maya
author
Glushkova, Natalya
author
Vento, Sandro
author
2018-01
Ivanova, Raifa, Goremykina, Maya, Glushkova, Natalya, Vento, Sandro. (2018) Successful Use of a Reduced Dose Regimen of Rituximab in a Case of Rheumatoid Arthritis with Raynaud’s Syndrome. IMAJ
http://nur.nu.edu.kz/handle/123456789/3334
Rheumatoid arthritis, Raynaud’s syndrome, rituximab, Kazakhstan
Successful use of a reduced Dose Regimen of Rituximab in a Case of Rheumatoid Arthritis with Raynaud’s Syndrome
oai:nur.nu.edu.kz:123456789/33352018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Султаналиев, Т.А.
author
Сагандыков, И.Н.
author
Парманов, А.Т.
author
Чиналиев, А.М.
author
2018
В данной статье, основываясь на большой опыт, мы рассмотрели результаты ранних и поздних послеоперационных осложнений у пациентов с варикозной патологией большой подкожной вены, находившимся на стационарном лечении в условиях нашей клиники.
Султаналиев, Т.А., Сагандыков, И.Н., Парманов, А.Т.,Чиналиев, А.М.(2018) Пятилетний анализ лечения варикозной трансформации большой подкожной вены. Национальный научный центр онкологии и трансплантологии КФ «UMC».
http://nur.nu.edu.kz/handle/123456789/3335
варикозная трансформация
кроссэктомия
эндовенозная термическая абляция
пенная склеротерапия
Пятилетний анализ лечения варикозной трансформации большой подкожной вены
oai:nur.nu.edu.kz:123456789/33362018-08-15T03:50:29Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Султаналиев, Т.А.
author
Сагандыков, И.Н.
author
Землянский, В.В.
author
Чиналиев, А.М.
author
2018
С сентября 2011 по декабрь 2015 года в КФ UMC ННЦОТ. г. Астана Казахстан, проведено 71 операций эндопротезирования аневризм брюшной аорты у пациентов с тяжелой сопутствующей патологией и высоким риском открытого оперативного лечения.
Султаналиев, Т.А., Сагандыков, И.Н.,Землянский, В.В., Чиналиев, А.М.(2018) Результаты эндопротезирования аневризмы инфраренального отдела брюшной аорты по материалам КФ UMC Национального научного центра онкологии и трансплантологии г. Астана. Национальный научный центр онкологии и трансплантологии КФ «UMC».
http://nur.nu.edu.kz/handle/123456789/3336
эндоваскулярное лечение
аневризма брюшной аорты
эндопротезирование
Результаты эндопротезирования аневризмы инфраренального отдела брюшной аорты по материалам КФ UMC Национального научного центра онкологии и трансплантологии г. Астана
oai:nur.nu.edu.kz:123456789/35742018-10-31T21:00:57Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Sultanaliev, T. A.
author
Sagandykov, I .N.
author
Parmanov, A. T.
author
Chinaliyev, A. M.
author
2018-10
The widely used treatment options for varicose transformation of the great saphenous vein in Kazakhstan are: cross-surgery (Troyanova-Trendelenburg surgery), safenectomy, endovenous thermal ablation (EVTA), foam sclerotherapy.
In this article, based on extensive experience, we reviewed the results of early and late postoperative complications in patients with varicose pathology of the great saphenous vein who were hospitalized in our clinic.
Sultanaliev T.A., Sagandykov I.N., Parmanov A.T., Chinaliyev A.M. (2018) Five-year analysis of the treatment of varicose transformation of the great saphenous vein. UMC. National Research Center for Oncology.
http://nur.nu.edu.kz/handle/123456789/3574
varicose
varicose transformation
vein
Five-year analysis of the treatment of varicose transformation of the great saphenous vein
oai:nur.nu.edu.kz:123456789/46632020-05-12T21:00:31Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Kovzel, Elena
author
Niespodziana, Katarzyna
author
Borochova, Kristina
author
Pazderova, Petra
author
Schlederer, Thomas
author
Astafyeva, Natalia
author
Baranovskaya, Tatiana
author
Barbouche, Mohamed-Ridha
author
Beltyukov, Evgeny
author
Berger, Angelika
author
Borzova, Elena
author
Bousquet, Jean
author
Bumbacea, Roxana S.
author
Bychkovskaya, Snezhana
author
Caraballo, Luis
author
FanChung, Kian
author
Custovic, Adnan
author
Docena, Guillermo
author
Eiwegger, Thomas
author
Evsegneeva, Irina
author
Emelyanov, Alexander
author
Errhalt, Peter
author
Fassakhov, Rustem
author
Fayzullina, Rezeda
author
Fedenko, Elena
author
Fomina, Daria
author
Gao, Zhongshan
author
Giavina-Bianchi, Pedro
author
Gotua, Maia
author
Greber-Platzer, Susanne
author
Hedlin, Gunilla
author
Ilina, Natalia
author
Ispayeva, Zhanat
author
Idzko, Marco
author
Johnston, Sebastian L.
author
Kalayci, Ömer
author
Karaulov, Alexander
author
Karsonova, Antonina
author
Khaitov, Musa
author
Kovzel, Elena
author
Kowalski, Marek L
author
Kudlay, Dmitry
author
Levin, Michael
author
Makarova, Svetlana
author
Matricardi, Paolo Maria
author
Nadeau, Kari C.
author
Namazova-Baranova, Leyla
author
Naumova, Olga
author
Nazarenko, Oleksandr
author
O’Byrne, Paul M.
author
Osier, Faith
author
Pampura, Alexander N.
author
Panaitescu, Carmen
author
Papadopoulos, Nikolaos G.
author
Park, Hae-Sim
author
Pawankar, Ruby
author
Pohl, Wolfgang
author
Renz, Harald
author
Riabova, Ksenja
author
Sampath, Vanitha
author
Sekerel, Bülent E.
author
Sibanda, Elopy
author
Siroux, Valérie
author
Sizyakina, Ludmila P.
author
Sun, Jin-Lyu
author
ZsoltSzepfalusi, Zsolt
author
Umanets, Tetiana
author
Van Bever, Hugo P.S.
author
Hage, Mariannevan
author
Vasileva, Margarita
author
Mutius, Erikavon
author
Wang, Jiu-Yao
author
Wong, Gary W.K.
author
Zaikov, Sergii
author
Zidarn, Mihaela
author
Valenta, Rudolf
author
2020-02-18
Asthma is a severe and chronic disabling disease affecting more than 300 million people worldwide. Although in the past few drugs for the treatment of asthma were available, new treatment options are currently emerging, which appear to be highly effective in certain subgroups of patients. Accordingly, there is a need for biomarkers that allow selection of patients for refined and personalized treatment strategies. Recently, serological chip tests based on microarrayed allergen molecules and peptides derived from the most common rhinovirus strains have been developed, which may discriminate 2 of the most common forms of asthma, that is, allergen- and virus-triggered asthma. In this perspective, we argue that classification of patients with asthma according to these common trigger factors may open new possibilities for personalized management of asthma.
Niespodziana, K., Borochova, K., Pazderova, P., Schlederer, T., Astafyeva, N., Baranovskaya, T., ... & Bousquet, J. (2020). Towards personalization of asthma treatment according to trigger factors. Journal of Allergy and Clinical Immunology.
https://doi.org/10.1016/j.jaci.2020.02.001
http://nur.nu.edu.kz/handle/123456789/4663
Toward personalization of asthma treatment according to trigger factors
oai:nur.nu.edu.kz:123456789/47472023-02-08T04:09:04Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Tchirikov, Michael
author
Saling, Erich
author
Bapayeva, Gauri
author
Bucher, Michael
author
Thews, Oliver
author
Seliger, Gregor
author
2018-03-13
In the first case, the AA and glucose were infused through a perinatal port system into the umbilical vein at 30 weeks' gestation due to severe IUGR. The patient received daily hyperbaric oxygenation (HBO, 100% O2) with 1.4 atmospheres absolute for 50 min for 7 days. At 31+4 weeks' gestation, the patient gave birth spontaneously to a newborn weighing 1378 g, pH 7.33, APGAR score 4/6/intubation. In follow‐up examinations at 5 years of age, the boy was doing well without any neurological disturbance or developmental delay. In the second case, the patient presented at 25/5 weeks' gestation suffering from severe IUGR received HBO and maternal AA infusions. The cardiotocography was monitored continuously during HBO treatment. The short‐time variations improved during HBO from 2.9 to 9 msec. The patient developed pathologic CTG and uterine contractions 1 day later and gave birth to a hypotrophic newborn weighing 420 g. After initial adequate stabilization, the extremely preterm newborn unfortunately died 6 days later. Fetal nutrition combined with HBO is technically possible and may allow the prolongation of the pregnancy. Fetal‐specific amino‐acid composition would facilitate the treatment options of IUGR fetuses and extremely preterm newborn.
Tchirikov, M., Saling, E., Bapayeva, G., Bucher, M., Thews, O., & Seliger, G. (2018). Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency. Physiological Reports, 6(5), e13589. https://doi.org/10.14814/phy2.13589
2051-817X
10.14814/phy2.13589
https://doi.org/10.14814/phy2.13589
https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13589
http://nur.nu.edu.kz/handle/123456789/4747
Amino acids
cordocentesis
fetal growthrestriction
HBO
hyperbaric oxygenation
intrauterine treatment
intravenous infusion
IUGR
placental insufficiency
portimplantation
Hyperbaric oxygenation and glucose/amino acids substitution in human severe placental insufficiency
oai:nur.nu.edu.kz:123456789/54822021-06-30T21:00:47Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Dossybayeva, Kuanysh
author
Abdukhakimova, Diyora
author
Poddighe, Dimitri
author
2020-09-23
Basophils are the rarest cell population in the blood. Even though basophils are known to participate in some allergic reactions and immune responses to parasitic infections, their immunological role is still largely elusive. Recent evidence has suggested that in some murine models of systemic lupus erythematosus and lupus-like nephritis, basophils may also be implicated in autoimmunity processes by promoting autoantibody production and tissue injury. We conducted a systematic search to collect the available evidence on basophils’ potential immunomodulatory role in autoimmunity and, particularly, systemic lupus erythematosus. We identified several articles investigating basophils’ role in murine models of lupus (n = 3) and in patients affected with systemic lupus erythematosus (n = 8). Even though the alteration of the “adaptive” immune response is considered the main immunopathological event in systemic lupus erythematosus, the contribution from the mechanisms of “innate” immunity and, particularly, basophils may be relevant as well, by modulating the activation, polarization, and survival of lymphocytes
Dossybayeva, K., Abdukhakimova, D., & Poddighe, D. (2020). Basophils and Systemic Lupus Erythematosus in Murine Models and Human Patients. Biology, 9(10), 308. doi:10.3390/biology9100308
http://nur.nu.edu.kz/handle/123456789/5482
autoimmunity
systemic lupus erythematosus
basophils
BASOPHILS AND SYSTEMIC LUPUS ERYTHEMATOSUS IN MURINE MODELS AND HUMAN PATIENTS
oai:nur.nu.edu.kz:123456789/55702023-02-08T04:09:03Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Terzic, Milan
author
Norton, Melanie
author
Terzic, Sanja
author
Bapayeva, Gauri
author
Aimagambetova, Gulzhanat
author
2020-05
Several different approaches have been designed by physicians in order to preserve fertility in younger patients with endometrial carcinoma. There are various options offering different advantages, but hysteroscopic resection of pathologic endometrial tissue with placement of a Levonorgestrel Intrauterine Device has proven to be the most successful in allowing patients to conceive and give birth afterwards. However, conservative treatments should only be considered in patients with low-grade and low-stage endometrial tumours. There are many published studies which have sought out a preferable approach to treating endometrial cancer whilst preserving fertility. However, more research on this matter is needed to allow a better understanding as to which techniques/approaches are optimal. In this review, we will summarise the current available treatment options for endometrial cancer in patients of reproductive age.
Terzic, M., Norton, M., Terzic, S., Bapayeva, G., & Aimagambetova, G. (2020). Fertility preservation in endometrial cancer patients: options, challenges and perspectives. Ecancermedicalscience, 14. https://doi.org/10.3332/ecancer.2020.1030
http://nur.nu.edu.kz/handle/123456789/5570
Type of access: Open Access
endometrial cancer
fertility preservation
conservative management intrauterine system
IUD
hysteroscopy
FERTILITY PRESERVATION IN ENDOMETRIAL CANCER PATIENTS: OPTIONS, CHALLENGES AND PERSPECTIVES
oai:nur.nu.edu.kz:123456789/58252023-02-08T04:09:03Zcom_123456789_128col_123456789_2840
00925njm 22002777a 4500
dc
Buzzaccarini, Giovanni
author
Noventa, Marco
author
D’Alterio, Maurizio Nicola
author
Terzic, Milan
author
Scioscia, Marco
author
Schäfer, Sebastian Daniel
author
Bianco, Bianca
author
Laganà, Antonio Simone
author
2021
Vaginally assisted Natural Orifice Transluminal Endoscopic
Surgery (vNOTES) is a recent and newly introduced technique which has a wide application in gynecologic surgery
and other medical specialties [1]. This technique involves
an endoscopic access creation in the vagina, through which
abdominal and pelvic structures can be reached with appropriate devices. Moreover, it gained popularity since it is
associated with short operative time, reduced post-operatory
pain, lack of visible scars, and a better cosmetic result, using
natural orifices to access the abdominal cavity. In this
regard, vNOTES was considered eligible for hysterectomy
and was firstly described in 2012. During the last decade,
several pieces of evidence suggested the efficacy and feasibility of this novel approach. Nevertheless, few metanalyses
and randomized controlled trials (RCTs) have been performed to evaluate vNOTES outcomes...
Buzzaccarini, G., Noventa, M., D’Alterio, M. N., Terzic, M., Scioscia, M., Schäfer, S. D., Bianco, B., & Laganà, A. S. (2021). vNOTES Hysterectomy: Can It Be Considered the Optimal Approach for Obese Patients? Journal of Investigative Surgery, 1–2. https://doi.org/10.1080/08941939.2021.1939467
http://nur.nu.edu.kz/handle/123456789/5825
Type of access: Open Access
vNOTES Hysterectomy
VNOTES HYSTERECTOMY: CAN IT BE CONSIDERED THE OPTIMAL APPROACH FOR OBESE PATIENTS?