2024-03-29T14:08:19Zhttp://nur.nu.edu.kz/oai/requestoai:nur.nu.edu.kz:123456789/11302018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
Impaired D-Serine-Mediated cotransmission mediates cognitive dysfunction in epilepsy
Klatte, Katharina
Kirschstein, Timo
Otte, David
Pothmann, Leonie
Muller, Lorenz
Tokay, Tursonjan
Kober, Maria
Uebachs, Mischa
Zimmer, Andreas
Beck, Heinz
Epilepsy
D-serine
NMDAR
Research Subject Categories::MEDICINE
The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory site of the receptor. In many forebrain
regions, this coagonist is D-serine. Here, we show that experimental epilepsy in rats is associated with a reduction in the CNS levels of
D-serine, which leads to a desaturation of the coagonist binding site of synaptic and extrasynaptic NMDARs. In addition, the subunit
composition of synaptic NMDARs changes in chronic epilepsy. The desaturation of NMDARs causes a deficit in hippocampal long-term
potentiation, which can be rescued with exogenously supplied D-serine. Importantly, exogenous D-serine improves spatial learning in epileptic animals. These results strongly suggest that D-serine deficiency is important in the amnestic symptoms of temporal lobe epilepsy. Our results point to a possible clinical utility of D-serine to alleviate these disease manifestations.
2016-02-03T03:21:01Z
2016-02-03T03:21:01Z
2013-08-07
Article
http://nur.nu.edu.kz/handle/123456789/1130
en
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Attribution-NonCommercial-NoDerivs 3.0 United States
Neurobiology of Disease
oai:nur.nu.edu.kz:123456789/11322018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulation
Tokay, Tursonjan
Kirschstein, Timo
Rohde, Marco
Zschorlich, Volker
Köhling, Rüdiger
high-frequency magnetic stimulation
receptor-dependent metaplasticity
metaplasticity
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-termpotentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 region of rat hippocampal slices using field excitatory postsynaptic potential (fEPSP) recordings. In control slices, electrical high-frequency conditioning stimulation (CS) could reliably induce LTP. In contrast,
the same CS protocol resulted in long-term depression when HFMS was delivered to the slice 30 min prior to the electrical stimulation. HFMS-primingwas diminishedwhen applied in the presence of themetabotropic glutamate receptor antagonists (RS)-
𝛼-methylserine-O-phosphate (MSOP) and (RS)-𝛼-methyl-4-carboxyphenylglycine (MCPG).Moreover,whenHFMSwas delivered in the presence of the NMDA receptor-antagonist D-2-amino-5-phosphonovalerate (50 𝜇M), CS-induced electrical LTP was again as high as under control conditions in slices without priming. These results demonstrate that HFMS significantly reduced the propensity of subsequent electrical LTP and show that both metabotropic glutamate and NMDA receptor activation were involved
in this form of HFMS-induced metaplasticity.
2016-02-03T04:33:44Z
2016-02-03T04:33:44Z
2014-10-28
Article
http://nur.nu.edu.kz/handle/123456789/1132
en
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Attribution-NonCommercial-NoDerivs 3.0 United States
Hindawi Publishing Corporation Neural Plasticity
oai:nur.nu.edu.kz:123456789/11332018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Status epilepticus enhances depotentiation after fully established LTP in an NMDAR-Dependent but GluN2B-independent manner
Guli, Xiati
Tokay, Tursonjan
Kirschstein, Timo
Köhling, Rüdiger
N-Methyl-D-aspartate
Epilepticus
Epilepticus enhances depotentiation
Research Subject Categories::MEDICINE
N-Methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) can be reversed by low-frequency stimulation (LFS) referred to as depotentiation (DP). We previously found GluN2B upregulated in CA1 neurons from post-status epilepticus
(post-SE) tissue associated with an enhanced LTP. Here,we testedwhether LFS-inducedDP is also altered in pathologicalGluN2B upregulation. Although LTP was enhanced in post-SE tissue, LTP was significantly reversed in this tissue, but not in controls. We next tested the effect of the GluN2B subunit-specific blocker Ro 25-6981 (1 𝜇M) on LFS-DP. As expected, LFS had no effect on synaptic strength in the presence of the GluN2B blocker in control tissue. In marked contrast, LFS-DP was also attained in
post-SE tissue indicating that GluN2B was obviously not involved in depotentiation. To test for NMDA receptor-dependence, we applied the NMDA receptor antagonist D-AP5 (50 𝜇M) prior to LFS and observed that DPwas abolished in both control and post-
SE tissue confirming NMDA receptor involvement. These results indicate that control Schaffer collateral-CA1 synapses cannot be depotentiated after fully established LTP, but LFS was able to reverse LTP significantly in post-SE tissue. However, while LFS-DP
clearly requiredNMDA receptor activation, GluN2B-containingNMDA receptors were not involved in this formof depotentiation
2016-02-03T04:41:58Z
2016-02-03T04:41:58Z
2015-11-15
Article
http://nur.nu.edu.kz/handle/123456789/1133
en
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Attribution-NonCommercial-NoDerivs 3.0 United States
Neural Plasticity
oai:nur.nu.edu.kz:123456789/11342018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants
Mayer, Johannes
Reichart, Gesine
Tokay, Tursonjan
Lange, Falko
Baltrusch, Simone
Junghanss, Christian
Wolkenhauer, Olaf
Jaster, Robert
Kunz, Manfred
Tiedge, Markus
Ibrahim, Saleh
Fuellen, Georg
Köhling, Rüdiger
Large-scale, heteroplasmic and generally pathogenic mtDNA defects (as induced by defective mitochondrial DNA polymerase, clonal mutations or DNA deletions) are known to negatively impact on life span and can result in apoptosis and tissue loss in, e.g., skeletal muscle or reduce learning abilities. The functional impact of homoplasmic specific mtDNA point mutations, e.g., in genes coding for the electron transport chain, however, remains a matter of debate. The present study contributes to this discussion and provides evidence that a single point mutation in complex I of the respiratory chain is associated with impairment of spatial navigation in adolescent (6-month-old) mice, i.e., reduced performance in the Morris Water Maze, which goes along with increased production of reactive oxygen species (ROS) in juvenile mice (3 months) but not at the age of phenotype expression. A point mutation in complex III goes along with only a mild and non-significant negative effect on cognitive performance and no significant changes in ROS production. These findings suggest to also consider the ontogenetic development of phenotypes when studying mtDNA mutations and highlights a possible impact of complex I dysfunction on the emergence of neurological deficits.
2016-02-03T04:55:04Z
2016-02-03T04:55:04Z
2015-04-15
Article
Mayer J, Reichart G, Tokay T, Lange F, Baltrusch S, Junghanss C, et al. (2015) Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants. PLoS ONE 10(4): e0123863. doi:10.1371/journal.pone.0123863
http://nur.nu.edu.kz/handle/123456789/1134
en
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Attribution-NonCommercial-NoDerivs 3.0 United States
PLOS ONE:Open Access journal
oai:nur.nu.edu.kz:123456789/11352018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
The universal non-neuronal nature of parkinson's disease: a theory
Valente, André
Adilbayeva, Altynai
Tokay, Tursonjan
Rizvanov, Albert A.
Various recent developments of relevance to Parkinson's disease (PD) are discussed and integrated into a comprehensive hypothesis on the nature, origin and inter-cellular mode of propagation of late-onset sporadic PD. We propose to define sporadic PD as a characteristic pathological deviation in the global gene expression program of a cell: the PD expression-state, or PD-state for short. Although a universal cell-generic state, the PD-state deviation would be particularly damaging in a neuronal context, ultimately leading to neuron death and the ensuing observed clinical signs. We review why age accumulated damage caused by oxidative stress in mitochondria could be the trigger for a primordial cell to shift to the PD-state. We put forward hematopoietic cells could be the first to acquire the PD-state, at hematopoiesis, from the disruption in reactive oxygen species (ROS) homeostasis that arises with age in the hematopoietic
stem-cell niche. We argue why, nonetheless, such a process is unlikely to explain the shift to the PD-state of all the subsequently affected cells in a patient, thus indicating the existence of a distinct mechanism of propagation of the PD-state. We highlight recent findings on the intercellular exchange of mitochondrial DNA and the ability of mitochondrial DNA to modulate the cellular global gene expression state and propose this could form the basis for the intercellular propagation of the PD-state.
2016-02-03T05:00:43Z
2016-02-03T05:00:43Z
2015-08-19
Article
http://nur.nu.edu.kz/handle/123456789/1135
en
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Attribution-NonCommercial-NoDerivs 3.0 United States
PeerJ PrePrints
oai:nur.nu.edu.kz:123456789/11362018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses
Guli, Xiati
Tokay, Tursonjan
Rohde, Marco
Bender, Roland A.
Kohling, Rudiger
Kirschstein, Timo
depression
nucleotide-gated nonselective
cell synapse
Research Subject Categories::MEDICINE
Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression
(LTD) at the medial perforant path-granule cell synapse in early postnatal (P9–15) and adult (P30–60) rats. LTD was elicited
in P9–15 slices using low-frequency stimulation (LFS, 900 pulses, 1Hz; 80 ± 4% of baseline). Application of the specific HCN
channel blocker ZD7288 (10 μM) before LFS significantly enhanced LTD (62 ± 4%; P < 0.01), showing HCN channels restrain LTD induction. However, when ZD7288 was applied after LFS, LTD was similar to control values and significantly different from
the values obtained with ZD7288 application before LFS (81 ± 5%; P < 0.01), indicating that HCN channels do not modulate
LTD expression. LTD in slices from adult rats were only marginally lower compared to those in P9–15 slices (85 ± 6%), but bath
application of ZD7288 prior to LFS resulted in the same amount of LTD (85 ± 5%). HCN channels in adult tissue hence lose their modulatory effect. In conclusion, we found that HCN channels at the medial perforant path-granule cell synapse compromise
LFS-associated induction, but not expression of LTD in early postnatal, but not in adult, rats.
2016-02-03T08:50:03Z
2016-02-03T08:50:03Z
2012-05-08
Article
Xiati Guli, Tursonjan Tokay, Marco Rohde, Roland A. Bender, Rüdiger Köhling, and Timo Kirschstein, “ZD7288 Enhances Long-Term Depression at Early Postnatal Medial Perforant Path-Granule Cell Synapses,” Neural Plasticity, vol. 2012, Article ID 237913, 9 pages, 2012. doi:10.1155/2012/237913
http://nur.nu.edu.kz/handle/123456789/1136
en
http://creativecommons.org/licenses/by-nc-nd/3.0/us/
Attribution-NonCommercial-NoDerivs 3.0 United States
Neural Plasticity
oai:nur.nu.edu.kz:123456789/11722018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Amyloid-b peptide on sialyl-LewisX-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface
Askarova, Sholpan
Sun, Zhe
Sun, Grace Y.
Meininger, Gerald A.
Lee, James C-M.
Amyloid-b
sialyl-lewisX-selectin-mediated membrane
cerebral endothelial cell surface
Alzheimer’s disease
neurodegenerative disease
Increased deposition of amyloid-b peptide (Ab) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer’s disease (AD). In this study, quantitative immunofluorescence microscopy (QIM) and atomic force microscopy (AFM) with cantilevers biofunctionalized
by sialyl-Lewisx (sLex) were employed to investigate Ab-altered mechanics of membrane tethers formed by bonding
between sLex and p-selectin at the CEC surface, the initial mechanical step governing the transmigration of monocytes. QIM results indicated the ability for Ab to increase p-selectin expression at the cell surface and promote actin polymerization in both bEND3 cells (immortalized mouse CECs) and human primary CECs. AFM data also showed the ability for Ab to increase cell stiffness and adhesion probability in bEND3 cells. On the contrary, Ab lowered the overall force of membrane tether formation (Fmtf), and produced a bimodal population of Fmtf, suggesting subcellular mechanical alterations in membrane tethering. The lower Fmtf population was similar to the results obtained from cells treated with an F-actin-disrupting drug, latrunculin A. Indeed, AFM results also showed that both Ab and latrunculin A decreased membrane stiffness, suggesting a
lower membrane-cytoskeleton adhesion, a factor resulting in lower Fmtf. In addition, these cerebral endothelial alterations induced by Ab were abrogated by lovastatin, consistent with its anti-inflammatory effects. In sum, these results demonstrated the ability for Ab to enhance p-selectin expression at the CEC surface and induce cytoskeleton
reorganization, which in turn, resulted in changes in membrane-cytoskeleton adhesion and membrane tethering, mechanical factors important in transmigration of monocytes through the BBB.
2016-02-08T05:56:50Z
2016-02-08T05:56:50Z
2013-04-12
Article
Askarova S, Sun Z, Sun GY, Meininger GA, Lee JC-M (2013) Amyloid-b Peptide on Sialyl-LewisX-Selectin-Mediated Membrane Tether Mechanics at the Cerebral Endothelial Cell Surface. PLoS ONE 8(4): e60972. doi:10.1371/journal.pone.0060972
http://nur.nu.edu.kz/handle/123456789/1172
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
PLOS ONE:Open Access journal
oai:nur.nu.edu.kz:123456789/11732018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Effects of amyloid beta peptide on neurovascular cells
Askarova, Sholpan
Tsoy, Andrey
Shalakhmetova, Tamara
Lee, James C-M.
amyloid-beta petide
Alzheimer’s disease
Research Subject Categories::MEDICINE
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the neurons, and progressive deterioration of cognition and memory of affected individuals. Although the cause and progression of AD are still not well understood, the amyloid hypothesis is dominant and widely accepted. According to this hypothesis, an increased deposition of amyloid-β peptide (Aβ) in the brain is the main cause of the AD’s onset and progression. There is increasing body of evidence that blood-brain barrier (BBB) dysfunction plays an important role in the development of AD, and may even precede neuron degeneration in AD brain. In the early stage of AD, microvasculature deficiencies, inflammatory reactions, surrounding the cerebral vasculature and endothelial dysfunctions are commonly observed. Continuous neurovascular degeneration and accumulation of Aβ on blood vessels resulting in cerebral amyloid angiopathy is associated with further progression of the disease and cognitive decline. However, little is known about molecular mechanisms that underlie Aβ induced damage of neurovascular cells. In this regards, this review is aimed to address how Aβ impacts the cerebral endothelium. Understanding the cellular pathways triggered by Aβ leading to alterations in cerebral endothelial cells structure and functions would provide insights into the mechanism of BBB dysfunction and inflammatory processes in Alzheimer’s, and may offer new approaches for prevention and treatment strategies for AD.
2016-02-08T06:03:00Z
2016-02-08T06:03:00Z
2012
Article
http://nur.nu.edu.kz/handle/123456789/1173
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Central Asian Journal of Global Health
oai:nur.nu.edu.kz:123456789/11752018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes
Askarova, Sholpan
Yang, Xiaoguang
Lee, James C-M.
Research Subject Categories::TECHNOLOGY::Bioengineering
regenerative medicine
Research Subject Categories::MEDICINE::Physiology and pharmacology::Physiology::Neurophysiology
An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact with membranes of neurons and
other cerebral cells. Aβ is derived from amyloidogenic cleavage of amyloid precursor protein (AβPP) by β- and γ-secretase. In the nonamyloidogenic pathway, AβPP is cleaved by α-secretases. These two pathways compete with each other, and enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological approach for the treatment of AD. Since AβPP, α-, β-, and γ-secretases are membrane-associated proteins, AβPP processing and Aβ production can be affected by the membrane composition and properties. There is evidence that membrane composition and properties, in turn, play a critical role in Aβ cytotoxicity associated with its conformational changes and aggregation into oligomers and fibrils. Understanding themechanisms leading to changes in a membrane’s biophysical properties and how they affect AβPP processing and Aβ toxicity should prove to provide new therapeutic strategies for prevention and treatment of AD.
2016-02-08T06:11:00Z
2016-02-08T06:11:00Z
2011-01-21
Article
http://nur.nu.edu.kz/handle/123456789/1175
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
SAGE-Hindawi Access to Research International Journal of Alzheimer’s Disease
oai:nur.nu.edu.kz:123456789/11772018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes
Yang, Xiaoguang
Askarova, Sholpan
Sheng, Wenwen
Chen, JK
Sun, Albert Y.
Sun, Grace Y.
Yao, Gang
Leea, James C-M.
phospholipase A2
interleukin-1β
iNOS
NADPH oxidase
oxidative stress
phosphorylation
inflammation
Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, oligomeric Aβ induces the assembly of NADPH oxidase complexes resulting in its activation to produce anionic superoxide. Aβ also promotes production of pro-inflammatory factors in astrocytes. Since low energy laser has previously been reported to attenuate oxidative stress and inflammation in biological systems, the objective of this study was to examine whether this type of laser light was able to abrogate the oxidative and inflammatory responses induced by Aβ. Primary rat astrocytes were exposed to Helium-Neon laser (λ=632.8 nm), followed by the treatment with oligomeric Aβ. Primary rat astrocytes were used to measure Aβ-induced production of superoxide anions using fluorescence microscopy of dihydroethidium (DHE), assembly of NADPH oxidase subunits by the colocalization between the cytosolic p47phox subunit and the membrane gp91phox subunit using fluorescent confocal microscopy, phosphorylation of cytosolic phospholipase A2 (cPLA2), and expressions of pro-inflammatory factors including interleukin-1β (IL-1β) and inducible nitric-oxide synthase (iNOS) using Western blot Analysis. Our data showed that laser light at 632.8 nm suppressed Aβ-induced superoxide production, colocalization between NADPH oxidase gp91phox and p47phox subunits, phosphorylation of cPLA2, and the expressions of IL-1β and iNOS in primary astrocytes. We demonstrated for the first time that 632.8 nm laser was capable of suppressing cellular pathways of oxidative stress and inflammatory responses critical in the pathogenesis in AD. This study should prove to provide the groundwork for further investigations for the potential use of laser therapy as a treatment for AD.
2016-02-08T06:21:54Z
2016-02-08T06:21:54Z
2010-09-25
Article
http://nur.nu.edu.kz/handle/123456789/1177
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
US National Library of Medicine National Institutes of Health
oai:nur.nu.edu.kz:123456789/11792018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Membrane biophysics and mechanics in Alzheimer's disease
Yang, Xiaoguang
Askarova, Sholpan
Lee, James C-M.
Amyloid-β
Alzheimer's disease
membrane properties
membrane order
membrane fluidity
membrane potential
cerebral endothelium
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Alzheimer's disease is a chronic neurodegenerative
disorder characterized by neuronal loss, cerebrovascular
inflammation, and accumulation of senile plaques in the
brain parenchyma and cerebral blood vessels. Amyloid-β
peptide (Aβ), a major component of senile plaques, has
been shown to exert multiple toxic effects to neurons,
astrocytes, glial cells, and brain endothelium. Oligomeric
Aβ can disturb the structure and function of cell membranes
and alter membrane mechanical properties, such as
membrane fluidity and molecular order. Much of these
effects are attributed to their capability to trigger oxidative
stress and inflammation. In this review, we discuss the
effects of Aβ on neuronal cells, astrocytes, and cerebral
endothelial cells with special emphasis on cell membrane
properties and cell functions.
2016-02-08T06:27:07Z
2016-02-08T06:27:07Z
2010-05-01
Article
http://nur.nu.edu.kz/handle/123456789/1179
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Mol Neurobiol
oai:nur.nu.edu.kz:123456789/11802018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells
Askarova, Sholpan
Yang, Xiaoguang
Sheng, Wenwen
Sun, Grace Y.
Lee, James C-M.
Aβ-receptor
oxidative stress
cerebral endothelial cells
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers (Aβ42) have been reported to mediate oxidative damage to the CECs and astrocytes and trigger the downstream mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, the cell surface binding site for Aβ42 and exact sequence of these events have yet to be elucidated. In this study, the receptor for advanced glycation endproducts (RAGE) was postulated to function as a signal transducing cell surface receptor for Aβ42 to induce reactive oxygen species (ROS) generation from NADPH oxidase and trigger downstream pathways for the phosphorylation of extracellular signal-regulated kinases (ERK1/2) and cytosolic phospholipase A2 (cPLA2). We found that Aβ42 competed with the anti-RAGE antibody (AbRAGE) to bind to RAGE on the surfaces of CECs and primary astrocytes. In addition, AbRAGE abrogate Aβ42-induced ROS production and the colocalization between the cytosolic (p47-phox) and membrane (gp91-phox) subunits of NADPH oxidase in both cell types. AbRAGE as well as NADPH oxidase inhibitor and ROS scavenger suppressed Aβ42-induced ERK1/2 and cPLA2 phosphorylation in CECs. At the same time, only AbRAGE, but neither NADPH oxidase inhibitor nor ROS scavenger, inhibited the ERK1/2 pathway and cPLA2 phosphorylation in primary astrocytes. Therefore, this study demonstrates that NADPH oxidase complex assembly and ROS production are not required for Aβ42 binding to RAGE at astrocytic surface leading to sequential phosphorylation of ERK1/2 and cPLA2, and suggests the presence of two different RAGE-dependent downstream pathways in the CECs and astrocytes.
2016-02-08T06:34:04Z
2016-02-08T06:34:04Z
2012-12-29
Article
http://nur.nu.edu.kz/handle/123456789/1180
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Neuroscience. Author manuscript; available in PMC
oai:nur.nu.edu.kz:123456789/11812018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Role of membrane biophysics in Alzheimer’s–related cell pathways
Zhu, Donghui
Bungart, BrittaniL
Yang, Xiaoguang
Zhumadilov, Zhaxybay
Lee, James C-M.
Askarova, Sholpan
amyloid-b peptide
membrane molecular order
amyloid precursor protein
membrane fluidity
cerebral endothelium
P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the
development and progression of Alzhemer’s disease. In this study we have evaluated the effects of Aβ42 oligomers on P-selectin expression and actin polymerization in mouse endothelial cells (bEnd3).
Our results indicated that Aβ42 induced plasma membrane accumulation of P-selectin and promoted actin polymerization, and these events were correlated with increased reactive oxygen species (ROS) generation. The rapid, posttranslational cell signaling response mediated by ROS may well represent an important physiological trigger of the microvascular inflammation in Alzheimer disease.
2016-02-08T07:41:09Z
2016-02-08T07:41:09Z
2015-05-27
Article
Zhu D,BungartBL,YangX, ZhumadilovZ,LeeJC-Mand Askarova S(2015)Roleofmembrane biophysics inAlzheimer’s–relatedcell pathways. Front.Neurosci.9:186. doi: 10.3389/fnins.2015.00186
http://nur.nu.edu.kz/handle/123456789/1181
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Frontiers inNeuroscience
oai:nur.nu.edu.kz:123456789/12512018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
Around Semipalatinsk nuclear test site: progress of dose estimations relevant to the consequences of nuclear tests
Stepanenko, Valeriy F.
Semipalatinsk nuclear
Semipalatinsk nuclear test site
Hiroshima University
Research Subject Categories::MEDICINE
Research Subject Categories::TECHNOLOGY::Chemical engineering::Chemical process and manufacturing engineering::Nuclear chemistry
(A summary of 3 rd Dosimetry Workshop on the Semipalatinsk Nuclear
Test Site Area, RIRBM, Hiroshima University, Hiroshima, 9-11 of March, 2005)
The paper is an analytical overview of the main results presented at the 3
rd Dosimetry Workshop in Hiroshima (9–11 of March 2005), where different aspects of the dose reconstruction around the Semipalatinsk nuclear test site (SNTS) were discussed and summarized.
2016-02-17T10:05:03Z
2016-02-17T10:05:03Z
2005-03-09
Article
http://nur.nu.edu.kz/handle/123456789/1251
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
J. Radiat. Res. Vol. 47, Suppl. A (2006); http://jrr.jstage.jst.go.jp
oai:nur.nu.edu.kz:123456789/12522018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1123
Deep phylogenetic analysis of haplogroup G1 provides estimates of SNP and STR utation rates on the human Y-Chromosome and reveals migrations of Iranic speakers
Balanovsky, Oleg
Zhabagin, Maxat
Agdzhoyan, Anastasiya
Chukhryaeva, Marina
Zaporozhchenko, Valery
Utevska, Olga
Highnam, Gareth
Sabitov, Zhaxylyk
Greenspan, Elliott
Dibirova, Khadizhat
Skhalyakho, Roza
Kuznetsova, Marina
Koshel, Sergey
Yusupov, Yuldash
Nymadawa, Pagbajabyn
Zhumadilov, Zhaxybay
Pocheshkhova, Elvira
Haber, Marc
Zalloua, Pierre A.
Yepiskoposyan, Levon
Dybo, Anna
Tyler-Smith, Chris
Balanovska, Elena
Y-chromosomal haplogroup
haplogroup G1
SNP and STR Mutation Rates
Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South-
West and Central Asia but reaches up to 80% frequency in some populations scattered
within this area. We have genotyped the G1-defining marker M285 in 27 Eurasian populations (n= 5,346), analyzed 367 M285-positive samples using 17 Y-STRs, and sequenced ~11 Mb of the Y-chromosome in 20 of these samples to an average coverage of 67X. This allowed detailed phylogenetic reconstruction. We identified five branches, all with high geographical specificity: G1-L1323 in Kazakhs, the closely related G1-GG1 in Mongols, G1- GG265 in Armenians and its distant brother clade G1-GG162 in Bashkirs, and G1-GG362 in West Indians.
2016-02-17T11:05:41Z
2016-02-17T11:05:41Z
2015-04-07
Article
Balanovsky O, Zhabagin M, Agdzhoyan A, Chukhryaeva M, Zaporozhchenko V, Utevska O, et al. (2015) Deep Phylogenetic Analysis of Haplogroup G1 Provides Estimates of SNP and STR Mutation Rates on the Human Y-Chromosome and Reveals Migrations of Iranic Speakers. PLoS ONE 10(4): e0122968. doi:10.1371/journal.pone.0122968
http://nur.nu.edu.kz/handle/123456789/1252
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
PLOS ONE
oai:nur.nu.edu.kz:123456789/12532018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Behavior and food consumption pattern of the population exposed in 1949–1962 to fallout from Semipalatinsk nuclear test site in Kazakhstan
Drozdovitch, Vladimir
Schonfeld, Sara
Akimzhanov, Kuat
Aldyngurov, Daulet
Land, Charles E.
Luckyanov, Nickolas
Mabuchi, Kiyohiko
Potischman, Nancy
J. Schwerin, Michael J.
Semenova, Yulia
Tokaeva, Alma
Zhumadilov, Zhaxybay
Bouville, André
Simon, Steven L.
Semipalatinsk nuclear test site in Kazakhstan
Semipalatinsk nuclear
Research Subject Categories::MEDICINE
The relationship between radiation exposure from nuclear weapons testing fallout and thyroid disease in a group of 2,994 subjects has been the subject of study by the US National Cancer Institute. In that study, radiation doses to the thyroid were estimated for residents of villages in Kazakhstan possibly exposed to deposition of radioactive fallout from nuclear testing conducted by the Soviet Union at the Semipalatinsk Nuclear Test Site in Kazakhstan between 1949 and 1962. The study subjects included individuals of both Kazakh and Russian origin who were exposed during childhood and adolescence. An initial dose reconstruction used for the risk analysis of Land et al. (Radiat Res 169:373-383, 2008) was based on individual information collected from basic questionnaires administered to the study population in 1998. However, because data on several key questions for accurately estimating doses were not obtained from the 1998 questionnaires, it was decided to conduct a second data collection campaign in 2007. Due to the many years elapsed since exposure, a well-developed strategy was necessary to encourage accurate memory recall.
2016-02-17T11:17:55Z
2016-02-17T11:17:55Z
2011-03
Article
The publisher's final edited version of this article is available at Radiat Environ Biophys DOI 10.1007/s00411-010-0334-9
http://nur.nu.edu.kz/handle/123456789/1253
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
Radiation and Environmental Biophysics
oai:nur.nu.edu.kz:123456789/12832018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis
Catanzaro, R.
Zerbinati, N.
Solimene, U.
Celep, G.
Marotta, F.
Kushugulova, A.
Milazzo, M.
Tomella, C.
Bertuccelli, G.
Zhumadilov, Z.
antimutagenic effect
cell cycle
apoptosis
celergen
marine compound
Research Subject Categories::MEDICINE
The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in the HepG2 human liver cancer cell
line. Celergen significantly inhibited the proliferation of cancer cells in a dose-dependent manner while limiting the cell cycle progression at the G1 phase and
significantly inducing apoptosis. Further examination showed that Celergen enhanced expression of the p21CIPl1WAF1, GADD153 genes and downregulated the
c-myc gene. These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.
2016-02-19T03:22:51Z
2016-02-19T03:22:51Z
2013
Article
DOI: 10.5582/ddt.2013.v7.5.196
http://nur.nu.edu.kz/handle/123456789/1283
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Drug Discoveries & Therapeutics. DOI: 10.5582/ddt.2013.v7.5.196
oai:nur.nu.edu.kz:123456789/12842018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Draft genome sequence of Lactobacillus rhamnosus CLS17
Zhumadilov, Zhaxybay
Kozhakhmetov, Samat S.
Kushugulova, Almagul R.
Saduakhasova, Saule A.
Shakhabayeva, Gulnara S.
Khassenbekova, Zhanagul R.
Molkenov, Askhat B.
Kairov, Ulykbek E.
Issayeva, Raushan B.
Nurgozhin, Talgat S.
lactobacillus
genome sequence
microbiome
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
The human gut microbiome is an organ that provides primary
barrier protection against foreign agents. Most of the microorganisms
are different strains of commensal bacteria that are colonized in the gut. Gut flora influence food metabolism and have an antagonistic effect on different pathogens and immunomodulatory properties (1). One of the main species of gut flora is
in the genus Lactobacillus...
2016-02-19T03:41:39Z
2016-02-19T03:41:39Z
2015
Article
Kozhakhmetov SS, Kushugulova AR, Saduakhasova SA, Shakhabayeva GS, Khassenbekova ZR, Molkenov AB, Kairov UE, Issayeva RB, Nurgozhin TS, Zhumadilov ZS. 2015. Draft genome sequence of Lactobacillus rhamnosus CLS17. Genome Announc 3(3):e00478-15. doi:10.1128/genomeA.00478-15.
http://nur.nu.edu.kz/handle/123456789/1284
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Genome Announc
oai:nur.nu.edu.kz:123456789/12852018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
ESR dosimetry study of population in the vicinity of the Semipalatinsk Nuclear Test Site
Zhumadilov, Kassym
Ivannikov, Alexander
Stepanenko, Valeriy
Zharlyganova, Dinara
Toyoda, Shin
Zhumadilov, Zhaxybay
Hoshi, Masaharu
ESR dosimetry
tooth enamel samples
Semipalatinsk Test Site
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
A tooth enamel electron spin resonance (ESR) dosimetry study was carried out with the purpose of obtaining the individual absorbed radiation doses of population from settlements in the Semipalatinsk region of Kazakhstan, which was exposed to radioactive fallout traces from nuclear explosions in the Semipalatinsk Nuclear Test Site and Lop Nor test base, China. Most of the settlements are located near the central axis of
radioactive fallout trace from the most contaminating surface nuclear test, which was conducted on 29 August 1949, with the maximum detected excess dose being 430 ± 93 mGy. A maximum dose of 268 ± 79 mGy was determined from the settlements located close to radioactive fallout trace resulting from surface nuclear tests on 24 August 1956 (Ust-Kamenogorsk, Znamenka, Shemonaikha, Glubokoe, Tavriya
and Gagarino). An accidental dose of 56 ± 42 mGy was found in Kurchatov city residents located close to fallout trace after the nuclear test on 7 August 1962. This method was applied to human tooth enamel to obtain individual absorbed doses of residents of the Makanchi, Urdzhar and Taskesken settlements located near the Kazakhstan–Chinese border due to the influence of nuclear tests (1964–1981) at Lop Nor. The
highest dose was 123 ± 32 mGy.
2016-02-19T03:54:34Z
2016-02-19T03:54:34Z
2013-02
Article
doi: 10.1093/jrr/rrt008
http://nur.nu.edu.kz/handle/123456789/1285
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Radiation Research. doi: 10.1093/jrr/rrt008
oai:nur.nu.edu.kz:123456789/12862018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk Nuclear Test Site
Takeichi, Nobuo
Hoshi, Masaharu
Iida, Shozo
Tanaka, Kimio
Harada, Yuka
Zhumadilov, Zhaxybay
Chaizhunusova, Nailya
Apsalikov, Kazbek N.
Noso, Yoshihiro
Inaba, Toshiya
Tanaka, Kenichi
Endo, Satoru
Semipalatinsk nuclear test site
thyroid cells
apparent nuclear abnormalities
chromosome aberrations
radiation effect
Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52–63 years old, were performed in 2001–2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village,
Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in
peripheral lymphocytes and on the follicular cells in the thyroid.
2016-02-19T04:11:18Z
2016-02-19T04:11:18Z
2006
Article
http://nur.nu.edu.kz/handle/123456789/1286
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Radiation Research. http://jrr.jstage.jst.go.jp
oai:nur.nu.edu.kz:123456789/12872018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
Draft genome sequences of two clinical Isolates of mycobacterium tuberculosis from sputum of Kazakh patients
Kairov, Ulykbek E.
Kozhamkulov, Ulan
Molkenov, Askhat
Rakhimova, Saule
Askapuli, Ayken
Zhabagin, Maxat
Akhmetova, Ainur
Yerezhepov, Dauren
Abilova, Zhannur
Abilmazhinova, Aliya
Bismilda, Venera
Chingisova, Leila
Akilzhanova, Ainur
Zhumadilov, Zhaxybay
genome sequences
mycobacterium tuberculosis
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
Here, we report the draft genome sequences of two clinical isolates of Mycobacterium tuberculosis (MTB-476 and MTB-489) isolated
from sputum of Kazakh patients.
2016-02-19T04:22:16Z
2016-02-19T04:22:16Z
2015
Article
Kairov U, Kozhamkulov U, Molkenov A, Rakhimova S, Askapuli A, Zhabagin M, Akhmetova A, Yerezhepov D, Abilova Z, Abilmazhinova A, Bismilda V, Chingisova L, Zhumadilov Z, Akilzhanova A. 2015. Draft genome sequences of two clinical isolates of Mycobacterium tuberculosis from sputum of Kazakh patients. Genome Announc 3(3): e00466-15. doi:10.1128/genomeA.00466-15.
http://nur.nu.edu.kz/handle/123456789/1287
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
Genome Announc
oai:nur.nu.edu.kz:123456789/12892018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Levels and distribution of self-rated health in the Kazakh population: results from the Kazakhstan household health survey 2012
Supiyev, Adil
Nurgozhin, Talgat
Zhumadilov, Zhaxybay
Sharman, Almaz
Marmot, Michael
Bobak, Martin
self-rated health
socioeconomic factors
Central Asian countries
Research Subject Categories::MEDICINE
The high and fluctuating mortality and rising health inequalities in post-Soviet countries have attracted considerable attention. However, there are very few individual-level data on distribution of health outcomes in Central Asian countries of the former Soviet Union. We analysed socioeconomic predictors of two self-rated health outcomes in a national survey in Kazakhstan.
2016-02-19T04:32:09Z
2016-02-19T04:32:09Z
2014
Article
http://www.biomedcentral.com/1471-2458/14/768
http://nur.nu.edu.kz/handle/123456789/1289
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
BioMed Central Public Health. http://www.biomedcentral.com/1471-2458/14/768
oai:nur.nu.edu.kz:123456789/12902018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Tooth enamel EPR dosimetry: optimization of EPR spectra recording parameters and effect of sample mass on spectral sensitivity
Zhumadilov, Kassym
Ivannikov, Alexander
Skvortsov, Valeriy
Stepanenko, Valeriy
Zhumadilov, Zhaxybay
Endo, Satoru
Tanaka, Kenichi
Hoshi, Masaharu
EPR spectroscopy
tooth enamel
dose determination
Research Subject Categories::MEDICINE
conditions were optimized. The uncertainty of dose determination was obtained as the mean square deviation of doses, determined with the use of a spectra deconvolution program, from the nominal doses for ten enamel samples irradiated in the range from 0 to 500 mGy. The spectra were recorded at different microwave powers and accumulation times. It was shown that minimal uncertainty is achieved at the microwave power of about 2 mW for a used spectrometer JEOL JES-FA100. It was found that a limit of the accumulation time exists beyond which uncertainty reduction is ineffective. At an established total time of measurement, reduced uncertainty is obtained by averaging the experimental doses determined from recorded spectra following intermittent sample shaking and sample tube rotation, rather than from one spectrum recorded at longer accumulation time. The effect of sample mass on the spectrometer’s sensitivity
was investigated in order to find out how to make appropriate corrections.
2016-02-19T04:42:24Z
2016-02-19T04:42:24Z
2005
Article
http://nur.nu.edu.kz/handle/123456789/1290
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Radiation Research. http://jrr.jstage.jst.go.jp
oai:nur.nu.edu.kz:123456789/12912018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
RYR2 sequencing reveals novel missense mutations in a Kazakh Idiopathic ventricular tachycardia study cohort
Akilzhanova, Ainur
Guelly, Christian
Nuralinov, Omirbek
Nurkina, Zhannur
Nazhat, Dinara
Smagulov, Shalkhar
Tursunbekov, Azat
Alzhanova, Anar
Rashbayeva, Gulzhaina
Abdrakhmanov, Ayan
Dosmagambet, Sholpan
Trajanoski, Slave
Zhumadilov, Zhaxybay
Sharman, Almaz
Bekbosynova, Mahabbat
RYR2 sequencing
human ryanodine receptor
ventricular arrhythmia
Tachycardia
Channelopathies, caused by disturbed potassium or calcium ion management in cardiac myocytes are a major cause of heart failure and sudden cardiac death worldwide. The human ryanodine receptor 2 (RYR2) is one of the key players tightly regulating calcium efflux from the sarcoplasmic reticulum to the cytosol and found frequently mutated (,60%) in context of catecholaminergic polymorphic ventricular tachycardia (CPVT1). We tested 35 Kazakhstani patients with episodes of ventricular arrhythmia, two of those with classical CPVT characteristics and 33 patients with monomorphic idiopathic
ventricular arrhythmia, for variants in the hot-spot regions of the RYR2 gene. This approach revealed two novel variants; one de-novo RYR2 mutation (c13892A.T; p.D4631V) in a CPVT patient and a novel rare variant (c5428G.C; p.V1810L) of
uncertain significance in a patient with VT of idiopathic origin which we suggest represents a low-penetrance or susceptibility variant. In addition we identified a known variant previously associated with arrhythmogenic right ventricular
dysplasia type2 (ARVD2). Combining sets of prediction scores and reference databases appeared fundamental to predict the pathogenic potential of novel and rare missense variants in populations where genotype data are rare.
2016-02-19T04:53:29Z
2016-02-19T04:53:29Z
2014
Article
Akilzhanova A, Guelly C, Nuralinov O, Nurkina Z, Nazhat D, et al. (2014) RYR2 Sequencing Reveals Novel Missense Mutations in a Kazakh Idiopathic Ventricular Tachycardia Study Cohort. PLoS ONE 9(6): e101059. doi:10.1371/journal.pone.0101059
http://nur.nu.edu.kz/handle/123456789/1291
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
PLOS ONE. doi:10.1371/journal.pone.0101059
oai:nur.nu.edu.kz:123456789/12922018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Thyroid abnormality trend over time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site: a case review of pathological findings for 7271 patients
Zhumadilov, Zhaxybay
GUSEV, BORIS I.
TAKADA, JUN
HOSHI, Masaharu
Kimura, AKIRO
Hayakawa, Norihiko
Takeichi, Nobuo
nuclear weapon testing
Semipalatinsk
thyroid abnormalities
pathological specimens
radiationinduced neoplasms
Research Subject Categories::MEDICINE
From 1949 through 1989 nuclear weapons testing carried out by the former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) resulted in local fallout affecting the residents of Semipalatinsk, Ust-Kamenogorsk and Pavlodar regions of Kazakstan. To investigate the possible relationship between radiation exposure and thyroid gland abnormalities, we conducted a case review of pathological findings of 7271 urban and rural patients who underwent surgery from 1966–96. Of the 7271 patients, 761
(10.5%) were men, and 6510 (89.5%) were women...
2016-02-19T05:12:50Z
2016-02-19T05:12:50Z
2000
Article
http://nur.nu.edu.kz/handle/123456789/1292
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Radiation Research
oai:nur.nu.edu.kz:123456789/12932018-01-29T21:17:56Zcom_123456789_107com_123456789_106col_123456789_1125
Results of EPR dosimetry for population in the vicinity of the most contaminating radioactive fallout trace after the first nuclear test in the Semipalatinsk Test Site
EPR spectroscopy
tooth enamel
Dose reconstruction
Semipalatinsk nuclear test site
The method of electron paramagnetic resonance (EPR) spectroscopy for tooth enamel is applied to individual radiation dose determination to residents of two villages (Dolon and Mostik) in the vicinity of the Semipalatinsk nuclear test site in Kazakhstan. These villages are located near the central axis of the radioactive fallout trace of the most contaminating surface nuclear test conducted in 1949. It is found that excess doses obtained by subtraction of natural background dose from dose absorbed in enamel range up
to 440 mGy to residents of Dolon, whose enamel was formed before 1949, and do not exceed 120 mGy to younger residents. To residents of Mostik, excess doses do not exceed 100 mGy regardless of age except for one resident with an extremely high dose of 1.25 Gy. These results are in agreement with the pattern of radioactive contamination of the territory after the nuclear test of 1949 except one case of extremely high dose, which should be additionally investigated.
2016-02-19T05:18:35Z
2016-02-19T05:18:35Z
2016
Article
http://nur.nu.edu.kz/handle/123456789/1293
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Radiation Research. http://jrr.jstage.jst.go.jp
oai:nur.nu.edu.kz:123456789/12942018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data
Terlikbayeva, Assel
Hermosilla, Sabrina
Galea, Sandro
Schluger, Neil
Yegeubayeva, Saltanat
Abildayev, Tleukhan
Muminov, Talgat
Akiyanova, Farida
Bartkowiak, Laura
Zhumadilov, Zhaxybay
Sharman, Almaz
El-Bassel, Nabila
tuberculosis
case notification rate
prevalence
risk factors
MDR-TB
Kazakhstan
spatial distribution
surveillance
National tuberculosis program
Oblast
Research Subject Categories::MEDICINE
Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan.
2016-02-19T05:27:52Z
2016-02-19T05:27:52Z
2012
Article
http://nur.nu.edu.kz/handle/123456789/1294
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
BMC Infectious Diseases. http://www.biomedcentral.com/1471-2334/12/262
oai:nur.nu.edu.kz:123456789/13012018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
EVALUATION OF EXTRACORPOREAL GAS EXCHANGE DEVICE HEMOLUNG FOR POTENTIAL APPLICATION IN PEDIATRIC PRACTICE/ ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ
Mussin (Мусин), Y.A. (Е.А.)
Bulanin (Буланин), D.S. (Д.С.)
Jeffries (Джеффрис), R.G. (Р.Дж.)
Zhumadilov (Жумадилов), Zhaxybay (Ж.Ш.)
Olzhayev, F.
Federspiel (Федерспил), W.J. (В.Дж.)
severe respiratory failure
extracorporeal gas exchange
oxygenation
pediatrics
тяжелая дыхательная недостаточность
экстракорпоральный газообмен
педиатрия
оксигенация
Research Subject Categories::MEDICINE
Основной целью данной работы является получение первичных данных о нагнетательной способности гемопомпы устройства Hemolung и способности обеспечить адекватный уровень газообмена при использовании катетеров уменьшенного диаметра и скорости кровообращения, применимой у детей.
The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using the catheters of smaller diameter and blood fl ow rates, applied in pediatrics.
2016-02-19T11:29:29Z
2016-02-19T11:29:29Z
2014
Article
Мусин Е.А., Буланин Д.С., Джеффрис Р.Д., Жумадилов Ж.Ш., Олжаев Ф.С., Федерспил В.Д. ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ. Вестник трансплантологии и искусственных органов. 2014;16(4):125-134. DOI:10.15825/1995-1191-2014-4-125-134
http://nur.nu.edu.kz/handle/123456789/1301
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ, том XVI, № 4
oai:nur.nu.edu.kz:123456789/13022018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Heart and lungs protection technique for cardiac surgery with cardiopulmonary bypass
Pichugin, Vladimir
Melnikov, Nikolay
Olzhayev, F.
Medvedev, Alexander
Jourko, Sergey
Gamzaev, Alishir
Chiginev, Vladimir
constant coronary perfusion
pulmonary artery perfusion
cardiopulmonary bypass
Research Subject Categories::MEDICINE
Cardioplegic cardiac arrest with subsequent ischemic-reperfusion injuries can lead to the development of inflammation of the myocardium, leucocyte activation, and release of cardiac enzymes. Flow reduction to the bronchial arteries, causing low-flow lung ischemia, leads to the development of a pulmonary regional inflammatory response...
2016-02-19T11:48:39Z
2016-02-19T11:48:39Z
2014
Article
http://nur.nu.edu.kz/handle/123456789/1302
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Central Asian Journal of Global Health
oai:nur.nu.edu.kz:123456789/13052018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Влияние ростовых факторов TGF-β1, IGF-I, BMP-2 и BMP-4 на хондрогенную дифференцировку мезенхимальных стволовых клеток, выделенных из синовинальной оболочки человека
Далина, А.Д.
Мухамбетова, А.Е.
Батпенов, Н.Д.
Раймагамбетов, Е.К.
Огай, В.Б.
мезенхимальные стволовые клетки
факторы роста
дифференцировка
синовиальная оболочка
хондрогенез
Research Subject Categories::TECHNOLOGY::Bioengineering::Biotechnological separation
В настоящее время мезенхимальные стволовые клетки (МСК), выделенные из синовиальной оболочки коленных суставов, представляют большой научный и практический интерес для регенеративной медицины и тканевой инженерии, поскольку они более эффективно участвуют в хондрогенезе и обладают более высоким пролиферативным и регенераторным потенциалом, чем МСК костного мозга и жировой ткани.
2016-02-24T05:44:00Z
2016-02-24T05:44:00Z
2013
Article
http://nur.nu.edu.kz/handle/123456789/1305
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Биотехнология. Теория и практика
oai:nur.nu.edu.kz:123456789/13062018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Transplantation of the fetal nerve cells in early post-reanimation period in rats
Tazhibaeva, D.
Olzhayev, F.
Kabdualieva, N.
Aitbaeva, Zh.
Zaripova, L.
cell technologies
embryos
rats
mechanical asphyxia
transplantation
Cell technologies are widely used in medical practice these days. In this research we evaluated the effect of the fetal nerve cell transplantation on the rat survival after the case of clinical death from the mechanical asphyxia.
2016-02-24T05:54:43Z
2016-02-24T05:54:43Z
2014
Other
http://nur.nu.edu.kz/handle/123456789/1306
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Center for Life Sciences, Nazarbayev University
oai:nur.nu.edu.kz:123456789/13072018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Получение и анализ поликлональных антител к рекомбинантному транскрипционному фактору SOX2
Секенова, А.Е.
Балтабекова, М.Ж.
Хасенов, Б.Б.
Огай, В.Б.
Sox2
антиген
антитела
плюрипотентные стволовые клетки
Research Subject Categories::TECHNOLOGY::Bioengineering::Biotechnological separation
Транскрипционный фактор Sox2, который экспрессируется в эмбриональных стволовых клетках, играет важную роль в самообновлении и поддержании плюрипотентности эмбриональных и индуцированных плюрипотентных стволовых клеток. В данном исследовании методом плазмидной экспрессии бактериального штамма Rosetta pLysS(DE3), несущего генетическую конструкцию рЕТ-28а/Sox2, был наработан рекомбинантный транскрипционный фактор Sox2.
2016-02-24T05:54:54Z
2016-02-24T05:54:54Z
2013
Article
http://nur.nu.edu.kz/handle/123456789/1307
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Биотехнология. Теория и практика
oai:nur.nu.edu.kz:123456789/13082018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Mesenchymal stem cells and osteophilic polymer as promising agents in bone regeneration
Yantsen, Y.
Idrissova, D.
Olzhayev, F.
Umbayev, B.
Murata, H.
Russell, A.
Askarova, Sh.
mesenchymal stem cells
osteophilic polymer
regeneration
polymer
cell
Mesenchymal stem cells (MSCs) are an attractive stem cell source for transplantation. MSCs can easily differentiate into osteoblasts and increase in osteoblast number will have positive effect on the bone regeneration in such conditions as osteoporosis or Paget disease. To provide the targeted delivery of MSCs to bone we have synthesized a novel osteophilic polymer. The primary active sites of the polymer are bisphosphonate functional groups that target hydroxyapatite molecules (HA) on the bone surface. NHS groups on the other end of the molecule allow polymer to bind to the cell surface components. Coating of cell surfaces with the polymer would allow the cells to bind specifically to HA component of bone and localize the cellular repair functions to areas of injured bone.
2016-02-24T06:03:23Z
2016-02-24T06:03:23Z
2014
Other
http://nur.nu.edu.kz/handle/123456789/1308
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Center for Life Sciences, Nazarbayev University
oai:nur.nu.edu.kz:123456789/13092018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Перспективы применения системы экстракорпоральной респираторной поддержки в детской практике
Мусин, Е.А.
Буланин, Д.С.
Жумадилов, Ж.Ш.
Олжаев, Ф.С.
Federspiel, W.
Jeffries, G.
система Hemolung
испытание системы
Hemolung в детской практике
скорость кровотока
скорость элиминации
Оценка перспективы применения системы Hemolung в детской практике.
2016-02-24T07:50:29Z
2016-02-24T07:50:29Z
2013
Other
http://nur.nu.edu.kz/handle/123456789/1309
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Национальное общество регенеративной медицины
oai:nur.nu.edu.kz:123456789/13102018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
In vivo оценка возможности применения системы экстракорпорального газообмена (Hemolung) в педиатрии
Мусин, Е.А.
Jeffries, R.G.
Олжаев, Ф.С.
Исаева, Р.Б.
Жумадилов, Ж.Ш.
Салиев, Т.М.
Federspiel, W.J.
оценка
применения системы Hemolung
эксперименты
Экспериментальная оценка возможности применения системы Hemolung
в педиатрической практике.
2016-02-24T08:03:25Z
2016-02-24T08:03:25Z
2015
Other
http://nur.nu.edu.kz/handle/123456789/1310
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Национальное общество регенеративной медицины
oai:nur.nu.edu.kz:123456789/13112018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Новый способ стимуляции репаративного остеогенеза в зоне перелома костей при остеопорозе с использованием клеточной терапии мезенхимальными стволовыми клетками, модифицированными синтетическим бисфосфонатным остеотропным полимером
Сафарова, Ю.И.
Олжаев, Ф.С.
Идрисова, Д.Ш.
Умбаев, Б.А.
Мурата, Х.
Рассел, А.
Аскарова, Ш.Н.
новый способ стимуляции
клеточная терапия
стволовые клетки
Целью данной работы явилась исследование эффективности нового спо-
соба стимулирования регенерации ОАП с помощью клеточной терапии мезенхималь-
ными стволовыми клетками (МСК), модифицированными синтетическим остеотроп-
ным бисфосфонатным полимером на основе N-акрилоил-6-аминогексановой кислоты
N’-оксисукцинимид эфира. В связи с тем, что бисфосфонаты имеют высокую степень
сродства к гидроксиапатитам, составляющим почти 2/3 сухой массы кости, данный син-
тетический полимер, ковалентно связанный с мембранами МСК, способен осуществлять
тканеспецифическую доставку клеток в очаги поражения костной ткани, и таким образом, локализовать процессы клеточной репарации.
2016-02-24T08:18:47Z
2016-02-24T08:18:47Z
2015
Other
http://nur.nu.edu.kz/handle/123456789/1311
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Национальное общество регенеративной медицины
oai:nur.nu.edu.kz:123456789/13122018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Остеофильный полимер и мезенхимальные стволовые клетки в регенерации костной ткани
Янцен, Ю.И.
Идриссова, Д.
Олжаев, Ф.С.
Умбаев, Б.А.
Мурата, Х.
Рассел, А.
Аскарова, Ш.Н.
остеопороз
костный метаболизм
мезенхимальные стволовые клетки
АТРП синтез
клеточная терапия
целенаправленная доставка клеток
На сегодняшний день регенерация костной ткани является очень важной и актуальной проблемой. Нарушение костного метаболизма при таких заболеваниях, как остеопороз или болезнь Педжета приводит к усилению остеокластной активности и потере как остеобластных клеток, так и клеток-предшественников остеобластов. Для восполнения пула остеобластов было предложено применение аутологичных мезенхимальных стволовых клеток (МСК). С целью разработки таргетной доставки клеток к очагам повреждения костной ткани был синтезирован полимер, способный стабильно связываться с МСК и обладающий тропностью к костной ткани.
2016-02-24T08:33:44Z
2016-02-24T08:33:44Z
2014
Other
http://nur.nu.edu.kz/handle/123456789/1312
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Российский фонд фундаментальных исследований
oai:nur.nu.edu.kz:123456789/13132018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Efficiency of screening colonoscopy for diagnosis of precancerous and canserous disease of digestive tract
Batyrbekov, K.
Olzhayev, F.
Shanazarov, N.
Maschkin, A.
colorectal cancer
chronic constipation
polyps
analysis
Colorectal cancer (CRC) is the third most common malignant neoplasm
worldwide. According to World Gastroenterology Organization CRC is the second leading
cause of cancer deaths among men and women that makes more than 500 000 cases in a
year. This type of cancer is difficult to diagnose at an early stage that indicates high demand
for introduction of the CRC population screening program. On recommendation WGO “ideal
colonoscopy screening” has to be simple and cheap. Though colonoscopy screening program is
partially functioning in US the CRC incidence steadily decreases by 3% each year. Nowadays
CS is not held for all population of Kazakhstan. The aim of this work is assessment of possibility
and efficiency of early endoscopy screening for malignancy of digestive tract.
2016-02-24T09:01:46Z
2016-02-24T09:01:46Z
2015
Other
http://nur.nu.edu.kz/handle/123456789/1313
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Personalized medicine and Global Health
oai:nur.nu.edu.kz:123456789/13142018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Evaluation of amino acid level in the blood of fetuses and newborns with intrauterine growth restriction
Chuvakova, T.
Bapayeva, G.
Issayeva, R.
Olzhayev, F.
Dzhamanaeva, K.
Kenbaeva, K.
intrauterine growth restriction
amino acids
newborn
The processes of growth of the fetus are provided by a constant supply of
amino acids from mother, which provides the production of proteins and muscle tissue of the
fetus. The purpose of this research was to study the amino acid level in blood of fetuses and
newborns with intrauterine growth restriction.
2016-02-24T09:09:32Z
2016-02-24T09:09:32Z
2015
Other
http://nur.nu.edu.kz/handle/123456789/1314
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Personalized medicine and Global Health
oai:nur.nu.edu.kz:123456789/13152018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Perinatal outcomes in preterm premature rupture of membranes
Chuvakova, T.
Bapayeva, G.
Issayeva, R.
Begimbetova, D.
Olzhayev, F.
Dzhamanaeva, K.
Kenbaeva, K.
preterm premature rupture of membranes
perinatal mortality
perinatal morbidity
Preterm premature rupture of membranes (PPROM) is one of the leading causes
of perinatal morbidity and mortality. Intrauterine continuous amnioinfusion via a subcutaneously
implanted port system for PPROM is an attempt to improve the perinatal outcomes.
2016-02-24T09:17:09Z
2016-02-24T09:17:09Z
2015
Other
http://nur.nu.edu.kz/handle/123456789/1315
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Personalized medicine and Global Health
oai:nur.nu.edu.kz:123456789/13162018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
First experience of using biological prosthesis "UniLine" for correction of heart valve diseases
Zhurko, S.
Olzhayev, F.
Chiginev, V.
Fedorov, S.
hemodynamic characteristics
valves correction
patients
To conduct a clinical study of immediate results, assessment of hemodynamic
characteristics of developed a new biological stented prosthesis «UniLine» (Russia, Kemerovo)
designed for correction of heart valve lesions of various etiologies.
2016-02-24T09:35:31Z
2016-02-24T09:35:31Z
2015
Other
http://nur.nu.edu.kz/handle/123456789/1316
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Personalized medicine and Global Health
oai:nur.nu.edu.kz:123456789/13272018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Electrical сharacterization of proposed transpositional acupoints on the Urinary Bladder Meridian in a Rat Model
Han, Hyun-Jung
Park, Sang-Jun
Soh, Kwang-sup
Myoung, Hyoun-Seok
Lee, Kyoung-Joung
Ogay, Vyacheslav
Lee, Yong-Heum
electrical characterization of proposed transpositional acupoints
acupointsmay
rat model
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Specific electrical characteristicsof acupointswere investigated on the urinary bladder (BL) meridian in 14 rats. BL acupointsand non-acupoints on the back were selected and their electrical voltages were measured by using aSPACsystem.The mean voltages of each point or each line were statistically analyzed by using the ANOVA test...
2016-02-29T04:49:09Z
2016-02-29T04:49:09Z
2011
Article
2011 Hyun-Jung Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://dx.doi.org/10.1155/2011/295475
http://nur.nu.edu.kz/handle/123456789/1327
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Hindawi Publishing Corporation. Evidence-Based Complementary and Alternative Medicine.
oai:nur.nu.edu.kz:123456789/13282018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Comparison of the characteristic features of bonghan ducts, blood and lymphatic capillaries
Ogay, Vyacheslav
Bae, Kyung Hee
Kim, Ki Woo
Soh, Kwang-sup
acupuncture meridian
blood capillary
Bonghan corpuscle and duct
circulatory system
endothelial cells
lymphatic capillary
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Objective: To show that the characteristic morphological and ultrastructural features
of a Bonghan corpuscle and duct presented here are consistent with the description
given in the early reports of Bonghan Kim.
Materials and Methods: We compared the morphological aspects of Bonghan ducts
with those of blood and lymphatic capillaries on the ultrastructural level to display
the manifestly distinctive nature of the Bonghan system.
Results: The walls of the ductules were observed to be composed of a single layer of
endothelial cells with characteristic rod-shaped nuclei and were not surrounded by
a basal lamina or by accessory cells, such as pericytes or smooth muscle cells. The
abluminal cell membranes of Bonghan ductules were not attached by anchoring filaments to the fibers of extracellular matrices as observed in lymphatic capillaries.
2016-02-29T04:57:08Z
2016-02-29T04:57:08Z
2009-03-31
Article
http://nur.nu.edu.kz/handle/123456789/1328
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Acupuncture and Meridian Studies
oai:nur.nu.edu.kz:123456789/13292018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
Visualization of Bonghan Microcells by Electron and Atomic Force Microscopy
Baik, Ku Youn
Ogay, Vyacheslav
Jeoung, Sae Chae
Soh, Kwang-sup
atomic force microscopy
Bonghan microcell
budding
electron microscopy
stem cell
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
*Corresponding author. Biomedical Physics Laboratory, Department of Physics, Seoul National University, Seoul 151-747, Korea.
E-mail: kssoh1@gmail.com
Objectives: The origin of adult stem cells remains an open question. If they derive
from embryos, it is difficult to determine the mechanism which interrupts their
differentiation during tissue formation. In the 1960s, the Bonghan microcell was
suggested as one possible, yet to be described, route of stem cell production, such
that they have the potential to proliferate to produce normal cells.
Materials and Methods: In this study, Bonghan microcells were isolated from
Bonghan tissues on rat organ surfaces, and their detailed morphology examined by
electron and atomic force microscopy.
Results: The ultrastructure observed distinguished them from apoptotic bodies and
other microorganisms, and their unique, possible proliferation feature, as protruding
threads, was imaged by atomic force microscopy.
2016-02-29T05:03:28Z
2016-02-29T05:03:28Z
2009-04-13
Article
©2009 Korean Pharmacopuncture Institute
http://nur.nu.edu.kz/handle/123456789/1329
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Acupuncture and Meridian Studies
oai:nur.nu.edu.kz:123456789/13302018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Bonghan Ducts as Possible Pathways for Cancer Metastasis
Yoo, Jung Sun
Kim, Hong Bae
Ogay, Vyacheslav
Lee, Byung-Cheon
Ahn, Saeyoung
Soh, Kwang-sup
Bonghan duct
cancer
metastasis
trypan blue
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Objective: The present study has been designed to find a possible new route for the
metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique
of trypan blue staining.
Materials and Methods: Tumor tissues were grown in the skin of nude mice after subcutaneous
inoculation with human lung cancer cells. Trypan blue was recently identified
as a dye with specificity for Bonghan ducts (BHDs) and not other tissues, such as
blood or lymph vessels or nerves.
Results: We demonstrate that the trypan blue staining technique allows the first
visualization of BHDs which are connected to tumor tissues.
2016-02-29T05:14:21Z
2016-02-29T05:14:21Z
2009-04-01
Article
http://nur.nu.edu.kz/handle/123456789/1330
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Acupuncture and Meridian Studies
oai:nur.nu.edu.kz:123456789/13312018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Паракринные регуляторы раковых стволовых клеток толстой кишки / Paracrine regulators of colon cancer stem cells
Ogay (Огай), Vyacheslav (Вячеслав)
Issabekova (Исабекова), A.S. (А.С.)
раковые стволовые клетки
микроокружение
индукторы
cancer stem cells
microenvironment
inductors
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Бағаналы ісік жасушалары аурудың емдеуден кейін қайталануының негізгі себепшісілері. Бұл клеткалармен нәтижелі күресу үшін бұл клеткалардың тірі қалу механизмдерін және оларды қоздыратын заттарды түсіну қажет. Бұл жұмыста ісік микроайналасының ісіктің өсуі мен өркендеуіне қосатын үлесі бағаланған. Бағаналы ісік клеткаларының негізгі реттеушілері ісікпен байланысқан миофибробластар мен макрофагтар және Th17 клеткалары.
Раковые стволовые клетки основная причина возобновления болезни после лечения. Для эффективной борьбы с этими клетками необходимо понимание механизмов выживание этих клеток и их стимуляторов. В данной работе оценено влияние микроокружение опухоли на рост и поддержание опухоли. Основными модуляторами раковых стволовых клеток являются опухоль ассоциированные миофибробласты и макрофаги, а также Th17 клетки.
Cancer stem cells are main cause of cancer recurrence. For effective treatment it is necessary to understand haw survive and stimulate these cells. In this work it was estimated influence of cancer microenvironment to growth and surveillance
of cancer. The main modulators of cancer are cancer associated miofibroblasts and macrophages, and also Th17 cells.
2016-02-29T05:22:54Z
2016-02-29T05:22:54Z
2014
Article
Вестник КазНУ. Серия биологическая. №1/1 (60). 2014
http://nur.nu.edu.kz/handle/123456789/1331
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Вестник КазНУ. Серия биологическая
oai:nur.nu.edu.kz:123456789/13322018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Саморегуляция раковых стволовых клеток толстой кишки / Colon cancer stem cells self regulation
Ogay (Огай), Vyacheslav (Вячеслав)
colon cancer
cancer stem cells
autocrine inductors
cytokines
growth factors
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
рак толстой кишки
раковые стволовые клетки
аутокринные стимуляторы
цитокины
ростовые факторы
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
тоқ ішек ісігі
бағаналы ісік жасушалары
аутокринды реттеушілер
цитокиндер
өсу факторлары
Тоқ ішек ісігінен өлім дәрежесінің жоғары болуы және ісіктен толық айығу үлесінің төмен болуы бағаналы ісік жасушаларымен (БІЖ) байланысты екені белгілі. БІЖ өміршеңдік, апоптозға сезімталдықтық болмауы сияқты қасиеттері бар. Бұл қасиеттерді БІЖ аутокринды жолмен реттей алады. Біздің жұмыста тоқ ішек БІЖ аутокринды реттеушілерінің мәліметтер базасы жасалды. БІЖ қорғаныс механизмдерін түсіну бұл жасушаларды жою әдістерін шығаруға көмектеседі.
Colon cancer high death rate and low percentage of recovery depend on tumor initiating cancer stem cells (CSCs). CSCs have ability such as survival in stress condition, absence of sensitivity to apoptose. These properties CSCs can regulate by autocrine way. In our work it was created data base of colon CSCs autocrine inductors. Understanding of CSCs protection mechanisms help to develop effective elimination methods of these cells.
Высокая смертность от рака толстой кишки и низкий процент полного выздоровления от рака связаны с сущетвованием опухоль инициирующих раковых стволовых клеток (РСК). РСК обладают такими свойствами как
выживаемость, отсутствие чувствительности к апоптозу. Эти свойства РСК способны регулировать аутокринным путем. В нашей работе была создана база данных по аутокринным стимуляторам РСК толстой кишки. Понимание защитных механизмов РСК поможет разработать эффективные методы элиминации этих клеток.
2016-02-29T05:30:16Z
2016-02-29T05:30:16Z
2014
Article
http://nur.nu.edu.kz/handle/123456789/1332
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Вестник КазНУ. Серия биологическая. №1/1 (60). 2014
oai:nur.nu.edu.kz:123456789/13332018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Клеточные технологии в трансплантации почки / Cell technologies in renal transplantation
Momynaliev (Момыналиев), K.T. (К.Т.)
Ogay (Огай), Vyacheslav (Вячеслав)
Khoroshun (Хорошун), E.V. (Е.В.)
Babenko (Бабенко), N.N. (Н.Н.)
Kaabak (Каабак), М.М. (M.M.)
мезенхимальные стволовые клетки
регуляторные Т-клетки
дендритные клетки
иммунологиче- ская толерантность
трансплантация почки
mesenchymal stem cells
regulatory T-cells
dendritic cells
immunological tolerance
renal transplantation
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
местительной терапии при хронической почечной недостаточности в терминальной стадии. Благодаря современным иммунодепрессантам, резко повысилась краткосрочная выживаемость пациентов и трансплантата. Однако долгосрочная выживаемость аллотрансплантата почки не улучшается такими же темпами. Хроническая нефропатия аллотрансплантата остается наиболее
частой причиной потери трансплантата, тогда как сердечно-сосудистые заболевания остаются ведущей причиной смертности пациентов после трансплантации...
Currently, renal transplantation has firmly established as the main method of replacement therapy in patients with the end stage chronic renal disease. Thanks to modern immunosuppressive drugs, shortterm graft and patient survival are dramatically increased. However, long-term renal allograft survival has improved in a lesser extent. Chronic allograft nephropathy is the most common cause of graft failure,
whereas cardiovascular diseases remain the leading cause of death among patients receiving renal transplantation. To improve the results of transplantation, it is important to continue developing new strategies for the prevention of acute and chronic rejection...
2016-02-29T05:44:56Z
2016-02-29T05:44:56Z
2014-04
Article
http://nur.nu.edu.kz/handle/123456789/1333
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Нефрология и диализ
oai:nur.nu.edu.kz:123456789/13362018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1126
Synthesis of trans-porphyrin dimers for nonlinear optics
Baptayev, Bakhytzhan
Tauanov, Zhandos
Bissengaliyeva, Moldir
Zhakiyeva, Zhanar
Berillo, Dmitriy
Adilov, Salimgerey
synthesis of trans-porphyrin dimers
synthesis of trans-porphyrins
crystal structure of dimers
dimerization with bidentate ligands
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Following the development of the idea of octupolar molecules as nonlinear optical materials a variety of compounds have been reported. Trans-porphyrins have a great potential to self-order into octupolar symmetry. Nonlinear optical properties can be tuned by using strong donor-acceptor groups in porphyrins as well as extention of conjugation. Here we report the syntheses of trans-A2D2-porphyrins and their dimerization into cubic octupoles by lanthanides and organic bidentate ligands. Bulky groups are employed to
induce non-centrosymmetric eclipsed or staggered conformations. Effect of donor acceptor groups, dimerization conditions and crystal packing of dimers are studied.
2016-03-02T06:01:39Z
2016-03-02T06:01:39Z
2014
Other
http://nur.nu.edu.kz/handle/123456789/1336
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
“NURIS”, Nazarbayev University, Astana, Kazakhstan
oai:nur.nu.edu.kz:123456789/13372018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1126
Синтез, строение и свойства гидразидов β-аминопропановой кислоты и их производных
Berillo (Берилло), Dmitriy (Дмитрий)
гидразид
нитрил
синтеза потенциально биологически активных веществ
гидразид β-аминопропановой кислоты
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Настоящая работа посвящена комплексному исследованию в области синтеза потенциально биологически активных веществ на основе гидразидов и нитрилов α-( и β-)-аминопропановых кислот, установлению закономерностей их гетероциклизации и изучению биологической активности новых производных гидразидов и нитрилов α-( и β-)- аминокислот.
2016-03-02T07:54:32Z
2016-03-02T07:54:32Z
2010
Other
http://nur.nu.edu.kz/handle/123456789/1337
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
КазНУ им. аль-Фараби
oai:nur.nu.edu.kz:123456789/13382018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1126
The role of infectious agents in urogenital cancers
Alibek, Kenneth
Karatayeva, Nargis
Bekniyazov, Ildar
urogenital cancers
ovarian cancer
cervical cancer
Bladder cancer
Kidney cancer
Chlamydia trachomatis
Neisseria gonorrhea
Mycoplasma genitalium
Schistosoma haematobium
HPV
Epstein-Barr
CMV
Human polyomaviruses
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Since the late 1990s, infectious agents have been thought to play a role in the pathogenesis of approximately 15% of cancers. It is now widely accepted that infection of stomach tissue with the bacteria Helicobacter pylori is an important cause of stomach adenocarcinoma. In addition, oncogenic viruses, such as papilloma viruses, herpes viruses, and hepadnaviruses are strongly associated with increased risk of cervical cancer, lymphomas, liver cancer, amongst others. However, in the scientific community the percentage of cancers caused by pathogens is believed to be far higher than 15%. A significant volume of data collected to date show an association between infectious agents and urogenital cancers. These agents include Chlamydia trachomatis, Neisseria gonorrhoea, Mycoplasma genitalium and certain viruses that have been implicated in ovarian cancer.
2016-03-02T10:54:51Z
2016-03-02T10:54:51Z
2012-12-03
Article
doi: 10.1186/1750-9378-7-35
http://nur.nu.edu.kz/handle/123456789/1338
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
BioMed Central
oai:nur.nu.edu.kz:123456789/13882018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1123
Влияние природной среды на формирование генефонда тюркоязычного населения гор и степных предгорий Алтае-Саян, Тянь-Шаня и Памира
Балановская, Е.В.
Балаганская, О.А.
Дамба, Л.Д.
Дибирова, Х.Д.
Агджоян, А.Т.
Богунов, Ю.В.
Жабагин, М.К.
Исакова, Ж.Т.
Лавряшина, М.Б.
Балановский, О.П.
природная среда
формирование генофондов
тюркоязычное население
население гор
степные предгорья
тюрки
хромосомы гены
Цель исследования - выявление роли горного рельефа в формировании генофондов горных и предгорных популяций Алтая, Саян, Тянь-Шаня, Памира.
2016-04-12T04:30:42Z
2016-04-12T04:30:42Z
2014
Article
http://nur.nu.edu.kz/handle/123456789/1388
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Вестник Московского университета. Серия 23. Антропология./2014/№ 2/
oai:nur.nu.edu.kz:123456789/13892018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1123
Связь изменчивости Y-хромосомы и родовой структуры: генофонд степной аристократии и духовенства казахов
Жабагин, М.К.
Дибирова, Х.Д.
Фролова, С.А.
Сабитов, Ж.М.
Юсупов, Ю.М.
Утевская, О.М.
Тарлыков, П.В.
Тажигулова, И.М.
Балаганская, О.А.
Нимадава, П.
Захаров, И.А.
Балановский, О.П.
Y-хромосомы
родовые структуры казахов
генофонд аристократия
духовенства казахов
геногеография
популяционная генетика
чингизиды
Цель работы - дать характеристику генофонда казахских родов и изучить связь изменчивости Y-хромосомы с родовой структурой.
2016-04-12T05:03:57Z
2016-04-12T05:03:57Z
2014
Article
http://nur.nu.edu.kz/handle/123456789/1389
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Вестник Московского университета. Серия 23. Антропология./2014/№ 1/
oai:nur.nu.edu.kz:123456789/13902018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1123
Генетический портрет тоболо-иртышских сибирских татар по гаплогруппам Y-хромосомы
Падюкова, А.Д.
Лавряшина, М.Б.
Кузнецова, М.А.
Жабагин, М.К.
Агджоян, А.Т.
Схаляхо, Р.А.
Тычинских, З.А.
Балановская, Е.В.
генетический портрет
Y-хромосомы
сибирские татары
этногенез сибирских татар
Сибирские татары – коренное население Запад-
ной Сибири. Этногенез сибирских татар, как и этноге-
нез большинства коренных народов Сибири, – это
растянувшийся во времени процесс смешения насе-
ления, говорившего на угорских, самодийских, тюрк-
ских и монгольских языках.
2016-04-12T05:36:44Z
2016-04-12T05:36:44Z
2014
Article
http://nur.nu.edu.kz/handle/123456789/1390
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Сборник научных трудов. Вып. 10. -Томск: Изд-во «Печатная мануфактура»
oai:nur.nu.edu.kz:123456789/13912018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1123
Этногенез казахов с точки зрения популяционной генетики
Сабитов, Ж.М.
Жабагин, М.К.
этногенез казахов
популяционная генетика
Y-хромосомы
Современная популяционная генетика в целом и исследования полиморфизма Y-
хромосомы в частности развиваются семимильными шагами. Качественное развитие и
удешевление технологий полного и частичного сиквенса Y-хромосомы делает эту
технологию доступной для широких масс исследователей, при этом освобождая от
надобности содержать дорогостоящие лаборатории.
2016-04-12T06:05:36Z
2016-04-12T06:05:36Z
2015
Article
http://nur.nu.edu.kz/handle/123456789/1391
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
III конгресс историков Казахстана. Астана.
oai:nur.nu.edu.kz:123456789/13922018-08-15T03:49:55Zcom_123456789_107com_123456789_106col_123456789_1123
Этногенетика: игнорировать нельзя использовать? (опыт анализа генофондов казахов, башкир, тюрков кавказа и крымских татар)
Схаляхо Р.А.
Агджоян А.Т.
Балановская Е.В.
Юсупов Ю.М.
Рыскулов Р.М.
Мустафаева Л. А.
Жабагин М.К.
этногенетика
генофонд
ДНК-генеалоги
Цель данной публикации - очертить возможности
этногенетики и попробовать поставить запятую в заголовке нашей статьи. Для этого мы
бегло рассмотрим, могут ли генетики сказать этнологам что-то интересное или важное
о четырех этнокультурных группах тюркоязычного мира Евразии - казахах, башкирах,
тюрках Кавказа и крымских татарах, объединенных языковым сходством, но
отличающихся по структуре генофонда.
2016-04-12T06:27:19Z
2016-04-12T06:27:19Z
2014
Article
http://nur.nu.edu.kz/handle/123456789/1392
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
ИИЯЛ УНЦ РАН
oai:nur.nu.edu.kz:123456789/13932018-08-15T03:50:26Zcom_123456789_107com_123456789_106col_123456789_1126
Role of viruses in the development of breast cancer
Alibek, Kenneth
Kakpenova, Ainur
Mussabekova, Assel
Sypabekova, Marzhan
Karatayeva, Nargis
carcinogenesis
Infectious agents
Breast cancer
Research Subject Categories::MEDICINE
The most common cancer worldwide among women is breast cancer. The initiation, promotion, and progression of this cancer result from both internal and external factors. The International Agency for Research on Cancer stated that 18-20% of cancers are linked to infection, and the list of definite, probable, and possible carcinogenic agents is
growing each year. Among them, biological carcinogens play a significant role. In this review, data covering infection-associated breast and lung cancers are discussed and presented as possible involvements as pathogens in cancer. Because carcinogenesis is a multistep process with several contributing factors, we evaluated to what extent
infection is significant, and concluded that members of the herpesvirus, polyomavirus, papillomavirus, and retrovirus families definitely associate with breast cancer. Detailed studies of viral mechanisms support this conclusion, but have presented problems with experimental settings. It is apparent that more effort needs to be devoted to
assessing the role of these viruses in carcinogenesis, by characterizing additional confounding and synergistic effects of carcinogenic factors. We propose that preventing and treating infections may possibly stop or even eliminate certain types of cancers.
2016-04-13T04:04:38Z
2016-04-13T04:04:38Z
2013-09-02
Article
http://nur.nu.edu.kz/handle/123456789/1393
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Infectious Agents and Cancer
oai:nur.nu.edu.kz:123456789/16762018-08-15T03:49:58Zcom_123456789_107com_123456789_106col_123456789_1126
Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways*
Talhaoui, Ibtissam
Shafirovich, Vladimir
Liu, Zhi
Saint-Pierre, Christine
Akishev, Zhiger
Matkarimov, Bakhyt T.
Gasparutto, Didier
Geacintov, Nicholas E.
Saparbaev, Murat
oxidatively generated guanine
double-stranded DNA
Oxidatively generated guanine radical cations in DNA can undergo various nucleophilic reactions including the formation of C8-guanine cross-links with adjacent or nearby N3-thymines in DNA in the presence of O2. The G*[C8-N3]T* lesions have been identified in the DNA of human cells exposed to oxidative stress, and are most likely genotoxic if not removed by cellular defense mechanisms. It has been shown that the G*[C8-N3]T* lesions are substrates of nucleotide excision repair in human cell extracts. Cleavage at the sites of the lesions was also observed but not further investigated (Ding et al. (2012) Nucleic Acids Res. 40, 2506–2517). Using a panel of eukaryotic and prokaryotic bifunctional DNA glycosylases/lyases (NEIL1, Nei, Fpg, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, and Nfo), the analysis of cleavage fragments by PAGE and MALDI-TOF/MS show that the G*[C8-N3]T* lesions in 17-mer duplexes are incised on either side of G*, that none of the recovered cleavage fragments contain G*, and that T* is converted to a normal T in the 3′-fragment cleavage products. The abilities of the DNA glycosylases to incise the DNA strand adjacent to G*, while this base is initially cross-linked with T*, is a surprising observation and an indication of the versatility of these base excision repair proteins.
2016-07-15T05:27:08Z
2016-07-15T05:27:08Z
2015-04-15
Article
Ibtissam Talhaoui, Vladimir Shafirovich, Zhi Liu, Christine Saint-Pierre, Zhiger Akishev, Bakhyt T. Matkarimov, Didier Gasparutto, Nicholas E. Geacintov, and Murat Saparbaev. (2015) Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 23, pp. 14610–14617, June 5, 2015. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
http://nur.nu.edu.kz/handle/123456789/1676
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
The Journal of Biological Chemistry
oai:nur.nu.edu.kz:123456789/16772018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1126
Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands
Talhaoui, Ibtissam
Couve, Sophie
Gros, Laurent
Ishchenko, Alexander A.
Matkarimov, Bakhyt
Saparbaev, Murat K.
aberrant repair
mismatch-specific thymine-DNA
The human thymine-DNA glycosylase (TDG) initiates
the base excision repair (BER) pathway to remove
spontaneous and induced DNA base damage. It was
first biochemically characterized for its ability to remove
T mispaired with G in CpG context. TDG is
involved in the epigenetic regulation of gene expressions
by protecting CpG-rich promoters from de
novo DNA methylation. Here we demonstrate that
TDG initiates aberrant repair by excising T when it
is paired with a damaged adenine residue in DNA
duplex. TDG targets the non-damaged DNA strand
and efficiently excises T opposite of hypoxanthine
(Hx), 1,N6-ethenoadenine, 7,8-dihydro-8-oxoadenine
and abasic site in TpG/CpX context, where X is
a modified residue. In vitro reconstitution of BER
with duplex DNA containing Hx•T pair and TDG results
in incorporation of cytosine across Hx. Furthermore,
analysis of the mutation spectra inferred from
single nucleotide polymorphisms in human population
revealed a highly biased mutation pattern within
CpG islands (CGIs), with enhanced mutation rate at
CpA and TpG sites. These findings demonstrate that
under experimental conditions used TDG catalyzes
sequence context-dependent aberrant removal of
thymine, which results in TpG, CpA→CpGmutations,
thus providing a plausible mechanism for the putative
evolutionary origin of the CGIs in mammalian
genomes.
2016-07-15T05:37:33Z
2016-07-15T05:37:33Z
2014-04-01
Article
Talhaoui, I., Couve, S., Gros, L., Ishchenko, A. A., Matkarimov, B., & Saparbaev, M. K. (2014). Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands. Nucleic Acids Research, 42(10), 6300–6313. http://doi.org/10.1093/nar/gku246
http://nur.nu.edu.kz/handle/123456789/1677
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Nucleic Acids Research
oai:nur.nu.edu.kz:123456789/16782018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1126
Включение важнейших многочастичных взаимодействий в силовое поле АМБЕР и применение обновленного поля к молекулярно-динамическим расчетам
Маткаримов (Matkarimov), Б.Т. (Bakhyt)
Балабаев (Balabaev), Н.К.(N.K.)
Гарбузинский (Garbuzinskiy), С.А. ( S.A.)
Галзитская (Galzitskaya), О.В. (O.V.)
Глякина (Glyakina), А.В. (A.V.)
Финкельштейн ( Finkelstein), А.В. (A.V.)
Маткаримов (Matkarimov), Б.Т. (B.Т.)
невалентные атом-атомные взаимодействия
трехчастичные взаимодействия
поляризуемость
парциальные заряды
взаимодействие «атом- ковалентная связь»
non-bonded atom-atom interactions
three-particle interactions
polarizability
partial charges
interaction of atoms with covalent bonds
Research Subject Categories::NATURAL SCIENCES::Chemistry::Theoretical chemistry::Bioinformatics
Выведены формулы для расчета потенциалов и сил в новом
силовом поле невалентных взаимодействий, включающем, наряду с
традиционными членами, наведенную парциальными зарядами поляризацию
всех атомов и трехчастичные дисперсионные взаимодействия «атом –
валентная связь». Соответствующие новые члены добавлены к стандартному
силовому полю АМБЕР. Проведены молекулярно-динамические расчеты с
использованием обновленного силового поля. Показано, что добавленные,
физически разумные члены не сильно замедляют молекулярно-динамическое
моделирование, несмотря на то, что они учитывают важнейшие
трехчастичные взаимодействия.
Formulas for calculation of energy and forces in the new force field of non bonded interactions including along with traditional members, the polarization, induced by partial atomic charges, and three-particle dispersive interactions of the atoms with covalent bonds are received. The corresponding new members are added to a standard AMBER force field. Molecular dynamics calculations with the use of the updated force field are carried out. It is shown that additional physically reasonable members, taking into account the major three-particle interactions, not strongly slow down molecular dynamics simulation.
2016-07-15T09:00:31Z
2016-07-15T09:00:31Z
2015
Article
Балабаев Н.К., Гарбузинский С.А., Галзитская О.В., Глякина А.В., Маткаримов Б.Т., Финкельштейн А.В. (2015). Включение важнейших многочастичных взаимодействий в силовое поле АМБЕР и применение обновленного поля к молекулярно-динамическим расчетам. Математическая биология и биоинформатика.Т. 10. № 2. С. 427–435. doi: 10.17537/2015.10.427
http://nur.nu.edu.kz/handle/123456789/1678
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Математическая биология и биоинформатика
oai:nur.nu.edu.kz:123456789/16792018-08-15T03:49:55Zcom_123456789_107com_123456789_106col_123456789_1126
Включение важнейших многочастичных взаимодействий в силовое поле AMBER и оптимизация энергетических параметров обновленного поля
Гарбузинский (Garbuzinskiy), С.А. ( S.A.)
Маткаримов (Matkarimov), Б.Т. (B.Т.)
Финкельштейн ( Finkelstein), А.В. (A.V.)
невалентные атом-атомные взаимодействия
трехчастичные взаимодействия
поляризуемость
парциальные заряды
взаимодействие «атом- ковалентная связь»
молекулярные кристаллы
энергия когезии
Research Subject Categories::NATURAL SCIENCES::Chemistry::Theoretical chemistry::Bioinformatics
non-covalent atom-atom interactions
three-particle interactions
polarizability
partial charges
atomic force microscopy
“atom-covalent bond” interaction
molecular crystals
energy of cohesion
Разработана новая функциональная форма для силового поля невалентных взаимодействий, учитывающая, наряду с традиционными членами, как наведенную парциальными зарядами поляризацию всех атомов, так и трехчастичные дисперсионные взаимодействия «атом – валентная связь». Соответствующие новые члены добавлены к стандартному силовому полю AMBER. В рамках этой единой функциональной формы силового поля оптимизированы, с использованием данных по молекулярным кристаллам, параметры всех типов невалентных взаимодействий. Показано заметное увеличение коэффициента корреляции между рассчитанной и экспериментально определенной энергией когезии молекул в молекулярных кристаллах.
A new functional form for force field of non-covalent interactions is developed. Besides traditional members, it involves induced (by partial charges) polarization of all atoms as well as three-particle dispersion interactions of atoms with covalent bonds. The corresponding new members are added to a standard AMBER force field. Within this unified functional form of the force field, parameters of all types of non-covalent interactions are optimized using data on molecular crystals. A noticeable increase in correlation coefficient between calculated and experimental energy of cohesion of molecules in molecular crystals is shown.
2016-07-15T09:14:16Z
2016-07-15T09:14:16Z
2015
Article
Гарбузинский С.А., Маткаримов Б.Т., Финкельштейн А.В. (2015). Включение важнейших многочастичных взаимодействий в силовое поле AMBER и оптимизация энергетических параметров обновленного поля. Математическая биология и биоинформатика. 2015. Т. 10. № 2. С. 580–592. doi: 10.17537/2015.10.580
http://nur.nu.edu.kz/handle/123456789/1679
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Математическая биология и биоинформатика
oai:nur.nu.edu.kz:123456789/18982018-08-15T03:50:08Zcom_123456789_107com_123456789_106col_123456789_1126
Самоорганизация дипептидного производного в гидрогели и криогели для биомедицинских целей
Берилло, Дмитрий
биомедицина
гидрогели
дипептидное производное
Способность биомолекул к молекулярному узнаванию в природных
системах выработана в процессе эволюции. Недавние исследования выявили
библиотеки пептидов с селективным сродством к самоструктурированию
(самоорганизацией или самосборки) в супрамолекулярные структуры
(нанотрубки, нанофибриллы) для создания новых искусственных
биоразлагаемых материалов...
2016-11-21T03:55:28Z
2016-11-21T03:55:28Z
2016
Article
Берилло Д.А. (2016) Самоорганизация дипептидного производного в гидрогели и криогели для биомедицинских целей. RAM Trade company
http://nur.nu.edu.kz/handle/123456789/1898
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
RAM Trade company
oai:nur.nu.edu.kz:123456789/22692018-08-15T03:50:05Zcom_123456789_107com_123456789_106col_123456789_1123
ТАТАРЫ ЕВРАЗИИ: СВОЕОБРАЗИЕ ГЕНОФОНДОВ КРЫМСКИХ, ПОВОЛЖСКИХ И СИБИРСКИХ ТАТАР
Балановская, Е.В.
Агджоян, А.Т.
Жабагин, М.К.
Юсупов, Ю. М.
Схаляхо, Р. А.
Долинина, Д. О.
Падюкова, А. Д.
Кузнецова, М. А.
Маркина, Н. В.
Атраментова, Л. А.
Лавряшина, М. Б.
Балановский, О. П.
этногенез
генофонд
геногеография
гаплогруппа
крымские татары
поволжские татары
сибирские татары
Research Subject Categories::MEDICINE
Изучены генофонды популяций с этнонимом "татары" трех регионов Евразии: крымские, поволжские и сибирские. Около 1000 представителей этих народов исследованы с помощбю наиболее информативного инструмента популяционной генетики - анализа 50 SNP- маркеров Y-хромосомы...
2017-01-20T08:17:12Z
2017-01-20T08:17:12Z
2016
Article
Балановская Е.В., Агджоян А.Т., Жабагин М.К., Юсупов Ю.М., Схаляхо Р.А., Долинина Д.О., Падюкова А.Д., Кузнецова М.А. и др. ТАТАРЫ ЕВРАЗИИ: СВОЕОБРАЗИЕ ГЕНОФОНДОВ КРЫМСКИХ, ПОВОЛЖСКИХ И СИБИРСКИХ ТАТАР. Вестник Московского университета. Серия XXIII. АНТРОПОЛОГИЯ № 2/2016: 75–85.
http://nur.nu.edu.kz/handle/123456789/2269
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Вестник Московского университета. Серия XXIII. АНТРОПОЛОГИЯ № 2/2016: 75–85
oai:nur.nu.edu.kz:123456789/22702018-08-15T03:50:07Zcom_123456789_107com_123456789_106col_123456789_1123
ГЕНЕЗИС КРУПНЕЙШЕЙ РОДОПЛЕМЕННОЙ ГРУППЫ КАЗАХОВ – АРГЫНОВ – В КОНТЕКСТЕ ПОПУЛЯЦИОННОЙ ГЕНЕТИКИ
Жабагин, М.К.
Сабитов, Ж. М.
Агджоян, А. А.
Юсупов, Ю. М.
Богунов, Ю. В.
Лавряшина, М. Б.
Тажигулова, И. М.
Акильжанова, А. Р.
Жумадилов, Ж. Ш.
Балановский, О. П.
Балановская, Е. В.
популяционная генетика
Y - хромосома
филогеография
генофонд
род
Центральная Азия
казахи
аргыны
Research Subject Categories::MEDICINE
Аргыны являются крупнейшим родоплеменным объединением казахов, однако их генезис до сих пор остается дискуссионным. Эти дискуссии можно свести к противостоянию двух точек зрения об истоках из происхождения - от тюркоязычных или же монголоязычных народов, и к противоречию между версией традиционной генеалогии казахов (шежире) об едином биологическом предке аргынов и весрий, что аргыны являются союзом племен различного происхождения. Цель нашего исследования: представить генетический портрет аргынов по данным полиморфизма Y-хромосомы и рассмотреть версии генезиса аргынов с точки зрения их генофонда....
2017-01-20T08:35:56Z
2017-01-20T08:35:56Z
2016
Article
Жабагин М.К., Сабитов Ж.М., Агджоян А.А., Юсупов Ю.М., Богунов Ю.В., Лавряшина М.Б., Тажигулова И.М., Акильжанова А.Р. ГЕНЕЗИС КРУПНЕЙШЕЙ РОДОПЛЕМЕННОЙ ГРУППЫ КАЗАХОВ – АРГЫНОВ – В КОНТЕКСТЕ ПОПУЛЯЦИОННОЙ ГЕНЕТИКИ. Вестник Московского университета. Серия XXIII. АНТРОПОЛОГИЯ № 4/2016: 59–68.
http://nur.nu.edu.kz/handle/123456789/2270
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Вестник Московского университета. Серия XXIII. АНТРОПОЛОГИЯ № 4/2016: 59–68
oai:nur.nu.edu.kz:123456789/22712018-08-15T03:50:03Zcom_123456789_107com_123456789_106col_123456789_1123
ГЕНОФОНД ТУРКМЕН КАРАКАЛПАКСТАНА В КОНТЕКСТЕ ПОПУЛЯЦИЙ ЦЕНТРАЛЬНОЙ АЗИИ (ПОЛИМОРФИЗМ Y-ХРОМОСОМЫ)
Схаляхо, Р. А.
Жабагин, М.К.
Юсупов, Ю. М.
Агджоян, А. Т.
Сабитов, Ж. М.
Гурьянов, В. М.
Балаганская, О. А.
Далимова, Д. А.
Давлетчурин, Д. Х.
Турдикулова, Ш. У.
Чухряева, М. И.
Асылгужин, Р. Р.
Акильжанова, А. Р.
Балановский, О. П.
Балановская, Е. В.
этногенез
генофонд
геногеография
гаплогруппа
туркмены
род
Центральная Азия
йомуд
Research Subject Categories::MEDICINE
Туркмены - один из наименее изученных народов Центральной Азии из-за недостаточной международной научной интеграции Туркменистана в исследования генофонда народов мира....
2017-01-20T08:55:39Z
2017-01-20T08:55:39Z
2016
Article
Схаляхо Р.А., Жабагин М.К., Юсупов Ю.М., Агджоян А.Т., Сабитов Ж.М., Гурьянов В.М., Балаганская О.А., Далимова Д.А. и др. ГЕНОФОНД ТУРКМЕН КАРАКАЛПАКСТАНА В КОНТЕКСТЕ ПОПУЛЯЦИЙ ЦЕНТРАЛЬНОЙ АЗИИ (ПОЛИМОРФИЗМ Y-ХРОМОСОМЫ). Вестник Московского университета. Серия XXIII АНТРОПОЛОГИЯ № 3/2016: 86–96
http://nur.nu.edu.kz/handle/123456789/2271
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Вестник Московского университета. Серия XXIII. АНТРОПОЛОГИЯ № 3/2016: 86–96
oai:nur.nu.edu.kz:123456789/22732018-08-15T03:50:02Zcom_123456789_107com_123456789_106col_123456789_1123
РОДОВЫЕ ОБЪЕДИНЕНИЯ СЕВЕРО-ВОСТОЧНЫХ БАШКИР В СВЕТЕ ДАННЫХ ГЕНОГЕОГРАФИИ (ПО ПОЛИМОРФИЗМУ Y-ХРОМОСОМЫ)*
Юсупов, Ю. М.
Схаляхо, Р. А.
Агджоян, А. Т.
Асылгужин, P. P.
Рыскулов, P. M.
Сабитов, Ж. М.
Жабагин, М. К.
Богунов Ю. В.
Дибирова Х. Д.
Балановская Е. В.
генофонд
гаплогруппа
Y-хромосома
SNP и STR маркеры
клан
северо-восточные башкиры
табын
катай
кудей
кошсо
упей
Research Subject Categories::MEDICINE
Исследованы пять родовых объединений северо-восточных
башкир (N=115) - табын, катай, кудей, кошсо (кушчи), упей - по широкой
панели 41 SNP и 17 STR маркеров Y-хромосомы. Исследования
охватили 6 сельских районов Республики Башкортостан. Данные
геногеографии позволяют выдвинуть гипотезу о формировании генофонда
северо-восточных башкир в основном через трансуральский
путь миграций кочевых племен, связывавший Западную Сибирь и При-
уралье в эпоху раннего железного века и средневековья....
2017-01-20T10:33:24Z
2017-01-20T10:33:24Z
2016
Article
http://nur.nu.edu.kz/handle/123456789/2273
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
ВЕСТНИК АКАДЕМИИ НАУК Р Б. 2016. том 21. № 4 (84)
oai:nur.nu.edu.kz:123456789/25342018-08-15T03:50:10Zcom_123456789_107com_123456789_106col_123456789_1126
Aberrant DNA glycosylase-initiated repair pathway of free radicals induced DNA damage: implications for age-related diseases and natural aging
Matkarimov, B.
Saparbaev, M.
oxidative DNA damage
crystal structure
base excision repair
nucleotide incision repair
AP endonuclease
Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring unrepaired oxidative DNA damage. In human cells, approximately 2000 to 8000 DNA lesions occur per hour in each cell, i.e. 40000 to 200000 per cell per day. DNA repair systems are able to discriminate between regular and modified bases. For example, DNA glycosylases specifically recognize and excise damaged bases among vast majority of regular bases in the base excision repair (BER) pathway. However, mismatched pairs between two regular bases occur due to spontaneous conversion of 5-methylcytosine to thymine and DNA polymerase errors during replication. To counteract these mutagenic threats to genome stability, cells evolved special DNA repair systems that target the non-damaged DNA strand in a duplex to remove mismatched regular DNA bases. Base excision repair (BER) and mismatch repair (MMR) pathways initiated by mismatch-specific adenine- and thymine-DNA glycosylases (MutY/MUTYH and TDG/MBD4, respectively) can recognize and remove normal DNA bases in mismatched DNA duplexes. Under certain circumstances in DNA repair deficient cells bacterial MutY and human TDG can act in an aberrant manner: MutY and TDG remove Adenine and Thymine opposite to misincorporated 8-oxoguanine and damaged Adenine, respectively. These unusual activities lead either to mutations or futile DNA repair, thus indicating that the DNA repair pathways which target non-damaged DNA strand can act in an aberrant manner and introduce genome instability in the presence of unrepaired DNA lesions. Both accumulation of oxidative DNA damage in cells and the aberrant DNA repair can contribute to cancer, brain disorders and premature senescence.
2017-08-09T09:33:43Z
2017-08-09T09:33:43Z
2017
Article
Matkarimov, B. Saparbaev, M. (2017) Aberrant DNA glycosylase-initiated repair pathway of free radicals induced DNA damage: implications for age-related diseases and natural aging. Vol. 33. N 1. pp.3–23
0233-7657
doi: http://dx.doi.org/10.7124/bc.000943
http://nur.nu.edu.kz/handle/123456789/2534
en
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Attribution-NonCommercial-ShareAlike 3.0 United States
Biopolymers and Cell. doi: http://dx.doi.org/10.7124/bc.000943
oai:nur.nu.edu.kz:123456789/27632018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1125
Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System
Han, Bo
Tokay, Tursonjan
Zhang, Guangming
Sun, Peng
Hou, Shangwei
K+ channel
EAG1
nervous system
channel regulation
Ether-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety
of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance
of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
2017-11-09T04:36:58Z
2017-11-09T04:36:58Z
2017-03-06
Article
Han Bo et al.(>4), 2017(March 6), Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System, Oxidative Medicine and Cellular Longevity, Volume 2017, 13 pages
https://doi.org/10.1155/2017/7371010
http://nur.nu.edu.kz/handle/123456789/2763
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Open Access - the content is available to the general public
Attribution-NonCommercial-ShareAlike 3.0 United States
Oxidative Medicine and Cellular Longevity
oai:nur.nu.edu.kz:123456789/27642018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1124
Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy
Mao, Xiao-Yuan
Tokay, Tursonjan
Zhou, Hong-Hao
Jin, Wei-Lin
brain tumor
tumor microenvironment
tumor-associated epilepsy
long-range mode
short-range mode
Epileptic seizures are frequently caused by brain tumors. Traditional anti-epileptic treatments do not acquire satisfactory responses. Preoperative and postoperative seizures seriously influence the quality of life of patients. Thus, tumor-associated
epilepsy (TAE) is an important subject of the current research. The delineation of the
etiology of epileptogenesis in patients with primary brain tumor may help to find the
novel and effective drug targets for treating this disease. In this review, we describe
the current status of treatment of TAE. More importantly, we focus on the factors
that are involved in the functional connectivity between tumors and stromal cells.
We propose that there exist two modes, namely, long-range and short-range modes,
which likely trigger neuronal hyperexcitation and subsequent epileptic seizures. The
long-range mode is referred to as factors released by tumors including glutamate
and GABA, binding to the corresponding receptor on the cellular membrane and
causing neuronal hyperactivity, while the short-range mode is considered to involve
direct intracellular communication between tumor cells and stromas. Gap junctions
and tunneling nanotube network are involved in cellular interconnections. Future
investigations focused on those two modes may find a potential novel therapeutic
target for treating TAE.
2017-11-09T04:55:56Z
2017-11-09T04:55:56Z
2016-03-07
Article
Mao Xiao-Yuan et al.(>3), 2016(March 7), Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy, Oncotarget
http://nur.nu.edu.kz/handle/123456789/2764
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Open Access - the content is available to the general public
Attribution-NonCommercial-ShareAlike 3.0 United States
Oncotarget
oai:nur.nu.edu.kz:123456789/27652018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1123
Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes
Dmitriev, Petr
Kairov, Ulykbek
Robert, Thomas
Barat, Ana
Lazar, Vladimir
Carnac, Gilles
Laoudj-Chenivesse, Dalila
Vassetzky, Yegor S.
cancer
rhabdomyosarcoma
Ewing’s sarcoma
FSHD
muscular dystrophy
Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing’s sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.
2017-11-09T05:12:23Z
2017-11-09T05:12:23Z
2013
Article
Dmitriev Petr et al.(>7), 2013, Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes, Journal of Cellular and Molecular Medicine, Vol.18, 208-217
doi: 10.1111/jcmm.12182
http://nur.nu.edu.kz/handle/123456789/2765
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Open Access - the content is available to the general public
Attribution-NonCommercial-ShareAlike 3.0 United States
Journal of Cellular and Molecular Medicine
oai:nur.nu.edu.kz:123456789/27662018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1126
Determining the optimal number of independent components for reproducible transcriptomic data analysis
Kairov, Ulykbek
Cantini, Laura
Greco, Alessandro
Molkenov, Askhat
Czerwinska, Urszula
Barillot, Emmanuel
Zinovyev, Andrei
transcriptome
Independent component analysis
Reproducibility
Cancer
Background: Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the number of components (factors) to compute. The optimal choice of this parameter, related to determining the effective data dimension, remains an open question in the application of blind source separation techniques to transcriptomic data.Results: Here we address the question of optimizing the number of statistically independent components in the analysis of transcriptomic data for reproducibility of the components in multiple runs of ICA (within the same or
within varying effective dimensions) and in multiple independent datasets. To this end, we introduce ranking of independent components based on their stability in multiple ICA computation runs and define a distinguished number of components (Most Stable Transcriptome Dimension, MSTD) corresponding to the point of the qualitative change of the stability profile. Based on a large body of data, we demonstrate that a sufficient number of dimensions is required for biological interpretability of the ICA decomposition and that the most stable components with ranks below MSTD have more chances to be reproduced in independent studies compared to the less stable ones. At the
same time, we show that a transcriptomics dataset can be reduced to a relatively high number of dimensions without losing the interpretability of ICA, even though higher dimensions give rise to components driven by small gene sets. Conclusions: We suggest a protocol of ICA application to transcriptomics data with a possibility of prioritizing components with respect to their reproducibility that strengthens the biological interpretation. Computing too few components (much less than MSTD) is not optimal for interpretability of the results. The components ranked within MSTD range have more chances to be reproduced in independent studies.
2017-11-09T05:25:42Z
2017-11-09T05:25:42Z
2017
Article
Kairov Ulykbek et al.(>6), 2017, Determining the optimal number of independent components for reproducible transcriptomic data analysis, BioMed Central,
DOI 10.1186/s12864-017-4112-9
http://nur.nu.edu.kz/handle/123456789/2766
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Open Access - the content is available to the general public
Attribution-NonCommercial-ShareAlike 3.0 United States
BioMed Central
oai:nur.nu.edu.kz:123456789/28672021-02-05T05:56:37Zcom_123456789_107com_123456789_106col_123456789_2866
PHP167 Influence of Some Factors on The Morphological Structure of Spermatozoa In Straight Intestine During Forensic - Medical Examination of Sodomy
Zhakupova, T
Turgambayeva, A
Mussina, A
Bukeyeva, Z
Kossumov, A
2017-12-13T08:35:54Z
2017-12-13T08:35:54Z
2015-11-01
Article
T Zhakupova, A Turgambayeva, A Mussina, Z Bukeyeva, A Kossumov, PHP167 - Influence of Some Factors on The Morphological Structure of Spermatozoa In Straight Intestine During Forensic - Medical Examination of Sodomy, In Value in Health, Volume 18, Issue 7, 2015, Page A543
10983015
https://www.sciencedirect.com/science/article/pii/S1098301515037973
http://nur.nu.edu.kz/handle/123456789/2867
Value in Health
Copyright © 2015 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28702021-02-05T05:56:37Zcom_123456789_107com_123456789_106col_123456789_2869
PIN17 Pharmacoeconomics of Cervarix Vaccines Against Human Papilloma Virus in the Republic of Kazakhstan
Nurgozhin, T.
Gulyaev, A.
Yermekbayeva, B.
Kushugulova, A.
Akhmetova, A.
Supiev, A.
2017-12-13T08:50:51Z
2017-12-13T08:50:51Z
2013-11-01
Article
T. Nurgozhin, A. Gulyaev, B. Yermekbayeva, A. Kushugulova, A. Akhmetova, A. Supiev, PIN17 - Pharmacoeconomics of Cervarix Vaccines Against Human Papilloma Virus in the Republic of Kazakhstan, In Value in Health, Volume 16, Issue 7, 2013, Pages A714-A715
10983015
https://www.sciencedirect.com/science/article/pii/S109830151304120X
http://nur.nu.edu.kz/handle/123456789/2870
Value in Health
Copyright © 2013 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28712021-02-05T05:56:38Zcom_123456789_107com_123456789_106col_123456789_1124
PCN14 A Pharmacoeconomic Appraisal of Cabazitaxel Versus Abiraterone for the Second-Line Treatment of Patients with Metastatic Hormone-Refractory Prostate Cancer (MHRPC) Progressing After the Treatment with Docetaxel: a Systematic Review
Bektur, C.
Nurgozhin, T.
2017-12-13T08:57:51Z
2017-12-13T08:57:51Z
2014-05-01
Article
10983015
https://www.sciencedirect.com/science/article/pii/S1098301514004604
http://nur.nu.edu.kz/handle/123456789/2871
Value in Health
Copyright © 2014 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28742021-02-05T05:56:39Zcom_123456789_107com_123456789_106col_123456789_2866
PMS17 Cost-Effectiveness of denosumab vs. Brand or generic zoledronic acid in patients with prostate cancer in kazakhstan
Bektur, C.
Nurgozhin, T.
A phase III clinical trial demonstrated the advantage of denosumab over zoledronic acid(ZA) in delaying the first on-study and subsequent skeletal-related events(SREs) in patients with prostate cancer(PC). Recently, generic ZA became available. The purpose of this study was to examine the cost-effectiveness of denosumab vs. brand or generic ZA in the prevention of SREs in Kazakhstani patients with PC.
2017-12-13T09:25:28Z
2017-12-13T09:25:28Z
2014-11-01
Article
C. Bektur, T. Nurgozhin, PMS17 - Cost-Effectiveness of denosumab vs. Brand or generic zoledronic acid in patients with prostate cancer in Kazakhstan, In Value in Health, Volume 17, Issue 7, 2014, Pages A773-A774
10983015
https://www.sciencedirect.com/science/article/pii/S1098301514022633
http://nur.nu.edu.kz/handle/123456789/2874
Value in Health
Copyright © 2014 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28772021-02-05T05:56:40Zcom_123456789_107com_123456789_106col_123456789_2866
PIH18 Cost-Effectiveness Of 13-Valent Pneumococcal Conjugate Vaccination In Kazakhstan
Bektur, C
Nurgozhin, T
The aim of the study was to investigate the cost-effectiveness of 13-valent pneumococcal conjugate vaccine (PCV-13) programme for children in Kazakhstan from the perspective of Ministry of Health.
2017-12-13T09:45:05Z
2017-12-13T09:45:05Z
2015-05-01
Article
C Bektur, T Nurgozhin, PIH18 - Cost-Effectiveness Of 13-Valent Pneumococcal Conjugate Vaccination In Kazakhstan, In Value in Health, Volume 18, Issue 3, 2015, Page A106
10983015
https://www.sciencedirect.com/science/article/pii/S1098301515006816
http://nur.nu.edu.kz/handle/123456789/2877
Value in Health
Copyright © 2015 Published by Elsevier Inc.
Value in Health
oai:nur.nu.edu.kz:123456789/28782021-02-05T05:56:41Zcom_123456789_107com_123456789_106col_123456789_1124
Cytisin Amidophosphate – Promising Role for The Liver Treatment
Gulyayev, A.
Shulgau, Z.
Yermekbayeva, B.
Sergazy, S.
Nurgozhin, T.
2017-12-13T09:50:49Z
2017-12-13T09:50:49Z
2015-08-01
Article
A. Gulyayev, Z. Shulgau, B. Yermekbayeva, S. Sergazy, T. Nurgozhin, Cytisin Amidophosphate – Promising Role for The Liver Treatment, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e66
A. Gulyayev, Z. Shulgau, B. Yermekbayeva, S. Sergazy, T. Nurgozhin, Cytisin Amidophosphate – Promising Role for The Liver Treatment, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e66
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815005068
http://nur.nu.edu.kz/handle/123456789/2878
Clinical Therapeutics
Copyright © 2015 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28792021-02-05T05:56:41Zcom_123456789_107com_123456789_106col_123456789_2866
Evaluation of health outcomes and cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccination for infants in Kazakhstan
Bektur, C.R.
Nurgozhin, T.S.
2017-12-14T03:08:35Z
2017-12-14T03:08:35Z
2015-08-01
Article
C.R. Bektur, T.S. Nurgozhin, Evaluation of health outcomes and cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccination for infants in Kazakhstan, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e76
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815005263
http://nur.nu.edu.kz/handle/123456789/2879
Clinical Therapeutics
Copyright © 2015 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28802021-02-05T05:56:42Zcom_123456789_107com_123456789_106col_123456789_1124
Cardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy
Shulgau, Z.
Gulyayev, A.
Yermekbayeva, B.
Adilgozhina, G.
Tritek, V.
Nurgozhin, T.
Present study aimed to investigate possible cardioprotective properties of polyphenol concentrates obtained from Cabernet Sauvignon type of Kazakhstani grapes using rat model doxorubicin-induced cardiomyopathy.
2017-12-14T04:03:28Z
2017-12-14T04:03:28Z
2015-08-01
Article
Z. Shulgau, A. Gulyayev, B. Yermekbayeva, G. Adilgozhina, V. Tritek, T. Nurgozhin, Cardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Pages e46-e47
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815004476
http://nur.nu.edu.kz/handle/123456789/2880
Clinical Therapeutics
Copyright © 2015 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28882021-02-05T05:56:43Zcom_123456789_107com_123456789_106col_123456789_1124
PCN99 Cost-Effectiveness Evaluation of Sunitinib as First-Line Targeted Therapy for Metastatic Renal Cell Carcinoma in Kazakhstan
Kostyuk, A.
Nurgozhin, T.
Mazhitov, T.
Almadiyeva, A.
2017-12-14T04:54:01Z
2017-12-14T04:54:01Z
2014-05-01
Article
A. Kostyuk, T. Nurgozhin, T. Mazhitov, A. Almadiyeva, PCN99 - Cost-Effectiveness Evaluation of Sunitinib as First-Line Targeted Therapy for Metastatic Renal Cell Carcinoma in Kazakhstan, In Value in Health, Volume 17, Issue 3, 2014, Page A85
10983015
https://www.sciencedirect.com/science/article/pii/S1098301514005452
http://nur.nu.edu.kz/handle/123456789/2888
Value in Health
Copyright © 2014 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28922021-02-05T05:56:44Zcom_123456789_107com_123456789_106col_123456789_2866
PIN23 Economic Evaluation of Protease Inhibitors for the Treatment of Patients with Genotype 1 Chronic Hepatitis C in Kazakhstan
Almadiyeva, A.
Ibrayev, S.
Turgambayeva, A.
Nurgozhin, T.
2017-12-14T05:51:58Z
2017-12-14T05:51:58Z
2016-11-01
Article
A Almadiyeva, S Ibrayev, A Turgambayeva, T Nurgozhin, PIN23 - Economic Evaluation of Protease Inhibitors for the Treatment of Patients with Genotype 1 Chronic Hepatitis C in Kazakhstan, In Value in Health, Volume 19, Issue 7, 2016, Pages A911-A912
10983015
https://www.sciencedirect.com/science/article/pii/S1098301516307240
http://nur.nu.edu.kz/handle/123456789/2892
Value in Health
Copyright © 2016 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/28932021-02-05T05:56:29Zcom_123456789_107com_123456789_106col_123456789_2866
Pharmacokinetics of Ceftriaxone Included In Cellular Transport System
Nurgozhin, T.
Gulyayev, A.
Lokhvytsky, S.
Yermekbayeva, B.
Sergazy, S.
Shulgau, Z.
Berikkhanova, K.
2017-12-14T05:56:59Z
2017-12-14T05:56:59Z
2015-08-01
Article
T. Nurgozhin, A. Gulyayev, S. Lokhvytsky, B. Yermekbayeva, S. Sergazy, Z. Shulgau, K. Berikkhanova, Pharmacokinetics of Ceftriaxone Included In Cellular Transport System, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e62
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815004944
http://nur.nu.edu.kz/handle/123456789/2893
Clinical Therapeutics
Copyright © 2015 Published by Elsevier Inc.
oai:nur.nu.edu.kz:123456789/29472021-02-05T05:59:53Zcom_123456789_107com_123456789_106col_123456789_2866
Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan
Supiyev, Adil
Kossumov, Alibek
Kassenova, Aliya
Nurgozhin, Talgat
Zhumadilov, Zhaxybay
Peasey, Anne
Bobak, Martin
Diabetes
Socioeconomic factors
Central Asian Countries
Kazakhstan
Abstract AimsThe evidence on the prevalence and distribution of diabetes and its determinants in Central Asia is sparse. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of diabetes and factors associated with these characteristics in the population of Astana (capital) city and adjacent rural area in Kazakhstan. MethodsParticipants aged 50-75 years old, residing in Astana city (the capital) and Akmol village were invited to participate in a cross-sectional study. The subjects were randomly selected from polyclinic registers. A total of 953 adults were interviewed (response rate 59%), and their fasting plasma glucose, blood pressure, height and weight were measured. Diabetes was defined as fasting plasma glucose (FPG) ≥7.0mmol/l (126mg/dl) and/or being on diabetes medication. ResultsThe overall prevalence of diabetes was 12.5%, and it was almost twice higher in the urban residents (16.3%) than in the rural population (8.6%). Diabetes prevalence was associated with age, men sex, hypertension, obesity, and Russian ethnicity. Among subjects with diabetes, 72.3% were aware of their condition; 65.6% were on treatment and 27.7% had controlled fasting plasma glucose. The awareness, treatment and control of diabetes were substantially higher in the urban population and among women. ConclusionsThe large differences in all diabetes indices between urban and rural regions, if confirmed in larger studies, may suggest an impact of westernised and urbanised lifestyle as well as access to health care.
2017-12-15T06:35:08Z
2017-12-15T06:35:08Z
2016-02-01
Article
Adil Supiyev, Alibek Kossumov, Aliya Kassenova, Talgat Nurgozhin, Zhaxybay Zhumadilov, Anne Peasey, Martin Bobak, Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan, In Diabetes Research and Clinical Practice, Volume 112, 2016, Pages 6-12
01688227
https://www.sciencedirect.com/science/article/pii/S0168822715004714
http://nur.nu.edu.kz/handle/123456789/2947
Diabetes Research and Clinical Practice
Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.
oai:nur.nu.edu.kz:123456789/30252020-12-29T08:43:05Zcom_123456789_107com_123456789_106col_123456789_2866
Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis
Kaiyrlykyzy, Aiym
Freese, Kyle E.
Elishaev, Esther
Bovbjerg, Dana H.
Ramanathan, Ramesh
Hamad, Giselle G.
McCloskey, Carol
Althouse, Andrew D.
Huang, Marilyn
Edwards, Robert P.
Linkov, Faina
Bariatric surgery
Endometrial cancer
Endometrial hyperplasia
Endometrial polyps
Obesity
Pipelle sampling
Abstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). MethodsTwenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. ResultsOf the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03–1.36], P = .01). ConclusionsThe findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.
2017-12-22T04:20:40Z
2017-12-22T04:20:40Z
2015-05-01
Article
15507289
https://www.sciencedirect.com/science/article/pii/S1550728914004924
http://nur.nu.edu.kz/handle/123456789/3025
Surgery for Obesity and Related Diseases
Copyright © 2015 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
oai:nur.nu.edu.kz:123456789/30262020-12-29T08:50:24Zcom_123456789_107com_123456789_106col_123456789_2866
Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis
Kaiyrlykyzy, Aiym
Freese, Kyle E.
Elishaev, Esther
Bovbjerg, Dana H.
Ramanathan, Ramesh
Hamad, Giselle G.
McCloskey, Carol
Althouse, Andrew D.
Huang, Marilyn
Edwards, Robert P.
Linkov, Faina
Bariatric surgery
Endometrial cancer
Endometrial hyperplasia
Endometrial polyps
Obesity
Pipelle sampling
Abstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). MethodsTwenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. ResultsOf the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03–1.36], P = .01). ConclusionsThe findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.
2017-12-22T04:20:42Z
2017-12-22T04:20:42Z
2015-05-01
Article
Aiym Kaiyrlykyzy, Kyle E. Freese, Esther Elishaev, Dana H. Bovbjerg, Ramesh Ramanathan, Giselle G. Hamad, Carol McCloskey, Andrew D. Althouse, Marilyn Huang, Robert P. Edwards, Faina Linkov, Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis, In Surgery for Obesity and Related Diseases, Volume 11, Issue 3, 2015, Pages 653-658
15507289
https://www.sciencedirect.com/science/article/pii/S1550728914004924
http://nur.nu.edu.kz/handle/123456789/3026
Surgery for Obesity and Related Diseases
Copyright © 2015 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
oai:nur.nu.edu.kz:123456789/30882019-09-13T10:51:23Zcom_123456789_107com_123456789_106col_123456789_2869
Clinical characterizations of children with bacterial meningitis (BM) in the Republic of Kazakhstan
Seidullayeva, A.
Zhaxylykova, G.
Kenzhebayeva, S.
Turdalina, B.
Volkova, G.
Nurtazina, G.
Kostrovskaya, T.
Greenberg, D.
Kushugulova, A.
Bayesheva, D.
2018-01-04T06:18:33Z
2018-01-04T06:18:33Z
2016-12-01
Article
A. Seidullayeva, G. Zhaxylykova, S. Kenzhebayeva, B. Turdalina, G. Volkova, G. Nurtazina, T. Kostrovskaya, D. Greenberg, A. Kushugulova, D. Bayesheva, Clinical characterizations of children with bacterial meningitis (BM) in the Republic of Kazakhstan, In International Journal of Infectious Diseases, Volume 53, Supplement, 2016, Page 148
12019712
https://www.sciencedirect.com/science/article/pii/S1201971216315818
http://nur.nu.edu.kz/handle/123456789/3088
International Journal of Infectious Diseases
Copyright © 2016 Published by Elsevier Ltd.
oai:nur.nu.edu.kz:123456789/30982021-02-05T05:59:58Zcom_123456789_107com_123456789_106col_123456789_1125
Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting
D'Souza, Sonia
Murata, Hironobu
Jose, Moncy V.
Askarova, Sholpan
Yantsen, Yuliya
Andersen, Jill D.
Edington, Collin D.J.
Clafshenkel, William P.
Koepsel, Richard R.
Russell, Alan J.
Membrane engineering
ATRP
Bone targeting polymer
Cell reactive polymers
Abstract The field of polymer-based membrane engineering has expanded since we first demonstrated the reaction of N-hydroxysuccinimide ester-terminated polymers with cells and tissues almost two decades ago. One remaining obstacle, especially for conjugation of polymers to cells, has been that exquisite control over polymer structure and functionality has not been used to influence the behavior of cells. Herein, we describe a multifunctional atom transfer radical polymerization initiator and its use to synthesize water-soluble polymers that are modified with bisphosphonate side chains and then covalently bound to the surface of live cells. The polymers contained between 1.7 and 3.1 bisphosphonates per chain and were shown to bind to hydroxyapatite crystals with kinetics similar to free bisphosphonate binding. We engineered the membranes of both HL-60 cells and mesenchymal stem cells in order to impart polymer-guided bone adhesion properties on the cells. Covalent coupling of the polymer to the non-adherent HL-60 cell line or mesenchymal stem cells was non-toxic by proliferation assays and enhanced the binding of these cells to bone.
2018-01-04T09:22:10Z
2018-01-04T09:22:10Z
2014-11-01
Article
Sonia D'Souza, Hironobu Murata, Moncy V. Jose, Sholpan Askarova, Yuliya Yantsen, Jill D. Andersen, Collin D.J. Edington, William P. Clafshenkel, Richard R. Koepsel, Alan J. Russell, Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting, In Biomaterials, Volume 35, Issue 35, 2014, Pages 9447-9458
01429612
https://www.sciencedirect.com/science/article/pii/S0142961214008503
http://nur.nu.edu.kz/handle/123456789/3098
Biomaterials
Copyright © 2014 Elsevier Ltd. All rights reserved.
oai:nur.nu.edu.kz:123456789/31082020-12-29T08:52:24Zcom_123456789_107com_123456789_106col_123456789_1123
Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue
González-Plaza, Juan José
Gutiérrez-Repiso, Carolina
García-Serrano, Sara
Rodriguez-Pacheco, Francisca
Garrido-Sánchez, Lourdes
Santiago-Fernández, Concepción
García-Arnés, Juan
Moreno-Ruiz, Francisco J.
Rodríguez-Cañete, Alberto
García-Fuentes, Eduardo
Transcriptomics
Microarray
Bariatric surgery
Gastric bypass
Subcutaneous adipose tissue
Morbid obesity
Functional annotation
Expression analysis
Abstract BackgroundThe changes in the transcriptomic profiling of subcutaneous adipose tissue (SAT) when weight loss stabilizes after a Roux-en-Y gastric bypass (RYGB) are still largely unknown. ObjectivesTo investigate the changes produced in SAT gene expression of morbidly obese women when their weight loss stabilizes 2 years after RYGB. SettingUniversity hospital. MethodsSAT biopsies of the periumbilical area were taken before and 2 years after RYGB. Gene expression levels were assessed by microarray analysis and significant differences in gene expression were validated by real-time quantitative polymerase chain reaction. The findings were also confirmed in an independent population of morbidly obese women. ResultsMicroarray analysis revealed that the overexpressed differentially expressed genes have a prominent role in the pathways involved in biosynthetic processes, especially lipid or carboxylic ones (stearoyl-Coenzyme A desaturase-1, fatty acid desaturase-1, fatty acid elongase-6, ATP citrate lyase, fatty acid synthase, lipin-1, monoacylglycerol O-acyltransferase, patatin-like phospholipase domain containing-3, phosphate cytidylyltransferase-2, cholesteryl ester transfer protein, transmembrane 7 superfamily member 2, pyruvate carboxylase, and glycogen synthase 2). Most of the underexpressed differentially expressed genes are related with immune system and inflammation processes (immune responses, response to stress, cell death, regulation of biological quality, immune effector process, the response to endogenous stimulus, and the response to other types of stimulus). ConclusionAn improvement of the SAT inflammatory and immune profile and an induction of genes involved in the regulation of lipid metabolism are shown when weight loss stabilizes 2 years after RYGB. Most of the genes shown are clearly linked to obesity and other metabolic disorders.
2018-01-04T11:00:51Z
2018-01-04T11:00:51Z
2016-02-01
Article
Juan José González-Plaza, Carolina Gutiérrez-Repiso, Sara García-Serrano, Francisca Rodriguez-Pacheco, Lourdes Garrido-Sánchez, Concepción Santiago-Fernández, Juan García-Arnés, Francisco J. Moreno-Ruiz, Alberto Rodríguez-Cañete, Eduardo García-Fuentes, Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue, In Surgery for Obesity and Related Diseases, Volume 12, Issue 2, 2016, Pages 257-263
15507289
https://www.sciencedirect.com/science/article/pii/S1550728915002920
http://nur.nu.edu.kz/handle/123456789/3108
Surgery for Obesity and Related Diseases
Copyright © 2016 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.
oai:nur.nu.edu.kz:123456789/43912019-12-11T21:02:04Zcom_123456789_107com_123456789_106col_123456789_4390
Assessing reproducibility of matrix factorization methods in independent transcriptomes
Cantini, Laura
Kairov, Ulykbek
de Reynies, Aurelien
Barillot, Emmanuel
Radvanyi, Francois
Zinovyev, Andrei
Assessing reproducibility
Gene expression
Matrix factorization
MF
colorectal cancer
CRC
breast cancer
BRCA
https://www.ncbi.nlm.nih.gov/pubmed/30938767
Motivation
Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on the between-datasets reproducibility of their outputs in similar independent datasets. Lack of this knowledge might have a crucial impact when generalizing the predictions made in a study to others.
Results
We systematically test widely used MF methods on several transcriptomic datasets collected from the same cancer type (14 colorectal, 8 breast and 4 ovarian cancer transcriptomic datasets). Inspired by concepts of evolutionary bioinformatics, we design a novel framework based on Reciprocally Best Hit (RBH) graphs in order to benchmark the MF methods for their ability to produce generalizable components. We show that a particular protocol of application of independent component analysis (ICA), accompanied by a stabilization procedure, leads to a significant increase in the between-datasets reproducibility. Moreover, we show that the signals detected through this method are systematically more interpretable than those of other standard methods. We developed a user-friendly tool for performing the Stabilized ICA-based RBH meta-analysis. We apply this methodology to the study of colorectal cancer (CRC) for which 14 independent transcriptomic datasets can be collected. The resulting RBH graph maps the landscape of interconnected factors associated to biological processes or to technological artifacts. These factors can be used as clinical biomarkers or robust and tumor-type specific transcriptomic signatures of tumoral cells or tumoral microenvironment. Their intensities in different samples shed light on the mechanistic basis of CRC molecular subtyping.
Availability and implementation
The RBH construction tool is available from http://goo.gl/DzpwYp
Supplementary information
Supplementary data are available at Bioinformatics online.
2019-12-11T09:30:18Z
2019-12-11T09:30:18Z
2019
Article
Cantini, L., Kairov, U., de Reyniès, A., Barillot, E., Radvanyi, F., & Zinovyev, A. (2019). Assessing reproducibility of matrix factorization methods in independent transcriptomes. Bioinformatics, 35(21), 4307–4313. https://doi.org/10.1093/bioinformatics/btz225
10.1093/bioinformatics/btz225
http://nur.nu.edu.kz/handle/123456789/4391
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
OXFORD UNIV PRESS
oai:nur.nu.edu.kz:123456789/44082019-12-12T21:02:57Zcom_123456789_107com_123456789_106col_123456789_2866
Genetic analysis of hemagglutinin proteins of H3 and H1 subtypes in Kazakhstan
Gritsenko, Dilyara
Pozharsky, Aleksandr
Deryabina, Nina
Kassenova, Aliya
Galiakparov, Nurbol
Influenza virus
subtype
genetic diversity
hemagglutinin
vaccine
http://www.doiserbia.nb.rs/Article.aspx?ID=0534-00121902511G#.XfG7_ugzZaQ
The influenza is one of the most dangerous and widespread infectious diseases on the planet. A natural reservoir of the influenza A virus is wild waterfowl, which subsequently contribute to the spread of viral infection among domestic animals. Currently, different influenza A subtypes were isolated from various animal species and their genetic diversity were investigated with the subsequent possibility to predict the places of outbreaks and the transfer between species. An investigation of genetic diversity of influenza A virus is also important for a timely response by developing suitable vaccines to the emergence of new strains. In the work, we investigated two subtypes of hemagglutinin (H3, H1) from wild waterfowl in the Republic of Kazakhstan (RK). This work was aimed to determine the homology between these subtypes and currently known isolates from the NCBI database. H3N8 isolates from Kazakhstan were located in a monophyletic group together with isolates from Mongolia and Altai according to phylogenetic analysis of the hemagglutinin sequences . The hemagglutinin homology of H3N8 isolates from Kazakhstan and A/eq/Richmond/1/2007 vaccine strain was 86.07% and with A/eq/Ohio/2003 vaccine strain was 86, 24%. In the case of H1N1 isolates from Kazakhstan, the highest hemagglutinin homology was with isolates from Europe. The homology with the A/California/07/2009 (H1N1) vaccine strain was 81.27%. Important amino acids of cleavage and receptor binding sites were not variable in both H3 and H1 subtypes. The investigation of antigenic sites showed presence of variations in all five sites for H3 subtype and in 4 sites for H1.
2019-12-12T04:10:06Z
2019-12-12T04:10:06Z
2019
Article
Gritsenko, D., Pozharsky, A., Deryabina, N., Kassenova, A., & Galiakparov, N. (2019). Genetic analysis of hemagglutinin proteins of H3 and H1 subtypes in Kazakhstan. Genetika, 51(2), 511–524. https://doi.org/10.2298/gensr1902511g
10.2298/GENSR1902511G
http://nur.nu.edu.kz/handle/123456789/4408
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Genetika-Belgrade
oai:nur.nu.edu.kz:123456789/44272019-12-12T21:01:41Zcom_123456789_107com_123456789_106col_123456789_1123
The genetic history of admixture across inner Eurasia
Jeong, Choongwon
Balanovsky, Oleg
Lukianova, Elena
Kahbatkyzy, Nurzhibek
Flegontov, Pavel
Zaporozhchenko, Valery
Immell, Alexander
Wang, Chuan-Chao
Ixan, Olzhas
Khussainova, Elmira
Bekmanov, Bakhytzhan
Zaibert, Victor
Lavryashina, Maria
Pocheshkhova, Elvira
Yusupov, Yuldash
Agdzhoyan, Anastasiya
Koshel, Sergey
Bukin, Andrei
Nymadawa, Pagbajabyn
Turdikulova, Shahlo
Dalimova, Dilbar
Churnosov, Mikhail
Skhalyakho, Roza
Daragan, Denis
Bogunov, Yuri
Bogunova, Anna
Shtrunov, Alexandr
Dubova, Nadezhda
Zhabagin, Maxat
Yepiskoposyan, Levon
Churakov, Vladimir
Pislegin, Nikolay
Damba, Larissa
Saroyants, Ludmila
Dibirova, Khadizhat
Atramentova, Lubov
Utevska, Olga
Idrisov, Eldar
Kamenshchikova, Evgeniya
Evseeva, Irina
Metspalu, Mait
Outram, Alan K.
Robbeets, Martine
Djansugurova, Leyla
Balanovska, Elena
Schiffels, Stephan
Haak, Wolfgang
Reich, David
Krause, Johannes
Admixture modeling
Admixture
genetic history
ancient North Eurasian
https://www.ncbi.nlm.nih.gov/pubmed/31036896
The indigenous populations of inner Eurasia-a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra-harbour tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 BP). We find that present-day inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries, mirroring geography. The Botai and more recent ancient genomes from Siberia show a decrease in contributions from so-called 'ancient North Eurasian' ancestry over time, which is detectable only in the northern-most 'forest-tundra' cline. The intermediate 'steppe-forest' cline descends from the Late Bronze Age steppe ancestries, while the 'southern steppe' cline further to the south shows a strong West/South Asian influence. Ancient genomes suggest a northward spread of the southern steppe cline in Central Asia during the first millennium BC. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North Caucasus populations from the steppe.
2019-12-12T06:08:31Z
2019-12-12T06:08:31Z
2019-04
Article
Jeong, C., Balanovsky, O., Lukianova, E., Kahbatkyzy, N., Flegontov, P., Zaporozhchenko, V., … Krause, J. (2019). The genetic history of admixture across inner Eurasia. Nature Ecology & Evolution, 3(6), 966–976. https://doi.org/10.1038/s41559-019-0878-2
10.1038/s41559-019-0878-2
http://nur.nu.edu.kz/handle/123456789/4427
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Nature Ecology & Evolution
oai:nur.nu.edu.kz:123456789/45092020-03-12T21:01:10Zcom_123456789_107com_123456789_106col_123456789_2866
The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults
Zhumadilov, Zhaxybay
Supiyev, Adil
Geldsetzer, Pascal
Manne-Goehler, Jennifer
Marcus, Maja-Emilia
Ebert, Cara
Wesseh, Chea S
Tsabedze, Lindiwe
Sturua, Lela
Bahendeka, Silver K
Sibai, Abla M
Quesnel-Crooks, Sarah
Norov, Bolormaa
Mwangi, Kibachio J
Mwalim, Omar
Wong-McClure, Roy
Mayige, Mary T
Martins, Joao S
Lunet, Nuno
Labadarios, Demetre
Karki, Khem B
Kagaruki, Gibson B
Jorgensen, Jutta M A
Hwalla, Nahla C
Houinato, Dismand
Houehanou, Corine
Msaidié, Mohamed
Guwatudde, David
Gurung, Mongal S
Gathecha, Gladwell
Dorobantu, Maria
Damasceno, Albertino
Bovet, Pascal
Bicaba, Brice W
Aryal, Krishna K
Andall-Brereton, Glennis
Andall-Brereton, Glennis
Agoudavi, Kokou
Stokes, Andrew
Davies, Justine I
Bärnighausen, Till
Atun, Rifat
Vollmer, Sebastian
Jaacks, Lindsay M
Our study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process in each of the 44 countries in our study. We also identified countries in each world region that perform better than expected from their economic development, which can direct policy makers to important policy lessons. Given the high disease burden caused by hypertension in LMICs, nationally representative hypertension care cascades, as constructed in this study, are an important measure of progress towards achieving universal health coverage.
2020-03-12T05:07:50Z
2020-03-12T05:07:50Z
2019-07-18
Article
Geldsetzer, P., Manne-Goehler, J., Marcus, M. E., Ebert, C., Zhumadilov, Z., Wesseh, C. S., … Jaacks, L. M. (2019). The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults. The Lancet, 394(10199), 652–662. https://doi.org/10.1016/S0140-6736(19)30955-9
https://doi.org/10.1016/S0140-6736(19)30955-9
http://nur.nu.edu.kz/handle/123456789/4509
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Elsevier
oai:nur.nu.edu.kz:123456789/45102020-03-12T21:01:15Zcom_123456789_107com_123456789_106col_123456789_2869
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage
Kozhakhmetov, Samat S.
Zhumadilov, Zhaxybay
Kushugulova, Almagul R.
Bartolomaeus, Hendrik
Balogh, András
Yakoub, Mina
Homann, Susanne
Markó, Lajos
Höges, Sascha
Tsvetkov, Dmitry
Krannich, Alexander
Wundersitz, Sebastian
Avery, Ellen G.
Haase, Nadine
Kräker, Kristin
Hering, Lydia
Maase, Martina
Kusche-Vihrog, Kristina
Grandoch, Maria
Fielitz, Jens
Kempa, Stefan
Gollasch, Maik
Eckardt, Kai-Uwe
Dechend, Ralf
Rump, Lars Christian
Forslund, Sofia K.
Müller, Dominik N.
Stegbauer, Johannes
Wilck, Nicola
Research Subject Categories::NATURAL SCIENCES
angiotensin II
apolipoproteins E
fatty acids
volatile
immunology
inflammation
microbiota
Th17 cells
T-lymphocytes
regulatory
Arterial hypertension and its organ sequelae show characteristics of T cell–mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, the CANTOS study (Canakinumab Antiinflammatory Thrombosis Outcome Study) targeting interleukin-1β demonstrated that anti-inflammatory therapy reduces cardiovascular risk. The gut microbiome plays a pivotal role in immune homeostasis and cardiovascular health. Short-chain fatty acids (SCFAs) are produced from dietary fiber by gut bacteria and affect host immune homeostasis. Here, we investigated effects of the SCFA propionate in 2 different mouse models of hypertensive cardiovascular damage. Our data emphasize an immune-modulatory role of SCFAs and their importance for cardiovascular health. The data suggest that lifestyle modifications leading to augmented SCFA production could be a beneficial nonpharmacological preventive strategy for patients with hypertensive cardiovascular disease.
2020-03-12T06:34:29Z
2020-03-12T06:34:29Z
2018-12-04
Article
Bartolomaeus, Hendrik, András Balogh, Mina Yakoub, Susanne Homann, Lajos Markó, Sascha Höges, Dmitry Tsvetkov, et al. 2019. “Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage.” Circulation 139 (11). Lippincott Williams and Wilkins: 1407–21. doi:10.1161/CIRCULATIONAHA.118.036652.
https://doi.org/10.1161/CIRCULATIONAHA.118.036652
http://nur.nu.edu.kz/handle/123456789/4510
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Wolters Kluwer Health; American Heart Association
oai:nur.nu.edu.kz:123456789/45252020-07-07T04:09:10Zcom_123456789_107com_123456789_106col_123456789_4390
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
Kairov, Ulykbek
Aynaud, Marie-Ming
Mirabeau, Olivier
Gruel, Nadege
Grossetête, Sandrine
Boeva, Valentina
Durand, Simon
Surdez, Didier
Zaïdi, Sakina
Gribkova, Svetlana
Fouché, Aziz
Raynal, Virginie
Tirode, Franck
Grünewald, Thomas G P
Bohec, Mylene
Baulande, Sylvain
Janoueix-Lerosey, Isabelle
Vert, Jean-Philippe
Barillot, Emmanuel
single-cell RNA-sequencing
Ewing sarcoma
EWSR1-FLI1
intratumor heterogeneity
patient-derived xenografts
Independent Component Analysis
time series
series transcriptomics
EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transcriptional programs. Here, we combine independent component analysis of single-cell RNA sequencing data from diverse cell types and model systems with time-resolved mapping of EWSR1-FLI1 binding sites and of open chromatin regions to characterize dynamic cellular processes associated with EWSR1-FLI1 activity. We thus define an exquisitely specific and direct enhancer-driven EWSR1-FLI1 program. In EwS tumors, cell proliferation and strong oxidative phosphorylation metabolism are associated with a well-defined range of EWSR1-FLI1 activity. In contrast, a subpopulation of cells from below and above the intermediary EWSR1-FLI1 activity is characterized by increased hypoxia. Overall, our study reveals sources of intratumoral heterogeneity within EwS tumors.
2020-03-16T08:23:47Z
2020-03-16T08:23:47Z
2020-02-11
Article
Aynaud, M-M., Mirabeau, O., Gruel, N., Grossetête, S., Boeva, V., Durand, S., ... Zinovyev, A. (2020). Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution. Cell Reports, 30(6), 1767-1779.e6. https://doi.org/10.1016/j.celrep.2020.01.049
https://doi.org/10.1016/j.celrep.2020.01.049
http://nur.nu.edu.kz/handle/123456789/4525
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Cell Press
oai:nur.nu.edu.kz:123456789/45362020-03-19T21:00:32Zcom_123456789_107com_123456789_106col_123456789_2869
Comparison of Phenolic Content in Cabernet Sauvignon and Saperavi Wines
Sergazy, Shynggys
Gulyayev, Alexandr
Dudikova, Galina
Chulenbayeva, Laura
Nurgaziyev, Madiyar
Krivyh, Elena
Nurgozhoina, Ayaulym
Ziyat, Arailym
Tritek, V.
Kozhakhmetov, Samat S.
Kushugulova, Almagul R.
Several studies reveal that the phenolic compounds present in the wine and their concentrations determine physiological activities of the red wine. In this study, the main polyphenol components, including hydroxycinnamic acids, flavones, flavan-3-ols and stilbenoids, were investigated via HLPC-UV in the “Cabernet Sauvignon” and “Saperavi” wines selected from different regions and different years. In assistance of a meta-analysis, we found that there are no fundamental differences in phenolic compounds between the wines Cabernet Sauvignon and Saperavi. However, the amounts of several important phenolic materials such as catechin, caffeic acid, p-coumaric acid, chlorogenic acid and myricetin significantly higher in Saperavi wine as compared to Cabernet Sauvignon. Moreover, on the basis of the correlation analysis, we assume that flavones synthesis and regulation of stilbenoids coordinated to a greater extent in “Saperavi” than in “Cabernet Sauvignon”.
2020-03-19T10:14:47Z
2020-03-19T10:14:47Z
2019-12-12
Article
Sergazy, S., Gulyayev, A., Dudikova, G., Chulenbayeva, L., Nurgaziyev, M., Elena, K., ... & Kushugulova, A. (2019). COMPARISON OF PHENOLIC CONTENT IN CABERNET SAUVIGNON AND SAPERAVI WINES. Journal of Microbiology, Biotechnology and Food Sciences, 2019, 557-561.
10.15414/jmbfs.2019/20.9.3.557-561
http://nur.nu.edu.kz/handle/123456789/4536
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra
oai:nur.nu.edu.kz:123456789/45442020-03-26T21:00:42Zcom_123456789_107com_123456789_106col_123456789_1126
Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation
Zarkovic, Gabriella
Belousova, Ekaterina
Talhaoui, Ibtissam
Saint-Pierre, Christine
Kutuzov, Mikhail M.
Matkarimov, Bakhyt
Biard, Denis
Gasparutto, Didier
Lavrik, Olga I.
Ishchenko, Alexander A.
genome integrity
repair and replication
PARP2
PARP3
Research Subject Categories::MEDICINE
https://academic.oup.com/nar/article/46/5/2417/4807332
Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both mammalian PARP1 and PARP2 PARylate double-strand break termini in DNA oligonucleotide duplexes in vitro. Here, we show that mammalian PARP2 and PARP3 can PARylate and mono(ADP-ribosyl)ate (MARylate), respectively, 5′- and 3′-terminal phosphate residues at double- and single-strand break termini of a DNA molecule containing multiple strand breaks. PARP3-catalyzed DNA MARylation can be considered a new type of reversible post-replicative DNA modification. According to DNA substrate specificity of PARP3 and PARP2, we propose a putative mechanistic model of PARP-catalyzed strand break–oriented ADP-ribosylation of DNA termini. Notably, PARP-mediated DNA ADP-ribosylation can be more effective than PARPs’ auto-ADP-ribosylation depending on the DNA substrates and reaction conditions used. Finally, we show an effective PARP3- or PARP2-catalyzed ADP-ribosylation of high-molecular-weight (∼3-kb) DNA molecules, PARP-mediated DNA PARylation in cell-free extracts and a persisting signal of anti-PAR antibodies in a serially purified genomic DNA from bleomycin-treated poly(ADP-ribose) glycohydrolase-depleted HeLa cells. These results suggest that certain types of complex DNA breaks can be effectively ADP-ribosylated by PARPs in cellular response to DNA damage.
2020-03-26T05:32:04Z
2020-03-26T05:32:04Z
2018-01
Article
Zarkovic, G., Belousova, E. A., Talhaoui, I., Saint-Pierre, C., Kutuzov, M. M., Matkarimov, B. T., Biard, D., Gasparutto, D., Lavrik, O. I., & Ishchenko, A. A. (2018). Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation. Nucleic Acids Research, 46(5), 2417–2431. https://doi.org/10.1093/nar/gkx1318
0305-1048
1362-4962
10.1093/nar/gkx1318
https://doi.org/10.1093/nar/gkx1318
http://nur.nu.edu.kz/handle/123456789/4544
en
Nucleic Acids Research;Vol. 46, No. 5
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Oxford University Press
oai:nur.nu.edu.kz:123456789/45482020-03-26T21:00:45Zcom_123456789_107com_123456789_106col_123456789_4547
Air Pollution in Kazakhstan and Its Health Risk Assessment
Saliev, Timur
Kenessary, D
Kenessary, A
Adilgereiuly, Z
Akzholova, N
Erzhanova, A
Dosmukhametov, A
Syzdykov, D
Masoud, Abdul-Razak
ir pollution in Kazakhstan is caused by many factors and poses serious threats to public health. Ambient air in the cities of Kazakhstan is polluted due to mining and processing of mineral resources, oil and gas production, gasoline and diesel fuel motor vehicles, industrial enterprises.
2020-03-26T09:44:27Z
2020-03-26T09:44:27Z
2019-11-08
Article
Kenessary, D., Kenessary, A., Adilgereiuly, Z., Akzholova, N., Erzhanova, A., Dosmukhametov, A., … Saliev, T. (2019). Air Pollution in Kazakhstan and Its Health Risk Assessment. Annals of Global Health, 85(1), 133. DOI: http://doi.org/10.5334/aogh.2535
http://doi.org/10.5334/aogh.2535
http://nur.nu.edu.kz/handle/123456789/4548
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Ubiquity Press
oai:nur.nu.edu.kz:123456789/45662020-03-31T21:00:37Zcom_123456789_107com_123456789_106col_123456789_2869
Metagenomic analysis of gut microbial communities from a Central Asian population
Kushugulova, Almagul
Forslund, Sofia K.
Costea, Paul Igor
Kozhakhmetov, Samat
Khassenbekova, Zhanagul
Urazova, Maira
Nurgozhin, Talgat
Zhumadilov, Zhaxybay
Benberin, Valery
Driessen, Marja
Hercog, Rajna
Voigt, Anita Yvonne
Benes, Vladimir
Kandels-Lewis, Stefanie
Sunagawa, Shinichi
Letunic, Ivica
Bork, Peer
gut microbial communities
Changes in the gut microbiota are increasingly recognised to be involved in many diseases. This ecosystem is known to be shaped by many factors, including climate, geography, host nutrition, lifestyle and medication. Thus, knowledge of varying populations with different habits is important for a better understanding of the microbiome...
2020-03-31T05:37:48Z
2020-03-31T05:37:48Z
2018-06-27
Article
Kushugulova A, Forslund SK, Costea PI, et alMetagenomic analysis of gut microbial communities from a Central Asian populationBMJ Open 2018;8:e021682. doi: 10.1136/bmjopen-2018-021682
http://nur.nu.edu.kz/handle/123456789/4566
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
BMJ Open
oai:nur.nu.edu.kz:123456789/45782020-04-03T21:00:19Zcom_123456789_107com_123456789_106col_123456789_1125
Статины: потенциал в лечении болезни альцгеймера
Askarova, S.
Adambekov, S.
Tsoy, A.
Isayeva, R.
Shalakhmetova, T.
амилоид
статины
гематоэнцефалический барьер
холестерин
Research Subject Categories::MEDICINE
https://bb.kaznu.kz/index.php/biology/article/view/192
Болезнь Альцгеймера (БА) является широко распространённым хроническим нейродегенеративным заболеванием, поражающим людей в возрасте 65 лет и старше, против которого до сих пор не разработано эффективных методов лечения. Данные эпидемиологических исследований свидетельствуют о том, что долговременное применение гиполиподемических препаратов статинов снижает риск развития болезни Альцгеймера.
2020-04-01T09:05:57Z
2020-04-01T09:05:57Z
2015-04
Article
Askarova, S., Adambekov, S., Tsoy, A., Isayeva, R., & Shalakhmetova, T. (2015). Статины: потенциал в лечении болезни альцгеймера. Статиндер: Альцгеймер ауруын емдеудегі потенциал. Experimental Biology, 61(2), 135-143. Получено с https://bb.kaznu.kz/index.php/biology/article/view/192
2617-7498
https://bb.kaznu.kz/index.php/biology/article/view/192/165
http://nur.nu.edu.kz/handle/123456789/4578
ru
Вестник КазНУ. Cерия биологическая;Том 61 № 2 (2014)
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Al-Farabi Kazakh National University
oai:nur.nu.edu.kz:123456789/45862020-04-28T21:00:28Zcom_123456789_107com_123456789_106col_123456789_1126
Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
Matkarimov, Bakhyt T.
Matta, Elie
Kiribayeva, Assel
Khassenov, Bekbolat
Ishchenko, Alexander A.
Research Subject Categories::NATURAL SCIENCES
DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise a monomer or polymer of ADP-ribose (MAR or PAR, respectively) covalently attached to the acceptor residue of target proteins. Recently, it was demonstrated that PARP1–3 proteins can directly ADP-ribosylate DNA breaks by attaching MAR and PAR moieties to terminal phosphates. Nevertheless, little is still known about the mechanisms governing substrate recognition and specificity of PARP1, which accounts for most of cellular PARylation activity. Here, we characterised PARP1-mediated DNA PARylation of DNA duplexes containing various types of breaks at different positions. The 3′-terminal phosphate residue at double-strand DNA break ends served as a major acceptor site for PARP1-catalysed PARylation depending on the orientation and distance between DNA strand breaks in a single DNA molecule. A preference for ADP-ribosylation of DNA molecules containing 3′-terminal phosphate over PARP1 auto-ADP-ribosylation was observed, and a model of DNA modification by PARP1 was proposed. Similar results were obtained with purified recombinant PARP1 and HeLa cell-free extracts. Thus, the biological effects of PARP-mediated ADP-ribosylation may strongly depend on the configuration of complex DNA strand breaks.
2020-04-28T10:32:48Z
2020-04-28T10:32:48Z
2020-02-28
Article
Matta, E., Kiribayeva, A., Khassenov, B. et al. Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation. Sci Rep 10, 3699 (2020). https://doi.org/10.1038/s41598-020-60631-0
https://doi.org/10.1038/s41598-020-60631-0
http://nur.nu.edu.kz/handle/123456789/4586
en
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
Springer Nature
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