2024-03-28T09:20:27Zhttp://nur.nu.edu.kz/oai/requestoai:nur.nu.edu.kz:123456789/11302018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Klatte, Katharina
author
Kirschstein, Timo
author
Otte, David
author
Pothmann, Leonie
author
Muller, Lorenz
author
Tokay, Tursonjan
author
Kober, Maria
author
Uebachs, Mischa
author
Zimmer, Andreas
author
Beck, Heinz
author
2013-08-07
The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory site of the receptor. In many forebrain
regions, this coagonist is D-serine. Here, we show that experimental epilepsy in rats is associated with a reduction in the CNS levels of
D-serine, which leads to a desaturation of the coagonist binding site of synaptic and extrasynaptic NMDARs. In addition, the subunit
composition of synaptic NMDARs changes in chronic epilepsy. The desaturation of NMDARs causes a deficit in hippocampal long-term
potentiation, which can be rescued with exogenously supplied D-serine. Importantly, exogenous D-serine improves spatial learning in epileptic animals. These results strongly suggest that D-serine deficiency is important in the amnestic symptoms of temporal lobe epilepsy. Our results point to a possible clinical utility of D-serine to alleviate these disease manifestations.
http://nur.nu.edu.kz/handle/123456789/1130
Epilepsy
D-serine
NMDAR
Research Subject Categories::MEDICINE
Impaired D-Serine-Mediated cotransmission mediates cognitive dysfunction in epilepsy
oai:nur.nu.edu.kz:123456789/11322018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Tokay, Tursonjan
author
Kirschstein, Timo
author
Rohde, Marco
author
Zschorlich, Volker
author
Köhling, Rüdiger
author
2014-10-28
High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-termpotentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 region of rat hippocampal slices using field excitatory postsynaptic potential (fEPSP) recordings. In control slices, electrical high-frequency conditioning stimulation (CS) could reliably induce LTP. In contrast,
the same CS protocol resulted in long-term depression when HFMS was delivered to the slice 30 min prior to the electrical stimulation. HFMS-primingwas diminishedwhen applied in the presence of themetabotropic glutamate receptor antagonists (RS)-
𝛼-methylserine-O-phosphate (MSOP) and (RS)-𝛼-methyl-4-carboxyphenylglycine (MCPG).Moreover,whenHFMSwas delivered in the presence of the NMDA receptor-antagonist D-2-amino-5-phosphonovalerate (50 𝜇M), CS-induced electrical LTP was again as high as under control conditions in slices without priming. These results demonstrate that HFMS significantly reduced the propensity of subsequent electrical LTP and show that both metabotropic glutamate and NMDA receptor activation were involved
in this form of HFMS-induced metaplasticity.
http://nur.nu.edu.kz/handle/123456789/1132
high-frequency magnetic stimulation
receptor-dependent metaplasticity
metaplasticity
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulation
oai:nur.nu.edu.kz:123456789/11332018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Guli, Xiati
author
Tokay, Tursonjan
author
Kirschstein, Timo
author
Köhling, Rüdiger
author
2015-11-15
N-Methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) can be reversed by low-frequency stimulation (LFS) referred to as depotentiation (DP). We previously found GluN2B upregulated in CA1 neurons from post-status epilepticus
(post-SE) tissue associated with an enhanced LTP. Here,we testedwhether LFS-inducedDP is also altered in pathologicalGluN2B upregulation. Although LTP was enhanced in post-SE tissue, LTP was significantly reversed in this tissue, but not in controls. We next tested the effect of the GluN2B subunit-specific blocker Ro 25-6981 (1 𝜇M) on LFS-DP. As expected, LFS had no effect on synaptic strength in the presence of the GluN2B blocker in control tissue. In marked contrast, LFS-DP was also attained in
post-SE tissue indicating that GluN2B was obviously not involved in depotentiation. To test for NMDA receptor-dependence, we applied the NMDA receptor antagonist D-AP5 (50 𝜇M) prior to LFS and observed that DPwas abolished in both control and post-
SE tissue confirming NMDA receptor involvement. These results indicate that control Schaffer collateral-CA1 synapses cannot be depotentiated after fully established LTP, but LFS was able to reverse LTP significantly in post-SE tissue. However, while LFS-DP
clearly requiredNMDA receptor activation, GluN2B-containingNMDA receptors were not involved in this formof depotentiation
http://nur.nu.edu.kz/handle/123456789/1133
N-Methyl-D-aspartate
Epilepticus
Epilepticus enhances depotentiation
Research Subject Categories::MEDICINE
Status epilepticus enhances depotentiation after fully established LTP in an NMDAR-Dependent but GluN2B-independent manner
oai:nur.nu.edu.kz:123456789/11342018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Mayer, Johannes
author
Reichart, Gesine
author
Tokay, Tursonjan
author
Lange, Falko
author
Baltrusch, Simone
author
Junghanss, Christian
author
Wolkenhauer, Olaf
author
Jaster, Robert
author
Kunz, Manfred
author
Tiedge, Markus
author
Ibrahim, Saleh
author
Fuellen, Georg
author
Köhling, Rüdiger
author
2015-04-15
Large-scale, heteroplasmic and generally pathogenic mtDNA defects (as induced by defective mitochondrial DNA polymerase, clonal mutations or DNA deletions) are known to negatively impact on life span and can result in apoptosis and tissue loss in, e.g., skeletal muscle or reduce learning abilities. The functional impact of homoplasmic specific mtDNA point mutations, e.g., in genes coding for the electron transport chain, however, remains a matter of debate. The present study contributes to this discussion and provides evidence that a single point mutation in complex I of the respiratory chain is associated with impairment of spatial navigation in adolescent (6-month-old) mice, i.e., reduced performance in the Morris Water Maze, which goes along with increased production of reactive oxygen species (ROS) in juvenile mice (3 months) but not at the age of phenotype expression. A point mutation in complex III goes along with only a mild and non-significant negative effect on cognitive performance and no significant changes in ROS production. These findings suggest to also consider the ontogenetic development of phenotypes when studying mtDNA mutations and highlights a possible impact of complex I dysfunction on the emergence of neurological deficits.
Mayer J, Reichart G, Tokay T, Lange F, Baltrusch S, Junghanss C, et al. (2015) Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants. PLoS ONE 10(4): e0123863. doi:10.1371/journal.pone.0123863
http://nur.nu.edu.kz/handle/123456789/1134
Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants
oai:nur.nu.edu.kz:123456789/11352018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Valente, André
author
Adilbayeva, Altynai
author
Tokay, Tursonjan
author
Rizvanov, Albert A.
author
2015-08-19
Various recent developments of relevance to Parkinson's disease (PD) are discussed and integrated into a comprehensive hypothesis on the nature, origin and inter-cellular mode of propagation of late-onset sporadic PD. We propose to define sporadic PD as a characteristic pathological deviation in the global gene expression program of a cell: the PD expression-state, or PD-state for short. Although a universal cell-generic state, the PD-state deviation would be particularly damaging in a neuronal context, ultimately leading to neuron death and the ensuing observed clinical signs. We review why age accumulated damage caused by oxidative stress in mitochondria could be the trigger for a primordial cell to shift to the PD-state. We put forward hematopoietic cells could be the first to acquire the PD-state, at hematopoiesis, from the disruption in reactive oxygen species (ROS) homeostasis that arises with age in the hematopoietic
stem-cell niche. We argue why, nonetheless, such a process is unlikely to explain the shift to the PD-state of all the subsequently affected cells in a patient, thus indicating the existence of a distinct mechanism of propagation of the PD-state. We highlight recent findings on the intercellular exchange of mitochondrial DNA and the ability of mitochondrial DNA to modulate the cellular global gene expression state and propose this could form the basis for the intercellular propagation of the PD-state.
http://nur.nu.edu.kz/handle/123456789/1135
The universal non-neuronal nature of parkinson's disease: a theory
oai:nur.nu.edu.kz:123456789/11362018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Guli, Xiati
author
Tokay, Tursonjan
author
Rohde, Marco
author
Bender, Roland A.
author
Kohling, Rudiger
author
Kirschstein, Timo
author
2012-05-08
Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression
(LTD) at the medial perforant path-granule cell synapse in early postnatal (P9–15) and adult (P30–60) rats. LTD was elicited
in P9–15 slices using low-frequency stimulation (LFS, 900 pulses, 1Hz; 80 ± 4% of baseline). Application of the specific HCN
channel blocker ZD7288 (10 μM) before LFS significantly enhanced LTD (62 ± 4%; P < 0.01), showing HCN channels restrain LTD induction. However, when ZD7288 was applied after LFS, LTD was similar to control values and significantly different from
the values obtained with ZD7288 application before LFS (81 ± 5%; P < 0.01), indicating that HCN channels do not modulate
LTD expression. LTD in slices from adult rats were only marginally lower compared to those in P9–15 slices (85 ± 6%), but bath
application of ZD7288 prior to LFS resulted in the same amount of LTD (85 ± 5%). HCN channels in adult tissue hence lose their modulatory effect. In conclusion, we found that HCN channels at the medial perforant path-granule cell synapse compromise
LFS-associated induction, but not expression of LTD in early postnatal, but not in adult, rats.
Xiati Guli, Tursonjan Tokay, Marco Rohde, Roland A. Bender, Rüdiger Köhling, and Timo Kirschstein, “ZD7288 Enhances Long-Term Depression at Early Postnatal Medial Perforant Path-Granule Cell Synapses,” Neural Plasticity, vol. 2012, Article ID 237913, 9 pages, 2012. doi:10.1155/2012/237913
http://nur.nu.edu.kz/handle/123456789/1136
depression
nucleotide-gated nonselective
cell synapse
Research Subject Categories::MEDICINE
ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses
oai:nur.nu.edu.kz:123456789/11722018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Askarova, Sholpan
author
Sun, Zhe
author
Sun, Grace Y.
author
Meininger, Gerald A.
author
Lee, James C-M.
author
2013-04-12
Increased deposition of amyloid-b peptide (Ab) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer’s disease (AD). In this study, quantitative immunofluorescence microscopy (QIM) and atomic force microscopy (AFM) with cantilevers biofunctionalized
by sialyl-Lewisx (sLex) were employed to investigate Ab-altered mechanics of membrane tethers formed by bonding
between sLex and p-selectin at the CEC surface, the initial mechanical step governing the transmigration of monocytes. QIM results indicated the ability for Ab to increase p-selectin expression at the cell surface and promote actin polymerization in both bEND3 cells (immortalized mouse CECs) and human primary CECs. AFM data also showed the ability for Ab to increase cell stiffness and adhesion probability in bEND3 cells. On the contrary, Ab lowered the overall force of membrane tether formation (Fmtf), and produced a bimodal population of Fmtf, suggesting subcellular mechanical alterations in membrane tethering. The lower Fmtf population was similar to the results obtained from cells treated with an F-actin-disrupting drug, latrunculin A. Indeed, AFM results also showed that both Ab and latrunculin A decreased membrane stiffness, suggesting a
lower membrane-cytoskeleton adhesion, a factor resulting in lower Fmtf. In addition, these cerebral endothelial alterations induced by Ab were abrogated by lovastatin, consistent with its anti-inflammatory effects. In sum, these results demonstrated the ability for Ab to enhance p-selectin expression at the CEC surface and induce cytoskeleton
reorganization, which in turn, resulted in changes in membrane-cytoskeleton adhesion and membrane tethering, mechanical factors important in transmigration of monocytes through the BBB.
Askarova S, Sun Z, Sun GY, Meininger GA, Lee JC-M (2013) Amyloid-b Peptide on Sialyl-LewisX-Selectin-Mediated Membrane Tether Mechanics at the Cerebral Endothelial Cell Surface. PLoS ONE 8(4): e60972. doi:10.1371/journal.pone.0060972
http://nur.nu.edu.kz/handle/123456789/1172
Amyloid-b
sialyl-lewisX-selectin-mediated membrane
cerebral endothelial cell surface
Alzheimer’s disease
neurodegenerative disease
Amyloid-b peptide on sialyl-LewisX-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface
oai:nur.nu.edu.kz:123456789/11732018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Askarova, Sholpan
author
Tsoy, Andrey
author
Shalakhmetova, Tamara
author
Lee, James C-M.
author
2012
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the neurons, and progressive deterioration of cognition and memory of affected individuals. Although the cause and progression of AD are still not well understood, the amyloid hypothesis is dominant and widely accepted. According to this hypothesis, an increased deposition of amyloid-β peptide (Aβ) in the brain is the main cause of the AD’s onset and progression. There is increasing body of evidence that blood-brain barrier (BBB) dysfunction plays an important role in the development of AD, and may even precede neuron degeneration in AD brain. In the early stage of AD, microvasculature deficiencies, inflammatory reactions, surrounding the cerebral vasculature and endothelial dysfunctions are commonly observed. Continuous neurovascular degeneration and accumulation of Aβ on blood vessels resulting in cerebral amyloid angiopathy is associated with further progression of the disease and cognitive decline. However, little is known about molecular mechanisms that underlie Aβ induced damage of neurovascular cells. In this regards, this review is aimed to address how Aβ impacts the cerebral endothelium. Understanding the cellular pathways triggered by Aβ leading to alterations in cerebral endothelial cells structure and functions would provide insights into the mechanism of BBB dysfunction and inflammatory processes in Alzheimer’s, and may offer new approaches for prevention and treatment strategies for AD.
http://nur.nu.edu.kz/handle/123456789/1173
amyloid-beta petide
Alzheimer’s disease
Research Subject Categories::MEDICINE
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Effects of amyloid beta peptide on neurovascular cells
oai:nur.nu.edu.kz:123456789/11752018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Askarova, Sholpan
author
Yang, Xiaoguang
author
Lee, James C-M.
author
2011-01-21
An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact with membranes of neurons and
other cerebral cells. Aβ is derived from amyloidogenic cleavage of amyloid precursor protein (AβPP) by β- and γ-secretase. In the nonamyloidogenic pathway, AβPP is cleaved by α-secretases. These two pathways compete with each other, and enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological approach for the treatment of AD. Since AβPP, α-, β-, and γ-secretases are membrane-associated proteins, AβPP processing and Aβ production can be affected by the membrane composition and properties. There is evidence that membrane composition and properties, in turn, play a critical role in Aβ cytotoxicity associated with its conformational changes and aggregation into oligomers and fibrils. Understanding themechanisms leading to changes in a membrane’s biophysical properties and how they affect AβPP processing and Aβ toxicity should prove to provide new therapeutic strategies for prevention and treatment of AD.
http://nur.nu.edu.kz/handle/123456789/1175
Research Subject Categories::TECHNOLOGY::Bioengineering
regenerative medicine
Research Subject Categories::MEDICINE::Physiology and pharmacology::Physiology::Neurophysiology
Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes
oai:nur.nu.edu.kz:123456789/11772018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Yang, Xiaoguang
author
Askarova, Sholpan
author
Sheng, Wenwen
author
Chen, JK
author
Sun, Albert Y.
author
Sun, Grace Y.
author
Yao, Gang
author
Leea, James C-M.
author
2010-09-25
Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, oligomeric Aβ induces the assembly of NADPH oxidase complexes resulting in its activation to produce anionic superoxide. Aβ also promotes production of pro-inflammatory factors in astrocytes. Since low energy laser has previously been reported to attenuate oxidative stress and inflammation in biological systems, the objective of this study was to examine whether this type of laser light was able to abrogate the oxidative and inflammatory responses induced by Aβ. Primary rat astrocytes were exposed to Helium-Neon laser (λ=632.8 nm), followed by the treatment with oligomeric Aβ. Primary rat astrocytes were used to measure Aβ-induced production of superoxide anions using fluorescence microscopy of dihydroethidium (DHE), assembly of NADPH oxidase subunits by the colocalization between the cytosolic p47phox subunit and the membrane gp91phox subunit using fluorescent confocal microscopy, phosphorylation of cytosolic phospholipase A2 (cPLA2), and expressions of pro-inflammatory factors including interleukin-1β (IL-1β) and inducible nitric-oxide synthase (iNOS) using Western blot Analysis. Our data showed that laser light at 632.8 nm suppressed Aβ-induced superoxide production, colocalization between NADPH oxidase gp91phox and p47phox subunits, phosphorylation of cPLA2, and the expressions of IL-1β and iNOS in primary astrocytes. We demonstrated for the first time that 632.8 nm laser was capable of suppressing cellular pathways of oxidative stress and inflammatory responses critical in the pathogenesis in AD. This study should prove to provide the groundwork for further investigations for the potential use of laser therapy as a treatment for AD.
http://nur.nu.edu.kz/handle/123456789/1177
phospholipase A2
interleukin-1β
iNOS
NADPH oxidase
oxidative stress
phosphorylation
inflammation
Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes
oai:nur.nu.edu.kz:123456789/11792018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Yang, Xiaoguang
author
Askarova, Sholpan
author
Lee, James C-M.
author
2010-05-01
Alzheimer's disease is a chronic neurodegenerative
disorder characterized by neuronal loss, cerebrovascular
inflammation, and accumulation of senile plaques in the
brain parenchyma and cerebral blood vessels. Amyloid-β
peptide (Aβ), a major component of senile plaques, has
been shown to exert multiple toxic effects to neurons,
astrocytes, glial cells, and brain endothelium. Oligomeric
Aβ can disturb the structure and function of cell membranes
and alter membrane mechanical properties, such as
membrane fluidity and molecular order. Much of these
effects are attributed to their capability to trigger oxidative
stress and inflammation. In this review, we discuss the
effects of Aβ on neuronal cells, astrocytes, and cerebral
endothelial cells with special emphasis on cell membrane
properties and cell functions.
http://nur.nu.edu.kz/handle/123456789/1179
Amyloid-β
Alzheimer's disease
membrane properties
membrane order
membrane fluidity
membrane potential
cerebral endothelium
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Membrane biophysics and mechanics in Alzheimer's disease
oai:nur.nu.edu.kz:123456789/11802018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Askarova, Sholpan
author
Yang, Xiaoguang
author
Sheng, Wenwen
author
Sun, Grace Y.
author
Lee, James C-M.
author
2012-12-29
Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers (Aβ42) have been reported to mediate oxidative damage to the CECs and astrocytes and trigger the downstream mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, the cell surface binding site for Aβ42 and exact sequence of these events have yet to be elucidated. In this study, the receptor for advanced glycation endproducts (RAGE) was postulated to function as a signal transducing cell surface receptor for Aβ42 to induce reactive oxygen species (ROS) generation from NADPH oxidase and trigger downstream pathways for the phosphorylation of extracellular signal-regulated kinases (ERK1/2) and cytosolic phospholipase A2 (cPLA2). We found that Aβ42 competed with the anti-RAGE antibody (AbRAGE) to bind to RAGE on the surfaces of CECs and primary astrocytes. In addition, AbRAGE abrogate Aβ42-induced ROS production and the colocalization between the cytosolic (p47-phox) and membrane (gp91-phox) subunits of NADPH oxidase in both cell types. AbRAGE as well as NADPH oxidase inhibitor and ROS scavenger suppressed Aβ42-induced ERK1/2 and cPLA2 phosphorylation in CECs. At the same time, only AbRAGE, but neither NADPH oxidase inhibitor nor ROS scavenger, inhibited the ERK1/2 pathway and cPLA2 phosphorylation in primary astrocytes. Therefore, this study demonstrates that NADPH oxidase complex assembly and ROS production are not required for Aβ42 binding to RAGE at astrocytic surface leading to sequential phosphorylation of ERK1/2 and cPLA2, and suggests the presence of two different RAGE-dependent downstream pathways in the CECs and astrocytes.
http://nur.nu.edu.kz/handle/123456789/1180
Aβ-receptor
oxidative stress
cerebral endothelial cells
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells
oai:nur.nu.edu.kz:123456789/11812018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Zhu, Donghui
author
Bungart, BrittaniL
author
Yang, Xiaoguang
author
Zhumadilov, Zhaxybay
author
Lee, James C-M.
author
Askarova, Sholpan
author
2015-05-27
P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the
development and progression of Alzhemer’s disease. In this study we have evaluated the effects of Aβ42 oligomers on P-selectin expression and actin polymerization in mouse endothelial cells (bEnd3).
Our results indicated that Aβ42 induced plasma membrane accumulation of P-selectin and promoted actin polymerization, and these events were correlated with increased reactive oxygen species (ROS) generation. The rapid, posttranslational cell signaling response mediated by ROS may well represent an important physiological trigger of the microvascular inflammation in Alzheimer disease.
Zhu D,BungartBL,YangX, ZhumadilovZ,LeeJC-Mand Askarova S(2015)Roleofmembrane biophysics inAlzheimer’s–relatedcell pathways. Front.Neurosci.9:186. doi: 10.3389/fnins.2015.00186
http://nur.nu.edu.kz/handle/123456789/1181
amyloid-b peptide
membrane molecular order
amyloid precursor protein
membrane fluidity
cerebral endothelium
Role of membrane biophysics in Alzheimer’s–related cell pathways
oai:nur.nu.edu.kz:123456789/12512018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Stepanenko, Valeriy F.
author
2005-03-09
The paper is an analytical overview of the main results presented at the 3
rd Dosimetry Workshop in Hiroshima (9–11 of March 2005), where different aspects of the dose reconstruction around the Semipalatinsk nuclear test site (SNTS) were discussed and summarized.
http://nur.nu.edu.kz/handle/123456789/1251
Semipalatinsk nuclear
Semipalatinsk nuclear test site
Hiroshima University
Research Subject Categories::MEDICINE
Research Subject Categories::TECHNOLOGY::Chemical engineering::Chemical process and manufacturing engineering::Nuclear chemistry
Around Semipalatinsk nuclear test site: progress of dose estimations relevant to the consequences of nuclear tests
oai:nur.nu.edu.kz:123456789/12522018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Balanovsky, Oleg
author
Zhabagin, Maxat
author
Agdzhoyan, Anastasiya
author
Chukhryaeva, Marina
author
Zaporozhchenko, Valery
author
Utevska, Olga
author
Highnam, Gareth
author
Sabitov, Zhaxylyk
author
Greenspan, Elliott
author
Dibirova, Khadizhat
author
Skhalyakho, Roza
author
Kuznetsova, Marina
author
Koshel, Sergey
author
Yusupov, Yuldash
author
Nymadawa, Pagbajabyn
author
Zhumadilov, Zhaxybay
author
Pocheshkhova, Elvira
author
Haber, Marc
author
Zalloua, Pierre A.
author
Yepiskoposyan, Levon
author
Dybo, Anna
author
Tyler-Smith, Chris
author
Balanovska, Elena
author
2015-04-07
Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South-
West and Central Asia but reaches up to 80% frequency in some populations scattered
within this area. We have genotyped the G1-defining marker M285 in 27 Eurasian populations (n= 5,346), analyzed 367 M285-positive samples using 17 Y-STRs, and sequenced ~11 Mb of the Y-chromosome in 20 of these samples to an average coverage of 67X. This allowed detailed phylogenetic reconstruction. We identified five branches, all with high geographical specificity: G1-L1323 in Kazakhs, the closely related G1-GG1 in Mongols, G1- GG265 in Armenians and its distant brother clade G1-GG162 in Bashkirs, and G1-GG362 in West Indians.
Balanovsky O, Zhabagin M, Agdzhoyan A, Chukhryaeva M, Zaporozhchenko V, Utevska O, et al. (2015) Deep Phylogenetic Analysis of Haplogroup G1 Provides Estimates of SNP and STR Mutation Rates on the Human Y-Chromosome and Reveals Migrations of Iranic Speakers. PLoS ONE 10(4): e0122968. doi:10.1371/journal.pone.0122968
http://nur.nu.edu.kz/handle/123456789/1252
Y-chromosomal haplogroup
haplogroup G1
SNP and STR Mutation Rates
Deep phylogenetic analysis of haplogroup G1 provides estimates of SNP and STR utation rates on the human Y-Chromosome and reveals migrations of Iranic speakers
oai:nur.nu.edu.kz:123456789/12532018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Drozdovitch, Vladimir
author
Schonfeld, Sara
author
Akimzhanov, Kuat
author
Aldyngurov, Daulet
author
Land, Charles E.
author
Luckyanov, Nickolas
author
Mabuchi, Kiyohiko
author
Potischman, Nancy
author
J. Schwerin, Michael J.
author
Semenova, Yulia
author
Tokaeva, Alma
author
Zhumadilov, Zhaxybay
author
Bouville, André
author
Simon, Steven L.
author
2011-03
The relationship between radiation exposure from nuclear weapons testing fallout and thyroid disease in a group of 2,994 subjects has been the subject of study by the US National Cancer Institute. In that study, radiation doses to the thyroid were estimated for residents of villages in Kazakhstan possibly exposed to deposition of radioactive fallout from nuclear testing conducted by the Soviet Union at the Semipalatinsk Nuclear Test Site in Kazakhstan between 1949 and 1962. The study subjects included individuals of both Kazakh and Russian origin who were exposed during childhood and adolescence. An initial dose reconstruction used for the risk analysis of Land et al. (Radiat Res 169:373-383, 2008) was based on individual information collected from basic questionnaires administered to the study population in 1998. However, because data on several key questions for accurately estimating doses were not obtained from the 1998 questionnaires, it was decided to conduct a second data collection campaign in 2007. Due to the many years elapsed since exposure, a well-developed strategy was necessary to encourage accurate memory recall.
The publisher's final edited version of this article is available at Radiat Environ Biophys DOI 10.1007/s00411-010-0334-9
http://nur.nu.edu.kz/handle/123456789/1253
Semipalatinsk nuclear test site in Kazakhstan
Semipalatinsk nuclear
Research Subject Categories::MEDICINE
Behavior and food consumption pattern of the population exposed in 1949–1962 to fallout from Semipalatinsk nuclear test site in Kazakhstan
oai:nur.nu.edu.kz:123456789/12832018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Catanzaro, R.
author
Zerbinati, N.
author
Solimene, U.
author
Celep, G.
author
Marotta, F.
author
Kushugulova, A.
author
Milazzo, M.
author
Tomella, C.
author
Bertuccelli, G.
author
Zhumadilov, Z.
author
2013
The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in the HepG2 human liver cancer cell
line. Celergen significantly inhibited the proliferation of cancer cells in a dose-dependent manner while limiting the cell cycle progression at the G1 phase and
significantly inducing apoptosis. Further examination showed that Celergen enhanced expression of the p21CIPl1WAF1, GADD153 genes and downregulated the
c-myc gene. These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.
DOI: 10.5582/ddt.2013.v7.5.196
http://nur.nu.edu.kz/handle/123456789/1283
antimutagenic effect
cell cycle
apoptosis
celergen
marine compound
Research Subject Categories::MEDICINE
Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis
oai:nur.nu.edu.kz:123456789/12842018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Zhumadilov, Zhaxybay
author
Kozhakhmetov, Samat S.
author
Kushugulova, Almagul R.
author
Saduakhasova, Saule A.
author
Shakhabayeva, Gulnara S.
author
Khassenbekova, Zhanagul R.
author
Molkenov, Askhat B.
author
Kairov, Ulykbek E.
author
Issayeva, Raushan B.
author
Nurgozhin, Talgat S.
author
2015
The human gut microbiome is an organ that provides primary
barrier protection against foreign agents. Most of the microorganisms
are different strains of commensal bacteria that are colonized in the gut. Gut flora influence food metabolism and have an antagonistic effect on different pathogens and immunomodulatory properties (1). One of the main species of gut flora is
in the genus Lactobacillus...
Kozhakhmetov SS, Kushugulova AR, Saduakhasova SA, Shakhabayeva GS, Khassenbekova ZR, Molkenov AB, Kairov UE, Issayeva RB, Nurgozhin TS, Zhumadilov ZS. 2015. Draft genome sequence of Lactobacillus rhamnosus CLS17. Genome Announc 3(3):e00478-15. doi:10.1128/genomeA.00478-15.
http://nur.nu.edu.kz/handle/123456789/1284
lactobacillus
genome sequence
microbiome
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
Draft genome sequence of Lactobacillus rhamnosus CLS17
oai:nur.nu.edu.kz:123456789/12852018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Zhumadilov, Kassym
author
Ivannikov, Alexander
author
Stepanenko, Valeriy
author
Zharlyganova, Dinara
author
Toyoda, Shin
author
Zhumadilov, Zhaxybay
author
Hoshi, Masaharu
author
2013-02
A tooth enamel electron spin resonance (ESR) dosimetry study was carried out with the purpose of obtaining the individual absorbed radiation doses of population from settlements in the Semipalatinsk region of Kazakhstan, which was exposed to radioactive fallout traces from nuclear explosions in the Semipalatinsk Nuclear Test Site and Lop Nor test base, China. Most of the settlements are located near the central axis of
radioactive fallout trace from the most contaminating surface nuclear test, which was conducted on 29 August 1949, with the maximum detected excess dose being 430 ± 93 mGy. A maximum dose of 268 ± 79 mGy was determined from the settlements located close to radioactive fallout trace resulting from surface nuclear tests on 24 August 1956 (Ust-Kamenogorsk, Znamenka, Shemonaikha, Glubokoe, Tavriya
and Gagarino). An accidental dose of 56 ± 42 mGy was found in Kurchatov city residents located close to fallout trace after the nuclear test on 7 August 1962. This method was applied to human tooth enamel to obtain individual absorbed doses of residents of the Makanchi, Urdzhar and Taskesken settlements located near the Kazakhstan–Chinese border due to the influence of nuclear tests (1964–1981) at Lop Nor. The
highest dose was 123 ± 32 mGy.
doi: 10.1093/jrr/rrt008
http://nur.nu.edu.kz/handle/123456789/1285
ESR dosimetry
tooth enamel samples
Semipalatinsk Test Site
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
ESR dosimetry study of population in the vicinity of the Semipalatinsk Nuclear Test Site
oai:nur.nu.edu.kz:123456789/12862018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Takeichi, Nobuo
author
Hoshi, Masaharu
author
Iida, Shozo
author
Tanaka, Kimio
author
Harada, Yuka
author
Zhumadilov, Zhaxybay
author
Chaizhunusova, Nailya
author
Apsalikov, Kazbek N.
author
Noso, Yoshihiro
author
Inaba, Toshiya
author
Tanaka, Kenichi
author
Endo, Satoru
author
2006
Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52–63 years old, were performed in 2001–2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village,
Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in
peripheral lymphocytes and on the follicular cells in the thyroid.
http://nur.nu.edu.kz/handle/123456789/1286
Semipalatinsk nuclear test site
thyroid cells
apparent nuclear abnormalities
chromosome aberrations
radiation effect
Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk Nuclear Test Site
oai:nur.nu.edu.kz:123456789/12872018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Kairov, Ulykbek E.
author
Kozhamkulov, Ulan
author
Molkenov, Askhat
author
Rakhimova, Saule
author
Askapuli, Ayken
author
Zhabagin, Maxat
author
Akhmetova, Ainur
author
Yerezhepov, Dauren
author
Abilova, Zhannur
author
Abilmazhinova, Aliya
author
Bismilda, Venera
author
Chingisova, Leila
author
Akilzhanova, Ainur
author
Zhumadilov, Zhaxybay
author
2015
Here, we report the draft genome sequences of two clinical isolates of Mycobacterium tuberculosis (MTB-476 and MTB-489) isolated
from sputum of Kazakh patients.
Kairov U, Kozhamkulov U, Molkenov A, Rakhimova S, Askapuli A, Zhabagin M, Akhmetova A, Yerezhepov D, Abilova Z, Abilmazhinova A, Bismilda V, Chingisova L, Zhumadilov Z, Akilzhanova A. 2015. Draft genome sequences of two clinical isolates of Mycobacterium tuberculosis from sputum of Kazakh patients. Genome Announc 3(3): e00466-15. doi:10.1128/genomeA.00466-15.
http://nur.nu.edu.kz/handle/123456789/1287
genome sequences
mycobacterium tuberculosis
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
Draft genome sequences of two clinical Isolates of mycobacterium tuberculosis from sputum of Kazakh patients
oai:nur.nu.edu.kz:123456789/12892018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Supiyev, Adil
author
Nurgozhin, Talgat
author
Zhumadilov, Zhaxybay
author
Sharman, Almaz
author
Marmot, Michael
author
Bobak, Martin
author
2014
The high and fluctuating mortality and rising health inequalities in post-Soviet countries have attracted considerable attention. However, there are very few individual-level data on distribution of health outcomes in Central Asian countries of the former Soviet Union. We analysed socioeconomic predictors of two self-rated health outcomes in a national survey in Kazakhstan.
http://www.biomedcentral.com/1471-2458/14/768
http://nur.nu.edu.kz/handle/123456789/1289
self-rated health
socioeconomic factors
Central Asian countries
Research Subject Categories::MEDICINE
Levels and distribution of self-rated health in the Kazakh population: results from the Kazakhstan household health survey 2012
oai:nur.nu.edu.kz:123456789/12902018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Zhumadilov, Kassym
author
Ivannikov, Alexander
author
Skvortsov, Valeriy
author
Stepanenko, Valeriy
author
Zhumadilov, Zhaxybay
author
Endo, Satoru
author
Tanaka, Kenichi
author
Hoshi, Masaharu
author
2005
conditions were optimized. The uncertainty of dose determination was obtained as the mean square deviation of doses, determined with the use of a spectra deconvolution program, from the nominal doses for ten enamel samples irradiated in the range from 0 to 500 mGy. The spectra were recorded at different microwave powers and accumulation times. It was shown that minimal uncertainty is achieved at the microwave power of about 2 mW for a used spectrometer JEOL JES-FA100. It was found that a limit of the accumulation time exists beyond which uncertainty reduction is ineffective. At an established total time of measurement, reduced uncertainty is obtained by averaging the experimental doses determined from recorded spectra following intermittent sample shaking and sample tube rotation, rather than from one spectrum recorded at longer accumulation time. The effect of sample mass on the spectrometer’s sensitivity
was investigated in order to find out how to make appropriate corrections.
http://nur.nu.edu.kz/handle/123456789/1290
EPR spectroscopy
tooth enamel
dose determination
Research Subject Categories::MEDICINE
Tooth enamel EPR dosimetry: optimization of EPR spectra recording parameters and effect of sample mass on spectral sensitivity
oai:nur.nu.edu.kz:123456789/12912018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Akilzhanova, Ainur
author
Guelly, Christian
author
Nuralinov, Omirbek
author
Nurkina, Zhannur
author
Nazhat, Dinara
author
Smagulov, Shalkhar
author
Tursunbekov, Azat
author
Alzhanova, Anar
author
Rashbayeva, Gulzhaina
author
Abdrakhmanov, Ayan
author
Dosmagambet, Sholpan
author
Trajanoski, Slave
author
Zhumadilov, Zhaxybay
author
Sharman, Almaz
author
Bekbosynova, Mahabbat
author
2014
Channelopathies, caused by disturbed potassium or calcium ion management in cardiac myocytes are a major cause of heart failure and sudden cardiac death worldwide. The human ryanodine receptor 2 (RYR2) is one of the key players tightly regulating calcium efflux from the sarcoplasmic reticulum to the cytosol and found frequently mutated (,60%) in context of catecholaminergic polymorphic ventricular tachycardia (CPVT1). We tested 35 Kazakhstani patients with episodes of ventricular arrhythmia, two of those with classical CPVT characteristics and 33 patients with monomorphic idiopathic
ventricular arrhythmia, for variants in the hot-spot regions of the RYR2 gene. This approach revealed two novel variants; one de-novo RYR2 mutation (c13892A.T; p.D4631V) in a CPVT patient and a novel rare variant (c5428G.C; p.V1810L) of
uncertain significance in a patient with VT of idiopathic origin which we suggest represents a low-penetrance or susceptibility variant. In addition we identified a known variant previously associated with arrhythmogenic right ventricular
dysplasia type2 (ARVD2). Combining sets of prediction scores and reference databases appeared fundamental to predict the pathogenic potential of novel and rare missense variants in populations where genotype data are rare.
Akilzhanova A, Guelly C, Nuralinov O, Nurkina Z, Nazhat D, et al. (2014) RYR2 Sequencing Reveals Novel Missense Mutations in a Kazakh Idiopathic Ventricular Tachycardia Study Cohort. PLoS ONE 9(6): e101059. doi:10.1371/journal.pone.0101059
http://nur.nu.edu.kz/handle/123456789/1291
RYR2 sequencing
human ryanodine receptor
ventricular arrhythmia
Tachycardia
RYR2 sequencing reveals novel missense mutations in a Kazakh Idiopathic ventricular tachycardia study cohort
oai:nur.nu.edu.kz:123456789/12922018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Zhumadilov, Zhaxybay
author
GUSEV, BORIS I.
author
TAKADA, JUN
author
HOSHI, Masaharu
author
Kimura, AKIRO
author
Hayakawa, Norihiko
author
Takeichi, Nobuo
author
2000
From 1949 through 1989 nuclear weapons testing carried out by the former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) resulted in local fallout affecting the residents of Semipalatinsk, Ust-Kamenogorsk and Pavlodar regions of Kazakstan. To investigate the possible relationship between radiation exposure and thyroid gland abnormalities, we conducted a case review of pathological findings of 7271 urban and rural patients who underwent surgery from 1966–96. Of the 7271 patients, 761
(10.5%) were men, and 6510 (89.5%) were women...
http://nur.nu.edu.kz/handle/123456789/1292
nuclear weapon testing
Semipalatinsk
thyroid abnormalities
pathological specimens
radiationinduced neoplasms
Research Subject Categories::MEDICINE
Thyroid abnormality trend over time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site: a case review of pathological findings for 7271 patients
oai:nur.nu.edu.kz:123456789/12932018-01-29T21:17:56Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
2016
The method of electron paramagnetic resonance (EPR) spectroscopy for tooth enamel is applied to individual radiation dose determination to residents of two villages (Dolon and Mostik) in the vicinity of the Semipalatinsk nuclear test site in Kazakhstan. These villages are located near the central axis of the radioactive fallout trace of the most contaminating surface nuclear test conducted in 1949. It is found that excess doses obtained by subtraction of natural background dose from dose absorbed in enamel range up
to 440 mGy to residents of Dolon, whose enamel was formed before 1949, and do not exceed 120 mGy to younger residents. To residents of Mostik, excess doses do not exceed 100 mGy regardless of age except for one resident with an extremely high dose of 1.25 Gy. These results are in agreement with the pattern of radioactive contamination of the territory after the nuclear test of 1949 except one case of extremely high dose, which should be additionally investigated.
http://nur.nu.edu.kz/handle/123456789/1293
EPR spectroscopy
tooth enamel
Dose reconstruction
Semipalatinsk nuclear test site
Results of EPR dosimetry for population in the vicinity of the most contaminating radioactive fallout trace after the first nuclear test in the Semipalatinsk Test Site
oai:nur.nu.edu.kz:123456789/12942018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Terlikbayeva, Assel
author
Hermosilla, Sabrina
author
Galea, Sandro
author
Schluger, Neil
author
Yegeubayeva, Saltanat
author
Abildayev, Tleukhan
author
Muminov, Talgat
author
Akiyanova, Farida
author
Bartkowiak, Laura
author
Zhumadilov, Zhaxybay
author
Sharman, Almaz
author
El-Bassel, Nabila
author
2012
Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan.
http://nur.nu.edu.kz/handle/123456789/1294
tuberculosis
case notification rate
prevalence
risk factors
MDR-TB
Kazakhstan
spatial distribution
surveillance
National tuberculosis program
Oblast
Research Subject Categories::MEDICINE
Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data
oai:nur.nu.edu.kz:123456789/13012018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Mussin (Мусин), Y.A. (Е.А.)
author
Bulanin (Буланин), D.S. (Д.С.)
author
Jeffries (Джеффрис), R.G. (Р.Дж.)
author
Zhumadilov (Жумадилов), Zhaxybay (Ж.Ш.)
author
Olzhayev, F.
author
Federspiel (Федерспил), W.J. (В.Дж.)
author
2014
Основной целью данной работы является получение первичных данных о нагнетательной способности гемопомпы устройства Hemolung и способности обеспечить адекватный уровень газообмена при использовании катетеров уменьшенного диаметра и скорости кровообращения, применимой у детей.
The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using the catheters of smaller diameter and blood fl ow rates, applied in pediatrics.
Мусин Е.А., Буланин Д.С., Джеффрис Р.Д., Жумадилов Ж.Ш., Олжаев Ф.С., Федерспил В.Д. ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ. Вестник трансплантологии и искусственных органов. 2014;16(4):125-134. DOI:10.15825/1995-1191-2014-4-125-134
http://nur.nu.edu.kz/handle/123456789/1301
severe respiratory failure
extracorporeal gas exchange
oxygenation
pediatrics
тяжелая дыхательная недостаточность
экстракорпоральный газообмен
педиатрия
оксигенация
Research Subject Categories::MEDICINE
EVALUATION OF EXTRACORPOREAL GAS EXCHANGE DEVICE HEMOLUNG FOR POTENTIAL APPLICATION IN PEDIATRIC PRACTICE/ ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ
oai:nur.nu.edu.kz:123456789/13022018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Pichugin, Vladimir
author
Melnikov, Nikolay
author
Olzhayev, F.
author
Medvedev, Alexander
author
Jourko, Sergey
author
Gamzaev, Alishir
author
Chiginev, Vladimir
author
2014
Cardioplegic cardiac arrest with subsequent ischemic-reperfusion injuries can lead to the development of inflammation of the myocardium, leucocyte activation, and release of cardiac enzymes. Flow reduction to the bronchial arteries, causing low-flow lung ischemia, leads to the development of a pulmonary regional inflammatory response...
http://nur.nu.edu.kz/handle/123456789/1302
constant coronary perfusion
pulmonary artery perfusion
cardiopulmonary bypass
Research Subject Categories::MEDICINE
Heart and lungs protection technique for cardiac surgery with cardiopulmonary bypass
oai:nur.nu.edu.kz:123456789/13052018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Далина, А.Д.
author
Мухамбетова, А.Е.
author
Батпенов, Н.Д.
author
Раймагамбетов, Е.К.
author
Огай, В.Б.
author
2013
В настоящее время мезенхимальные стволовые клетки (МСК), выделенные из синовиальной оболочки коленных суставов, представляют большой научный и практический интерес для регенеративной медицины и тканевой инженерии, поскольку они более эффективно участвуют в хондрогенезе и обладают более высоким пролиферативным и регенераторным потенциалом, чем МСК костного мозга и жировой ткани.
http://nur.nu.edu.kz/handle/123456789/1305
мезенхимальные стволовые клетки
факторы роста
дифференцировка
синовиальная оболочка
хондрогенез
Research Subject Categories::TECHNOLOGY::Bioengineering::Biotechnological separation
Влияние ростовых факторов TGF-β1, IGF-I, BMP-2 и BMP-4 на хондрогенную дифференцировку мезенхимальных стволовых клеток, выделенных из синовинальной оболочки человека
oai:nur.nu.edu.kz:123456789/13062018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Tazhibaeva, D.
author
Olzhayev, F.
author
Kabdualieva, N.
author
Aitbaeva, Zh.
author
Zaripova, L.
author
2014
Cell technologies are widely used in medical practice these days. In this research we evaluated the effect of the fetal nerve cell transplantation on the rat survival after the case of clinical death from the mechanical asphyxia.
http://nur.nu.edu.kz/handle/123456789/1306
cell technologies
embryos
rats
mechanical asphyxia
transplantation
Transplantation of the fetal nerve cells in early post-reanimation period in rats
oai:nur.nu.edu.kz:123456789/13072018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Секенова, А.Е.
author
Балтабекова, М.Ж.
author
Хасенов, Б.Б.
author
Огай, В.Б.
author
2013
Транскрипционный фактор Sox2, который экспрессируется в эмбриональных стволовых клетках, играет важную роль в самообновлении и поддержании плюрипотентности эмбриональных и индуцированных плюрипотентных стволовых клеток. В данном исследовании методом плазмидной экспрессии бактериального штамма Rosetta pLysS(DE3), несущего генетическую конструкцию рЕТ-28а/Sox2, был наработан рекомбинантный транскрипционный фактор Sox2.
http://nur.nu.edu.kz/handle/123456789/1307
Sox2
антиген
антитела
плюрипотентные стволовые клетки
Research Subject Categories::TECHNOLOGY::Bioengineering::Biotechnological separation
Получение и анализ поликлональных антител к рекомбинантному транскрипционному фактору SOX2
oai:nur.nu.edu.kz:123456789/13082018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Yantsen, Y.
author
Idrissova, D.
author
Olzhayev, F.
author
Umbayev, B.
author
Murata, H.
author
Russell, A.
author
Askarova, Sh.
author
2014
Mesenchymal stem cells (MSCs) are an attractive stem cell source for transplantation. MSCs can easily differentiate into osteoblasts and increase in osteoblast number will have positive effect on the bone regeneration in such conditions as osteoporosis or Paget disease. To provide the targeted delivery of MSCs to bone we have synthesized a novel osteophilic polymer. The primary active sites of the polymer are bisphosphonate functional groups that target hydroxyapatite molecules (HA) on the bone surface. NHS groups on the other end of the molecule allow polymer to bind to the cell surface components. Coating of cell surfaces with the polymer would allow the cells to bind specifically to HA component of bone and localize the cellular repair functions to areas of injured bone.
http://nur.nu.edu.kz/handle/123456789/1308
mesenchymal stem cells
osteophilic polymer
regeneration
polymer
cell
Mesenchymal stem cells and osteophilic polymer as promising agents in bone regeneration
oai:nur.nu.edu.kz:123456789/13092018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Мусин, Е.А.
author
Буланин, Д.С.
author
Жумадилов, Ж.Ш.
author
Олжаев, Ф.С.
author
Federspiel, W.
author
Jeffries, G.
author
2013
Оценка перспективы применения системы Hemolung в детской практике.
http://nur.nu.edu.kz/handle/123456789/1309
система Hemolung
испытание системы
Hemolung в детской практике
скорость кровотока
скорость элиминации
Перспективы применения системы экстракорпоральной респираторной поддержки в детской практике
oai:nur.nu.edu.kz:123456789/13102018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
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dc
Мусин, Е.А.
author
Jeffries, R.G.
author
Олжаев, Ф.С.
author
Исаева, Р.Б.
author
Жумадилов, Ж.Ш.
author
Салиев, Т.М.
author
Federspiel, W.J.
author
2015
Экспериментальная оценка возможности применения системы Hemolung
в педиатрической практике.
http://nur.nu.edu.kz/handle/123456789/1310
оценка
применения системы Hemolung
эксперименты
In vivo оценка возможности применения системы экстракорпорального газообмена (Hemolung) в педиатрии
oai:nur.nu.edu.kz:123456789/13112018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
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Сафарова, Ю.И.
author
Олжаев, Ф.С.
author
Идрисова, Д.Ш.
author
Умбаев, Б.А.
author
Мурата, Х.
author
Рассел, А.
author
Аскарова, Ш.Н.
author
2015
Целью данной работы явилась исследование эффективности нового спо-
соба стимулирования регенерации ОАП с помощью клеточной терапии мезенхималь-
ными стволовыми клетками (МСК), модифицированными синтетическим остеотроп-
ным бисфосфонатным полимером на основе N-акрилоил-6-аминогексановой кислоты
N’-оксисукцинимид эфира. В связи с тем, что бисфосфонаты имеют высокую степень
сродства к гидроксиапатитам, составляющим почти 2/3 сухой массы кости, данный син-
тетический полимер, ковалентно связанный с мембранами МСК, способен осуществлять
тканеспецифическую доставку клеток в очаги поражения костной ткани, и таким образом, локализовать процессы клеточной репарации.
http://nur.nu.edu.kz/handle/123456789/1311
новый способ стимуляции
клеточная терапия
стволовые клетки
Новый способ стимуляции репаративного остеогенеза в зоне перелома костей при остеопорозе с использованием клеточной терапии мезенхимальными стволовыми клетками, модифицированными синтетическим бисфосфонатным остеотропным полимером
oai:nur.nu.edu.kz:123456789/13122018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
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Янцен, Ю.И.
author
Идриссова, Д.
author
Олжаев, Ф.С.
author
Умбаев, Б.А.
author
Мурата, Х.
author
Рассел, А.
author
Аскарова, Ш.Н.
author
2014
На сегодняшний день регенерация костной ткани является очень важной и актуальной проблемой. Нарушение костного метаболизма при таких заболеваниях, как остеопороз или болезнь Педжета приводит к усилению остеокластной активности и потере как остеобластных клеток, так и клеток-предшественников остеобластов. Для восполнения пула остеобластов было предложено применение аутологичных мезенхимальных стволовых клеток (МСК). С целью разработки таргетной доставки клеток к очагам повреждения костной ткани был синтезирован полимер, способный стабильно связываться с МСК и обладающий тропностью к костной ткани.
http://nur.nu.edu.kz/handle/123456789/1312
остеопороз
костный метаболизм
мезенхимальные стволовые клетки
АТРП синтез
клеточная терапия
целенаправленная доставка клеток
Остеофильный полимер и мезенхимальные стволовые клетки в регенерации костной ткани
oai:nur.nu.edu.kz:123456789/13132018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
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Batyrbekov, K.
author
Olzhayev, F.
author
Shanazarov, N.
author
Maschkin, A.
author
2015
Colorectal cancer (CRC) is the third most common malignant neoplasm
worldwide. According to World Gastroenterology Organization CRC is the second leading
cause of cancer deaths among men and women that makes more than 500 000 cases in a
year. This type of cancer is difficult to diagnose at an early stage that indicates high demand
for introduction of the CRC population screening program. On recommendation WGO “ideal
colonoscopy screening” has to be simple and cheap. Though colonoscopy screening program is
partially functioning in US the CRC incidence steadily decreases by 3% each year. Nowadays
CS is not held for all population of Kazakhstan. The aim of this work is assessment of possibility
and efficiency of early endoscopy screening for malignancy of digestive tract.
http://nur.nu.edu.kz/handle/123456789/1313
colorectal cancer
chronic constipation
polyps
analysis
Efficiency of screening colonoscopy for diagnosis of precancerous and canserous disease of digestive tract
oai:nur.nu.edu.kz:123456789/13142018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
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Chuvakova, T.
author
Bapayeva, G.
author
Issayeva, R.
author
Olzhayev, F.
author
Dzhamanaeva, K.
author
Kenbaeva, K.
author
2015
The processes of growth of the fetus are provided by a constant supply of
amino acids from mother, which provides the production of proteins and muscle tissue of the
fetus. The purpose of this research was to study the amino acid level in blood of fetuses and
newborns with intrauterine growth restriction.
http://nur.nu.edu.kz/handle/123456789/1314
intrauterine growth restriction
amino acids
newborn
Evaluation of amino acid level in the blood of fetuses and newborns with intrauterine growth restriction
oai:nur.nu.edu.kz:123456789/13152018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
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Chuvakova, T.
author
Bapayeva, G.
author
Issayeva, R.
author
Begimbetova, D.
author
Olzhayev, F.
author
Dzhamanaeva, K.
author
Kenbaeva, K.
author
2015
Preterm premature rupture of membranes (PPROM) is one of the leading causes
of perinatal morbidity and mortality. Intrauterine continuous amnioinfusion via a subcutaneously
implanted port system for PPROM is an attempt to improve the perinatal outcomes.
http://nur.nu.edu.kz/handle/123456789/1315
preterm premature rupture of membranes
perinatal mortality
perinatal morbidity
Perinatal outcomes in preterm premature rupture of membranes
oai:nur.nu.edu.kz:123456789/13162018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
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Zhurko, S.
author
Olzhayev, F.
author
Chiginev, V.
author
Fedorov, S.
author
2015
To conduct a clinical study of immediate results, assessment of hemodynamic
characteristics of developed a new biological stented prosthesis «UniLine» (Russia, Kemerovo)
designed for correction of heart valve lesions of various etiologies.
http://nur.nu.edu.kz/handle/123456789/1316
hemodynamic characteristics
valves correction
patients
First experience of using biological prosthesis "UniLine" for correction of heart valve diseases
oai:nur.nu.edu.kz:123456789/13272018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
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Han, Hyun-Jung
author
Park, Sang-Jun
author
Soh, Kwang-sup
author
Myoung, Hyoun-Seok
author
Lee, Kyoung-Joung
author
Ogay, Vyacheslav
author
Lee, Yong-Heum
author
2011
Specific electrical characteristicsof acupointswere investigated on the urinary bladder (BL) meridian in 14 rats. BL acupointsand non-acupoints on the back were selected and their electrical voltages were measured by using aSPACsystem.The mean voltages of each point or each line were statistically analyzed by using the ANOVA test...
2011 Hyun-Jung Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://dx.doi.org/10.1155/2011/295475
http://nur.nu.edu.kz/handle/123456789/1327
electrical characterization of proposed transpositional acupoints
acupointsmay
rat model
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Electrical сharacterization of proposed transpositional acupoints on the Urinary Bladder Meridian in a Rat Model
oai:nur.nu.edu.kz:123456789/13282018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
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Ogay, Vyacheslav
author
Bae, Kyung Hee
author
Kim, Ki Woo
author
Soh, Kwang-sup
author
2009-03-31
Objective: To show that the characteristic morphological and ultrastructural features
of a Bonghan corpuscle and duct presented here are consistent with the description
given in the early reports of Bonghan Kim.
Materials and Methods: We compared the morphological aspects of Bonghan ducts
with those of blood and lymphatic capillaries on the ultrastructural level to display
the manifestly distinctive nature of the Bonghan system.
Results: The walls of the ductules were observed to be composed of a single layer of
endothelial cells with characteristic rod-shaped nuclei and were not surrounded by
a basal lamina or by accessory cells, such as pericytes or smooth muscle cells. The
abluminal cell membranes of Bonghan ductules were not attached by anchoring filaments to the fibers of extracellular matrices as observed in lymphatic capillaries.
http://nur.nu.edu.kz/handle/123456789/1328
acupuncture meridian
blood capillary
Bonghan corpuscle and duct
circulatory system
endothelial cells
lymphatic capillary
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Comparison of the characteristic features of bonghan ducts, blood and lymphatic capillaries
oai:nur.nu.edu.kz:123456789/13292018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
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Baik, Ku Youn
author
Ogay, Vyacheslav
author
Jeoung, Sae Chae
author
Soh, Kwang-sup
author
2009-04-13
Objectives: The origin of adult stem cells remains an open question. If they derive
from embryos, it is difficult to determine the mechanism which interrupts their
differentiation during tissue formation. In the 1960s, the Bonghan microcell was
suggested as one possible, yet to be described, route of stem cell production, such
that they have the potential to proliferate to produce normal cells.
Materials and Methods: In this study, Bonghan microcells were isolated from
Bonghan tissues on rat organ surfaces, and their detailed morphology examined by
electron and atomic force microscopy.
Results: The ultrastructure observed distinguished them from apoptotic bodies and
other microorganisms, and their unique, possible proliferation feature, as protruding
threads, was imaged by atomic force microscopy.
©2009 Korean Pharmacopuncture Institute
http://nur.nu.edu.kz/handle/123456789/1329
atomic force microscopy
Bonghan microcell
budding
electron microscopy
stem cell
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Visualization of Bonghan Microcells by Electron and Atomic Force Microscopy
oai:nur.nu.edu.kz:123456789/13302018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
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Yoo, Jung Sun
author
Kim, Hong Bae
author
Ogay, Vyacheslav
author
Lee, Byung-Cheon
author
Ahn, Saeyoung
author
Soh, Kwang-sup
author
2009-04-01
Objective: The present study has been designed to find a possible new route for the
metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique
of trypan blue staining.
Materials and Methods: Tumor tissues were grown in the skin of nude mice after subcutaneous
inoculation with human lung cancer cells. Trypan blue was recently identified
as a dye with specificity for Bonghan ducts (BHDs) and not other tissues, such as
blood or lymph vessels or nerves.
Results: We demonstrate that the trypan blue staining technique allows the first
visualization of BHDs which are connected to tumor tissues.
http://nur.nu.edu.kz/handle/123456789/1330
Bonghan duct
cancer
metastasis
trypan blue
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Bonghan Ducts as Possible Pathways for Cancer Metastasis
oai:nur.nu.edu.kz:123456789/13312018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
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Ogay (Огай), Vyacheslav (Вячеслав)
author
Issabekova (Исабекова), A.S. (А.С.)
author
2014
Раковые стволовые клетки основная причина возобновления болезни после лечения. Для эффективной борьбы с этими клетками необходимо понимание механизмов выживание этих клеток и их стимуляторов. В данной работе оценено влияние микроокружение опухоли на рост и поддержание опухоли. Основными модуляторами раковых стволовых клеток являются опухоль ассоциированные миофибробласты и макрофаги, а также Th17 клетки.
Cancer stem cells are main cause of cancer recurrence. For effective treatment it is necessary to understand haw survive and stimulate these cells. In this work it was estimated influence of cancer microenvironment to growth and surveillance
of cancer. The main modulators of cancer are cancer associated miofibroblasts and macrophages, and also Th17 cells.
Вестник КазНУ. Серия биологическая. №1/1 (60). 2014
http://nur.nu.edu.kz/handle/123456789/1331
раковые стволовые клетки
микроокружение
индукторы
cancer stem cells
microenvironment
inductors
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Паракринные регуляторы раковых стволовых клеток толстой кишки / Paracrine regulators of colon cancer stem cells
oai:nur.nu.edu.kz:123456789/13322018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
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Ogay (Огай), Vyacheslav (Вячеслав)
author
2014
Colon cancer high death rate and low percentage of recovery depend on tumor initiating cancer stem cells (CSCs). CSCs have ability such as survival in stress condition, absence of sensitivity to apoptose. These properties CSCs can regulate by autocrine way. In our work it was created data base of colon CSCs autocrine inductors. Understanding of CSCs protection mechanisms help to develop effective elimination methods of these cells.
Высокая смертность от рака толстой кишки и низкий процент полного выздоровления от рака связаны с сущетвованием опухоль инициирующих раковых стволовых клеток (РСК). РСК обладают такими свойствами как
выживаемость, отсутствие чувствительности к апоптозу. Эти свойства РСК способны регулировать аутокринным путем. В нашей работе была создана база данных по аутокринным стимуляторам РСК толстой кишки. Понимание защитных механизмов РСК поможет разработать эффективные методы элиминации этих клеток.
http://nur.nu.edu.kz/handle/123456789/1332
colon cancer
cancer stem cells
autocrine inductors
cytokines
growth factors
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
рак толстой кишки
раковые стволовые клетки
аутокринные стимуляторы
цитокины
ростовые факторы
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
тоқ ішек ісігі
бағаналы ісік жасушалары
аутокринды реттеушілер
цитокиндер
өсу факторлары
Саморегуляция раковых стволовых клеток толстой кишки / Colon cancer stem cells self regulation
oai:nur.nu.edu.kz:123456789/13332018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
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Momynaliev (Момыналиев), K.T. (К.Т.)
author
Ogay (Огай), Vyacheslav (Вячеслав)
author
Khoroshun (Хорошун), E.V. (Е.В.)
author
Babenko (Бабенко), N.N. (Н.Н.)
author
Kaabak (Каабак), М.М. (M.M.)
author
2014-04
местительной терапии при хронической почечной недостаточности в терминальной стадии. Благодаря современным иммунодепрессантам, резко повысилась краткосрочная выживаемость пациентов и трансплантата. Однако долгосрочная выживаемость аллотрансплантата почки не улучшается такими же темпами. Хроническая нефропатия аллотрансплантата остается наиболее
частой причиной потери трансплантата, тогда как сердечно-сосудистые заболевания остаются ведущей причиной смертности пациентов после трансплантации...
Currently, renal transplantation has firmly established as the main method of replacement therapy in patients with the end stage chronic renal disease. Thanks to modern immunosuppressive drugs, shortterm graft and patient survival are dramatically increased. However, long-term renal allograft survival has improved in a lesser extent. Chronic allograft nephropathy is the most common cause of graft failure,
whereas cardiovascular diseases remain the leading cause of death among patients receiving renal transplantation. To improve the results of transplantation, it is important to continue developing new strategies for the prevention of acute and chronic rejection...
http://nur.nu.edu.kz/handle/123456789/1333
мезенхимальные стволовые клетки
регуляторные Т-клетки
дендритные клетки
иммунологиче- ская толерантность
трансплантация почки
mesenchymal stem cells
regulatory T-cells
dendritic cells
immunological tolerance
renal transplantation
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Клеточные технологии в трансплантации почки / Cell technologies in renal transplantation
oai:nur.nu.edu.kz:123456789/13362018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1126
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Baptayev, Bakhytzhan
author
Tauanov, Zhandos
author
Bissengaliyeva, Moldir
author
Zhakiyeva, Zhanar
author
Berillo, Dmitriy
author
Adilov, Salimgerey
author
2014
Following the development of the idea of octupolar molecules as nonlinear optical materials a variety of compounds have been reported. Trans-porphyrins have a great potential to self-order into octupolar symmetry. Nonlinear optical properties can be tuned by using strong donor-acceptor groups in porphyrins as well as extention of conjugation. Here we report the syntheses of trans-A2D2-porphyrins and their dimerization into cubic octupoles by lanthanides and organic bidentate ligands. Bulky groups are employed to
induce non-centrosymmetric eclipsed or staggered conformations. Effect of donor acceptor groups, dimerization conditions and crystal packing of dimers are studied.
http://nur.nu.edu.kz/handle/123456789/1336
synthesis of trans-porphyrin dimers
synthesis of trans-porphyrins
crystal structure of dimers
dimerization with bidentate ligands
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Synthesis of trans-porphyrin dimers for nonlinear optics
oai:nur.nu.edu.kz:123456789/13372018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1126
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Berillo (Берилло), Dmitriy (Дмитрий)
author
2010
Настоящая работа посвящена комплексному исследованию в области синтеза потенциально биологически активных веществ на основе гидразидов и нитрилов α-( и β-)-аминопропановых кислот, установлению закономерностей их гетероциклизации и изучению биологической активности новых производных гидразидов и нитрилов α-( и β-)- аминокислот.
http://nur.nu.edu.kz/handle/123456789/1337
гидразид
нитрил
синтеза потенциально биологически активных веществ
гидразид β-аминопропановой кислоты
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Синтез, строение и свойства гидразидов β-аминопропановой кислоты и их производных
oai:nur.nu.edu.kz:123456789/13382018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1126
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Alibek, Kenneth
author
Karatayeva, Nargis
author
Bekniyazov, Ildar
author
2012-12-03
Since the late 1990s, infectious agents have been thought to play a role in the pathogenesis of approximately 15% of cancers. It is now widely accepted that infection of stomach tissue with the bacteria Helicobacter pylori is an important cause of stomach adenocarcinoma. In addition, oncogenic viruses, such as papilloma viruses, herpes viruses, and hepadnaviruses are strongly associated with increased risk of cervical cancer, lymphomas, liver cancer, amongst others. However, in the scientific community the percentage of cancers caused by pathogens is believed to be far higher than 15%. A significant volume of data collected to date show an association between infectious agents and urogenital cancers. These agents include Chlamydia trachomatis, Neisseria gonorrhoea, Mycoplasma genitalium and certain viruses that have been implicated in ovarian cancer.
doi: 10.1186/1750-9378-7-35
http://nur.nu.edu.kz/handle/123456789/1338
urogenital cancers
ovarian cancer
cervical cancer
Bladder cancer
Kidney cancer
Chlamydia trachomatis
Neisseria gonorrhea
Mycoplasma genitalium
Schistosoma haematobium
HPV
Epstein-Barr
CMV
Human polyomaviruses
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
The role of infectious agents in urogenital cancers
oai:nur.nu.edu.kz:123456789/13882018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Балановская, Е.В.
author
Балаганская, О.А.
author
Дамба, Л.Д.
author
Дибирова, Х.Д.
author
Агджоян, А.Т.
author
Богунов, Ю.В.
author
Жабагин, М.К.
author
Исакова, Ж.Т.
author
Лавряшина, М.Б.
author
Балановский, О.П.
author
2014
Цель исследования - выявление роли горного рельефа в формировании генофондов горных и предгорных популяций Алтая, Саян, Тянь-Шаня, Памира.
http://nur.nu.edu.kz/handle/123456789/1388
природная среда
формирование генофондов
тюркоязычное население
население гор
степные предгорья
тюрки
хромосомы гены
Влияние природной среды на формирование генефонда тюркоязычного населения гор и степных предгорий Алтае-Саян, Тянь-Шаня и Памира
oai:nur.nu.edu.kz:123456789/13892018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Жабагин, М.К.
author
Дибирова, Х.Д.
author
Фролова, С.А.
author
Сабитов, Ж.М.
author
Юсупов, Ю.М.
author
Утевская, О.М.
author
Тарлыков, П.В.
author
Тажигулова, И.М.
author
Балаганская, О.А.
author
Нимадава, П.
author
Захаров, И.А.
author
Балановский, О.П.
author
2014
Цель работы - дать характеристику генофонда казахских родов и изучить связь изменчивости Y-хромосомы с родовой структурой.
http://nur.nu.edu.kz/handle/123456789/1389
Y-хромосомы
родовые структуры казахов
генофонд аристократия
духовенства казахов
геногеография
популяционная генетика
чингизиды
Связь изменчивости Y-хромосомы и родовой структуры: генофонд степной аристократии и духовенства казахов
oai:nur.nu.edu.kz:123456789/13902018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Падюкова, А.Д.
author
Лавряшина, М.Б.
author
Кузнецова, М.А.
author
Жабагин, М.К.
author
Агджоян, А.Т.
author
Схаляхо, Р.А.
author
Тычинских, З.А.
author
Балановская, Е.В.
author
2014
Сибирские татары – коренное население Запад-
ной Сибири. Этногенез сибирских татар, как и этноге-
нез большинства коренных народов Сибири, – это
растянувшийся во времени процесс смешения насе-
ления, говорившего на угорских, самодийских, тюрк-
ских и монгольских языках.
http://nur.nu.edu.kz/handle/123456789/1390
генетический портрет
Y-хромосомы
сибирские татары
этногенез сибирских татар
Генетический портрет тоболо-иртышских сибирских татар по гаплогруппам Y-хромосомы
oai:nur.nu.edu.kz:123456789/13912018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Сабитов, Ж.М.
author
Жабагин, М.К.
author
2015
Современная популяционная генетика в целом и исследования полиморфизма Y-
хромосомы в частности развиваются семимильными шагами. Качественное развитие и
удешевление технологий полного и частичного сиквенса Y-хромосомы делает эту
технологию доступной для широких масс исследователей, при этом освобождая от
надобности содержать дорогостоящие лаборатории.
http://nur.nu.edu.kz/handle/123456789/1391
этногенез казахов
популяционная генетика
Y-хромосомы
Этногенез казахов с точки зрения популяционной генетики
oai:nur.nu.edu.kz:123456789/13922018-08-15T03:49:55Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Схаляхо Р.А.
author
Агджоян А.Т.
author
Балановская Е.В.
author
Юсупов Ю.М.
author
Рыскулов Р.М.
author
Мустафаева Л. А.
author
Жабагин М.К.
author
2014
Цель данной публикации - очертить возможности
этногенетики и попробовать поставить запятую в заголовке нашей статьи. Для этого мы
бегло рассмотрим, могут ли генетики сказать этнологам что-то интересное или важное
о четырех этнокультурных группах тюркоязычного мира Евразии - казахах, башкирах,
тюрках Кавказа и крымских татарах, объединенных языковым сходством, но
отличающихся по структуре генофонда.
http://nur.nu.edu.kz/handle/123456789/1392
этногенетика
генофонд
ДНК-генеалоги
Этногенетика: игнорировать нельзя использовать? (опыт анализа генофондов казахов, башкир, тюрков кавказа и крымских татар)
oai:nur.nu.edu.kz:123456789/13932018-08-15T03:50:26Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Alibek, Kenneth
author
Kakpenova, Ainur
author
Mussabekova, Assel
author
Sypabekova, Marzhan
author
Karatayeva, Nargis
author
2013-09-02
The most common cancer worldwide among women is breast cancer. The initiation, promotion, and progression of this cancer result from both internal and external factors. The International Agency for Research on Cancer stated that 18-20% of cancers are linked to infection, and the list of definite, probable, and possible carcinogenic agents is
growing each year. Among them, biological carcinogens play a significant role. In this review, data covering infection-associated breast and lung cancers are discussed and presented as possible involvements as pathogens in cancer. Because carcinogenesis is a multistep process with several contributing factors, we evaluated to what extent
infection is significant, and concluded that members of the herpesvirus, polyomavirus, papillomavirus, and retrovirus families definitely associate with breast cancer. Detailed studies of viral mechanisms support this conclusion, but have presented problems with experimental settings. It is apparent that more effort needs to be devoted to
assessing the role of these viruses in carcinogenesis, by characterizing additional confounding and synergistic effects of carcinogenic factors. We propose that preventing and treating infections may possibly stop or even eliminate certain types of cancers.
http://nur.nu.edu.kz/handle/123456789/1393
carcinogenesis
Infectious agents
Breast cancer
Research Subject Categories::MEDICINE
Role of viruses in the development of breast cancer
oai:nur.nu.edu.kz:123456789/16762018-08-15T03:49:58Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Talhaoui, Ibtissam
author
Shafirovich, Vladimir
author
Liu, Zhi
author
Saint-Pierre, Christine
author
Akishev, Zhiger
author
Matkarimov, Bakhyt T.
author
Gasparutto, Didier
author
Geacintov, Nicholas E.
author
Saparbaev, Murat
author
2015-04-15
Oxidatively generated guanine radical cations in DNA can undergo various nucleophilic reactions including the formation of C8-guanine cross-links with adjacent or nearby N3-thymines in DNA in the presence of O2. The G*[C8-N3]T* lesions have been identified in the DNA of human cells exposed to oxidative stress, and are most likely genotoxic if not removed by cellular defense mechanisms. It has been shown that the G*[C8-N3]T* lesions are substrates of nucleotide excision repair in human cell extracts. Cleavage at the sites of the lesions was also observed but not further investigated (Ding et al. (2012) Nucleic Acids Res. 40, 2506–2517). Using a panel of eukaryotic and prokaryotic bifunctional DNA glycosylases/lyases (NEIL1, Nei, Fpg, Nth, and NTH1) and apurinic/apyrimidinic (AP) endonucleases (Apn1, APE1, and Nfo), the analysis of cleavage fragments by PAGE and MALDI-TOF/MS show that the G*[C8-N3]T* lesions in 17-mer duplexes are incised on either side of G*, that none of the recovered cleavage fragments contain G*, and that T* is converted to a normal T in the 3′-fragment cleavage products. The abilities of the DNA glycosylases to incise the DNA strand adjacent to G*, while this base is initially cross-linked with T*, is a surprising observation and an indication of the versatility of these base excision repair proteins.
Ibtissam Talhaoui, Vladimir Shafirovich, Zhi Liu, Christine Saint-Pierre, Zhiger Akishev, Bakhyt T. Matkarimov, Didier Gasparutto, Nicholas E. Geacintov, and Murat Saparbaev. (2015) Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways. THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 23, pp. 14610–14617, June 5, 2015. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.
http://nur.nu.edu.kz/handle/123456789/1676
oxidatively generated guanine
double-stranded DNA
Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways*
oai:nur.nu.edu.kz:123456789/16772018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Talhaoui, Ibtissam
author
Couve, Sophie
author
Gros, Laurent
author
Ishchenko, Alexander A.
author
Matkarimov, Bakhyt
author
Saparbaev, Murat K.
author
2014-04-01
The human thymine-DNA glycosylase (TDG) initiates
the base excision repair (BER) pathway to remove
spontaneous and induced DNA base damage. It was
first biochemically characterized for its ability to remove
T mispaired with G in CpG context. TDG is
involved in the epigenetic regulation of gene expressions
by protecting CpG-rich promoters from de
novo DNA methylation. Here we demonstrate that
TDG initiates aberrant repair by excising T when it
is paired with a damaged adenine residue in DNA
duplex. TDG targets the non-damaged DNA strand
and efficiently excises T opposite of hypoxanthine
(Hx), 1,N6-ethenoadenine, 7,8-dihydro-8-oxoadenine
and abasic site in TpG/CpX context, where X is
a modified residue. In vitro reconstitution of BER
with duplex DNA containing Hx•T pair and TDG results
in incorporation of cytosine across Hx. Furthermore,
analysis of the mutation spectra inferred from
single nucleotide polymorphisms in human population
revealed a highly biased mutation pattern within
CpG islands (CGIs), with enhanced mutation rate at
CpA and TpG sites. These findings demonstrate that
under experimental conditions used TDG catalyzes
sequence context-dependent aberrant removal of
thymine, which results in TpG, CpA→CpGmutations,
thus providing a plausible mechanism for the putative
evolutionary origin of the CGIs in mammalian
genomes.
Talhaoui, I., Couve, S., Gros, L., Ishchenko, A. A., Matkarimov, B., & Saparbaev, M. K. (2014). Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands. Nucleic Acids Research, 42(10), 6300–6313. http://doi.org/10.1093/nar/gku246
http://nur.nu.edu.kz/handle/123456789/1677
aberrant repair
mismatch-specific thymine-DNA
Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands
oai:nur.nu.edu.kz:123456789/16782018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Маткаримов (Matkarimov), Б.Т. (Bakhyt)
author
Балабаев (Balabaev), Н.К.(N.K.)
author
Гарбузинский (Garbuzinskiy), С.А. ( S.A.)
author
Галзитская (Galzitskaya), О.В. (O.V.)
author
Глякина (Glyakina), А.В. (A.V.)
author
Финкельштейн ( Finkelstein), А.В. (A.V.)
author
Маткаримов (Matkarimov), Б.Т. (B.Т.)
author
2015
Выведены формулы для расчета потенциалов и сил в новом
силовом поле невалентных взаимодействий, включающем, наряду с
традиционными членами, наведенную парциальными зарядами поляризацию
всех атомов и трехчастичные дисперсионные взаимодействия «атом –
валентная связь». Соответствующие новые члены добавлены к стандартному
силовому полю АМБЕР. Проведены молекулярно-динамические расчеты с
использованием обновленного силового поля. Показано, что добавленные,
физически разумные члены не сильно замедляют молекулярно-динамическое
моделирование, несмотря на то, что они учитывают важнейшие
трехчастичные взаимодействия.
Formulas for calculation of energy and forces in the new force field of non bonded interactions including along with traditional members, the polarization, induced by partial atomic charges, and three-particle dispersive interactions of the atoms with covalent bonds are received. The corresponding new members are added to a standard AMBER force field. Molecular dynamics calculations with the use of the updated force field are carried out. It is shown that additional physically reasonable members, taking into account the major three-particle interactions, not strongly slow down molecular dynamics simulation.
Балабаев Н.К., Гарбузинский С.А., Галзитская О.В., Глякина А.В., Маткаримов Б.Т., Финкельштейн А.В. (2015). Включение важнейших многочастичных взаимодействий в силовое поле АМБЕР и применение обновленного поля к молекулярно-динамическим расчетам. Математическая биология и биоинформатика.Т. 10. № 2. С. 427–435. doi: 10.17537/2015.10.427
http://nur.nu.edu.kz/handle/123456789/1678
невалентные атом-атомные взаимодействия
трехчастичные взаимодействия
поляризуемость
парциальные заряды
взаимодействие «атом- ковалентная связь»
non-bonded atom-atom interactions
three-particle interactions
polarizability
partial charges
interaction of atoms with covalent bonds
Research Subject Categories::NATURAL SCIENCES::Chemistry::Theoretical chemistry::Bioinformatics
Включение важнейших многочастичных взаимодействий в силовое поле АМБЕР и применение обновленного поля к молекулярно-динамическим расчетам
oai:nur.nu.edu.kz:123456789/16792018-08-15T03:49:55Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Гарбузинский (Garbuzinskiy), С.А. ( S.A.)
author
Маткаримов (Matkarimov), Б.Т. (B.Т.)
author
Финкельштейн ( Finkelstein), А.В. (A.V.)
author
2015
Разработана новая функциональная форма для силового поля невалентных взаимодействий, учитывающая, наряду с традиционными членами, как наведенную парциальными зарядами поляризацию всех атомов, так и трехчастичные дисперсионные взаимодействия «атом – валентная связь». Соответствующие новые члены добавлены к стандартному силовому полю AMBER. В рамках этой единой функциональной формы силового поля оптимизированы, с использованием данных по молекулярным кристаллам, параметры всех типов невалентных взаимодействий. Показано заметное увеличение коэффициента корреляции между рассчитанной и экспериментально определенной энергией когезии молекул в молекулярных кристаллах.
A new functional form for force field of non-covalent interactions is developed. Besides traditional members, it involves induced (by partial charges) polarization of all atoms as well as three-particle dispersion interactions of atoms with covalent bonds. The corresponding new members are added to a standard AMBER force field. Within this unified functional form of the force field, parameters of all types of non-covalent interactions are optimized using data on molecular crystals. A noticeable increase in correlation coefficient between calculated and experimental energy of cohesion of molecules in molecular crystals is shown.
Гарбузинский С.А., Маткаримов Б.Т., Финкельштейн А.В. (2015). Включение важнейших многочастичных взаимодействий в силовое поле AMBER и оптимизация энергетических параметров обновленного поля. Математическая биология и биоинформатика. 2015. Т. 10. № 2. С. 580–592. doi: 10.17537/2015.10.580
http://nur.nu.edu.kz/handle/123456789/1679
невалентные атом-атомные взаимодействия
трехчастичные взаимодействия
поляризуемость
парциальные заряды
взаимодействие «атом- ковалентная связь»
молекулярные кристаллы
энергия когезии
Research Subject Categories::NATURAL SCIENCES::Chemistry::Theoretical chemistry::Bioinformatics
non-covalent atom-atom interactions
three-particle interactions
polarizability
partial charges
atomic force microscopy
“atom-covalent bond” interaction
molecular crystals
energy of cohesion
Включение важнейших многочастичных взаимодействий в силовое поле AMBER и оптимизация энергетических параметров обновленного поля
oai:nur.nu.edu.kz:123456789/18982018-08-15T03:50:08Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Берилло, Дмитрий
author
2016
Способность биомолекул к молекулярному узнаванию в природных
системах выработана в процессе эволюции. Недавние исследования выявили
библиотеки пептидов с селективным сродством к самоструктурированию
(самоорганизацией или самосборки) в супрамолекулярные структуры
(нанотрубки, нанофибриллы) для создания новых искусственных
биоразлагаемых материалов...
Берилло Д.А. (2016) Самоорганизация дипептидного производного в гидрогели и криогели для биомедицинских целей. RAM Trade company
http://nur.nu.edu.kz/handle/123456789/1898
биомедицина
гидрогели
дипептидное производное
Самоорганизация дипептидного производного в гидрогели и криогели для биомедицинских целей
oai:nur.nu.edu.kz:123456789/22692018-08-15T03:50:05Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Балановская, Е.В.
author
Агджоян, А.Т.
author
Жабагин, М.К.
author
Юсупов, Ю. М.
author
Схаляхо, Р. А.
author
Долинина, Д. О.
author
Падюкова, А. Д.
author
Кузнецова, М. А.
author
Маркина, Н. В.
author
Атраментова, Л. А.
author
Лавряшина, М. Б.
author
Балановский, О. П.
author
2016
Изучены генофонды популяций с этнонимом "татары" трех регионов Евразии: крымские, поволжские и сибирские. Около 1000 представителей этих народов исследованы с помощбю наиболее информативного инструмента популяционной генетики - анализа 50 SNP- маркеров Y-хромосомы...
Балановская Е.В., Агджоян А.Т., Жабагин М.К., Юсупов Ю.М., Схаляхо Р.А., Долинина Д.О., Падюкова А.Д., Кузнецова М.А. и др. ТАТАРЫ ЕВРАЗИИ: СВОЕОБРАЗИЕ ГЕНОФОНДОВ КРЫМСКИХ, ПОВОЛЖСКИХ И СИБИРСКИХ ТАТАР. Вестник Московского университета. Серия XXIII. АНТРОПОЛОГИЯ № 2/2016: 75–85.
http://nur.nu.edu.kz/handle/123456789/2269
этногенез
генофонд
геногеография
гаплогруппа
крымские татары
поволжские татары
сибирские татары
Research Subject Categories::MEDICINE
ТАТАРЫ ЕВРАЗИИ: СВОЕОБРАЗИЕ ГЕНОФОНДОВ КРЫМСКИХ, ПОВОЛЖСКИХ И СИБИРСКИХ ТАТАР
oai:nur.nu.edu.kz:123456789/22702018-08-15T03:50:07Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Жабагин, М.К.
author
Сабитов, Ж. М.
author
Агджоян, А. А.
author
Юсупов, Ю. М.
author
Богунов, Ю. В.
author
Лавряшина, М. Б.
author
Тажигулова, И. М.
author
Акильжанова, А. Р.
author
Жумадилов, Ж. Ш.
author
Балановский, О. П.
author
Балановская, Е. В.
author
2016
Аргыны являются крупнейшим родоплеменным объединением казахов, однако их генезис до сих пор остается дискуссионным. Эти дискуссии можно свести к противостоянию двух точек зрения об истоках из происхождения - от тюркоязычных или же монголоязычных народов, и к противоречию между версией традиционной генеалогии казахов (шежире) об едином биологическом предке аргынов и весрий, что аргыны являются союзом племен различного происхождения. Цель нашего исследования: представить генетический портрет аргынов по данным полиморфизма Y-хромосомы и рассмотреть версии генезиса аргынов с точки зрения их генофонда....
Жабагин М.К., Сабитов Ж.М., Агджоян А.А., Юсупов Ю.М., Богунов Ю.В., Лавряшина М.Б., Тажигулова И.М., Акильжанова А.Р. ГЕНЕЗИС КРУПНЕЙШЕЙ РОДОПЛЕМЕННОЙ ГРУППЫ КАЗАХОВ – АРГЫНОВ – В КОНТЕКСТЕ ПОПУЛЯЦИОННОЙ ГЕНЕТИКИ. Вестник Московского университета. Серия XXIII. АНТРОПОЛОГИЯ № 4/2016: 59–68.
http://nur.nu.edu.kz/handle/123456789/2270
популяционная генетика
Y - хромосома
филогеография
генофонд
род
Центральная Азия
казахи
аргыны
Research Subject Categories::MEDICINE
ГЕНЕЗИС КРУПНЕЙШЕЙ РОДОПЛЕМЕННОЙ ГРУППЫ КАЗАХОВ – АРГЫНОВ – В КОНТЕКСТЕ ПОПУЛЯЦИОННОЙ ГЕНЕТИКИ
oai:nur.nu.edu.kz:123456789/22712018-08-15T03:50:03Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Схаляхо, Р. А.
author
Жабагин, М.К.
author
Юсупов, Ю. М.
author
Агджоян, А. Т.
author
Сабитов, Ж. М.
author
Гурьянов, В. М.
author
Балаганская, О. А.
author
Далимова, Д. А.
author
Давлетчурин, Д. Х.
author
Турдикулова, Ш. У.
author
Чухряева, М. И.
author
Асылгужин, Р. Р.
author
Акильжанова, А. Р.
author
Балановский, О. П.
author
Балановская, Е. В.
author
2016
Туркмены - один из наименее изученных народов Центральной Азии из-за недостаточной международной научной интеграции Туркменистана в исследования генофонда народов мира....
Схаляхо Р.А., Жабагин М.К., Юсупов Ю.М., Агджоян А.Т., Сабитов Ж.М., Гурьянов В.М., Балаганская О.А., Далимова Д.А. и др. ГЕНОФОНД ТУРКМЕН КАРАКАЛПАКСТАНА В КОНТЕКСТЕ ПОПУЛЯЦИЙ ЦЕНТРАЛЬНОЙ АЗИИ (ПОЛИМОРФИЗМ Y-ХРОМОСОМЫ). Вестник Московского университета. Серия XXIII АНТРОПОЛОГИЯ № 3/2016: 86–96
http://nur.nu.edu.kz/handle/123456789/2271
этногенез
генофонд
геногеография
гаплогруппа
туркмены
род
Центральная Азия
йомуд
Research Subject Categories::MEDICINE
ГЕНОФОНД ТУРКМЕН КАРАКАЛПАКСТАНА В КОНТЕКСТЕ ПОПУЛЯЦИЙ ЦЕНТРАЛЬНОЙ АЗИИ (ПОЛИМОРФИЗМ Y-ХРОМОСОМЫ)
oai:nur.nu.edu.kz:123456789/22732018-08-15T03:50:02Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Юсупов, Ю. М.
author
Схаляхо, Р. А.
author
Агджоян, А. Т.
author
Асылгужин, P. P.
author
Рыскулов, P. M.
author
Сабитов, Ж. М.
author
Жабагин, М. К.
author
Богунов Ю. В.
author
Дибирова Х. Д.
author
Балановская Е. В.
author
2016
Исследованы пять родовых объединений северо-восточных
башкир (N=115) - табын, катай, кудей, кошсо (кушчи), упей - по широкой
панели 41 SNP и 17 STR маркеров Y-хромосомы. Исследования
охватили 6 сельских районов Республики Башкортостан. Данные
геногеографии позволяют выдвинуть гипотезу о формировании генофонда
северо-восточных башкир в основном через трансуральский
путь миграций кочевых племен, связывавший Западную Сибирь и При-
уралье в эпоху раннего железного века и средневековья....
http://nur.nu.edu.kz/handle/123456789/2273
генофонд
гаплогруппа
Y-хромосома
SNP и STR маркеры
клан
северо-восточные башкиры
табын
катай
кудей
кошсо
упей
Research Subject Categories::MEDICINE
РОДОВЫЕ ОБЪЕДИНЕНИЯ СЕВЕРО-ВОСТОЧНЫХ БАШКИР В СВЕТЕ ДАННЫХ ГЕНОГЕОГРАФИИ (ПО ПОЛИМОРФИЗМУ Y-ХРОМОСОМЫ)*
oai:nur.nu.edu.kz:123456789/25342018-08-15T03:50:10Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Matkarimov, B.
author
Saparbaev, M.
author
2017
Aerobic cellular respiration generates reactive oxygen species (ROS), which can damage macro-molecules including lipids, proteins and DNA. It was proposed that aging is a consequence of accumulation of naturally occurring unrepaired oxidative DNA damage. In human cells, approximately 2000 to 8000 DNA lesions occur per hour in each cell, i.e. 40000 to 200000 per cell per day. DNA repair systems are able to discriminate between regular and modified bases. For example, DNA glycosylases specifically recognize and excise damaged bases among vast majority of regular bases in the base excision repair (BER) pathway. However, mismatched pairs between two regular bases occur due to spontaneous conversion of 5-methylcytosine to thymine and DNA polymerase errors during replication. To counteract these mutagenic threats to genome stability, cells evolved special DNA repair systems that target the non-damaged DNA strand in a duplex to remove mismatched regular DNA bases. Base excision repair (BER) and mismatch repair (MMR) pathways initiated by mismatch-specific adenine- and thymine-DNA glycosylases (MutY/MUTYH and TDG/MBD4, respectively) can recognize and remove normal DNA bases in mismatched DNA duplexes. Under certain circumstances in DNA repair deficient cells bacterial MutY and human TDG can act in an aberrant manner: MutY and TDG remove Adenine and Thymine opposite to misincorporated 8-oxoguanine and damaged Adenine, respectively. These unusual activities lead either to mutations or futile DNA repair, thus indicating that the DNA repair pathways which target non-damaged DNA strand can act in an aberrant manner and introduce genome instability in the presence of unrepaired DNA lesions. Both accumulation of oxidative DNA damage in cells and the aberrant DNA repair can contribute to cancer, brain disorders and premature senescence.
Matkarimov, B. Saparbaev, M. (2017) Aberrant DNA glycosylase-initiated repair pathway of free radicals induced DNA damage: implications for age-related diseases and natural aging. Vol. 33. N 1. pp.3–23
0233-7657
doi: http://dx.doi.org/10.7124/bc.000943
http://nur.nu.edu.kz/handle/123456789/2534
oxidative DNA damage
crystal structure
base excision repair
nucleotide incision repair
AP endonuclease
Aberrant DNA glycosylase-initiated repair pathway of free radicals induced DNA damage: implications for age-related diseases and natural aging
oai:nur.nu.edu.kz:123456789/27632018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Han, Bo
author
Tokay, Tursonjan
author
Zhang, Guangming
author
Sun, Peng
author
Hou, Shangwei
author
2017-03-06
Ether-a-go-go ` 1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells. Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety
of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family. The role of EAG1 channels in tumor development and its therapeutic significance have been well established. Meanwhile, the importance
of hEAG1 channels in the nervous system is now increasingly appreciated. The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
Han Bo et al.(>4), 2017(March 6), Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System, Oxidative Medicine and Cellular Longevity, Volume 2017, 13 pages
https://doi.org/10.1155/2017/7371010
http://nur.nu.edu.kz/handle/123456789/2763
K+ channel
EAG1
nervous system
channel regulation
Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System
oai:nur.nu.edu.kz:123456789/27642018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1124
00925njm 22002777a 4500
dc
Mao, Xiao-Yuan
author
Tokay, Tursonjan
author
Zhou, Hong-Hao
author
Jin, Wei-Lin
author
2016-03-07
Epileptic seizures are frequently caused by brain tumors. Traditional anti-epileptic treatments do not acquire satisfactory responses. Preoperative and postoperative seizures seriously influence the quality of life of patients. Thus, tumor-associated
epilepsy (TAE) is an important subject of the current research. The delineation of the
etiology of epileptogenesis in patients with primary brain tumor may help to find the
novel and effective drug targets for treating this disease. In this review, we describe
the current status of treatment of TAE. More importantly, we focus on the factors
that are involved in the functional connectivity between tumors and stromal cells.
We propose that there exist two modes, namely, long-range and short-range modes,
which likely trigger neuronal hyperexcitation and subsequent epileptic seizures. The
long-range mode is referred to as factors released by tumors including glutamate
and GABA, binding to the corresponding receptor on the cellular membrane and
causing neuronal hyperactivity, while the short-range mode is considered to involve
direct intracellular communication between tumor cells and stromas. Gap junctions
and tunneling nanotube network are involved in cellular interconnections. Future
investigations focused on those two modes may find a potential novel therapeutic
target for treating TAE.
Mao Xiao-Yuan et al.(>3), 2016(March 7), Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy, Oncotarget
http://nur.nu.edu.kz/handle/123456789/2764
brain tumor
tumor microenvironment
tumor-associated epilepsy
long-range mode
short-range mode
Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy
oai:nur.nu.edu.kz:123456789/27652018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Dmitriev, Petr
author
Kairov, Ulykbek
author
Robert, Thomas
author
Barat, Ana
author
Lazar, Vladimir
author
Carnac, Gilles
author
Laoudj-Chenivesse, Dalila
author
Vassetzky, Yegor S.
author
2013
Muscular dystrophy is a condition potentially predisposing for cancer; however, currently, only Myotonic dystrophy patients are known to have a higher risk of cancer. Here, we have searched for a link between facioscapulohumeral dystrophy (FSHD) and cancer by comparing published transcriptome signatures of FSHD and various malignant tumours and have found a significant enrichment of cancer-related genes among the genes differentially expressed in FSHD. The analysis has shown that gene expression profiles of FSHD myoblasts and myotubes resemble that of Ewing’s sarcoma more than that of other cancer types tested. This is the first study demonstrating a similarity between FSHD and cancer cell expression profiles, a finding that might indicate the existence of a common step in the pathogenesis of these two diseases.
Dmitriev Petr et al.(>7), 2013, Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes, Journal of Cellular and Molecular Medicine, Vol.18, 208-217
doi: 10.1111/jcmm.12182
http://nur.nu.edu.kz/handle/123456789/2765
cancer
rhabdomyosarcoma
Ewing’s sarcoma
FSHD
muscular dystrophy
Cancer-related genes in the transcription signature of facioscapulohumeral dystrophy myoblasts and myotubes
oai:nur.nu.edu.kz:123456789/27662018-08-15T03:50:15Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Kairov, Ulykbek
author
Cantini, Laura
author
Greco, Alessandro
author
Molkenov, Askhat
author
Czerwinska, Urszula
author
Barillot, Emmanuel
author
Zinovyev, Andrei
author
2017
Background: Independent Component Analysis (ICA) is a method that models gene expression data as an action of a set of statistically independent hidden factors. The output of ICA depends on a fundamental parameter: the number of components (factors) to compute. The optimal choice of this parameter, related to determining the effective data dimension, remains an open question in the application of blind source separation techniques to transcriptomic data.Results: Here we address the question of optimizing the number of statistically independent components in the analysis of transcriptomic data for reproducibility of the components in multiple runs of ICA (within the same or
within varying effective dimensions) and in multiple independent datasets. To this end, we introduce ranking of independent components based on their stability in multiple ICA computation runs and define a distinguished number of components (Most Stable Transcriptome Dimension, MSTD) corresponding to the point of the qualitative change of the stability profile. Based on a large body of data, we demonstrate that a sufficient number of dimensions is required for biological interpretability of the ICA decomposition and that the most stable components with ranks below MSTD have more chances to be reproduced in independent studies compared to the less stable ones. At the
same time, we show that a transcriptomics dataset can be reduced to a relatively high number of dimensions without losing the interpretability of ICA, even though higher dimensions give rise to components driven by small gene sets. Conclusions: We suggest a protocol of ICA application to transcriptomics data with a possibility of prioritizing components with respect to their reproducibility that strengthens the biological interpretation. Computing too few components (much less than MSTD) is not optimal for interpretability of the results. The components ranked within MSTD range have more chances to be reproduced in independent studies.
Kairov Ulykbek et al.(>6), 2017, Determining the optimal number of independent components for reproducible transcriptomic data analysis, BioMed Central,
DOI 10.1186/s12864-017-4112-9
http://nur.nu.edu.kz/handle/123456789/2766
transcriptome
Independent component analysis
Reproducibility
Cancer
Determining the optimal number of independent components for reproducible transcriptomic data analysis
oai:nur.nu.edu.kz:123456789/28672021-02-05T05:56:37Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Zhakupova, T
author
Turgambayeva, A
author
Mussina, A
author
Bukeyeva, Z
author
Kossumov, A
author
2015-11-01
T Zhakupova, A Turgambayeva, A Mussina, Z Bukeyeva, A Kossumov, PHP167 - Influence of Some Factors on The Morphological Structure of Spermatozoa In Straight Intestine During Forensic - Medical Examination of Sodomy, In Value in Health, Volume 18, Issue 7, 2015, Page A543
10983015
https://www.sciencedirect.com/science/article/pii/S1098301515037973
http://nur.nu.edu.kz/handle/123456789/2867
PHP167 Influence of Some Factors on The Morphological Structure of Spermatozoa In Straight Intestine During Forensic - Medical Examination of Sodomy
oai:nur.nu.edu.kz:123456789/28702021-02-05T05:56:37Zcom_123456789_107com_123456789_106col_123456789_2869
00925njm 22002777a 4500
dc
Nurgozhin, T.
author
Gulyaev, A.
author
Yermekbayeva, B.
author
Kushugulova, A.
author
Akhmetova, A.
author
Supiev, A.
author
2013-11-01
T. Nurgozhin, A. Gulyaev, B. Yermekbayeva, A. Kushugulova, A. Akhmetova, A. Supiev, PIN17 - Pharmacoeconomics of Cervarix Vaccines Against Human Papilloma Virus in the Republic of Kazakhstan, In Value in Health, Volume 16, Issue 7, 2013, Pages A714-A715
10983015
https://www.sciencedirect.com/science/article/pii/S109830151304120X
http://nur.nu.edu.kz/handle/123456789/2870
PIN17 Pharmacoeconomics of Cervarix Vaccines Against Human Papilloma Virus in the Republic of Kazakhstan
oai:nur.nu.edu.kz:123456789/28712021-02-05T05:56:38Zcom_123456789_107com_123456789_106col_123456789_1124
00925njm 22002777a 4500
dc
Bektur, C.
author
Nurgozhin, T.
author
2014-05-01
10983015
https://www.sciencedirect.com/science/article/pii/S1098301514004604
http://nur.nu.edu.kz/handle/123456789/2871
PCN14 A Pharmacoeconomic Appraisal of Cabazitaxel Versus Abiraterone for the Second-Line Treatment of Patients with Metastatic Hormone-Refractory Prostate Cancer (MHRPC) Progressing After the Treatment with Docetaxel: a Systematic Review
oai:nur.nu.edu.kz:123456789/28742021-02-05T05:56:39Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Bektur, C.
author
Nurgozhin, T.
author
2014-11-01
A phase III clinical trial demonstrated the advantage of denosumab over zoledronic acid(ZA) in delaying the first on-study and subsequent skeletal-related events(SREs) in patients with prostate cancer(PC). Recently, generic ZA became available. The purpose of this study was to examine the cost-effectiveness of denosumab vs. brand or generic ZA in the prevention of SREs in Kazakhstani patients with PC.
C. Bektur, T. Nurgozhin, PMS17 - Cost-Effectiveness of denosumab vs. Brand or generic zoledronic acid in patients with prostate cancer in Kazakhstan, In Value in Health, Volume 17, Issue 7, 2014, Pages A773-A774
10983015
https://www.sciencedirect.com/science/article/pii/S1098301514022633
http://nur.nu.edu.kz/handle/123456789/2874
PMS17 Cost-Effectiveness of denosumab vs. Brand or generic zoledronic acid in patients with prostate cancer in kazakhstan
oai:nur.nu.edu.kz:123456789/28772021-02-05T05:56:40Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Bektur, C
author
Nurgozhin, T
author
2015-05-01
The aim of the study was to investigate the cost-effectiveness of 13-valent pneumococcal conjugate vaccine (PCV-13) programme for children in Kazakhstan from the perspective of Ministry of Health.
C Bektur, T Nurgozhin, PIH18 - Cost-Effectiveness Of 13-Valent Pneumococcal Conjugate Vaccination In Kazakhstan, In Value in Health, Volume 18, Issue 3, 2015, Page A106
10983015
https://www.sciencedirect.com/science/article/pii/S1098301515006816
http://nur.nu.edu.kz/handle/123456789/2877
PIH18 Cost-Effectiveness Of 13-Valent Pneumococcal Conjugate Vaccination In Kazakhstan
oai:nur.nu.edu.kz:123456789/28782021-02-05T05:56:41Zcom_123456789_107com_123456789_106col_123456789_1124
00925njm 22002777a 4500
dc
Gulyayev, A.
author
Shulgau, Z.
author
Yermekbayeva, B.
author
Sergazy, S.
author
Nurgozhin, T.
author
2015-08-01
A. Gulyayev, Z. Shulgau, B. Yermekbayeva, S. Sergazy, T. Nurgozhin, Cytisin Amidophosphate – Promising Role for The Liver Treatment, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e66
A. Gulyayev, Z. Shulgau, B. Yermekbayeva, S. Sergazy, T. Nurgozhin, Cytisin Amidophosphate – Promising Role for The Liver Treatment, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e66
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815005068
http://nur.nu.edu.kz/handle/123456789/2878
Cytisin Amidophosphate – Promising Role for The Liver Treatment
oai:nur.nu.edu.kz:123456789/28792021-02-05T05:56:41Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Bektur, C.R.
author
Nurgozhin, T.S.
author
2015-08-01
C.R. Bektur, T.S. Nurgozhin, Evaluation of health outcomes and cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccination for infants in Kazakhstan, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e76
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815005263
http://nur.nu.edu.kz/handle/123456789/2879
Evaluation of health outcomes and cost-effectiveness of 13-valent Pneumococcal Conjugate Vaccination for infants in Kazakhstan
oai:nur.nu.edu.kz:123456789/28802021-02-05T05:56:42Zcom_123456789_107com_123456789_106col_123456789_1124
00925njm 22002777a 4500
dc
Shulgau, Z.
author
Gulyayev, A.
author
Yermekbayeva, B.
author
Adilgozhina, G.
author
Tritek, V.
author
Nurgozhin, T.
author
2015-08-01
Present study aimed to investigate possible cardioprotective properties of polyphenol concentrates obtained from Cabernet Sauvignon type of Kazakhstani grapes using rat model doxorubicin-induced cardiomyopathy.
Z. Shulgau, A. Gulyayev, B. Yermekbayeva, G. Adilgozhina, V. Tritek, T. Nurgozhin, Cardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Pages e46-e47
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815004476
http://nur.nu.edu.kz/handle/123456789/2880
Cardioprotective properties of polyphenol concentrate in Rat model of Doxorubicin-induced Cardiomyopathy
oai:nur.nu.edu.kz:123456789/28882021-02-05T05:56:43Zcom_123456789_107com_123456789_106col_123456789_1124
00925njm 22002777a 4500
dc
Kostyuk, A.
author
Nurgozhin, T.
author
Mazhitov, T.
author
Almadiyeva, A.
author
2014-05-01
A. Kostyuk, T. Nurgozhin, T. Mazhitov, A. Almadiyeva, PCN99 - Cost-Effectiveness Evaluation of Sunitinib as First-Line Targeted Therapy for Metastatic Renal Cell Carcinoma in Kazakhstan, In Value in Health, Volume 17, Issue 3, 2014, Page A85
10983015
https://www.sciencedirect.com/science/article/pii/S1098301514005452
http://nur.nu.edu.kz/handle/123456789/2888
PCN99 Cost-Effectiveness Evaluation of Sunitinib as First-Line Targeted Therapy for Metastatic Renal Cell Carcinoma in Kazakhstan
oai:nur.nu.edu.kz:123456789/28922021-02-05T05:56:44Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Almadiyeva, A.
author
Ibrayev, S.
author
Turgambayeva, A.
author
Nurgozhin, T.
author
2016-11-01
A Almadiyeva, S Ibrayev, A Turgambayeva, T Nurgozhin, PIN23 - Economic Evaluation of Protease Inhibitors for the Treatment of Patients with Genotype 1 Chronic Hepatitis C in Kazakhstan, In Value in Health, Volume 19, Issue 7, 2016, Pages A911-A912
10983015
https://www.sciencedirect.com/science/article/pii/S1098301516307240
http://nur.nu.edu.kz/handle/123456789/2892
PIN23 Economic Evaluation of Protease Inhibitors for the Treatment of Patients with Genotype 1 Chronic Hepatitis C in Kazakhstan
oai:nur.nu.edu.kz:123456789/28932021-02-05T05:56:29Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Nurgozhin, T.
author
Gulyayev, A.
author
Lokhvytsky, S.
author
Yermekbayeva, B.
author
Sergazy, S.
author
Shulgau, Z.
author
Berikkhanova, K.
author
2015-08-01
T. Nurgozhin, A. Gulyayev, S. Lokhvytsky, B. Yermekbayeva, S. Sergazy, Z. Shulgau, K. Berikkhanova, Pharmacokinetics of Ceftriaxone Included In Cellular Transport System, In Clinical Therapeutics, Volume 37, Issue 8, Supplement, 2015, Page e62
01492918
https://www.sciencedirect.com/science/article/pii/S0149291815004944
http://nur.nu.edu.kz/handle/123456789/2893
Pharmacokinetics of Ceftriaxone Included In Cellular Transport System
oai:nur.nu.edu.kz:123456789/29472021-02-05T05:59:53Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Supiyev, Adil
author
Kossumov, Alibek
author
Kassenova, Aliya
author
Nurgozhin, Talgat
author
Zhumadilov, Zhaxybay
author
Peasey, Anne
author
Bobak, Martin
author
2016-02-01
Abstract AimsThe evidence on the prevalence and distribution of diabetes and its determinants in Central Asia is sparse. The aim of the present study was to investigate the prevalence, awareness, treatment, and control of diabetes and factors associated with these characteristics in the population of Astana (capital) city and adjacent rural area in Kazakhstan. MethodsParticipants aged 50-75 years old, residing in Astana city (the capital) and Akmol village were invited to participate in a cross-sectional study. The subjects were randomly selected from polyclinic registers. A total of 953 adults were interviewed (response rate 59%), and their fasting plasma glucose, blood pressure, height and weight were measured. Diabetes was defined as fasting plasma glucose (FPG) ≥7.0mmol/l (126mg/dl) and/or being on diabetes medication. ResultsThe overall prevalence of diabetes was 12.5%, and it was almost twice higher in the urban residents (16.3%) than in the rural population (8.6%). Diabetes prevalence was associated with age, men sex, hypertension, obesity, and Russian ethnicity. Among subjects with diabetes, 72.3% were aware of their condition; 65.6% were on treatment and 27.7% had controlled fasting plasma glucose. The awareness, treatment and control of diabetes were substantially higher in the urban population and among women. ConclusionsThe large differences in all diabetes indices between urban and rural regions, if confirmed in larger studies, may suggest an impact of westernised and urbanised lifestyle as well as access to health care.
Adil Supiyev, Alibek Kossumov, Aliya Kassenova, Talgat Nurgozhin, Zhaxybay Zhumadilov, Anne Peasey, Martin Bobak, Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan, In Diabetes Research and Clinical Practice, Volume 112, 2016, Pages 6-12
01688227
https://www.sciencedirect.com/science/article/pii/S0168822715004714
http://nur.nu.edu.kz/handle/123456789/2947
Diabetes
Socioeconomic factors
Central Asian Countries
Kazakhstan
Diabetes prevalence, awareness and treatment and their correlates in older persons in urban and rural population in the Astana region, Kazakhstan
oai:nur.nu.edu.kz:123456789/30252020-12-29T08:43:05Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Kaiyrlykyzy, Aiym
author
Freese, Kyle E.
author
Elishaev, Esther
author
Bovbjerg, Dana H.
author
Ramanathan, Ramesh
author
Hamad, Giselle G.
author
McCloskey, Carol
author
Althouse, Andrew D.
author
Huang, Marilyn
author
Edwards, Robert P.
author
Linkov, Faina
author
2015-05-01
Abstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). MethodsTwenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. ResultsOf the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03–1.36], P = .01). ConclusionsThe findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.
15507289
https://www.sciencedirect.com/science/article/pii/S1550728914004924
http://nur.nu.edu.kz/handle/123456789/3025
Bariatric surgery
Endometrial cancer
Endometrial hyperplasia
Endometrial polyps
Obesity
Pipelle sampling
Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis
oai:nur.nu.edu.kz:123456789/30262020-12-29T08:50:24Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Kaiyrlykyzy, Aiym
author
Freese, Kyle E.
author
Elishaev, Esther
author
Bovbjerg, Dana H.
author
Ramanathan, Ramesh
author
Hamad, Giselle G.
author
McCloskey, Carol
author
Althouse, Andrew D.
author
Huang, Marilyn
author
Edwards, Robert P.
author
Linkov, Faina
author
2015-05-01
Abstract BackgroundEndometrial pathology risk has been linked to obesity; however, little is known of its prevalence in severely obese women not seeking care for endometrial pathology associated symptoms. This pilot study was designed to explore the frequency and risk factors associated with endometrial pathology in cancer-free, severely obese, bariatric surgery candidates using the Pipelle endometrial sampling technique (SureFlex Preferred Curette, Bioteque America, Inc, New Taipei City, Taiwan). MethodsTwenty-nine severely obese bariatric surgery candidates with intact uteruses and no history of endometrial cancer or endometrial ablation were included in this subanalysis from a larger cohort of 47. Endometrial samples were obtained using a Pipelle endometrial suction curette at a single time point before surgery. Logistic regression was used to assess the relationship between body mass index and endometrial pathology when adjusting for age and race. ResultsOf the 29 successful biopsies, 8 (27.6%) were classified as abnormal endometrium: 1 was classified as complex atypical hyperplasia, 1 was classified as hyperplasia without atypia, 4 samples were identified with endometrial polyps, and 2 samples were identified with metaplasia. None presented with cancer. Increasing body mass index was significantly associated with higher risk of abnormal endometrium (OR = 1.19, 95% CI [1.03–1.36], P = .01). ConclusionsThe findings in this sample suggest that obesity may be associated with increased risk of having undiagnosed endometrial pathology. More thorough examination of relationships between levels of obesity and endometrial pathology are needed to better characterize high cancer risk groups who may benefit from introducing new screening measures.
Aiym Kaiyrlykyzy, Kyle E. Freese, Esther Elishaev, Dana H. Bovbjerg, Ramesh Ramanathan, Giselle G. Hamad, Carol McCloskey, Andrew D. Althouse, Marilyn Huang, Robert P. Edwards, Faina Linkov, Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis, In Surgery for Obesity and Related Diseases, Volume 11, Issue 3, 2015, Pages 653-658
15507289
https://www.sciencedirect.com/science/article/pii/S1550728914004924
http://nur.nu.edu.kz/handle/123456789/3026
Bariatric surgery
Endometrial cancer
Endometrial hyperplasia
Endometrial polyps
Obesity
Pipelle sampling
Endometrial histology in severely obese bariatric surgery candidates: an exploratory analysis
oai:nur.nu.edu.kz:123456789/30882019-09-13T10:51:23Zcom_123456789_107com_123456789_106col_123456789_2869
00925njm 22002777a 4500
dc
Seidullayeva, A.
author
Zhaxylykova, G.
author
Kenzhebayeva, S.
author
Turdalina, B.
author
Volkova, G.
author
Nurtazina, G.
author
Kostrovskaya, T.
author
Greenberg, D.
author
Kushugulova, A.
author
Bayesheva, D.
author
2016-12-01
A. Seidullayeva, G. Zhaxylykova, S. Kenzhebayeva, B. Turdalina, G. Volkova, G. Nurtazina, T. Kostrovskaya, D. Greenberg, A. Kushugulova, D. Bayesheva, Clinical characterizations of children with bacterial meningitis (BM) in the Republic of Kazakhstan, In International Journal of Infectious Diseases, Volume 53, Supplement, 2016, Page 148
12019712
https://www.sciencedirect.com/science/article/pii/S1201971216315818
http://nur.nu.edu.kz/handle/123456789/3088
Clinical characterizations of children with bacterial meningitis (BM) in the Republic of Kazakhstan
oai:nur.nu.edu.kz:123456789/30982021-02-05T05:59:58Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
D'Souza, Sonia
author
Murata, Hironobu
author
Jose, Moncy V.
author
Askarova, Sholpan
author
Yantsen, Yuliya
author
Andersen, Jill D.
author
Edington, Collin D.J.
author
Clafshenkel, William P.
author
Koepsel, Richard R.
author
Russell, Alan J.
author
2014-11-01
Abstract The field of polymer-based membrane engineering has expanded since we first demonstrated the reaction of N-hydroxysuccinimide ester-terminated polymers with cells and tissues almost two decades ago. One remaining obstacle, especially for conjugation of polymers to cells, has been that exquisite control over polymer structure and functionality has not been used to influence the behavior of cells. Herein, we describe a multifunctional atom transfer radical polymerization initiator and its use to synthesize water-soluble polymers that are modified with bisphosphonate side chains and then covalently bound to the surface of live cells. The polymers contained between 1.7 and 3.1 bisphosphonates per chain and were shown to bind to hydroxyapatite crystals with kinetics similar to free bisphosphonate binding. We engineered the membranes of both HL-60 cells and mesenchymal stem cells in order to impart polymer-guided bone adhesion properties on the cells. Covalent coupling of the polymer to the non-adherent HL-60 cell line or mesenchymal stem cells was non-toxic by proliferation assays and enhanced the binding of these cells to bone.
Sonia D'Souza, Hironobu Murata, Moncy V. Jose, Sholpan Askarova, Yuliya Yantsen, Jill D. Andersen, Collin D.J. Edington, William P. Clafshenkel, Richard R. Koepsel, Alan J. Russell, Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting, In Biomaterials, Volume 35, Issue 35, 2014, Pages 9447-9458
01429612
https://www.sciencedirect.com/science/article/pii/S0142961214008503
http://nur.nu.edu.kz/handle/123456789/3098
Membrane engineering
ATRP
Bone targeting polymer
Cell reactive polymers
Engineering of cell membranes with a bisphosphonate-containing polymer using ATRP synthesis for bone targeting
oai:nur.nu.edu.kz:123456789/31082020-12-29T08:52:24Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
González-Plaza, Juan José
author
Gutiérrez-Repiso, Carolina
author
García-Serrano, Sara
author
Rodriguez-Pacheco, Francisca
author
Garrido-Sánchez, Lourdes
author
Santiago-Fernández, Concepción
author
García-Arnés, Juan
author
Moreno-Ruiz, Francisco J.
author
Rodríguez-Cañete, Alberto
author
García-Fuentes, Eduardo
author
2016-02-01
Abstract BackgroundThe changes in the transcriptomic profiling of subcutaneous adipose tissue (SAT) when weight loss stabilizes after a Roux-en-Y gastric bypass (RYGB) are still largely unknown. ObjectivesTo investigate the changes produced in SAT gene expression of morbidly obese women when their weight loss stabilizes 2 years after RYGB. SettingUniversity hospital. MethodsSAT biopsies of the periumbilical area were taken before and 2 years after RYGB. Gene expression levels were assessed by microarray analysis and significant differences in gene expression were validated by real-time quantitative polymerase chain reaction. The findings were also confirmed in an independent population of morbidly obese women. ResultsMicroarray analysis revealed that the overexpressed differentially expressed genes have a prominent role in the pathways involved in biosynthetic processes, especially lipid or carboxylic ones (stearoyl-Coenzyme A desaturase-1, fatty acid desaturase-1, fatty acid elongase-6, ATP citrate lyase, fatty acid synthase, lipin-1, monoacylglycerol O-acyltransferase, patatin-like phospholipase domain containing-3, phosphate cytidylyltransferase-2, cholesteryl ester transfer protein, transmembrane 7 superfamily member 2, pyruvate carboxylase, and glycogen synthase 2). Most of the underexpressed differentially expressed genes are related with immune system and inflammation processes (immune responses, response to stress, cell death, regulation of biological quality, immune effector process, the response to endogenous stimulus, and the response to other types of stimulus). ConclusionAn improvement of the SAT inflammatory and immune profile and an induction of genes involved in the regulation of lipid metabolism are shown when weight loss stabilizes 2 years after RYGB. Most of the genes shown are clearly linked to obesity and other metabolic disorders.
Juan José González-Plaza, Carolina Gutiérrez-Repiso, Sara García-Serrano, Francisca Rodriguez-Pacheco, Lourdes Garrido-Sánchez, Concepción Santiago-Fernández, Juan García-Arnés, Francisco J. Moreno-Ruiz, Alberto Rodríguez-Cañete, Eduardo García-Fuentes, Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue, In Surgery for Obesity and Related Diseases, Volume 12, Issue 2, 2016, Pages 257-263
15507289
https://www.sciencedirect.com/science/article/pii/S1550728915002920
http://nur.nu.edu.kz/handle/123456789/3108
Transcriptomics
Microarray
Bariatric surgery
Gastric bypass
Subcutaneous adipose tissue
Morbid obesity
Functional annotation
Expression analysis
Effect of Roux-en-Y gastric bypass-induced weight loss on the transcriptomic profiling of subcutaneous adipose tissue
oai:nur.nu.edu.kz:123456789/43912019-12-11T21:02:04Zcom_123456789_107com_123456789_106col_123456789_4390
00925njm 22002777a 4500
dc
Cantini, Laura
author
Kairov, Ulykbek
author
de Reynies, Aurelien
author
Barillot, Emmanuel
author
Radvanyi, Francois
author
Zinovyev, Andrei
author
2019
Motivation
Matrix factorization (MF) methods are widely used in order to reduce dimensionality of transcriptomic datasets to the action of few hidden factors (metagenes). MF algorithms have never been compared based on the between-datasets reproducibility of their outputs in similar independent datasets. Lack of this knowledge might have a crucial impact when generalizing the predictions made in a study to others.
Results
We systematically test widely used MF methods on several transcriptomic datasets collected from the same cancer type (14 colorectal, 8 breast and 4 ovarian cancer transcriptomic datasets). Inspired by concepts of evolutionary bioinformatics, we design a novel framework based on Reciprocally Best Hit (RBH) graphs in order to benchmark the MF methods for their ability to produce generalizable components. We show that a particular protocol of application of independent component analysis (ICA), accompanied by a stabilization procedure, leads to a significant increase in the between-datasets reproducibility. Moreover, we show that the signals detected through this method are systematically more interpretable than those of other standard methods. We developed a user-friendly tool for performing the Stabilized ICA-based RBH meta-analysis. We apply this methodology to the study of colorectal cancer (CRC) for which 14 independent transcriptomic datasets can be collected. The resulting RBH graph maps the landscape of interconnected factors associated to biological processes or to technological artifacts. These factors can be used as clinical biomarkers or robust and tumor-type specific transcriptomic signatures of tumoral cells or tumoral microenvironment. Their intensities in different samples shed light on the mechanistic basis of CRC molecular subtyping.
Availability and implementation
The RBH construction tool is available from http://goo.gl/DzpwYp
Supplementary information
Supplementary data are available at Bioinformatics online.
Cantini, L., Kairov, U., de Reyniès, A., Barillot, E., Radvanyi, F., & Zinovyev, A. (2019). Assessing reproducibility of matrix factorization methods in independent transcriptomes. Bioinformatics, 35(21), 4307–4313. https://doi.org/10.1093/bioinformatics/btz225
10.1093/bioinformatics/btz225
http://nur.nu.edu.kz/handle/123456789/4391
Assessing reproducibility
Gene expression
Matrix factorization
MF
colorectal cancer
CRC
breast cancer
BRCA
Assessing reproducibility of matrix factorization methods in independent transcriptomes
oai:nur.nu.edu.kz:123456789/44082019-12-12T21:02:57Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Gritsenko, Dilyara
author
Pozharsky, Aleksandr
author
Deryabina, Nina
author
Kassenova, Aliya
author
Galiakparov, Nurbol
author
2019
The influenza is one of the most dangerous and widespread infectious diseases on the planet. A natural reservoir of the influenza A virus is wild waterfowl, which subsequently contribute to the spread of viral infection among domestic animals. Currently, different influenza A subtypes were isolated from various animal species and their genetic diversity were investigated with the subsequent possibility to predict the places of outbreaks and the transfer between species. An investigation of genetic diversity of influenza A virus is also important for a timely response by developing suitable vaccines to the emergence of new strains. In the work, we investigated two subtypes of hemagglutinin (H3, H1) from wild waterfowl in the Republic of Kazakhstan (RK). This work was aimed to determine the homology between these subtypes and currently known isolates from the NCBI database. H3N8 isolates from Kazakhstan were located in a monophyletic group together with isolates from Mongolia and Altai according to phylogenetic analysis of the hemagglutinin sequences . The hemagglutinin homology of H3N8 isolates from Kazakhstan and A/eq/Richmond/1/2007 vaccine strain was 86.07% and with A/eq/Ohio/2003 vaccine strain was 86, 24%. In the case of H1N1 isolates from Kazakhstan, the highest hemagglutinin homology was with isolates from Europe. The homology with the A/California/07/2009 (H1N1) vaccine strain was 81.27%. Important amino acids of cleavage and receptor binding sites were not variable in both H3 and H1 subtypes. The investigation of antigenic sites showed presence of variations in all five sites for H3 subtype and in 4 sites for H1.
Gritsenko, D., Pozharsky, A., Deryabina, N., Kassenova, A., & Galiakparov, N. (2019). Genetic analysis of hemagglutinin proteins of H3 and H1 subtypes in Kazakhstan. Genetika, 51(2), 511–524. https://doi.org/10.2298/gensr1902511g
10.2298/GENSR1902511G
http://nur.nu.edu.kz/handle/123456789/4408
Influenza virus
subtype
genetic diversity
hemagglutinin
vaccine
Genetic analysis of hemagglutinin proteins of H3 and H1 subtypes in Kazakhstan
oai:nur.nu.edu.kz:123456789/44272019-12-12T21:01:41Zcom_123456789_107com_123456789_106col_123456789_1123
00925njm 22002777a 4500
dc
Jeong, Choongwon
author
Balanovsky, Oleg
author
Lukianova, Elena
author
Kahbatkyzy, Nurzhibek
author
Flegontov, Pavel
author
Zaporozhchenko, Valery
author
Immell, Alexander
author
Wang, Chuan-Chao
author
Ixan, Olzhas
author
Khussainova, Elmira
author
Bekmanov, Bakhytzhan
author
Zaibert, Victor
author
Lavryashina, Maria
author
Pocheshkhova, Elvira
author
Yusupov, Yuldash
author
Agdzhoyan, Anastasiya
author
Koshel, Sergey
author
Bukin, Andrei
author
Nymadawa, Pagbajabyn
author
Turdikulova, Shahlo
author
Dalimova, Dilbar
author
Churnosov, Mikhail
author
Skhalyakho, Roza
author
Daragan, Denis
author
Bogunov, Yuri
author
Bogunova, Anna
author
Shtrunov, Alexandr
author
Dubova, Nadezhda
author
Zhabagin, Maxat
author
Yepiskoposyan, Levon
author
Churakov, Vladimir
author
Pislegin, Nikolay
author
Damba, Larissa
author
Saroyants, Ludmila
author
Dibirova, Khadizhat
author
Atramentova, Lubov
author
Utevska, Olga
author
Idrisov, Eldar
author
Kamenshchikova, Evgeniya
author
Evseeva, Irina
author
Metspalu, Mait
author
Outram, Alan K.
author
Robbeets, Martine
author
Djansugurova, Leyla
author
Balanovska, Elena
author
Schiffels, Stephan
author
Haak, Wolfgang
author
Reich, David
author
Krause, Johannes
author
2019-04
The indigenous populations of inner Eurasia-a huge geographic region covering the central Eurasian steppe and the northern Eurasian taiga and tundra-harbour tremendous diversity in their genes, cultures and languages. In this study, we report novel genome-wide data for 763 individuals from Armenia, Georgia, Kazakhstan, Moldova, Mongolia, Russia, Tajikistan, Ukraine and Uzbekistan. We furthermore report additional damage-reduced genome-wide data of two previously published individuals from the Eneolithic Botai culture in Kazakhstan (~5,400 BP). We find that present-day inner Eurasian populations are structured into three distinct admixture clines stretching between various western and eastern Eurasian ancestries, mirroring geography. The Botai and more recent ancient genomes from Siberia show a decrease in contributions from so-called 'ancient North Eurasian' ancestry over time, which is detectable only in the northern-most 'forest-tundra' cline. The intermediate 'steppe-forest' cline descends from the Late Bronze Age steppe ancestries, while the 'southern steppe' cline further to the south shows a strong West/South Asian influence. Ancient genomes suggest a northward spread of the southern steppe cline in Central Asia during the first millennium BC. Finally, the genetic structure of Caucasus populations highlights a role of the Caucasus Mountains as a barrier to gene flow and suggests a post-Neolithic gene flow into North Caucasus populations from the steppe.
Jeong, C., Balanovsky, O., Lukianova, E., Kahbatkyzy, N., Flegontov, P., Zaporozhchenko, V., … Krause, J. (2019). The genetic history of admixture across inner Eurasia. Nature Ecology & Evolution, 3(6), 966–976. https://doi.org/10.1038/s41559-019-0878-2
10.1038/s41559-019-0878-2
http://nur.nu.edu.kz/handle/123456789/4427
Admixture modeling
Admixture
genetic history
ancient North Eurasian
The genetic history of admixture across inner Eurasia
oai:nur.nu.edu.kz:123456789/45092020-03-12T21:01:10Zcom_123456789_107com_123456789_106col_123456789_2866
00925njm 22002777a 4500
dc
Zhumadilov, Zhaxybay
author
Supiyev, Adil
author
Geldsetzer, Pascal
author
Manne-Goehler, Jennifer
author
Marcus, Maja-Emilia
author
Ebert, Cara
author
Wesseh, Chea S
author
Tsabedze, Lindiwe
author
Sturua, Lela
author
Bahendeka, Silver K
author
Sibai, Abla M
author
Quesnel-Crooks, Sarah
author
Norov, Bolormaa
author
Mwangi, Kibachio J
author
Mwalim, Omar
author
Wong-McClure, Roy
author
Mayige, Mary T
author
Martins, Joao S
author
Lunet, Nuno
author
Labadarios, Demetre
author
Karki, Khem B
author
Kagaruki, Gibson B
author
Jorgensen, Jutta M A
author
Hwalla, Nahla C
author
Houinato, Dismand
author
Houehanou, Corine
author
Msaidié, Mohamed
author
Guwatudde, David
author
Gurung, Mongal S
author
Gathecha, Gladwell
author
Dorobantu, Maria
author
Damasceno, Albertino
author
Bovet, Pascal
author
Bicaba, Brice W
author
Aryal, Krishna K
author
Andall-Brereton, Glennis
author
Andall-Brereton, Glennis
author
Agoudavi, Kokou
author
Stokes, Andrew
author
Davies, Justine I
author
Bärnighausen, Till
author
Atun, Rifat
author
Vollmer, Sebastian
author
Jaacks, Lindsay M
author
2019-07-18
Our study provides important evidence for the design and targeting of health policies and service interventions for hypertension in LMICs. We show at what steps and for whom there are gaps in the hypertension care process in each of the 44 countries in our study. We also identified countries in each world region that perform better than expected from their economic development, which can direct policy makers to important policy lessons. Given the high disease burden caused by hypertension in LMICs, nationally representative hypertension care cascades, as constructed in this study, are an important measure of progress towards achieving universal health coverage.
Geldsetzer, P., Manne-Goehler, J., Marcus, M. E., Ebert, C., Zhumadilov, Z., Wesseh, C. S., … Jaacks, L. M. (2019). The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults. The Lancet, 394(10199), 652–662. https://doi.org/10.1016/S0140-6736(19)30955-9
https://doi.org/10.1016/S0140-6736(19)30955-9
http://nur.nu.edu.kz/handle/123456789/4509
The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults
oai:nur.nu.edu.kz:123456789/45102020-03-12T21:01:15Zcom_123456789_107com_123456789_106col_123456789_2869
00925njm 22002777a 4500
dc
Kozhakhmetov, Samat S.
author
Zhumadilov, Zhaxybay
author
Kushugulova, Almagul R.
author
Bartolomaeus, Hendrik
author
Balogh, András
author
Yakoub, Mina
author
Homann, Susanne
author
Markó, Lajos
author
Höges, Sascha
author
Tsvetkov, Dmitry
author
Krannich, Alexander
author
Wundersitz, Sebastian
author
Avery, Ellen G.
author
Haase, Nadine
author
Kräker, Kristin
author
Hering, Lydia
author
Maase, Martina
author
Kusche-Vihrog, Kristina
author
Grandoch, Maria
author
Fielitz, Jens
author
Kempa, Stefan
author
Gollasch, Maik
author
Eckardt, Kai-Uwe
author
Dechend, Ralf
author
Rump, Lars Christian
author
Forslund, Sofia K.
author
Müller, Dominik N.
author
Stegbauer, Johannes
author
Wilck, Nicola
author
2018-12-04
Arterial hypertension and its organ sequelae show characteristics of T cell–mediated inflammatory diseases. Experimental anti-inflammatory therapies have been shown to ameliorate hypertensive end-organ damage. Recently, the CANTOS study (Canakinumab Antiinflammatory Thrombosis Outcome Study) targeting interleukin-1β demonstrated that anti-inflammatory therapy reduces cardiovascular risk. The gut microbiome plays a pivotal role in immune homeostasis and cardiovascular health. Short-chain fatty acids (SCFAs) are produced from dietary fiber by gut bacteria and affect host immune homeostasis. Here, we investigated effects of the SCFA propionate in 2 different mouse models of hypertensive cardiovascular damage. Our data emphasize an immune-modulatory role of SCFAs and their importance for cardiovascular health. The data suggest that lifestyle modifications leading to augmented SCFA production could be a beneficial nonpharmacological preventive strategy for patients with hypertensive cardiovascular disease.
Bartolomaeus, Hendrik, András Balogh, Mina Yakoub, Susanne Homann, Lajos Markó, Sascha Höges, Dmitry Tsvetkov, et al. 2019. “Short-Chain Fatty Acid Propionate Protects from Hypertensive Cardiovascular Damage.” Circulation 139 (11). Lippincott Williams and Wilkins: 1407–21. doi:10.1161/CIRCULATIONAHA.118.036652.
https://doi.org/10.1161/CIRCULATIONAHA.118.036652
http://nur.nu.edu.kz/handle/123456789/4510
Research Subject Categories::NATURAL SCIENCES
angiotensin II
apolipoproteins E
fatty acids
volatile
immunology
inflammation
microbiota
Th17 cells
T-lymphocytes
regulatory
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage
oai:nur.nu.edu.kz:123456789/45252020-07-07T04:09:10Zcom_123456789_107com_123456789_106col_123456789_4390
00925njm 22002777a 4500
dc
Kairov, Ulykbek
author
Aynaud, Marie-Ming
author
Mirabeau, Olivier
author
Gruel, Nadege
author
Grossetête, Sandrine
author
Boeva, Valentina
author
Durand, Simon
author
Surdez, Didier
author
Zaïdi, Sakina
author
Gribkova, Svetlana
author
Fouché, Aziz
author
Raynal, Virginie
author
Tirode, Franck
author
Grünewald, Thomas G P
author
Bohec, Mylene
author
Baulande, Sylvain
author
Janoueix-Lerosey, Isabelle
author
Vert, Jean-Philippe
author
Barillot, Emmanuel
author
2020-02-11
EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transcriptional programs. Here, we combine independent component analysis of single-cell RNA sequencing data from diverse cell types and model systems with time-resolved mapping of EWSR1-FLI1 binding sites and of open chromatin regions to characterize dynamic cellular processes associated with EWSR1-FLI1 activity. We thus define an exquisitely specific and direct enhancer-driven EWSR1-FLI1 program. In EwS tumors, cell proliferation and strong oxidative phosphorylation metabolism are associated with a well-defined range of EWSR1-FLI1 activity. In contrast, a subpopulation of cells from below and above the intermediary EWSR1-FLI1 activity is characterized by increased hypoxia. Overall, our study reveals sources of intratumoral heterogeneity within EwS tumors.
Aynaud, M-M., Mirabeau, O., Gruel, N., Grossetête, S., Boeva, V., Durand, S., ... Zinovyev, A. (2020). Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution. Cell Reports, 30(6), 1767-1779.e6. https://doi.org/10.1016/j.celrep.2020.01.049
https://doi.org/10.1016/j.celrep.2020.01.049
http://nur.nu.edu.kz/handle/123456789/4525
single-cell RNA-sequencing
Ewing sarcoma
EWSR1-FLI1
intratumor heterogeneity
patient-derived xenografts
Independent Component Analysis
time series
series transcriptomics
Transcriptional Programs Define Intratumoral Heterogeneity of Ewing Sarcoma at Single-Cell Resolution
oai:nur.nu.edu.kz:123456789/45362020-03-19T21:00:32Zcom_123456789_107com_123456789_106col_123456789_2869
00925njm 22002777a 4500
dc
Sergazy, Shynggys
author
Gulyayev, Alexandr
author
Dudikova, Galina
author
Chulenbayeva, Laura
author
Nurgaziyev, Madiyar
author
Krivyh, Elena
author
Nurgozhoina, Ayaulym
author
Ziyat, Arailym
author
Tritek, V.
author
Kozhakhmetov, Samat S.
author
Kushugulova, Almagul R.
author
2019-12-12
Several studies reveal that the phenolic compounds present in the wine and their concentrations determine physiological activities of the red wine. In this study, the main polyphenol components, including hydroxycinnamic acids, flavones, flavan-3-ols and stilbenoids, were investigated via HLPC-UV in the “Cabernet Sauvignon” and “Saperavi” wines selected from different regions and different years. In assistance of a meta-analysis, we found that there are no fundamental differences in phenolic compounds between the wines Cabernet Sauvignon and Saperavi. However, the amounts of several important phenolic materials such as catechin, caffeic acid, p-coumaric acid, chlorogenic acid and myricetin significantly higher in Saperavi wine as compared to Cabernet Sauvignon. Moreover, on the basis of the correlation analysis, we assume that flavones synthesis and regulation of stilbenoids coordinated to a greater extent in “Saperavi” than in “Cabernet Sauvignon”.
Sergazy, S., Gulyayev, A., Dudikova, G., Chulenbayeva, L., Nurgaziyev, M., Elena, K., ... & Kushugulova, A. (2019). COMPARISON OF PHENOLIC CONTENT IN CABERNET SAUVIGNON AND SAPERAVI WINES. Journal of Microbiology, Biotechnology and Food Sciences, 2019, 557-561.
10.15414/jmbfs.2019/20.9.3.557-561
http://nur.nu.edu.kz/handle/123456789/4536
Comparison of Phenolic Content in Cabernet Sauvignon and Saperavi Wines
oai:nur.nu.edu.kz:123456789/45442020-03-26T21:00:42Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Zarkovic, Gabriella
author
Belousova, Ekaterina
author
Talhaoui, Ibtissam
author
Saint-Pierre, Christine
author
Kutuzov, Mikhail M.
author
Matkarimov, Bakhyt
author
Biard, Denis
author
Gasparutto, Didier
author
Lavrik, Olga I.
author
Ishchenko, Alexander A.
author
2018-01
Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage sites. It has been demonstrated that both mammalian PARP1 and PARP2 PARylate double-strand break termini in DNA oligonucleotide duplexes in vitro. Here, we show that mammalian PARP2 and PARP3 can PARylate and mono(ADP-ribosyl)ate (MARylate), respectively, 5′- and 3′-terminal phosphate residues at double- and single-strand break termini of a DNA molecule containing multiple strand breaks. PARP3-catalyzed DNA MARylation can be considered a new type of reversible post-replicative DNA modification. According to DNA substrate specificity of PARP3 and PARP2, we propose a putative mechanistic model of PARP-catalyzed strand break–oriented ADP-ribosylation of DNA termini. Notably, PARP-mediated DNA ADP-ribosylation can be more effective than PARPs’ auto-ADP-ribosylation depending on the DNA substrates and reaction conditions used. Finally, we show an effective PARP3- or PARP2-catalyzed ADP-ribosylation of high-molecular-weight (∼3-kb) DNA molecules, PARP-mediated DNA PARylation in cell-free extracts and a persisting signal of anti-PAR antibodies in a serially purified genomic DNA from bleomycin-treated poly(ADP-ribose) glycohydrolase-depleted HeLa cells. These results suggest that certain types of complex DNA breaks can be effectively ADP-ribosylated by PARPs in cellular response to DNA damage.
Zarkovic, G., Belousova, E. A., Talhaoui, I., Saint-Pierre, C., Kutuzov, M. M., Matkarimov, B. T., Biard, D., Gasparutto, D., Lavrik, O. I., & Ishchenko, A. A. (2018). Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation. Nucleic Acids Research, 46(5), 2417–2431. https://doi.org/10.1093/nar/gkx1318
0305-1048
1362-4962
10.1093/nar/gkx1318
https://doi.org/10.1093/nar/gkx1318
http://nur.nu.edu.kz/handle/123456789/4544
genome integrity
repair and replication
PARP2
PARP3
Research Subject Categories::MEDICINE
Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation
oai:nur.nu.edu.kz:123456789/45482020-03-26T21:00:45Zcom_123456789_107com_123456789_106col_123456789_4547
00925njm 22002777a 4500
dc
Saliev, Timur
author
Kenessary, D
author
Kenessary, A
author
Adilgereiuly, Z
author
Akzholova, N
author
Erzhanova, A
author
Dosmukhametov, A
author
Syzdykov, D
author
Masoud, Abdul-Razak
author
2019-11-08
ir pollution in Kazakhstan is caused by many factors and poses serious threats to public health. Ambient air in the cities of Kazakhstan is polluted due to mining and processing of mineral resources, oil and gas production, gasoline and diesel fuel motor vehicles, industrial enterprises.
Kenessary, D., Kenessary, A., Adilgereiuly, Z., Akzholova, N., Erzhanova, A., Dosmukhametov, A., … Saliev, T. (2019). Air Pollution in Kazakhstan and Its Health Risk Assessment. Annals of Global Health, 85(1), 133. DOI: http://doi.org/10.5334/aogh.2535
http://doi.org/10.5334/aogh.2535
http://nur.nu.edu.kz/handle/123456789/4548
Air Pollution in Kazakhstan and Its Health Risk Assessment
oai:nur.nu.edu.kz:123456789/45662020-03-31T21:00:37Zcom_123456789_107com_123456789_106col_123456789_2869
00925njm 22002777a 4500
dc
Kushugulova, Almagul
author
Forslund, Sofia K.
author
Costea, Paul Igor
author
Kozhakhmetov, Samat
author
Khassenbekova, Zhanagul
author
Urazova, Maira
author
Nurgozhin, Talgat
author
Zhumadilov, Zhaxybay
author
Benberin, Valery
author
Driessen, Marja
author
Hercog, Rajna
author
Voigt, Anita Yvonne
author
Benes, Vladimir
author
Kandels-Lewis, Stefanie
author
Sunagawa, Shinichi
author
Letunic, Ivica
author
Bork, Peer
author
2018-06-27
Changes in the gut microbiota are increasingly recognised to be involved in many diseases. This ecosystem is known to be shaped by many factors, including climate, geography, host nutrition, lifestyle and medication. Thus, knowledge of varying populations with different habits is important for a better understanding of the microbiome...
Kushugulova A, Forslund SK, Costea PI, et alMetagenomic analysis of gut microbial communities from a Central Asian populationBMJ Open 2018;8:e021682. doi: 10.1136/bmjopen-2018-021682
http://nur.nu.edu.kz/handle/123456789/4566
gut microbial communities
Metagenomic analysis of gut microbial communities from a Central Asian population
oai:nur.nu.edu.kz:123456789/45782020-04-03T21:00:19Zcom_123456789_107com_123456789_106col_123456789_1125
00925njm 22002777a 4500
dc
Askarova, S.
author
Adambekov, S.
author
Tsoy, A.
author
Isayeva, R.
author
Shalakhmetova, T.
author
2015-04
Болезнь Альцгеймера (БА) является широко распространённым хроническим нейродегенеративным заболеванием, поражающим людей в возрасте 65 лет и старше, против которого до сих пор не разработано эффективных методов лечения. Данные эпидемиологических исследований свидетельствуют о том, что долговременное применение гиполиподемических препаратов статинов снижает риск развития болезни Альцгеймера.
Askarova, S., Adambekov, S., Tsoy, A., Isayeva, R., & Shalakhmetova, T. (2015). Статины: потенциал в лечении болезни альцгеймера. Статиндер: Альцгеймер ауруын емдеудегі потенциал. Experimental Biology, 61(2), 135-143. Получено с https://bb.kaznu.kz/index.php/biology/article/view/192
2617-7498
https://bb.kaznu.kz/index.php/biology/article/view/192/165
http://nur.nu.edu.kz/handle/123456789/4578
амилоид
статины
гематоэнцефалический барьер
холестерин
Research Subject Categories::MEDICINE
Статины: потенциал в лечении болезни альцгеймера
oai:nur.nu.edu.kz:123456789/45862020-04-28T21:00:28Zcom_123456789_107com_123456789_106col_123456789_1126
00925njm 22002777a 4500
dc
Matkarimov, Bakhyt T.
author
Matta, Elie
author
Kiribayeva, Assel
author
Khassenov, Bekbolat
author
Ishchenko, Alexander A.
author
2020-02-28
DNA-dependent poly(ADP-ribose) polymerases (PARPs) PARP1, PARP2 and PARP3 act as DNA break sensors signalling DNA damage. Upon detecting DNA damage, these PARPs use nicotine adenine dinucleotide as a substrate to synthesise a monomer or polymer of ADP-ribose (MAR or PAR, respectively) covalently attached to the acceptor residue of target proteins. Recently, it was demonstrated that PARP1–3 proteins can directly ADP-ribosylate DNA breaks by attaching MAR and PAR moieties to terminal phosphates. Nevertheless, little is still known about the mechanisms governing substrate recognition and specificity of PARP1, which accounts for most of cellular PARylation activity. Here, we characterised PARP1-mediated DNA PARylation of DNA duplexes containing various types of breaks at different positions. The 3′-terminal phosphate residue at double-strand DNA break ends served as a major acceptor site for PARP1-catalysed PARylation depending on the orientation and distance between DNA strand breaks in a single DNA molecule. A preference for ADP-ribosylation of DNA molecules containing 3′-terminal phosphate over PARP1 auto-ADP-ribosylation was observed, and a model of DNA modification by PARP1 was proposed. Similar results were obtained with purified recombinant PARP1 and HeLa cell-free extracts. Thus, the biological effects of PARP-mediated ADP-ribosylation may strongly depend on the configuration of complex DNA strand breaks.
Matta, E., Kiribayeva, A., Khassenov, B. et al. Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation. Sci Rep 10, 3699 (2020). https://doi.org/10.1038/s41598-020-60631-0
https://doi.org/10.1038/s41598-020-60631-0
http://nur.nu.edu.kz/handle/123456789/4586
Research Subject Categories::NATURAL SCIENCES
Insight into DNA substrate specificity of PARP1-catalysed DNA poly(ADP-ribosyl)ation
marc///com_123456789_107/100