2024-03-28T19:18:53Zhttp://nur.nu.edu.kz/oai/requestoai:nur.nu.edu.kz:123456789/11302018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
Klatte, Katharina
Kirschstein, Timo
Otte, David
Pothmann, Leonie
Muller, Lorenz
Tokay, Tursonjan
Kober, Maria
Uebachs, Mischa
Zimmer, Andreas
Beck, Heinz
2016-02-03T03:21:01Z
2016-02-03T03:21:01Z
2013-08-07
http://nur.nu.edu.kz/handle/123456789/1130
The modulation of synaptic plasticity by NMDA receptor (NMDAR)-mediated processes is essential for many forms of learning and memory. Activation of NMDARs by glutamate requires the binding of a coagonist to a regulatory site of the receptor. In many forebrain
regions, this coagonist is D-serine. Here, we show that experimental epilepsy in rats is associated with a reduction in the CNS levels of
D-serine, which leads to a desaturation of the coagonist binding site of synaptic and extrasynaptic NMDARs. In addition, the subunit
composition of synaptic NMDARs changes in chronic epilepsy. The desaturation of NMDARs causes a deficit in hippocampal long-term
potentiation, which can be rescued with exogenously supplied D-serine. Importantly, exogenous D-serine improves spatial learning in epileptic animals. These results strongly suggest that D-serine deficiency is important in the amnestic symptoms of temporal lobe epilepsy. Our results point to a possible clinical utility of D-serine to alleviate these disease manifestations.
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Epilepsy
D-serine
NMDAR
Research Subject Categories::MEDICINE
Impaired D-Serine-Mediated cotransmission mediates cognitive dysfunction in epilepsy
Article
oai:nur.nu.edu.kz:123456789/11322018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Tokay, Tursonjan
Kirschstein, Timo
Rohde, Marco
Zschorlich, Volker
Köhling, Rüdiger
2016-02-03T04:33:44Z
2016-02-03T04:33:44Z
2014-10-28
http://nur.nu.edu.kz/handle/123456789/1132
High-frequency magnetic stimulation (HFMS) can elicit N-methyl-D-aspartate (NMDA) receptor-dependent long-termpotentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses. Here, we investigated the priming effect of HFMS on the subsequent magnitude of electrically induced LTP in the CA1 region of rat hippocampal slices using field excitatory postsynaptic potential (fEPSP) recordings. In control slices, electrical high-frequency conditioning stimulation (CS) could reliably induce LTP. In contrast,
the same CS protocol resulted in long-term depression when HFMS was delivered to the slice 30 min prior to the electrical stimulation. HFMS-primingwas diminishedwhen applied in the presence of themetabotropic glutamate receptor antagonists (RS)-
𝛼-methylserine-O-phosphate (MSOP) and (RS)-𝛼-methyl-4-carboxyphenylglycine (MCPG).Moreover,whenHFMSwas delivered in the presence of the NMDA receptor-antagonist D-2-amino-5-phosphonovalerate (50 𝜇M), CS-induced electrical LTP was again as high as under control conditions in slices without priming. These results demonstrate that HFMS significantly reduced the propensity of subsequent electrical LTP and show that both metabotropic glutamate and NMDA receptor activation were involved
in this form of HFMS-induced metaplasticity.
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high-frequency magnetic stimulation
receptor-dependent metaplasticity
metaplasticity
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
NMDA receptor-dependent metaplasticity by high-frequency magnetic stimulation
Article
oai:nur.nu.edu.kz:123456789/11332018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Guli, Xiati
Tokay, Tursonjan
Kirschstein, Timo
Köhling, Rüdiger
2016-02-03T04:41:58Z
2016-02-03T04:41:58Z
2015-11-15
http://nur.nu.edu.kz/handle/123456789/1133
N-Methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) can be reversed by low-frequency stimulation (LFS) referred to as depotentiation (DP). We previously found GluN2B upregulated in CA1 neurons from post-status epilepticus
(post-SE) tissue associated with an enhanced LTP. Here,we testedwhether LFS-inducedDP is also altered in pathologicalGluN2B upregulation. Although LTP was enhanced in post-SE tissue, LTP was significantly reversed in this tissue, but not in controls. We next tested the effect of the GluN2B subunit-specific blocker Ro 25-6981 (1 𝜇M) on LFS-DP. As expected, LFS had no effect on synaptic strength in the presence of the GluN2B blocker in control tissue. In marked contrast, LFS-DP was also attained in
post-SE tissue indicating that GluN2B was obviously not involved in depotentiation. To test for NMDA receptor-dependence, we applied the NMDA receptor antagonist D-AP5 (50 𝜇M) prior to LFS and observed that DPwas abolished in both control and post-
SE tissue confirming NMDA receptor involvement. These results indicate that control Schaffer collateral-CA1 synapses cannot be depotentiated after fully established LTP, but LFS was able to reverse LTP significantly in post-SE tissue. However, while LFS-DP
clearly requiredNMDA receptor activation, GluN2B-containingNMDA receptors were not involved in this formof depotentiation
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N-Methyl-D-aspartate
Epilepticus
Epilepticus enhances depotentiation
Research Subject Categories::MEDICINE
Status epilepticus enhances depotentiation after fully established LTP in an NMDAR-Dependent but GluN2B-independent manner
Article
oai:nur.nu.edu.kz:123456789/11342018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Mayer, Johannes
Reichart, Gesine
Tokay, Tursonjan
Lange, Falko
Baltrusch, Simone
Junghanss, Christian
Wolkenhauer, Olaf
Jaster, Robert
Kunz, Manfred
Tiedge, Markus
Ibrahim, Saleh
Fuellen, Georg
Köhling, Rüdiger
2016-02-03T04:55:04Z
2016-02-03T04:55:04Z
2015-04-15
Mayer J, Reichart G, Tokay T, Lange F, Baltrusch S, Junghanss C, et al. (2015) Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants. PLoS ONE 10(4): e0123863. doi:10.1371/journal.pone.0123863
http://nur.nu.edu.kz/handle/123456789/1134
Large-scale, heteroplasmic and generally pathogenic mtDNA defects (as induced by defective mitochondrial DNA polymerase, clonal mutations or DNA deletions) are known to negatively impact on life span and can result in apoptosis and tissue loss in, e.g., skeletal muscle or reduce learning abilities. The functional impact of homoplasmic specific mtDNA point mutations, e.g., in genes coding for the electron transport chain, however, remains a matter of debate. The present study contributes to this discussion and provides evidence that a single point mutation in complex I of the respiratory chain is associated with impairment of spatial navigation in adolescent (6-month-old) mice, i.e., reduced performance in the Morris Water Maze, which goes along with increased production of reactive oxygen species (ROS) in juvenile mice (3 months) but not at the age of phenotype expression. A point mutation in complex III goes along with only a mild and non-significant negative effect on cognitive performance and no significant changes in ROS production. These findings suggest to also consider the ontogenetic development of phenotypes when studying mtDNA mutations and highlights a possible impact of complex I dysfunction on the emergence of neurological deficits.
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Reduced adolescent-age spatial learning ability associated with elevated juvenile-age superoxide levels in complex I mouse mutants
Article
oai:nur.nu.edu.kz:123456789/11352018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Valente, André
Adilbayeva, Altynai
Tokay, Tursonjan
Rizvanov, Albert A.
2016-02-03T05:00:43Z
2016-02-03T05:00:43Z
2015-08-19
http://nur.nu.edu.kz/handle/123456789/1135
Various recent developments of relevance to Parkinson's disease (PD) are discussed and integrated into a comprehensive hypothesis on the nature, origin and inter-cellular mode of propagation of late-onset sporadic PD. We propose to define sporadic PD as a characteristic pathological deviation in the global gene expression program of a cell: the PD expression-state, or PD-state for short. Although a universal cell-generic state, the PD-state deviation would be particularly damaging in a neuronal context, ultimately leading to neuron death and the ensuing observed clinical signs. We review why age accumulated damage caused by oxidative stress in mitochondria could be the trigger for a primordial cell to shift to the PD-state. We put forward hematopoietic cells could be the first to acquire the PD-state, at hematopoiesis, from the disruption in reactive oxygen species (ROS) homeostasis that arises with age in the hematopoietic
stem-cell niche. We argue why, nonetheless, such a process is unlikely to explain the shift to the PD-state of all the subsequently affected cells in a patient, thus indicating the existence of a distinct mechanism of propagation of the PD-state. We highlight recent findings on the intercellular exchange of mitochondrial DNA and the ability of mitochondrial DNA to modulate the cellular global gene expression state and propose this could form the basis for the intercellular propagation of the PD-state.
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The universal non-neuronal nature of parkinson's disease: a theory
Article
oai:nur.nu.edu.kz:123456789/11362018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Guli, Xiati
Tokay, Tursonjan
Rohde, Marco
Bender, Roland A.
Kohling, Rudiger
Kirschstein, Timo
2016-02-03T08:50:03Z
2016-02-03T08:50:03Z
2012-05-08
Xiati Guli, Tursonjan Tokay, Marco Rohde, Roland A. Bender, Rüdiger Köhling, and Timo Kirschstein, “ZD7288 Enhances Long-Term Depression at Early Postnatal Medial Perforant Path-Granule Cell Synapses,” Neural Plasticity, vol. 2012, Article ID 237913, 9 pages, 2012. doi:10.1155/2012/237913
http://nur.nu.edu.kz/handle/123456789/1136
Hyperpolarization-activated, cyclic nucleotide-gated nonselective (HCN) channels modulate both membrane potential and resistance and play a significant role in synaptic plasticity. We compared the influence of HCN channels on long-term depression
(LTD) at the medial perforant path-granule cell synapse in early postnatal (P9–15) and adult (P30–60) rats. LTD was elicited
in P9–15 slices using low-frequency stimulation (LFS, 900 pulses, 1Hz; 80 ± 4% of baseline). Application of the specific HCN
channel blocker ZD7288 (10 μM) before LFS significantly enhanced LTD (62 ± 4%; P < 0.01), showing HCN channels restrain LTD induction. However, when ZD7288 was applied after LFS, LTD was similar to control values and significantly different from
the values obtained with ZD7288 application before LFS (81 ± 5%; P < 0.01), indicating that HCN channels do not modulate
LTD expression. LTD in slices from adult rats were only marginally lower compared to those in P9–15 slices (85 ± 6%), but bath
application of ZD7288 prior to LFS resulted in the same amount of LTD (85 ± 5%). HCN channels in adult tissue hence lose their modulatory effect. In conclusion, we found that HCN channels at the medial perforant path-granule cell synapse compromise
LFS-associated induction, but not expression of LTD in early postnatal, but not in adult, rats.
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depression
nucleotide-gated nonselective
cell synapse
Research Subject Categories::MEDICINE
ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses
Article
oai:nur.nu.edu.kz:123456789/11722018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Askarova, Sholpan
Sun, Zhe
Sun, Grace Y.
Meininger, Gerald A.
Lee, James C-M.
2016-02-08T05:56:50Z
2016-02-08T05:56:50Z
2013-04-12
Askarova S, Sun Z, Sun GY, Meininger GA, Lee JC-M (2013) Amyloid-b Peptide on Sialyl-LewisX-Selectin-Mediated Membrane Tether Mechanics at the Cerebral Endothelial Cell Surface. PLoS ONE 8(4): e60972. doi:10.1371/journal.pone.0060972
http://nur.nu.edu.kz/handle/123456789/1172
Increased deposition of amyloid-b peptide (Ab) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer’s disease (AD). In this study, quantitative immunofluorescence microscopy (QIM) and atomic force microscopy (AFM) with cantilevers biofunctionalized
by sialyl-Lewisx (sLex) were employed to investigate Ab-altered mechanics of membrane tethers formed by bonding
between sLex and p-selectin at the CEC surface, the initial mechanical step governing the transmigration of monocytes. QIM results indicated the ability for Ab to increase p-selectin expression at the cell surface and promote actin polymerization in both bEND3 cells (immortalized mouse CECs) and human primary CECs. AFM data also showed the ability for Ab to increase cell stiffness and adhesion probability in bEND3 cells. On the contrary, Ab lowered the overall force of membrane tether formation (Fmtf), and produced a bimodal population of Fmtf, suggesting subcellular mechanical alterations in membrane tethering. The lower Fmtf population was similar to the results obtained from cells treated with an F-actin-disrupting drug, latrunculin A. Indeed, AFM results also showed that both Ab and latrunculin A decreased membrane stiffness, suggesting a
lower membrane-cytoskeleton adhesion, a factor resulting in lower Fmtf. In addition, these cerebral endothelial alterations induced by Ab were abrogated by lovastatin, consistent with its anti-inflammatory effects. In sum, these results demonstrated the ability for Ab to enhance p-selectin expression at the CEC surface and induce cytoskeleton
reorganization, which in turn, resulted in changes in membrane-cytoskeleton adhesion and membrane tethering, mechanical factors important in transmigration of monocytes through the BBB.
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Amyloid-b
sialyl-lewisX-selectin-mediated membrane
cerebral endothelial cell surface
Alzheimer’s disease
neurodegenerative disease
Amyloid-b peptide on sialyl-LewisX-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface
Article
oai:nur.nu.edu.kz:123456789/11732018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Askarova, Sholpan
Tsoy, Andrey
Shalakhmetova, Tamara
Lee, James C-M.
2016-02-08T06:03:00Z
2016-02-08T06:03:00Z
2012
http://nur.nu.edu.kz/handle/123456789/1173
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder, which is characterized by the accumulation of amyloid plaques and neurofibrillary tangles in specific regions of the brain, accompanied by impairment of the neurons, and progressive deterioration of cognition and memory of affected individuals. Although the cause and progression of AD are still not well understood, the amyloid hypothesis is dominant and widely accepted. According to this hypothesis, an increased deposition of amyloid-β peptide (Aβ) in the brain is the main cause of the AD’s onset and progression. There is increasing body of evidence that blood-brain barrier (BBB) dysfunction plays an important role in the development of AD, and may even precede neuron degeneration in AD brain. In the early stage of AD, microvasculature deficiencies, inflammatory reactions, surrounding the cerebral vasculature and endothelial dysfunctions are commonly observed. Continuous neurovascular degeneration and accumulation of Aβ on blood vessels resulting in cerebral amyloid angiopathy is associated with further progression of the disease and cognitive decline. However, little is known about molecular mechanisms that underlie Aβ induced damage of neurovascular cells. In this regards, this review is aimed to address how Aβ impacts the cerebral endothelium. Understanding the cellular pathways triggered by Aβ leading to alterations in cerebral endothelial cells structure and functions would provide insights into the mechanism of BBB dysfunction and inflammatory processes in Alzheimer’s, and may offer new approaches for prevention and treatment strategies for AD.
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amyloid-beta petide
Alzheimer’s disease
Research Subject Categories::MEDICINE
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Effects of amyloid beta peptide on neurovascular cells
Article
oai:nur.nu.edu.kz:123456789/11752018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Askarova, Sholpan
Yang, Xiaoguang
Lee, James C-M.
2016-02-08T06:11:00Z
2016-02-08T06:11:00Z
2011-01-21
http://nur.nu.edu.kz/handle/123456789/1175
An increasing amount of evidence supports the notion that cytotoxic effects of amyloid-β peptide (Aβ), the main constituent of senile plaques in Alzheimer’s disease (AD), are strongly associated with its ability to interact with membranes of neurons and
other cerebral cells. Aβ is derived from amyloidogenic cleavage of amyloid precursor protein (AβPP) by β- and γ-secretase. In the nonamyloidogenic pathway, AβPP is cleaved by α-secretases. These two pathways compete with each other, and enhancing the non-amyloidogenic pathway has been suggested as a potential pharmacological approach for the treatment of AD. Since AβPP, α-, β-, and γ-secretases are membrane-associated proteins, AβPP processing and Aβ production can be affected by the membrane composition and properties. There is evidence that membrane composition and properties, in turn, play a critical role in Aβ cytotoxicity associated with its conformational changes and aggregation into oligomers and fibrils. Understanding themechanisms leading to changes in a membrane’s biophysical properties and how they affect AβPP processing and Aβ toxicity should prove to provide new therapeutic strategies for prevention and treatment of AD.
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Research Subject Categories::TECHNOLOGY::Bioengineering
regenerative medicine
Research Subject Categories::MEDICINE::Physiology and pharmacology::Physiology::Neurophysiology
Impacts of membrane biophysics in Alzheimer’s disease: from amyloid precursor protein processing to Aβ peptide-induced membrane changes
Article
oai:nur.nu.edu.kz:123456789/11772018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
Yang, Xiaoguang
Askarova, Sholpan
Sheng, Wenwen
Chen, JK
Sun, Albert Y.
Sun, Grace Y.
Yao, Gang
Leea, James C-M.
2016-02-08T06:21:54Z
2016-02-08T06:21:54Z
2010-09-25
http://nur.nu.edu.kz/handle/123456789/1177
Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, oligomeric Aβ induces the assembly of NADPH oxidase complexes resulting in its activation to produce anionic superoxide. Aβ also promotes production of pro-inflammatory factors in astrocytes. Since low energy laser has previously been reported to attenuate oxidative stress and inflammation in biological systems, the objective of this study was to examine whether this type of laser light was able to abrogate the oxidative and inflammatory responses induced by Aβ. Primary rat astrocytes were exposed to Helium-Neon laser (λ=632.8 nm), followed by the treatment with oligomeric Aβ. Primary rat astrocytes were used to measure Aβ-induced production of superoxide anions using fluorescence microscopy of dihydroethidium (DHE), assembly of NADPH oxidase subunits by the colocalization between the cytosolic p47phox subunit and the membrane gp91phox subunit using fluorescent confocal microscopy, phosphorylation of cytosolic phospholipase A2 (cPLA2), and expressions of pro-inflammatory factors including interleukin-1β (IL-1β) and inducible nitric-oxide synthase (iNOS) using Western blot Analysis. Our data showed that laser light at 632.8 nm suppressed Aβ-induced superoxide production, colocalization between NADPH oxidase gp91phox and p47phox subunits, phosphorylation of cPLA2, and the expressions of IL-1β and iNOS in primary astrocytes. We demonstrated for the first time that 632.8 nm laser was capable of suppressing cellular pathways of oxidative stress and inflammatory responses critical in the pathogenesis in AD. This study should prove to provide the groundwork for further investigations for the potential use of laser therapy as a treatment for AD.
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phospholipase A2
interleukin-1β
iNOS
NADPH oxidase
oxidative stress
phosphorylation
inflammation
Low energy laser light (632.8 nm) suppresses amyloid-β peptide-induced oxidative and inflammatory responses in astrocytes
Article
oai:nur.nu.edu.kz:123456789/11792018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Yang, Xiaoguang
Askarova, Sholpan
Lee, James C-M.
2016-02-08T06:27:07Z
2016-02-08T06:27:07Z
2010-05-01
http://nur.nu.edu.kz/handle/123456789/1179
Alzheimer's disease is a chronic neurodegenerative
disorder characterized by neuronal loss, cerebrovascular
inflammation, and accumulation of senile plaques in the
brain parenchyma and cerebral blood vessels. Amyloid-β
peptide (Aβ), a major component of senile plaques, has
been shown to exert multiple toxic effects to neurons,
astrocytes, glial cells, and brain endothelium. Oligomeric
Aβ can disturb the structure and function of cell membranes
and alter membrane mechanical properties, such as
membrane fluidity and molecular order. Much of these
effects are attributed to their capability to trigger oxidative
stress and inflammation. In this review, we discuss the
effects of Aβ on neuronal cells, astrocytes, and cerebral
endothelial cells with special emphasis on cell membrane
properties and cell functions.
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Amyloid-β
Alzheimer's disease
membrane properties
membrane order
membrane fluidity
membrane potential
cerebral endothelium
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Membrane biophysics and mechanics in Alzheimer's disease
Article
oai:nur.nu.edu.kz:123456789/11802018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Askarova, Sholpan
Yang, Xiaoguang
Sheng, Wenwen
Sun, Grace Y.
Lee, James C-M.
2016-02-08T06:34:04Z
2016-02-08T06:34:04Z
2012-12-29
http://nur.nu.edu.kz/handle/123456789/1180
Blood–brain barrier (BBB) dysfunctions have been implicated in the progression of Alzheimer's disease. Cerebral endothelial cells (CECs) and astrocytes are the main cell components of the BBB. Although amyloid-β oligomers (Aβ42) have been reported to mediate oxidative damage to the CECs and astrocytes and trigger the downstream mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway, the cell surface binding site for Aβ42 and exact sequence of these events have yet to be elucidated. In this study, the receptor for advanced glycation endproducts (RAGE) was postulated to function as a signal transducing cell surface receptor for Aβ42 to induce reactive oxygen species (ROS) generation from NADPH oxidase and trigger downstream pathways for the phosphorylation of extracellular signal-regulated kinases (ERK1/2) and cytosolic phospholipase A2 (cPLA2). We found that Aβ42 competed with the anti-RAGE antibody (AbRAGE) to bind to RAGE on the surfaces of CECs and primary astrocytes. In addition, AbRAGE abrogate Aβ42-induced ROS production and the colocalization between the cytosolic (p47-phox) and membrane (gp91-phox) subunits of NADPH oxidase in both cell types. AbRAGE as well as NADPH oxidase inhibitor and ROS scavenger suppressed Aβ42-induced ERK1/2 and cPLA2 phosphorylation in CECs. At the same time, only AbRAGE, but neither NADPH oxidase inhibitor nor ROS scavenger, inhibited the ERK1/2 pathway and cPLA2 phosphorylation in primary astrocytes. Therefore, this study demonstrates that NADPH oxidase complex assembly and ROS production are not required for Aβ42 binding to RAGE at astrocytic surface leading to sequential phosphorylation of ERK1/2 and cPLA2, and suggests the presence of two different RAGE-dependent downstream pathways in the CECs and astrocytes.
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Aβ-receptor
oxidative stress
cerebral endothelial cells
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Role of Aβ-RAGE interaction in oxidative stress and cPLA2 activation in astrocytes and cerebral endothelial cells
Article
oai:nur.nu.edu.kz:123456789/11812018-08-15T03:49:49Zcom_123456789_107com_123456789_106col_123456789_1125
Zhu, Donghui
Bungart, BrittaniL
Yang, Xiaoguang
Zhumadilov, Zhaxybay
Lee, James C-M.
Askarova, Sholpan
2016-02-08T07:41:09Z
2016-02-08T07:41:09Z
2015-05-27
Zhu D,BungartBL,YangX, ZhumadilovZ,LeeJC-Mand Askarova S(2015)Roleofmembrane biophysics inAlzheimer’s–relatedcell pathways. Front.Neurosci.9:186. doi: 10.3389/fnins.2015.00186
http://nur.nu.edu.kz/handle/123456789/1181
P-selectin and actin cytoskeleton reorganization play an important role in vascular inflammation. In turn, there is increasing evidence that cerebrovascular factors contribute significantly to the
development and progression of Alzhemer’s disease. In this study we have evaluated the effects of Aβ42 oligomers on P-selectin expression and actin polymerization in mouse endothelial cells (bEnd3).
Our results indicated that Aβ42 induced plasma membrane accumulation of P-selectin and promoted actin polymerization, and these events were correlated with increased reactive oxygen species (ROS) generation. The rapid, posttranslational cell signaling response mediated by ROS may well represent an important physiological trigger of the microvascular inflammation in Alzheimer disease.
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amyloid-b peptide
membrane molecular order
amyloid precursor protein
membrane fluidity
cerebral endothelium
Role of membrane biophysics in Alzheimer’s–related cell pathways
Article
oai:nur.nu.edu.kz:123456789/12212018-08-15T03:49:52Zcom_123456789_108com_123456789_106col_123456789_1119
Leclerc, Nicolas
Chávez, Patricia
Ibraikulov, Olzhas A.
Heiser, Thomas
Lévêque, Patrick
2016-02-11T05:30:59Z
2016-02-11T05:30:59Z
2016-01-12
http://nur.nu.edu.kz/handle/123456789/1221
Solution-processed bulk heterojunction solar cells have experienced a remarkable
acceleration in performances in the last two decades, reaching power conversion efficiencies above 10%. This impressive progress is the outcome of a simultaneous development of more advanced device architectures and of optimized semiconducting polymers. Several chemical approaches have
been developed to fine-tune the optoelectronics and structural polymer parameters required to reach
high efficiencies. Fluorination of the conjugated polymer backbone has appeared recently to be
an especially promising approach for the development of efficient semiconducting polymers. As a
matter of fact, most currently best-performing semiconducting polymers are using fluorine atoms in their conjugated backbone. In this review, we attempt to give an up-to-date overview of the latest results achieved on fluorinated polymers for solar cells and to highlight general polymer properties’ evolution trends related to the fluorination of their conjugated backbone.
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fluorine
organic photovoltaics
conjugated polymer
optoelectronic
Research Subject Categories::NATURAL SCIENCES::Physics::Nuclear physics::Middle energy physics
Impact of Backbone fluorination on -conjugated polymers in organic photovoltaic devices: a review
Article
oai:nur.nu.edu.kz:123456789/12512018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
Stepanenko, Valeriy F.
2016-02-17T10:05:03Z
2016-02-17T10:05:03Z
2005-03-09
http://nur.nu.edu.kz/handle/123456789/1251
The paper is an analytical overview of the main results presented at the 3
rd Dosimetry Workshop in Hiroshima (9–11 of March 2005), where different aspects of the dose reconstruction around the Semipalatinsk nuclear test site (SNTS) were discussed and summarized.
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Semipalatinsk nuclear
Semipalatinsk nuclear test site
Hiroshima University
Research Subject Categories::MEDICINE
Research Subject Categories::TECHNOLOGY::Chemical engineering::Chemical process and manufacturing engineering::Nuclear chemistry
Around Semipalatinsk nuclear test site: progress of dose estimations relevant to the consequences of nuclear tests
Article
oai:nur.nu.edu.kz:123456789/12522018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1123
Balanovsky, Oleg
Zhabagin, Maxat
Agdzhoyan, Anastasiya
Chukhryaeva, Marina
Zaporozhchenko, Valery
Utevska, Olga
Highnam, Gareth
Sabitov, Zhaxylyk
Greenspan, Elliott
Dibirova, Khadizhat
Skhalyakho, Roza
Kuznetsova, Marina
Koshel, Sergey
Yusupov, Yuldash
Nymadawa, Pagbajabyn
Zhumadilov, Zhaxybay
Pocheshkhova, Elvira
Haber, Marc
Zalloua, Pierre A.
Yepiskoposyan, Levon
Dybo, Anna
Tyler-Smith, Chris
Balanovska, Elena
2016-02-17T11:05:41Z
2016-02-17T11:05:41Z
2015-04-07
Balanovsky O, Zhabagin M, Agdzhoyan A, Chukhryaeva M, Zaporozhchenko V, Utevska O, et al. (2015) Deep Phylogenetic Analysis of Haplogroup G1 Provides Estimates of SNP and STR Mutation Rates on the Human Y-Chromosome and Reveals Migrations of Iranic Speakers. PLoS ONE 10(4): e0122968. doi:10.1371/journal.pone.0122968
http://nur.nu.edu.kz/handle/123456789/1252
Y-chromosomal haplogroup G1 is a minor component of the overall gene pool of South-
West and Central Asia but reaches up to 80% frequency in some populations scattered
within this area. We have genotyped the G1-defining marker M285 in 27 Eurasian populations (n= 5,346), analyzed 367 M285-positive samples using 17 Y-STRs, and sequenced ~11 Mb of the Y-chromosome in 20 of these samples to an average coverage of 67X. This allowed detailed phylogenetic reconstruction. We identified five branches, all with high geographical specificity: G1-L1323 in Kazakhs, the closely related G1-GG1 in Mongols, G1- GG265 in Armenians and its distant brother clade G1-GG162 in Bashkirs, and G1-GG362 in West Indians.
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Y-chromosomal haplogroup
haplogroup G1
SNP and STR Mutation Rates
Deep phylogenetic analysis of haplogroup G1 provides estimates of SNP and STR utation rates on the human Y-Chromosome and reveals migrations of Iranic speakers
Article
oai:nur.nu.edu.kz:123456789/12532018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Drozdovitch, Vladimir
Schonfeld, Sara
Akimzhanov, Kuat
Aldyngurov, Daulet
Land, Charles E.
Luckyanov, Nickolas
Mabuchi, Kiyohiko
Potischman, Nancy
J. Schwerin, Michael J.
Semenova, Yulia
Tokaeva, Alma
Zhumadilov, Zhaxybay
Bouville, André
Simon, Steven L.
2016-02-17T11:17:55Z
2016-02-17T11:17:55Z
2011-03
The publisher's final edited version of this article is available at Radiat Environ Biophys DOI 10.1007/s00411-010-0334-9
http://nur.nu.edu.kz/handle/123456789/1253
The relationship between radiation exposure from nuclear weapons testing fallout and thyroid disease in a group of 2,994 subjects has been the subject of study by the US National Cancer Institute. In that study, radiation doses to the thyroid were estimated for residents of villages in Kazakhstan possibly exposed to deposition of radioactive fallout from nuclear testing conducted by the Soviet Union at the Semipalatinsk Nuclear Test Site in Kazakhstan between 1949 and 1962. The study subjects included individuals of both Kazakh and Russian origin who were exposed during childhood and adolescence. An initial dose reconstruction used for the risk analysis of Land et al. (Radiat Res 169:373-383, 2008) was based on individual information collected from basic questionnaires administered to the study population in 1998. However, because data on several key questions for accurately estimating doses were not obtained from the 1998 questionnaires, it was decided to conduct a second data collection campaign in 2007. Due to the many years elapsed since exposure, a well-developed strategy was necessary to encourage accurate memory recall.
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Semipalatinsk nuclear test site in Kazakhstan
Semipalatinsk nuclear
Research Subject Categories::MEDICINE
Behavior and food consumption pattern of the population exposed in 1949–1962 to fallout from Semipalatinsk nuclear test site in Kazakhstan
Article
oai:nur.nu.edu.kz:123456789/12832018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Catanzaro, R.
Zerbinati, N.
Solimene, U.
Celep, G.
Marotta, F.
Kushugulova, A.
Milazzo, M.
Tomella, C.
Bertuccelli, G.
Zhumadilov, Z.
2016-02-19T03:22:51Z
2016-02-19T03:22:51Z
2013
DOI: 10.5582/ddt.2013.v7.5.196
http://nur.nu.edu.kz/handle/123456789/1283
The aim of this study was to test for a potential anticarcinogenic effect of Celergen, a marine derivative devoid of traceable amounts of inorganic arsenic, on cell proliferation, cell cycle progression and apoptosis in the HepG2 human liver cancer cell
line. Celergen significantly inhibited the proliferation of cancer cells in a dose-dependent manner while limiting the cell cycle progression at the G1 phase and
significantly inducing apoptosis. Further examination showed that Celergen enhanced expression of the p21CIPl1WAF1, GADD153 genes and downregulated the
c-myc gene. These results suggest that Celergen exerts promising chemopreventive properties to be further investigated.
en
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antimutagenic effect
cell cycle
apoptosis
celergen
marine compound
Research Subject Categories::MEDICINE
Effect of Celergen, a marine derivative, on in vitro hepatocarcinogenesis
Article
oai:nur.nu.edu.kz:123456789/12842018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Zhumadilov, Zhaxybay
Kozhakhmetov, Samat S.
Kushugulova, Almagul R.
Saduakhasova, Saule A.
Shakhabayeva, Gulnara S.
Khassenbekova, Zhanagul R.
Molkenov, Askhat B.
Kairov, Ulykbek E.
Issayeva, Raushan B.
Nurgozhin, Talgat S.
2016-02-19T03:41:39Z
2016-02-19T03:41:39Z
2015
Kozhakhmetov SS, Kushugulova AR, Saduakhasova SA, Shakhabayeva GS, Khassenbekova ZR, Molkenov AB, Kairov UE, Issayeva RB, Nurgozhin TS, Zhumadilov ZS. 2015. Draft genome sequence of Lactobacillus rhamnosus CLS17. Genome Announc 3(3):e00478-15. doi:10.1128/genomeA.00478-15.
http://nur.nu.edu.kz/handle/123456789/1284
The human gut microbiome is an organ that provides primary
barrier protection against foreign agents. Most of the microorganisms
are different strains of commensal bacteria that are colonized in the gut. Gut flora influence food metabolism and have an antagonistic effect on different pathogens and immunomodulatory properties (1). One of the main species of gut flora is
in the genus Lactobacillus...
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lactobacillus
genome sequence
microbiome
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
Draft genome sequence of Lactobacillus rhamnosus CLS17
Article
oai:nur.nu.edu.kz:123456789/12852018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Zhumadilov, Kassym
Ivannikov, Alexander
Stepanenko, Valeriy
Zharlyganova, Dinara
Toyoda, Shin
Zhumadilov, Zhaxybay
Hoshi, Masaharu
2016-02-19T03:54:34Z
2016-02-19T03:54:34Z
2013-02
doi: 10.1093/jrr/rrt008
http://nur.nu.edu.kz/handle/123456789/1285
A tooth enamel electron spin resonance (ESR) dosimetry study was carried out with the purpose of obtaining the individual absorbed radiation doses of population from settlements in the Semipalatinsk region of Kazakhstan, which was exposed to radioactive fallout traces from nuclear explosions in the Semipalatinsk Nuclear Test Site and Lop Nor test base, China. Most of the settlements are located near the central axis of
radioactive fallout trace from the most contaminating surface nuclear test, which was conducted on 29 August 1949, with the maximum detected excess dose being 430 ± 93 mGy. A maximum dose of 268 ± 79 mGy was determined from the settlements located close to radioactive fallout trace resulting from surface nuclear tests on 24 August 1956 (Ust-Kamenogorsk, Znamenka, Shemonaikha, Glubokoe, Tavriya
and Gagarino). An accidental dose of 56 ± 42 mGy was found in Kurchatov city residents located close to fallout trace after the nuclear test on 7 August 1962. This method was applied to human tooth enamel to obtain individual absorbed doses of residents of the Makanchi, Urdzhar and Taskesken settlements located near the Kazakhstan–Chinese border due to the influence of nuclear tests (1964–1981) at Lop Nor. The
highest dose was 123 ± 32 mGy.
en
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ESR dosimetry
tooth enamel samples
Semipalatinsk Test Site
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
ESR dosimetry study of population in the vicinity of the Semipalatinsk Nuclear Test Site
Article
oai:nur.nu.edu.kz:123456789/12862018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Takeichi, Nobuo
Hoshi, Masaharu
Iida, Shozo
Tanaka, Kimio
Harada, Yuka
Zhumadilov, Zhaxybay
Chaizhunusova, Nailya
Apsalikov, Kazbek N.
Noso, Yoshihiro
Inaba, Toshiya
Tanaka, Kenichi
Endo, Satoru
2016-02-19T04:11:18Z
2016-02-19T04:11:18Z
2006
http://nur.nu.edu.kz/handle/123456789/1286
Chromosomal studies in peripheral lymphocytes from 63 residents near the Semipalatinsk nuclear test site, at ages of 52–63 years old, were performed in 2001–2002. A higher rate of chromosome aberrations was observed in the two contaminated villages, Dolon and Sarjal, compared with the control village,
Kokpekti. Moreover, a relationship of frequency of cells with radiation induced chromosome aberrations and the previously estimated exposure dose was observed. Furthermore, apparent nuclear abnormalities (ANA) of thyroid follicular cells were studied in 30 out of 63 residents, who were examined for chromosome aberrations. A higher rate of ANA was also found in the residents in the exposed villages compared with those in the control village. These results suggest radiation effects both on the chromosomes in
peripheral lymphocytes and on the follicular cells in the thyroid.
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Semipalatinsk nuclear test site
thyroid cells
apparent nuclear abnormalities
chromosome aberrations
radiation effect
Nuclear abnormalities in aspirated thyroid cells and chromosome aberrations in lymphocytes of residents near the Semipalatinsk Nuclear Test Site
Article
oai:nur.nu.edu.kz:123456789/12872018-08-15T03:49:50Zcom_123456789_107com_123456789_106col_123456789_1125
Kairov, Ulykbek E.
Kozhamkulov, Ulan
Molkenov, Askhat
Rakhimova, Saule
Askapuli, Ayken
Zhabagin, Maxat
Akhmetova, Ainur
Yerezhepov, Dauren
Abilova, Zhannur
Abilmazhinova, Aliya
Bismilda, Venera
Chingisova, Leila
Akilzhanova, Ainur
Zhumadilov, Zhaxybay
2016-02-19T04:22:16Z
2016-02-19T04:22:16Z
2015
Kairov U, Kozhamkulov U, Molkenov A, Rakhimova S, Askapuli A, Zhabagin M, Akhmetova A, Yerezhepov D, Abilova Z, Abilmazhinova A, Bismilda V, Chingisova L, Zhumadilov Z, Akilzhanova A. 2015. Draft genome sequences of two clinical isolates of Mycobacterium tuberculosis from sputum of Kazakh patients. Genome Announc 3(3): e00466-15. doi:10.1128/genomeA.00466-15.
http://nur.nu.edu.kz/handle/123456789/1287
Here, we report the draft genome sequences of two clinical isolates of Mycobacterium tuberculosis (MTB-476 and MTB-489) isolated
from sputum of Kazakh patients.
en
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genome sequences
mycobacterium tuberculosis
Research Subject Categories::MEDICINE::Morphology, cell biology, pathology
Draft genome sequences of two clinical Isolates of mycobacterium tuberculosis from sputum of Kazakh patients
Article
oai:nur.nu.edu.kz:123456789/12892018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Supiyev, Adil
Nurgozhin, Talgat
Zhumadilov, Zhaxybay
Sharman, Almaz
Marmot, Michael
Bobak, Martin
2016-02-19T04:32:09Z
2016-02-19T04:32:09Z
2014
http://www.biomedcentral.com/1471-2458/14/768
http://nur.nu.edu.kz/handle/123456789/1289
The high and fluctuating mortality and rising health inequalities in post-Soviet countries have attracted considerable attention. However, there are very few individual-level data on distribution of health outcomes in Central Asian countries of the former Soviet Union. We analysed socioeconomic predictors of two self-rated health outcomes in a national survey in Kazakhstan.
en
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self-rated health
socioeconomic factors
Central Asian countries
Research Subject Categories::MEDICINE
Levels and distribution of self-rated health in the Kazakh population: results from the Kazakhstan household health survey 2012
Article
oai:nur.nu.edu.kz:123456789/12902018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Zhumadilov, Kassym
Ivannikov, Alexander
Skvortsov, Valeriy
Stepanenko, Valeriy
Zhumadilov, Zhaxybay
Endo, Satoru
Tanaka, Kenichi
Hoshi, Masaharu
2016-02-19T04:42:24Z
2016-02-19T04:42:24Z
2005
http://nur.nu.edu.kz/handle/123456789/1290
conditions were optimized. The uncertainty of dose determination was obtained as the mean square deviation of doses, determined with the use of a spectra deconvolution program, from the nominal doses for ten enamel samples irradiated in the range from 0 to 500 mGy. The spectra were recorded at different microwave powers and accumulation times. It was shown that minimal uncertainty is achieved at the microwave power of about 2 mW for a used spectrometer JEOL JES-FA100. It was found that a limit of the accumulation time exists beyond which uncertainty reduction is ineffective. At an established total time of measurement, reduced uncertainty is obtained by averaging the experimental doses determined from recorded spectra following intermittent sample shaking and sample tube rotation, rather than from one spectrum recorded at longer accumulation time. The effect of sample mass on the spectrometer’s sensitivity
was investigated in order to find out how to make appropriate corrections.
en
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EPR spectroscopy
tooth enamel
dose determination
Research Subject Categories::MEDICINE
Tooth enamel EPR dosimetry: optimization of EPR spectra recording parameters and effect of sample mass on spectral sensitivity
Article
oai:nur.nu.edu.kz:123456789/12912018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Akilzhanova, Ainur
Guelly, Christian
Nuralinov, Omirbek
Nurkina, Zhannur
Nazhat, Dinara
Smagulov, Shalkhar
Tursunbekov, Azat
Alzhanova, Anar
Rashbayeva, Gulzhaina
Abdrakhmanov, Ayan
Dosmagambet, Sholpan
Trajanoski, Slave
Zhumadilov, Zhaxybay
Sharman, Almaz
Bekbosynova, Mahabbat
2016-02-19T04:53:29Z
2016-02-19T04:53:29Z
2014
Akilzhanova A, Guelly C, Nuralinov O, Nurkina Z, Nazhat D, et al. (2014) RYR2 Sequencing Reveals Novel Missense Mutations in a Kazakh Idiopathic Ventricular Tachycardia Study Cohort. PLoS ONE 9(6): e101059. doi:10.1371/journal.pone.0101059
http://nur.nu.edu.kz/handle/123456789/1291
Channelopathies, caused by disturbed potassium or calcium ion management in cardiac myocytes are a major cause of heart failure and sudden cardiac death worldwide. The human ryanodine receptor 2 (RYR2) is one of the key players tightly regulating calcium efflux from the sarcoplasmic reticulum to the cytosol and found frequently mutated (,60%) in context of catecholaminergic polymorphic ventricular tachycardia (CPVT1). We tested 35 Kazakhstani patients with episodes of ventricular arrhythmia, two of those with classical CPVT characteristics and 33 patients with monomorphic idiopathic
ventricular arrhythmia, for variants in the hot-spot regions of the RYR2 gene. This approach revealed two novel variants; one de-novo RYR2 mutation (c13892A.T; p.D4631V) in a CPVT patient and a novel rare variant (c5428G.C; p.V1810L) of
uncertain significance in a patient with VT of idiopathic origin which we suggest represents a low-penetrance or susceptibility variant. In addition we identified a known variant previously associated with arrhythmogenic right ventricular
dysplasia type2 (ARVD2). Combining sets of prediction scores and reference databases appeared fundamental to predict the pathogenic potential of novel and rare missense variants in populations where genotype data are rare.
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RYR2 sequencing
human ryanodine receptor
ventricular arrhythmia
Tachycardia
RYR2 sequencing reveals novel missense mutations in a Kazakh Idiopathic ventricular tachycardia study cohort
Article
oai:nur.nu.edu.kz:123456789/12922018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Zhumadilov, Zhaxybay
GUSEV, BORIS I.
TAKADA, JUN
HOSHI, Masaharu
Kimura, AKIRO
Hayakawa, Norihiko
Takeichi, Nobuo
2016-02-19T05:12:50Z
2016-02-19T05:12:50Z
2000
http://nur.nu.edu.kz/handle/123456789/1292
From 1949 through 1989 nuclear weapons testing carried out by the former Soviet Union at the Semipalatinsk Nuclear Test Site (SNTS) resulted in local fallout affecting the residents of Semipalatinsk, Ust-Kamenogorsk and Pavlodar regions of Kazakstan. To investigate the possible relationship between radiation exposure and thyroid gland abnormalities, we conducted a case review of pathological findings of 7271 urban and rural patients who underwent surgery from 1966–96. Of the 7271 patients, 761
(10.5%) were men, and 6510 (89.5%) were women...
en
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nuclear weapon testing
Semipalatinsk
thyroid abnormalities
pathological specimens
radiationinduced neoplasms
Research Subject Categories::MEDICINE
Thyroid abnormality trend over time in Northeastern Regions of Kazakstan, adjacent to the Semipalatinsk Nuclear Test Site: a case review of pathological findings for 7271 patients
Article
oai:nur.nu.edu.kz:123456789/12932018-01-29T21:17:56Zcom_123456789_107com_123456789_106col_123456789_1125
2016-02-19T05:18:35Z
2016-02-19T05:18:35Z
2016
http://nur.nu.edu.kz/handle/123456789/1293
The method of electron paramagnetic resonance (EPR) spectroscopy for tooth enamel is applied to individual radiation dose determination to residents of two villages (Dolon and Mostik) in the vicinity of the Semipalatinsk nuclear test site in Kazakhstan. These villages are located near the central axis of the radioactive fallout trace of the most contaminating surface nuclear test conducted in 1949. It is found that excess doses obtained by subtraction of natural background dose from dose absorbed in enamel range up
to 440 mGy to residents of Dolon, whose enamel was formed before 1949, and do not exceed 120 mGy to younger residents. To residents of Mostik, excess doses do not exceed 100 mGy regardless of age except for one resident with an extremely high dose of 1.25 Gy. These results are in agreement with the pattern of radioactive contamination of the territory after the nuclear test of 1949 except one case of extremely high dose, which should be additionally investigated.
en
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EPR spectroscopy
tooth enamel
Dose reconstruction
Semipalatinsk nuclear test site
Results of EPR dosimetry for population in the vicinity of the most contaminating radioactive fallout trace after the first nuclear test in the Semipalatinsk Test Site
Article
oai:nur.nu.edu.kz:123456789/12942018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
Terlikbayeva, Assel
Hermosilla, Sabrina
Galea, Sandro
Schluger, Neil
Yegeubayeva, Saltanat
Abildayev, Tleukhan
Muminov, Talgat
Akiyanova, Farida
Bartkowiak, Laura
Zhumadilov, Zhaxybay
Sharman, Almaz
El-Bassel, Nabila
2016-02-19T05:27:52Z
2016-02-19T05:27:52Z
2012
http://nur.nu.edu.kz/handle/123456789/1294
Development of tuberculosis (TB) is determined by various risk factors and the interactions of temporal and spatial distributions. The aim of this study was to identify the most salient risk factors for TB disease as well as multidrug resistant TB (MDR-TB) at the oblast (provincial) level in Kazakhstan.
en
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tuberculosis
case notification rate
prevalence
risk factors
MDR-TB
Kazakhstan
spatial distribution
surveillance
National tuberculosis program
Oblast
Research Subject Categories::MEDICINE
Tuberculosis in Kazakhstan: analysis of risk determinants in national surveillance data
Article
oai:nur.nu.edu.kz:123456789/13012018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Mussin (Мусин), Y.A. (Е.А.)
Bulanin (Буланин), D.S. (Д.С.)
Jeffries (Джеффрис), R.G. (Р.Дж.)
Zhumadilov (Жумадилов), Zhaxybay (Ж.Ш.)
Olzhayev, F.
Federspiel (Федерспил), W.J. (В.Дж.)
2016-02-19T11:29:29Z
2016-02-19T11:29:29Z
2014
Мусин Е.А., Буланин Д.С., Джеффрис Р.Д., Жумадилов Ж.Ш., Олжаев Ф.С., Федерспил В.Д. ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ. Вестник трансплантологии и искусственных органов. 2014;16(4):125-134. DOI:10.15825/1995-1191-2014-4-125-134
http://nur.nu.edu.kz/handle/123456789/1301
Основной целью данной работы является получение первичных данных о нагнетательной способности гемопомпы устройства Hemolung и способности обеспечить адекватный уровень газообмена при использовании катетеров уменьшенного диаметра и скорости кровообращения, применимой у детей.
The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange effectiveness while using the catheters of smaller diameter and blood fl ow rates, applied in pediatrics.
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severe respiratory failure
extracorporeal gas exchange
oxygenation
pediatrics
тяжелая дыхательная недостаточность
экстракорпоральный газообмен
педиатрия
оксигенация
Research Subject Categories::MEDICINE
EVALUATION OF EXTRACORPOREAL GAS EXCHANGE DEVICE HEMOLUNG FOR POTENTIAL APPLICATION IN PEDIATRIC PRACTICE/ ОЦЕНКА ВОЗМОЖНОСТИ ПРИМЕНЕНИЯ СИСТЕМЫ ЭКСТРАКОРПОРАЛЬНОГО ГАЗООБМЕНА (HEMOLUNG) В ПЕДИАТРИИ
Article
oai:nur.nu.edu.kz:123456789/13022018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Pichugin, Vladimir
Melnikov, Nikolay
Olzhayev, F.
Medvedev, Alexander
Jourko, Sergey
Gamzaev, Alishir
Chiginev, Vladimir
2016-02-19T11:48:39Z
2016-02-19T11:48:39Z
2014
http://nur.nu.edu.kz/handle/123456789/1302
Cardioplegic cardiac arrest with subsequent ischemic-reperfusion injuries can lead to the development of inflammation of the myocardium, leucocyte activation, and release of cardiac enzymes. Flow reduction to the bronchial arteries, causing low-flow lung ischemia, leads to the development of a pulmonary regional inflammatory response...
en
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constant coronary perfusion
pulmonary artery perfusion
cardiopulmonary bypass
Research Subject Categories::MEDICINE
Heart and lungs protection technique for cardiac surgery with cardiopulmonary bypass
Article
oai:nur.nu.edu.kz:123456789/13052018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Далина, А.Д.
Мухамбетова, А.Е.
Батпенов, Н.Д.
Раймагамбетов, Е.К.
Огай, В.Б.
2016-02-24T05:44:00Z
2016-02-24T05:44:00Z
2013
http://nur.nu.edu.kz/handle/123456789/1305
В настоящее время мезенхимальные стволовые клетки (МСК), выделенные из синовиальной оболочки коленных суставов, представляют большой научный и практический интерес для регенеративной медицины и тканевой инженерии, поскольку они более эффективно участвуют в хондрогенезе и обладают более высоким пролиферативным и регенераторным потенциалом, чем МСК костного мозга и жировой ткани.
ru
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мезенхимальные стволовые клетки
факторы роста
дифференцировка
синовиальная оболочка
хондрогенез
Research Subject Categories::TECHNOLOGY::Bioengineering::Biotechnological separation
Влияние ростовых факторов TGF-β1, IGF-I, BMP-2 и BMP-4 на хондрогенную дифференцировку мезенхимальных стволовых клеток, выделенных из синовинальной оболочки человека
Article
oai:nur.nu.edu.kz:123456789/13062018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Tazhibaeva, D.
Olzhayev, F.
Kabdualieva, N.
Aitbaeva, Zh.
Zaripova, L.
2016-02-24T05:54:43Z
2016-02-24T05:54:43Z
2014
http://nur.nu.edu.kz/handle/123456789/1306
Cell technologies are widely used in medical practice these days. In this research we evaluated the effect of the fetal nerve cell transplantation on the rat survival after the case of clinical death from the mechanical asphyxia.
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cell technologies
embryos
rats
mechanical asphyxia
transplantation
Transplantation of the fetal nerve cells in early post-reanimation period in rats
Other
oai:nur.nu.edu.kz:123456789/13072018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Секенова, А.Е.
Балтабекова, М.Ж.
Хасенов, Б.Б.
Огай, В.Б.
2016-02-24T05:54:54Z
2016-02-24T05:54:54Z
2013
http://nur.nu.edu.kz/handle/123456789/1307
Транскрипционный фактор Sox2, который экспрессируется в эмбриональных стволовых клетках, играет важную роль в самообновлении и поддержании плюрипотентности эмбриональных и индуцированных плюрипотентных стволовых клеток. В данном исследовании методом плазмидной экспрессии бактериального штамма Rosetta pLysS(DE3), несущего генетическую конструкцию рЕТ-28а/Sox2, был наработан рекомбинантный транскрипционный фактор Sox2.
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Sox2
антиген
антитела
плюрипотентные стволовые клетки
Research Subject Categories::TECHNOLOGY::Bioengineering::Biotechnological separation
Получение и анализ поликлональных антител к рекомбинантному транскрипционному фактору SOX2
Article
oai:nur.nu.edu.kz:123456789/13082018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Yantsen, Y.
Idrissova, D.
Olzhayev, F.
Umbayev, B.
Murata, H.
Russell, A.
Askarova, Sh.
2016-02-24T06:03:23Z
2016-02-24T06:03:23Z
2014
http://nur.nu.edu.kz/handle/123456789/1308
Mesenchymal stem cells (MSCs) are an attractive stem cell source for transplantation. MSCs can easily differentiate into osteoblasts and increase in osteoblast number will have positive effect on the bone regeneration in such conditions as osteoporosis or Paget disease. To provide the targeted delivery of MSCs to bone we have synthesized a novel osteophilic polymer. The primary active sites of the polymer are bisphosphonate functional groups that target hydroxyapatite molecules (HA) on the bone surface. NHS groups on the other end of the molecule allow polymer to bind to the cell surface components. Coating of cell surfaces with the polymer would allow the cells to bind specifically to HA component of bone and localize the cellular repair functions to areas of injured bone.
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mesenchymal stem cells
osteophilic polymer
regeneration
polymer
cell
Mesenchymal stem cells and osteophilic polymer as promising agents in bone regeneration
Other
oai:nur.nu.edu.kz:123456789/13092018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Мусин, Е.А.
Буланин, Д.С.
Жумадилов, Ж.Ш.
Олжаев, Ф.С.
Federspiel, W.
Jeffries, G.
2016-02-24T07:50:29Z
2016-02-24T07:50:29Z
2013
http://nur.nu.edu.kz/handle/123456789/1309
Оценка перспективы применения системы Hemolung в детской практике.
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система Hemolung
испытание системы
Hemolung в детской практике
скорость кровотока
скорость элиминации
Перспективы применения системы экстракорпоральной респираторной поддержки в детской практике
Other
oai:nur.nu.edu.kz:123456789/13102018-08-15T03:49:51Zcom_123456789_107com_123456789_106col_123456789_1125
Мусин, Е.А.
Jeffries, R.G.
Олжаев, Ф.С.
Исаева, Р.Б.
Жумадилов, Ж.Ш.
Салиев, Т.М.
Federspiel, W.J.
2016-02-24T08:03:25Z
2016-02-24T08:03:25Z
2015
http://nur.nu.edu.kz/handle/123456789/1310
Экспериментальная оценка возможности применения системы Hemolung
в педиатрической практике.
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оценка
применения системы Hemolung
эксперименты
In vivo оценка возможности применения системы экстракорпорального газообмена (Hemolung) в педиатрии
Other
oai:nur.nu.edu.kz:123456789/13112018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Сафарова, Ю.И.
Олжаев, Ф.С.
Идрисова, Д.Ш.
Умбаев, Б.А.
Мурата, Х.
Рассел, А.
Аскарова, Ш.Н.
2016-02-24T08:18:47Z
2016-02-24T08:18:47Z
2015
http://nur.nu.edu.kz/handle/123456789/1311
Целью данной работы явилась исследование эффективности нового спо-
соба стимулирования регенерации ОАП с помощью клеточной терапии мезенхималь-
ными стволовыми клетками (МСК), модифицированными синтетическим остеотроп-
ным бисфосфонатным полимером на основе N-акрилоил-6-аминогексановой кислоты
N’-оксисукцинимид эфира. В связи с тем, что бисфосфонаты имеют высокую степень
сродства к гидроксиапатитам, составляющим почти 2/3 сухой массы кости, данный син-
тетический полимер, ковалентно связанный с мембранами МСК, способен осуществлять
тканеспецифическую доставку клеток в очаги поражения костной ткани, и таким образом, локализовать процессы клеточной репарации.
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новый способ стимуляции
клеточная терапия
стволовые клетки
Новый способ стимуляции репаративного остеогенеза в зоне перелома костей при остеопорозе с использованием клеточной терапии мезенхимальными стволовыми клетками, модифицированными синтетическим бисфосфонатным остеотропным полимером
Other
oai:nur.nu.edu.kz:123456789/13122018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Янцен, Ю.И.
Идриссова, Д.
Олжаев, Ф.С.
Умбаев, Б.А.
Мурата, Х.
Рассел, А.
Аскарова, Ш.Н.
2016-02-24T08:33:44Z
2016-02-24T08:33:44Z
2014
http://nur.nu.edu.kz/handle/123456789/1312
На сегодняшний день регенерация костной ткани является очень важной и актуальной проблемой. Нарушение костного метаболизма при таких заболеваниях, как остеопороз или болезнь Педжета приводит к усилению остеокластной активности и потере как остеобластных клеток, так и клеток-предшественников остеобластов. Для восполнения пула остеобластов было предложено применение аутологичных мезенхимальных стволовых клеток (МСК). С целью разработки таргетной доставки клеток к очагам повреждения костной ткани был синтезирован полимер, способный стабильно связываться с МСК и обладающий тропностью к костной ткани.
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остеопороз
костный метаболизм
мезенхимальные стволовые клетки
АТРП синтез
клеточная терапия
целенаправленная доставка клеток
Остеофильный полимер и мезенхимальные стволовые клетки в регенерации костной ткани
Other
oai:nur.nu.edu.kz:123456789/13132018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Batyrbekov, K.
Olzhayev, F.
Shanazarov, N.
Maschkin, A.
2016-02-24T09:01:46Z
2016-02-24T09:01:46Z
2015
http://nur.nu.edu.kz/handle/123456789/1313
Colorectal cancer (CRC) is the third most common malignant neoplasm
worldwide. According to World Gastroenterology Organization CRC is the second leading
cause of cancer deaths among men and women that makes more than 500 000 cases in a
year. This type of cancer is difficult to diagnose at an early stage that indicates high demand
for introduction of the CRC population screening program. On recommendation WGO “ideal
colonoscopy screening” has to be simple and cheap. Though colonoscopy screening program is
partially functioning in US the CRC incidence steadily decreases by 3% each year. Nowadays
CS is not held for all population of Kazakhstan. The aim of this work is assessment of possibility
and efficiency of early endoscopy screening for malignancy of digestive tract.
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colorectal cancer
chronic constipation
polyps
analysis
Efficiency of screening colonoscopy for diagnosis of precancerous and canserous disease of digestive tract
Other
oai:nur.nu.edu.kz:123456789/13142018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Chuvakova, T.
Bapayeva, G.
Issayeva, R.
Olzhayev, F.
Dzhamanaeva, K.
Kenbaeva, K.
2016-02-24T09:09:32Z
2016-02-24T09:09:32Z
2015
http://nur.nu.edu.kz/handle/123456789/1314
The processes of growth of the fetus are provided by a constant supply of
amino acids from mother, which provides the production of proteins and muscle tissue of the
fetus. The purpose of this research was to study the amino acid level in blood of fetuses and
newborns with intrauterine growth restriction.
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intrauterine growth restriction
amino acids
newborn
Evaluation of amino acid level in the blood of fetuses and newborns with intrauterine growth restriction
Other
oai:nur.nu.edu.kz:123456789/13152018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Chuvakova, T.
Bapayeva, G.
Issayeva, R.
Begimbetova, D.
Olzhayev, F.
Dzhamanaeva, K.
Kenbaeva, K.
2016-02-24T09:17:09Z
2016-02-24T09:17:09Z
2015
http://nur.nu.edu.kz/handle/123456789/1315
Preterm premature rupture of membranes (PPROM) is one of the leading causes
of perinatal morbidity and mortality. Intrauterine continuous amnioinfusion via a subcutaneously
implanted port system for PPROM is an attempt to improve the perinatal outcomes.
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preterm premature rupture of membranes
perinatal mortality
perinatal morbidity
Perinatal outcomes in preterm premature rupture of membranes
Other
oai:nur.nu.edu.kz:123456789/13162018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Zhurko, S.
Olzhayev, F.
Chiginev, V.
Fedorov, S.
2016-02-24T09:35:31Z
2016-02-24T09:35:31Z
2015
http://nur.nu.edu.kz/handle/123456789/1316
To conduct a clinical study of immediate results, assessment of hemodynamic
characteristics of developed a new biological stented prosthesis «UniLine» (Russia, Kemerovo)
designed for correction of heart valve lesions of various etiologies.
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hemodynamic characteristics
valves correction
patients
First experience of using biological prosthesis "UniLine" for correction of heart valve diseases
Other
oai:nur.nu.edu.kz:123456789/13272018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Han, Hyun-Jung
Park, Sang-Jun
Soh, Kwang-sup
Myoung, Hyoun-Seok
Lee, Kyoung-Joung
Ogay, Vyacheslav
Lee, Yong-Heum
2016-02-29T04:49:09Z
2016-02-29T04:49:09Z
2011
2011 Hyun-Jung Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://dx.doi.org/10.1155/2011/295475
http://nur.nu.edu.kz/handle/123456789/1327
Specific electrical characteristicsof acupointswere investigated on the urinary bladder (BL) meridian in 14 rats. BL acupointsand non-acupoints on the back were selected and their electrical voltages were measured by using aSPACsystem.The mean voltages of each point or each line were statistically analyzed by using the ANOVA test...
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electrical characterization of proposed transpositional acupoints
acupointsmay
rat model
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Electrical сharacterization of proposed transpositional acupoints on the Urinary Bladder Meridian in a Rat Model
Article
oai:nur.nu.edu.kz:123456789/13282018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Ogay, Vyacheslav
Bae, Kyung Hee
Kim, Ki Woo
Soh, Kwang-sup
2016-02-29T04:57:08Z
2016-02-29T04:57:08Z
2009-03-31
http://nur.nu.edu.kz/handle/123456789/1328
Objective: To show that the characteristic morphological and ultrastructural features
of a Bonghan corpuscle and duct presented here are consistent with the description
given in the early reports of Bonghan Kim.
Materials and Methods: We compared the morphological aspects of Bonghan ducts
with those of blood and lymphatic capillaries on the ultrastructural level to display
the manifestly distinctive nature of the Bonghan system.
Results: The walls of the ductules were observed to be composed of a single layer of
endothelial cells with characteristic rod-shaped nuclei and were not surrounded by
a basal lamina or by accessory cells, such as pericytes or smooth muscle cells. The
abluminal cell membranes of Bonghan ductules were not attached by anchoring filaments to the fibers of extracellular matrices as observed in lymphatic capillaries.
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acupuncture meridian
blood capillary
Bonghan corpuscle and duct
circulatory system
endothelial cells
lymphatic capillary
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Comparison of the characteristic features of bonghan ducts, blood and lymphatic capillaries
Article
oai:nur.nu.edu.kz:123456789/13292018-08-15T03:50:25Zcom_123456789_107com_123456789_106col_123456789_1125
Baik, Ku Youn
Ogay, Vyacheslav
Jeoung, Sae Chae
Soh, Kwang-sup
2016-02-29T05:03:28Z
2016-02-29T05:03:28Z
2009-04-13
©2009 Korean Pharmacopuncture Institute
http://nur.nu.edu.kz/handle/123456789/1329
Objectives: The origin of adult stem cells remains an open question. If they derive
from embryos, it is difficult to determine the mechanism which interrupts their
differentiation during tissue formation. In the 1960s, the Bonghan microcell was
suggested as one possible, yet to be described, route of stem cell production, such
that they have the potential to proliferate to produce normal cells.
Materials and Methods: In this study, Bonghan microcells were isolated from
Bonghan tissues on rat organ surfaces, and their detailed morphology examined by
electron and atomic force microscopy.
Results: The ultrastructure observed distinguished them from apoptotic bodies and
other microorganisms, and their unique, possible proliferation feature, as protruding
threads, was imaged by atomic force microscopy.
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atomic force microscopy
Bonghan microcell
budding
electron microscopy
stem cell
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Visualization of Bonghan Microcells by Electron and Atomic Force Microscopy
Article
oai:nur.nu.edu.kz:123456789/13302018-08-15T03:49:52Zcom_123456789_107com_123456789_106col_123456789_1125
Yoo, Jung Sun
Kim, Hong Bae
Ogay, Vyacheslav
Lee, Byung-Cheon
Ahn, Saeyoung
Soh, Kwang-sup
2016-02-29T05:14:21Z
2016-02-29T05:14:21Z
2009-04-01
http://nur.nu.edu.kz/handle/123456789/1330
Objective: The present study has been designed to find a possible new route for the
metastasis of cancer cells on the fascia surrounding tumor tissue using a novel technique
of trypan blue staining.
Materials and Methods: Tumor tissues were grown in the skin of nude mice after subcutaneous
inoculation with human lung cancer cells. Trypan blue was recently identified
as a dye with specificity for Bonghan ducts (BHDs) and not other tissues, such as
blood or lymph vessels or nerves.
Results: We demonstrate that the trypan blue staining technique allows the first
visualization of BHDs which are connected to tumor tissues.
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Bonghan duct
cancer
metastasis
trypan blue
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Bonghan Ducts as Possible Pathways for Cancer Metastasis
Article
oai:nur.nu.edu.kz:123456789/13312018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1125
Ogay (Огай), Vyacheslav (Вячеслав)
Issabekova (Исабекова), A.S. (А.С.)
2016-02-29T05:22:54Z
2016-02-29T05:22:54Z
2014
Вестник КазНУ. Серия биологическая. №1/1 (60). 2014
http://nur.nu.edu.kz/handle/123456789/1331
Раковые стволовые клетки основная причина возобновления болезни после лечения. Для эффективной борьбы с этими клетками необходимо понимание механизмов выживание этих клеток и их стимуляторов. В данной работе оценено влияние микроокружение опухоли на рост и поддержание опухоли. Основными модуляторами раковых стволовых клеток являются опухоль ассоциированные миофибробласты и макрофаги, а также Th17 клетки.
Cancer stem cells are main cause of cancer recurrence. For effective treatment it is necessary to understand haw survive and stimulate these cells. In this work it was estimated influence of cancer microenvironment to growth and surveillance
of cancer. The main modulators of cancer are cancer associated miofibroblasts and macrophages, and also Th17 cells.
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раковые стволовые клетки
микроокружение
индукторы
cancer stem cells
microenvironment
inductors
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Паракринные регуляторы раковых стволовых клеток толстой кишки / Paracrine regulators of colon cancer stem cells
Article
oai:nur.nu.edu.kz:123456789/13322018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Ogay (Огай), Vyacheslav (Вячеслав)
2016-02-29T05:30:16Z
2016-02-29T05:30:16Z
2014
http://nur.nu.edu.kz/handle/123456789/1332
Colon cancer high death rate and low percentage of recovery depend on tumor initiating cancer stem cells (CSCs). CSCs have ability such as survival in stress condition, absence of sensitivity to apoptose. These properties CSCs can regulate by autocrine way. In our work it was created data base of colon CSCs autocrine inductors. Understanding of CSCs protection mechanisms help to develop effective elimination methods of these cells.
Высокая смертность от рака толстой кишки и низкий процент полного выздоровления от рака связаны с сущетвованием опухоль инициирующих раковых стволовых клеток (РСК). РСК обладают такими свойствами как
выживаемость, отсутствие чувствительности к апоптозу. Эти свойства РСК способны регулировать аутокринным путем. В нашей работе была создана база данных по аутокринным стимуляторам РСК толстой кишки. Понимание защитных механизмов РСК поможет разработать эффективные методы элиминации этих клеток.
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colon cancer
cancer stem cells
autocrine inductors
cytokines
growth factors
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
рак толстой кишки
раковые стволовые клетки
аутокринные стимуляторы
цитокины
ростовые факторы
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
тоқ ішек ісігі
бағаналы ісік жасушалары
аутокринды реттеушілер
цитокиндер
өсу факторлары
Саморегуляция раковых стволовых клеток толстой кишки / Colon cancer stem cells self regulation
Article
oai:nur.nu.edu.kz:123456789/13332018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1125
Momynaliev (Момыналиев), K.T. (К.Т.)
Ogay (Огай), Vyacheslav (Вячеслав)
Khoroshun (Хорошун), E.V. (Е.В.)
Babenko (Бабенко), N.N. (Н.Н.)
Kaabak (Каабак), М.М. (M.M.)
2016-02-29T05:44:56Z
2016-02-29T05:44:56Z
2014-04
http://nur.nu.edu.kz/handle/123456789/1333
местительной терапии при хронической почечной недостаточности в терминальной стадии. Благодаря современным иммунодепрессантам, резко повысилась краткосрочная выживаемость пациентов и трансплантата. Однако долгосрочная выживаемость аллотрансплантата почки не улучшается такими же темпами. Хроническая нефропатия аллотрансплантата остается наиболее
частой причиной потери трансплантата, тогда как сердечно-сосудистые заболевания остаются ведущей причиной смертности пациентов после трансплантации...
Currently, renal transplantation has firmly established as the main method of replacement therapy in patients with the end stage chronic renal disease. Thanks to modern immunosuppressive drugs, shortterm graft and patient survival are dramatically increased. However, long-term renal allograft survival has improved in a lesser extent. Chronic allograft nephropathy is the most common cause of graft failure,
whereas cardiovascular diseases remain the leading cause of death among patients receiving renal transplantation. To improve the results of transplantation, it is important to continue developing new strategies for the prevention of acute and chronic rejection...
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мезенхимальные стволовые клетки
регуляторные Т-клетки
дендритные клетки
иммунологиче- ская толерантность
трансплантация почки
mesenchymal stem cells
regulatory T-cells
dendritic cells
immunological tolerance
renal transplantation
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases::Microbiology
Клеточные технологии в трансплантации почки / Cell technologies in renal transplantation
Article
oai:nur.nu.edu.kz:123456789/13362018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1126
Baptayev, Bakhytzhan
Tauanov, Zhandos
Bissengaliyeva, Moldir
Zhakiyeva, Zhanar
Berillo, Dmitriy
Adilov, Salimgerey
2016-03-02T06:01:39Z
2016-03-02T06:01:39Z
2014
http://nur.nu.edu.kz/handle/123456789/1336
Following the development of the idea of octupolar molecules as nonlinear optical materials a variety of compounds have been reported. Trans-porphyrins have a great potential to self-order into octupolar symmetry. Nonlinear optical properties can be tuned by using strong donor-acceptor groups in porphyrins as well as extention of conjugation. Here we report the syntheses of trans-A2D2-porphyrins and their dimerization into cubic octupoles by lanthanides and organic bidentate ligands. Bulky groups are employed to
induce non-centrosymmetric eclipsed or staggered conformations. Effect of donor acceptor groups, dimerization conditions and crystal packing of dimers are studied.
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synthesis of trans-porphyrin dimers
synthesis of trans-porphyrins
crystal structure of dimers
dimerization with bidentate ligands
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Synthesis of trans-porphyrin dimers for nonlinear optics
Other
oai:nur.nu.edu.kz:123456789/13372018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1126
Berillo (Берилло), Dmitriy (Дмитрий)
2016-03-02T07:54:32Z
2016-03-02T07:54:32Z
2010
http://nur.nu.edu.kz/handle/123456789/1337
Настоящая работа посвящена комплексному исследованию в области синтеза потенциально биологически активных веществ на основе гидразидов и нитрилов α-( и β-)-аминопропановых кислот, установлению закономерностей их гетероциклизации и изучению биологической активности новых производных гидразидов и нитрилов α-( и β-)- аминокислот.
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гидразид
нитрил
синтеза потенциально биологически активных веществ
гидразид β-аминопропановой кислоты
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
Синтез, строение и свойства гидразидов β-аминопропановой кислоты и их производных
Other
oai:nur.nu.edu.kz:123456789/13382018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1126
Alibek, Kenneth
Karatayeva, Nargis
Bekniyazov, Ildar
2016-03-02T10:54:51Z
2016-03-02T10:54:51Z
2012-12-03
doi: 10.1186/1750-9378-7-35
http://nur.nu.edu.kz/handle/123456789/1338
Since the late 1990s, infectious agents have been thought to play a role in the pathogenesis of approximately 15% of cancers. It is now widely accepted that infection of stomach tissue with the bacteria Helicobacter pylori is an important cause of stomach adenocarcinoma. In addition, oncogenic viruses, such as papilloma viruses, herpes viruses, and hepadnaviruses are strongly associated with increased risk of cervical cancer, lymphomas, liver cancer, amongst others. However, in the scientific community the percentage of cancers caused by pathogens is believed to be far higher than 15%. A significant volume of data collected to date show an association between infectious agents and urogenital cancers. These agents include Chlamydia trachomatis, Neisseria gonorrhoea, Mycoplasma genitalium and certain viruses that have been implicated in ovarian cancer.
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urogenital cancers
ovarian cancer
cervical cancer
Bladder cancer
Kidney cancer
Chlamydia trachomatis
Neisseria gonorrhea
Mycoplasma genitalium
Schistosoma haematobium
HPV
Epstein-Barr
CMV
Human polyomaviruses
Research Subject Categories::MEDICINE::Microbiology, immunology, infectious diseases
The role of infectious agents in urogenital cancers
Article
oai:nur.nu.edu.kz:123456789/13882018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1123
Балановская, Е.В.
Балаганская, О.А.
Дамба, Л.Д.
Дибирова, Х.Д.
Агджоян, А.Т.
Богунов, Ю.В.
Жабагин, М.К.
Исакова, Ж.Т.
Лавряшина, М.Б.
Балановский, О.П.
2016-04-12T04:30:42Z
2016-04-12T04:30:42Z
2014
http://nur.nu.edu.kz/handle/123456789/1388
Цель исследования - выявление роли горного рельефа в формировании генофондов горных и предгорных популяций Алтая, Саян, Тянь-Шаня, Памира.
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природная среда
формирование генофондов
тюркоязычное население
население гор
степные предгорья
тюрки
хромосомы гены
Влияние природной среды на формирование генефонда тюркоязычного населения гор и степных предгорий Алтае-Саян, Тянь-Шаня и Памира
Article
oai:nur.nu.edu.kz:123456789/13892018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1123
Жабагин, М.К.
Дибирова, Х.Д.
Фролова, С.А.
Сабитов, Ж.М.
Юсупов, Ю.М.
Утевская, О.М.
Тарлыков, П.В.
Тажигулова, И.М.
Балаганская, О.А.
Нимадава, П.
Захаров, И.А.
Балановский, О.П.
2016-04-12T05:03:57Z
2016-04-12T05:03:57Z
2014
http://nur.nu.edu.kz/handle/123456789/1389
Цель работы - дать характеристику генофонда казахских родов и изучить связь изменчивости Y-хромосомы с родовой структурой.
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Y-хромосомы
родовые структуры казахов
генофонд аристократия
духовенства казахов
геногеография
популяционная генетика
чингизиды
Связь изменчивости Y-хромосомы и родовой структуры: генофонд степной аристократии и духовенства казахов
Article
oai:nur.nu.edu.kz:123456789/13902018-08-15T03:49:53Zcom_123456789_107com_123456789_106col_123456789_1123
Падюкова, А.Д.
Лавряшина, М.Б.
Кузнецова, М.А.
Жабагин, М.К.
Агджоян, А.Т.
Схаляхо, Р.А.
Тычинских, З.А.
Балановская, Е.В.
2016-04-12T05:36:44Z
2016-04-12T05:36:44Z
2014
http://nur.nu.edu.kz/handle/123456789/1390
Сибирские татары – коренное население Запад-
ной Сибири. Этногенез сибирских татар, как и этноге-
нез большинства коренных народов Сибири, – это
растянувшийся во времени процесс смешения насе-
ления, говорившего на угорских, самодийских, тюрк-
ских и монгольских языках.
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генетический портрет
Y-хромосомы
сибирские татары
этногенез сибирских татар
Генетический портрет тоболо-иртышских сибирских татар по гаплогруппам Y-хромосомы
Article
oai:nur.nu.edu.kz:123456789/13912018-08-15T03:49:54Zcom_123456789_107com_123456789_106col_123456789_1123
Сабитов, Ж.М.
Жабагин, М.К.
2016-04-12T06:05:36Z
2016-04-12T06:05:36Z
2015
http://nur.nu.edu.kz/handle/123456789/1391
Современная популяционная генетика в целом и исследования полиморфизма Y-
хромосомы в частности развиваются семимильными шагами. Качественное развитие и
удешевление технологий полного и частичного сиквенса Y-хромосомы делает эту
технологию доступной для широких масс исследователей, при этом освобождая от
надобности содержать дорогостоящие лаборатории.
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этногенез казахов
популяционная генетика
Y-хромосомы
Этногенез казахов с точки зрения популяционной генетики
Article
oai:nur.nu.edu.kz:123456789/13922018-08-15T03:49:55Zcom_123456789_107com_123456789_106col_123456789_1123
Схаляхо Р.А.
Агджоян А.Т.
Балановская Е.В.
Юсупов Ю.М.
Рыскулов Р.М.
Мустафаева Л. А.
Жабагин М.К.
2016-04-12T06:27:19Z
2016-04-12T06:27:19Z
2014
http://nur.nu.edu.kz/handle/123456789/1392
Цель данной публикации - очертить возможности
этногенетики и попробовать поставить запятую в заголовке нашей статьи. Для этого мы
бегло рассмотрим, могут ли генетики сказать этнологам что-то интересное или важное
о четырех этнокультурных группах тюркоязычного мира Евразии - казахах, башкирах,
тюрках Кавказа и крымских татарах, объединенных языковым сходством, но
отличающихся по структуре генофонда.
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этногенетика
генофонд
ДНК-генеалоги
Этногенетика: игнорировать нельзя использовать? (опыт анализа генофондов казахов, башкир, тюрков кавказа и крымских татар)
Article
oai:nur.nu.edu.kz:123456789/13932018-08-15T03:50:26Zcom_123456789_107com_123456789_106col_123456789_1126
Alibek, Kenneth
Kakpenova, Ainur
Mussabekova, Assel
Sypabekova, Marzhan
Karatayeva, Nargis
2016-04-13T04:04:38Z
2016-04-13T04:04:38Z
2013-09-02
http://nur.nu.edu.kz/handle/123456789/1393
The most common cancer worldwide among women is breast cancer. The initiation, promotion, and progression of this cancer result from both internal and external factors. The International Agency for Research on Cancer stated that 18-20% of cancers are linked to infection, and the list of definite, probable, and possible carcinogenic agents is
growing each year. Among them, biological carcinogens play a significant role. In this review, data covering infection-associated breast and lung cancers are discussed and presented as possible involvements as pathogens in cancer. Because carcinogenesis is a multistep process with several contributing factors, we evaluated to what extent
infection is significant, and concluded that members of the herpesvirus, polyomavirus, papillomavirus, and retrovirus families definitely associate with breast cancer. Detailed studies of viral mechanisms support this conclusion, but have presented problems with experimental settings. It is apparent that more effort needs to be devoted to
assessing the role of these viruses in carcinogenesis, by characterizing additional confounding and synergistic effects of carcinogenic factors. We propose that preventing and treating infections may possibly stop or even eliminate certain types of cancers.
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carcinogenesis
Infectious agents
Breast cancer
Research Subject Categories::MEDICINE
Role of viruses in the development of breast cancer
Article
oai:nur.nu.edu.kz:123456789/14952018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Akilzhanova, A.
Guelly, Ch.
Abilova, Zh.
Rakhimova, S.
Akhmetova, A.
Kairov, U.
Nuralinov, O.
Rashbayeva, G.
Trajanoski, S.
Zhumadilov, Zh.
Bebosynova, M.
2016-05-30T03:47:37Z
2016-05-30T03:47:37Z
2016-05
Akilzhanova, A., Guelly, Ch., Abilova, Zh., Rakhimova, S., Akhmetova, A., Kairov, U., Nuralinov, O., Rashbayeva, G., Trajanoski, S., Zhumadilov, Zh., Bebosynova, M. 2016. A targeted sequencing reveal overlapping pattern of genetic variants in patients with cardiomyopathy with cardiac arrhythmias in Kazakhstan. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1495
http://nur.nu.edu.kz/handle/123456789/1495
Ventricular tachycardia (VT) is a common symptom in cardiac disorders of
different etiology. Abnormalities of ion channels are attributed to mutations in the genes
encoding the channel protein and cause altered function of channels, which can predispose to
arrhythmias. Due to the high incidence of cardiovascular disorders in Kazakhstan, we enrolled a
study cohort of 95 patients of different clinical phenotypes of cardiomyopathies, including DCM,
idiopathic VT but also patients with myocardial infarction as a consequence of coronary heart
disease. The common denominator among the three main groups was the occurrence of severe
episodes of VT in all patients. Using targeted resequencing, we investigated 96 cardiomyopathy
associated candidate-genes in this cohort with the aim to detect rare and common variations in
these genes associated with VT molecular basis
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targeted sequencing
cardiac arrhythmias
HaloPlex cardiopanel
A targeted sequencing reveal overlapping pattern of genetic variants in patients with cardiomyopathy with cardiac arrhythmias in Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/14962018-08-15T03:49:56Zcom_123456789_1487com_123456789_106col_123456789_1491
Kaiyrlykyzy, A.
Umbayev, B.
Masoud, A.
Shramko, A.
Idrissova, D.
Zhussupova, A.
Alzhanova, D.
Alimbetov, D.
Askarova, S.
2016-05-30T04:10:53Z
2016-05-30T04:10:53Z
2016-05
Kaiyrlykyzy A., Umbayev B., Masoud A., Shramko A., Idrissova D., Zhussupova A., Alzhanova D., Alimbetov D., and Askarova S. 2016. Adiponectin plasma levels in patients with age-related dementia. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1496.
http://nur.nu.edu.kz/handle/123456789/1496
Adiponectin play a significant role in the regulation of type 2 diabetes, obesity,
atherosclerosis, non-alcoholic fatty liver disease and neurodegenerative disorders. Evidence
suggests that adiponectin may be an independent risk factor for all-cause dementia and
Alzheimer's disease (AD) and the level of adiponectin in plasma reflects its level in cerebrospinal
fluid (CSF). Studies demonstrated that elevated adiponectin level in blood was associated with
an increased risk of dementia and AD in women and indicates that the sex dimorphism with
regard to adiponectin levels association with Alzheimer's disease was clearly observed
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Adiponectin
dementia
Alzheimer's disease
Adiponectin plasma levels in patients with age-related dementia
Abstract
oai:nur.nu.edu.kz:123456789/14982018-08-15T03:49:59Zcom_123456789_1487com_123456789_106col_123456789_1491
Ogay, V.
2016-05-30T04:26:22Z
2016-05-30T04:26:22Z
2016-05
V. Ogay. 2016. Adipose-derived perivascular stem cell as a source for cell therapy. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1498.
http://nur.nu.edu.kz/handle/123456789/1498
Perivascular stem cells (PSCs) have been isolated from several organs and tissues, including
adipose tissue. They have unique features resembling both pericytes and mesenchymal stem
cells (MSCs). PSCs as MSCs are capable to multilineage differentiation into neurons, astrocytes
and oligodendrocytes, as well as to produce angiogenic and neurotrophic factors, indicating their
regenerative and neuroprotective properties. It was recently shown that PSCs play an important
role in repairing of the nervous tissue during cerebral ischemia, as they can differentiate into
neurons, endothelial and glial cells in the hippocampal subgranular zone. In this connection,
recently PSCs have been considered as a potential alternative to MSCs for the treatment of
cardiovascular diseases. Here we review the recent literature and own data on PSCs, discuss
their unique features, regenerative potential and possible applications in cell therapy and tissue
engineering.
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adipose tissue
pericytes
stem cells
regeneration
cell therapy
Adipose-derived perivascular stem cell as a source for cell therapy
Abstract
oai:nur.nu.edu.kz:123456789/15022018-08-15T03:49:59Zcom_123456789_1487com_123456789_106col_123456789_1491
Bexeitov, Y
Myngbay, A
Adilbayeva, A
Yevstratenko, B.P.
Aitzhanova, R.M.
Otarbayev, N.K.
Adarichev, V.A.
2016-05-30T05:04:51Z
2016-05-30T05:04:51Z
2016-05-11
Bexeitov, Y., Myngbay, A., Adilbayeva, A., Yevstratenko, B.P., Aitzhanova, R.M., Otarbayev, N.K., Adarichev, V.A. 2016. Serum collagen triple helix repeat-containing (CTHRC1) levels is associated with circulating stem cell factor and pro-inflammatory cytokines in rheumatoid arthritis. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1502.
http://nur.nu.edu.kz/handle/123456789/1502
Everyday monitoring disease activity of chronic inflammatory diseases such as Rheumatoid Arthritis (RA) is a tempting approach for every patient for attaining personalized treatment strategies. Still underdeveloped area of RA biomarkers needs sensitive and specific analytes. CTHRC1 was found earlier expressed in activated synoviocytes and present in circulation that makes it potential valuable RA marker.
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serum collagen
stem cell
arthritis
Serum collagen triple helix repeat-containing (CTHRC1) levels is associated with circulating stem cell factor and pro-inflammatory cytokines in rheumatoid arthritis
Abstract
oai:nur.nu.edu.kz:123456789/14992018-08-15T03:49:53Zcom_123456789_1487com_123456789_106col_123456789_1491
Amirbekov, A.
Eraliyeva, L.
Zakiryanova, G.
2016-05-30T04:33:37Z
2016-05-30T04:33:37Z
2016-05
A. Amirbekov, L. Eraliyeva, G. Zakiryanova. 2016. Alterations of oncogenes expression in human NK cells in cancer patients. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1499
http://nur.nu.edu.kz/handle/123456789/1499
C-kit/SCF signaling play a key role in regulating NK cell homeostasis,
maturation, proliferation and cytotoxicity. C-kit-deficiency in NK results in significant reduction of
their, suggesting imperative role fore-kit signaling in NKcell immunobiology. We have recently
showed that human NK cells express not only c-kit-receptor, but also both membrane-bound
and soluble forms of c-kit ligand - Stem cell factor. The goal of this study was to characterize the
c-kit/SCF autocrine loop in peripheral blood NK cells obtained from patients with cancer.
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NK cells
c-Kit
SCF
c-Myc
STAT3
Alterations of oncogenes expression in human NK cells in cancer patients
Abstract
oai:nur.nu.edu.kz:123456789/15002018-08-15T03:49:54Zcom_123456789_1487com_123456789_106col_123456789_1491
Murzakhmetova, S.
Janzakova, D.
Mektepbayeva, D.
2016-05-30T04:42:23Z
2016-05-30T04:42:23Z
2016-05
S. Murzakhmetova, D. Janzakova, D. Mektepbayeva. 2016. Anticancer effects of leech extract on breast cancer cells. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1500
http://nur.nu.edu.kz/handle/123456789/1500
Throughout the history of humanity, leech therapy appeared as a procedure
in medicine all over the world. The very first use of leech in human treatment was mentioned
in Eqypt 3500 years ago. In 2004, Food and Drug Administration approved leeches as medical
devices and, nowadays, leeches are used in treatment of diseases, such as hypertension,
varicose ulcer, thrombophlebitis and musculoskeletal diseases. In this experiment we are trying
to see whether the leech saliva extract (LSE) has anti-cancer effects on MCF-7 breast cancer
cells. Several studies were conducted previously that have shown positive effects of LSE on
cancer cells. Warfarin and heparin from the extract are found to have antimetastatic effect.
Experiments on lung tumor cells also indicated inhibitory effect of LSE.
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cancer
breast cancer
leech
proliferation
viability
soft agar
Anticancer effects of leech extract on breast cancer cells
Abstract
oai:nur.nu.edu.kz:123456789/15012018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Yermekbayeva, B.
Shulgau, Z.
Sergazy, Sh.
Kabdullina, A.
Khassenbekova, Zh.
Tritek, V.
Abuova, G.
Zhaugasheva, S.
Gulyayev, A.
Nurgozhin, T.
2016-05-30T04:54:14Z
2016-05-30T04:54:14Z
2016-05
B. Yermekbayeva, Z. Shulgau, Sh. Sergazy, A. Kabdullina, Zh. Khassenbekova, V. Tritek, G. Abuova, S. Zhaugasheva, A. Gulyayev, and T. Nurgozhin. 2016. Antioxidant properties of grape polyphenol concentrate from Kazakhstan region. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1501
http://nur.nu.edu.kz/handle/123456789/1501
It is believed that the antioxidant effects are widespread among plant
polyphenols. Antioxidant effect is associated with main biological activities of polyphenols. Objective. To describe the antioxidant effect of grape polyphenol concentrate from Kazakhstan selection in vivo on models of pathologies with overproduction of free radicals.
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antioxidant effects
polyphenols
grape
pathology models
Antioxidant properties of grape polyphenol concentrate from Kazakhstan region
Abstract
oai:nur.nu.edu.kz:123456789/15032018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Kassenova, A.
Kossumov, A.
Nurgozhin, T.
Supiyev, A.
2016-05-30T05:10:29Z
2016-05-30T05:10:29Z
2016-05
A. Kassenova, A. Kossumov, T. Nurgozhin, and A. Supiyev. 2016. Apolipoprotein E genetic variation and statin therapy appointment. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1503
http://nur.nu.edu.kz/handle/123456789/1503
Dyslipidemia is an important risk factor for cardiovascular disease due to the
significant influence of cholesterol on atherosclerosis. Several genetic variants in genes related
with triglyceride (TG) metabolism has been described, including LPL, apolipoprotein A5 and
apolipoprotein E (Apo E) are associated with dyslipidemia by involvement to lipid metabolism. The
combined analysis of these polymorphisms could produce clinically meaningful complementary
information. Changes in TG levels are now considered an independent cardiovascular risk
factor; hence, the study of combined variants in genes involved in TG metabolism may help
explain part of the risk for CVD. The most informative polymorphisms within the Apo E gene are
the Arg158Cys (rs7412) and Cys112Arg (rs429358) which define Apo E gene alleles, epsilon2,
3 and 4 (£2, £3 and £4).
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Dyslipidemia
apolipoprotein
genotype
statin therapy
Apolipoprotein E genetic variation and statin therapy appointment
Abstract
oai:nur.nu.edu.kz:123456789/15042018-08-15T03:49:57Zcom_123456789_1487com_123456789_106col_123456789_1491
Masoud, A.
Umbayev, B.
Olzhayev, F.
Idrissova, D.
Shramko, A.
Kaiyrlykyzy, A.
Askarova, Sh.
2016-05-30T05:20:08Z
2016-05-30T05:20:08Z
2016-05
Masoud A., Umbayev B., Olzhayev F., Idrissova D., Shramko A., Kaiyrlykyzy A., and Askarova Sh. 2016. Assesing the cytokine content of human platelet-rich plasma. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1504.
http://nur.nu.edu.kz/handle/123456789/1504
Human platelet-rich plasma (PRP) is plasma that is enriched with thrombocytes
at a concentration of 1000 * 109 per litre, higher than normal (150 - 350 * 109 per litre).
Thrombocytes are known to contain growth factors including IGF, PDGF, EGF, FGF, TGF-li,
PDEGF, VEGF or PDAF as well as thrombospondin and osteonectin. The release of these
growth factors is induced by thrombocyte activation resulting from their exposure to a variety of
substances such as thrombin, Calciom chloride or collagen. Growth factors are found in higher
concentrations in PRP than in blood, and could be used to facilitate wound healing at a faster
rate. Currently, PRP is employed in dentistry, dermatology, traumatology and orthopedics. In
developed countries, PRP is also actively used in treating acute and chronic skin lesions. Though
commercial devices for clinical preparation of autologous PRP are available, standardized
PRP-preparation protocols are yet to be developed. Furthermore, only a handful of research
work is aimed at optimizing methods of obtaining platelet-rich plasma. Therefore, two different
modifications of the Araki et al method, the most standardized of all available methods, were
used to prepare high cytokine-containing platelet-rich plasma.
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Human platelet-rich plasma
Assesing the cytokine content of human platelet-rich plasma
Abstract
oai:nur.nu.edu.kz:123456789/15052018-08-15T03:50:00Zcom_123456789_1487com_123456789_106col_123456789_1491
Saduakassova, A.B.
Akparova, A.Yu.
Abdrahmanova, В. M.
Bersimbay, R.I.
2016-05-30T05:34:03Z
2016-05-30T05:34:03Z
2016-05-11
Saduakassova, A.B., Akparova, A.Yu., Abdrahmanova, В. M., Bersimbay, R.I. 2016. Serum levels of apoptosis - related markers (P53, BCL-2, SFAS-L, CASPASE-9) in copd patients. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1505.
http://nur.nu.edu.kz/handle/123456789/1505
Apoptosis is a complex process of regulated and programmed cell death. In this process, the activation of many genes and signaling pathways is involved. Apoptosis provides a protective function due to the elimination of autoreactive immune cells and thus limits the destruction of their own cells and tissues. Of great interest is the study of the influence of apoptosis on a variety of pathological processes.
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apoptosis
COPD
Bcl-2
caspase-9
p-53
sFAS-L
Serum levels of apoptosis - related markers (P53, BCL-2, SFAS-L, CASPASE-9) in copd patients
Abstract
oai:nur.nu.edu.kz:123456789/15062018-08-15T03:49:56Zcom_123456789_1487com_123456789_106col_123456789_1491
Doszhanova, G.N.
Abduldayeva, A.A.
Dalenov, E.D.
2016-05-30T05:36:51Z
2016-05-30T05:36:51Z
2016-05
Doszhanova G.N., Abduldayeva A.A., and Dalenov E.D. 2016. Assessment of nutritional status of elderly and senile age people. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1506
http://nur.nu.edu.kz/handle/123456789/1506
Introduction: A healthy nutrition is a predictor of active longevity, contributing to improve the
life span and quality of life.
Objective: To evaluate the nutritional status of elderly people living in Astana, depending on
the sex and age of the respondents.
Methods: The study involved 354 people between ages 60-89 years. For studying the actual
nutrition a 24 hours method of food reproduction was used. All data were processed using a
computer program developed by Kazakh academy of nutrition in 2008, based on the WHO
program.
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nutrition
nutritional status
Assessment of nutritional status of elderly and senile age people
Abstract
oai:nur.nu.edu.kz:123456789/15072018-08-15T03:49:54Zcom_123456789_1487com_123456789_106col_123456789_1491
Shayakhmetov, Y.
Tsoy, A.
Zhussupova, G.
Askarova, Sh.
2016-05-30T05:45:17Z
2016-05-30T05:45:17Z
2016-05
Shayakhmetov Y., Tsoy A., Zhussupova G., and Askarova Sh. 2016. Astroprotective potential of extract from limonium gmelinii for stroke therapy. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1507
http://nur.nu.edu.kz/handle/123456789/1507
It's known that proinflammatory cytokines, such asTNF-a, produced by injured
neurons and infiltrated leukocytes, involved in every aspect of stroke. Cytokines promote
activation of astroglia, induce oxidative stress thereby exacerbating brain tissue damage. There
is a number of data indicating that polyphenols can provide protection against neurodegenerative
changes. It has been reported previously, that reach with polyphenols extract of Limonium
gmelinii exerts a wide range of therapeutic actions. Here, we aimed to study antioxidant and
anti-inflammatory potential of L. gmelinii under exposure of TNF-a in vitro.
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Limonium gmelinii
stroke therapy
Astroprotective potential of extract from limonium gmelinii for stroke therapy
Abstract
oai:nur.nu.edu.kz:123456789/15082018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Kang, Kyung-Sun
2016-05-30T05:51:25Z
2016-05-30T05:51:25Z
2016-05-11
Kang, Kyung-Sun. 2016. Stem cells in inflammatory diseases. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1508.
http://nur.nu.edu.kz/handle/123456789/1508
The systemic application of MSCs derived from various origins including bone marrow, adipose tissue, gingiva, and umbilical cord has been tested for its efficacy to suppress chemically induced colitis in animals. Most studies showed that the application of MSCs exhibits a protective and therapeutic effect against Atopic dermatitis, inflammatory bowl diseases and Rheumatoid arthritis etc. Recently, autologous bone marrow MSCs have been successfully applied in a phase I study for the treatment of refractory Crohn's disease without serious adverse effects. These findings suggest that MSCs can be an effective therapeutic candidate for inflammatory bowel disease, although the underlying mechanism of their effect remains to be elucidated. Our study revealed that NOD1 and NOD2 are functionally expressed in human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) and regulate the differentiation of hUCB-MSCs. Although some Toll-like receptors (TLRs) are known to enhance the immunosuppressive activity of MSCs, the role of NOD2 in the immunomodulation of MSCs has not been investigated. We report here that NOD2 activation enhances the protective and therapeutic effects of hUCB-MSCs against inflammatory diseases in both mice and human. MDP stimulation augmented the ability of hUCB-MSCs to suppress the proliferation of hMNCs by producing PGE2 via the NOD2-RIP2 pathway.
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stem cells
inflammatory diseases
Stem cells in inflammatory diseases
Abstract
oai:nur.nu.edu.kz:123456789/15092018-08-15T03:49:57Zcom_123456789_1487com_123456789_106col_123456789_1491
Saliev, T.
2016-05-30T05:55:33Z
2016-05-30T05:55:33Z
2016-05
T. Saliev. 2016. Bio-medical applications of ultrasound. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1509
http://nur.nu.edu.kz/handle/123456789/1509
Despite of the classical perception of an ultrasound as a diagnostic modality, it possesses
a great potential for therapeutic applications. In the range of experimental studies it has been
shown that the ultrasound is capable to trigger biological effects including direct cell lysis,
apoptosis and drug delivery. All those effects have a potential to be harnessed for therapeutic
purposes such as cancer treatment. For an example, the induction of apoptosis with ultrasound
provides a unique opportunity to eliminate tumour tissues in safe and non-contact mode.
Currently, few companies (USA, EU and Japan) offer ultrasound systems capable to directly
destroy cancer tissue via ablation. The main trends of therapeutic applications of ultrasound will
be highlighted in the presentation.
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ultrasound
ultrasound systems
Bio-medical applications of ultrasound
Abstract
oai:nur.nu.edu.kz:123456789/15102018-08-15T03:50:26Zcom_123456789_1487com_123456789_106col_123456789_1491
Akilbekova, D.
Alimzhanov, D.
Utegulov, Zh.
2016-05-30T06:06:33Z
2016-05-30T06:06:33Z
2016-05
D. Akilbekova, D. Alimzhanov, and Zh. Utegulov. 2016. Biomechanical properties of collagens studied by brillouin light scattering spectroscopy and atomic force microscopy. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1510
http://nur.nu.edu.kz/handle/123456789/1510
Collagen is the most abundant protein in the human body and the main
component of highly organized tissue structures. Its fibrillar structure is responsible for
biomechanical anisotropies in the tissues and their exceptional elastic properties. In the present
work we use Brillouin light scattering (BLS) spectroscopy and atomic force microscopy (AFM)
for probing elastic properties of collagen fibers harvested from different tissues. While BLS
spectroscopy is non-invasive and label-free modality for probing mechanical properties of fibrous
tissues that can give information on structure-function properties of normal and pathological
tissues on micrometer scale, AFM provides elastic property information in contact manner on
nanometer scale
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Collagen
orientation
biomechanical
elastic
Brillouin light scattering spectroscopy
atomic force microscopy
Biomechanical properties of collagens studied by brillouin light scattering spectroscopy and atomic force microscopy
Abstract
oai:nur.nu.edu.kz:123456789/15112018-08-15T03:49:58Zcom_123456789_1487com_123456789_106col_123456789_1491
Gard, P. R.
2016-05-30T07:43:33Z
2016-05-30T07:43:33Z
2016-05
Gard P.R. 2016. Brain-derived neurotrophic factor, neuronal repair and mental health. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1511
http://nur.nu.edu.kz/handle/123456789/1511
Brain Derived Neurotrophic Factor (BDNF) is initially synthesized as a 247 amino acid preproBDNF
which is cleaved to form a 228 a.a. pro-BDNF and finally 119 a.a. mature BDNF
(14 kDa). BDNF is expressed in fibroblasts, astrocytes, neurons, megakaryocytes, Schwann
cells, and smooth muscle cells where, acting via its tyrosine kinase receptor TrkB, it is involved
in neuronal differentiation and maturation, synapse formation, neuroprotection and neuronal
repair.
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Brain Derived Neurotrophic Factor
Brain-derived neurotrophic factor, neuronal repair and mental health
Abstract
oai:nur.nu.edu.kz:123456789/15122018-08-15T03:49:57Zcom_123456789_1487com_123456789_106col_123456789_1491
Balabiyev, A.
Kakpenova, A.
Kauanova, S.
Vorobjev, I.A.
2016-05-30T08:21:42Z
2016-05-30T08:21:42Z
2016-05
Balabiyev A., Kakpenova A., Kauanova S., and Vorobjev I.A. 2016. Cancer cells response on the microtubuler-inhibiting drugs. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1512
http://nur.nu.edu.kz/handle/123456789/1512
Cancer is one of the age-related diseases with detrimental impact on people
survival. Improvement of cancer therapies is a major focus of many scientists around the world.
Anticancer drugs based on the microtubules inhibition are successfully used to treat widerange
of cancers. Anti-microtubules drugs directly bind to colchicine, vinca and taxol binding
sites on beta-tubulin, resulting in the impairment of spindle formation, vesicle transport, cell
structure and migration. One of the modes of action anti-tubulin drugs is through causing faults
in mitotic spindle function, which lead to the prolonged mitotic block and consequently to cell
death. Although, drugs' high toxicity and development of resistance in patients lead to the idea
of revisiting the dosage and combination therapies of anti-tubulin drugs, some sources reported
that cell migration is more sensitive to microtubule inhibiting drugs than to cell proliferation
in endothelial cells. Previously, we reported observations on NIH/3T3 (normal fibroblasts) cell
proliferative activity, cell migration and direct test of microtubule dynamics. Thus, we aimed to
identify effect of microtubule inhibitors on cancer cell lines. In addition, we compare normal cell
lines with human cancer cell lines such as A549 (lung carcinoma), HT1080 (fibrosarcoma) and
U118 (glioma).
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Cancer
cancer therapies
Anticancer drugs
microtubules inhibiting drugs
Cancer cells response on the microtubuler-inhibiting drugs
Abstract
oai:nur.nu.edu.kz:123456789/15132018-08-15T03:49:56Zcom_123456789_1487com_123456789_106col_123456789_1491
Xie, Y.
Istayeva, Sh.
Tokay, T.
Zhumadilov, Zh.
Chen, Zh.
2016-05-30T08:34:46Z
2016-05-30T08:34:46Z
2016-05
Y. Xie, Sh. Istayeva, T. Tokay, Zh. Zhumadilov, and Zh. Chen. 2016. c-Met signaling as a promise of targeted therapy in glioblastoma tumor. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1513
http://nur.nu.edu.kz/handle/123456789/1513
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Nuclear c-Met
cancer
glioblastoma
c-Met signaling as a promise of targeted therapy in glioblastoma tumor
Abstract
oai:nur.nu.edu.kz:123456789/15152018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Kozhakhmetov, S.S.
Kushugulova, A.R.
Kakimova, A.B.
Saduakhassova, S.A.
Urasova, M.S.
Khassenbekova, Zh.R.
Kozhakhmetova, S.S.
Kazhybayev, A.K.
Urazbayeva, G.S.
Tuleutayeva, G.K.
Ongarbayeva, A.E.
Beysembayeva, S.Ch.
Nurgozhin, T.S.
Zhumadilov, Zh.
2016-05-30T08:51:32Z
2016-05-30T08:51:32Z
2016-05-11
Kozhakhmetov, S.S., Kushugulova, A.R., Kakimova, A.B., Saduakhassova, S.A., Urasova, M.S., Khassenbekova, Zh.R., Kozhakhmetova, S.S., Kazhybayev, A.K., Urazbayeva, G.S., Tuleutayeva, G.K., Ongarbayeva, A.E., Beysembayeva, S.Ch., Nurgozhin, T.S., Zhumadilov, Zh.Sh. 2016. Study the effect of gene polymorphism contribution of statin biotransformation and lipid metabolism for parameters of statin efficacy. Recruiting. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1515.
http://nur.nu.edu.kz/handle/123456789/1515
Rosuvastatin is high-performance hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, which commonly used in the treatment of hyperlipidemia. It significantly reduces levels of LDL, which accompanied by a moderate increase in HDL and a decrease triglycerides in blood serum. Nowadays rozuvastatin is the safest among statin preparation and it differs from simvastatin, lovastatin and atorvastatin by minimal hepatic metabolism.
Endogenous characteristics of drugs metabolism, which depends on polymorphisms of transformation genes and statin transportation, can reflect on achievement of final efficacy.
Individual variability in the effectiveness and safety of drugs is one of the topical problems of clinical practice. It is known that genetic variations are factors in determining an individual response to drug therapy. There are many examples of cause-effect relationships between genotype and response to drug therapy.
Based on written above, the purpose of this study is to research the pharmacokinetic characteristics of the therapy with rosuvastatin.
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effect of the gene
polymorphism
biotransformation
metabolism
Study the effect of gene polymorphism contribution of statin biotransformation and lipid metabolism for parameters of statin efficacy. Recruiting
Abstract
oai:nur.nu.edu.kz:123456789/15142018-08-15T03:49:57Zcom_123456789_1487com_123456789_106col_123456789_1491
Shashkinl, Ch.
Akshulakovl, S.
Makhambetovl, Y.
Shpekovl, A.
Dzhamantaeval, B.
Akhmetzhanovl, V.
2016-05-30T08:44:05Z
2016-05-30T08:44:05Z
2016-05
Ch. Shashkinl, S. Akshulakovl, Y. Makhambetovl, A. Shpekovl, B. Dzhamantaeval, and V. Akhmetzhanovl. 2016. Deep brain stimulation for neurodegenerative diseases. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University.
http://nur.nu.edu.kz/handle/123456789/1514
Neurodegenerative diseases (ND) with movement and cognitive disorders are
very complicated diseases to treat. Sometimes medical treatment is not successful or results in
unpleasant complications. Nowadays neurosurgical treatment as deep brain stimulation (DBS)
became possible in clinical medicine. http://nur.nu.edu.kz/handle/123456789/1514
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Neurodegenerative diseases
Deep brain stimulation for neurodegenerative diseases
Abstract
oai:nur.nu.edu.kz:123456789/15162018-08-15T03:50:26Zcom_123456789_1487com_123456789_106col_123456789_1491
Akilzhanov, K.
2016-05-30T08:59:17Z
2016-05-30T08:59:17Z
2016-05
K. Akilzhanov. 2016. Development of a new method of surgical treatment of patellofemoral pain syndrome. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1516
http://nur.nu.edu.kz/handle/123456789/1516
Patellofemoral pain syndrome (PFBS) - one of the most frequent symptom
in orthopedic practice. According to available statistics, from 18% to 33% of all calls to the
Orthopaedic Trauma and sports doctors about the pathology of the knee associated with this
syndrome. Creation of modern methods of complex operational and functional-restorative
treatment of patients suffering from pathological changes patella-femoral joint, has great
scientific and practical importance. Therefore, the development and improvement of the
most effective and pathogenetically justified treatment technologies using innovative surgical
techniques for injuries and diseases of the knee joint in a complex improvement of trauma care
determines the relevance of our research.
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Patellofemoral pain syndrome
Development of a new method of surgical treatment of patellofemoral pain syndrome
Abstract
oai:nur.nu.edu.kz:123456789/15172018-08-15T03:50:00Zcom_123456789_1487com_123456789_106col_123456789_1491
Sarsenova, M.
Karzhauov, M.
Kaliev, Ye.
Raimagambetov, E.
Ogay, V.
2016-05-30T09:06:29Z
2016-05-30T09:06:29Z
2016-05-11
Sarsenova, M., Karzhauov, M., Kaliev, Ye., Raimagambetov, E., Ogay, V. 2016. The study of the therapeutic effects of hyaluronic acid, chondroinductive factors and mesenchymal stem cells on regeneration of articular cartilage defects in rabbits. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1517.
http://nur.nu.edu.kz/handle/123456789/1517
Regeneration of injured articular cartilage is one of the most difficult problems in traumatology and orthopedics. Applied nowadays surgical methods that are aimed at stimulation of cartilage regeneration in damaged joint can not provide the complete treatment of complications. Thus, it is necessary to search for alternative therapy, such as autologous chondrocyte transplantation for articular cartilage regeneration, which has been successfully used abroad.
The purpose of present study was to investigate the effect of synovium derived mesenchymal stem cells (MSCs), chondroinductive growth factors and hyaluronic acid on regeneration of articular cartilage defect in rabbits.
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mesenchymal stem cells
growth factors
synovial membrane
articular cartilage defect
hyaluronic acid
The study of the therapeutic effects of hyaluronic acid, chondroinductive factors and mesenchymal stem cells on regeneration of articular cartilage defects in rabbits
Abstract
oai:nur.nu.edu.kz:123456789/15182018-08-15T03:50:00Zcom_123456789_1487com_123456789_106col_123456789_1491
Tokay, T.
Mueller, L.
Xie, Y.
Kirschstein, T.
Beck, H.
Koehling, R.
2016-05-30T09:07:43Z
2016-05-30T09:07:43Z
2016-05
T. Tokay, L. Mueller, Y. Xie, T. Kirschstein, H. Beck, and R. Koehling. 2016. D-series improves learning and memory in epileptic animals. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1518
http://nur.nu.edu.kz/handle/123456789/1518
The N-methyl-D-aspartate receptor (NMDAR) is critical for the induction of
synaptic plasticity and is essential for many forms of learning and memory. Activation of NMDAR
by glutamate requires the presence of D-Serine, which is an endogenous physiological coagonist
of the receptor and plays an important role in glutamate mediated NMDAR-dependent
synaptic plasticity in the brain. However, the role of D-serine in synaptic plasticity and learning
in chronic epilepsy is not known.
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Hippocampus
astrocytes
epilepsy
rat
D-serine
D-serine improves learning and memory in epileptic animals
Abstract
oai:nur.nu.edu.kz:123456789/15192018-08-15T03:49:54Zcom_123456789_1487com_123456789_106col_123456789_1491
Rakhimova, S.
Kairov, U.
Molkenov, A.
Zhukov, Y.
Omarov, M.
Popova, M.
Zhumadilov, Zh.
Akilzhanova, A.
2016-05-30T09:45:38Z
2016-05-30T09:45:38Z
2016-05-11
Rakhimova, S., Kairov, U., Molkenov, A., Zhukov, Y., Omarov, M., Popova, M., Zhumadilov, Zh., Akilzhanova, A. 2016. Transcriptome profiling by next - generation sequencing and pathway analysis of esophageal squamous cell carcinoma in Kazakhstan. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1519.
http://nur.nu.edu.kz/handle/123456789/1519
Esophageal cancer is the eighth most common cancer in the world and the highest in Eastern Asia. The incidence rate in Kazakhstan is 10.1: 100 000. Esophageal squamous cell carcinoma (ESCC) is the dominant histological type (> 90%) of esophageal cancer cases. Usage of NGS technologies allows determining effective diagnostic markers and therapeutic approaches for to increase the longevity of the patients. The aim of the project is to identify genetic basis of ESCC by performing whole transcriptome sequencing in Kazakhstani patients.
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esophageal cancer
transcriptome
molecular pathways
up and down-regulated genes
Transcriptome profiling by next - generation sequencing and pathway analysis of esophageal squamous cell carcinoma in Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/15202018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Tashtitova, L.B.
Botabekova, Т.К.
Aldasheva, N.A.
Uteuliyev, E.S.
2016-05-30T10:21:44Z
2016-05-30T10:21:44Z
2016-05
Tashtitova L.B, Botabekova Т.К., Aldasheva N.A., and Uteuliyev E.S. 2016. Effectiveness of pulic screening for glaucoma in republic of Kazakhstan. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1520
http://nur.nu.edu.kz/handle/123456789/1520
In the Republic of Kazakhstan (RK) glaucoma is the second place ranking in
the structure of primary disability on eyesight. In 80.2% of cases-these are invalids of the first or
second group (Islamova S.E., 2009). In 2010 there was signed a decree of the President of the
RK «On approval of the State Program for Health Development in RK «Salamatty Kazakhstan/
Healthy Kazakhstan)) for 2011-2015». According to decree glaucoma entered in the category of
socially significant diseases subject to screening detection
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screening for glaucoma
the detection of glaucoma
Effectiveness of pulic screening for glaucoma in republic of Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/15212018-08-15T03:49:59Zcom_123456789_1487com_123456789_106col_123456789_1491
Myngbay, A.
Bexeitov, Y.
Adilbayeva, A.
Yevstratenko, B. P.
Aitzhanova, R. M.
Otarbayev, N. K.
Adarichev, V.A.
2016-05-30T10:35:00Z
2016-05-30T10:35:00Z
2016-05
A. Myngbay, Y. Bexeitov, A. Adilbayeva, B. P. Yevstratenko, R. M. Aitzhanova, N. K. Otarbayev, and V.A. Adarichev. 2016. Elevated levels of plasma collagen priple helix repeat-containing (CTHRC1) protein correlates with increased granul ocytopoiesis and higher rheumatoid arthritis disease severity score. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1521
http://nur.nu.edu.kz/handle/123456789/1521
Monitoring and suppressing activity of the pathological granulating pannus
tissue is essential for Rheumatoid Arthritis (RA) management. Synovial joints pain and tissue
destruction is a derivative of the pannus activity. In a mouse model for RAwe found CTHRC1,
a secreted and circulating protein, to be inducible in arthritis and correlated with the disease
severity. We performed a clinical investigation to ascertain the role of CTHRC1 in the progression
of the disease.
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Rheumatoid Arthritis
Elevated levels of plasma collagen priple helix repeat-containing (CTHRC1) protein correlates with increased granul ocytopoiesis and higher rheumatoid arthritis disease severity score
Abstract
oai:nur.nu.edu.kz:123456789/15222018-08-15T03:49:59Zcom_123456789_1487com_123456789_106col_123456789_1491
Yesmembetov, K.
Kaliaskarova, K.
Muratova, Zh.
Borovskiy, S.
Sultanaliyev, T.
Mukazhanov, A.
Zharkimbekov, B.
Zhexembayev, A.
Kuttymuratov, G.
Amanzholov, B.
2016-05-30T10:39:28Z
2016-05-30T10:39:28Z
2016-05-11
Yesmembetov, K., Kaliaskarova, K., Muratova, Zh., Borovskiy, S., Sultanaliyev, T., Mukazhanov, A., Zharkimbekov, B., Zhexembayev, A., Kuttymuratov, G., Amanzholov, B. 2016. Treatment of end - stage liver disease in the jsc national scientific center for oncology and transplantology, Astana: views and perspectives. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1522.
http://nur.nu.edu.kz/handle/123456789/1522
End-stage liver disease represents a major healthcare problem worldwide and in Kazakhstan, carrying a high risk for mortality. Around 1000 patients with end-stage liver disease need liver transplantation in Kazakhstan, more than 50 of them dying yearly without being transplanted.
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cirrhosis
end-stage liver disease
endoscopic variceal ligation
splenic artery and esophageal varices embolisation
liver transplantation
Treatment of end - stage liver disease in the jsc national scientific center for oncology and transplantology, Astana: views and perspectives
Abstract
oai:nur.nu.edu.kz:123456789/15232018-08-15T03:49:58Zcom_123456789_1487com_123456789_106col_123456789_1491
Khassenbekova, Zh.
Berikkhanova, K.
Gulyayev, A.
Sergazy, Sh.
Yermekbayeva, В.
Kushugulova, A.R.
Omarova, D.
Akhmetova, A.
Nurgozhin, T.
Zhumadilov, Zh.
2016-05-30T10:51:30Z
2016-05-30T10:51:30Z
2016-05
Khassenbekova Zh., Berikkhanova K., Gulyayev A., Sergazy Sh., Yermekbayeva В., Kushugulova A.R., Omarova D., Akhmetova A., Nurgozhin T., and Zhumadilov Zh. 2016. Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1523
http://nur.nu.edu.kz/handle/123456789/1523
Correction of phenotypic plasticity of macrophages for reprogramming inflammatory
response is of great interest to modern medicine. To date, there are lots of factors, which can
alter macrophages' phenotype to M1 or M2. The introduction of drug containing autologous
erythrocyte ghosts is one of such factors.
We have developed a method for the targeted delivery of autologous erythrocyte ghosts loaded
with antibiotic (pharmacocytes) directly into the wound tissues. Introduction of pharmacocytes
to the purulent wound ensures high therapeutic concentrations of the antibiotic, which leads to
rapid arresting of the phase of the inflammatory process and thus results in early healing.
In order to explain this phenomenon, we investigated the effect of the pharmacocytes on the
phenotypic polarization of macrophages.
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phenotypic plasticity of macrophages
Erythrocyte ghosts` influence on the phenotypic plasticity of macrophage
Abstract
oai:nur.nu.edu.kz:123456789/15242018-08-15T03:49:56Zcom_123456789_1487com_123456789_106col_123456789_1491
Sharipov, D.K.
Agibayeva, A.G.
Malimbaev, S.T.
2016-05-30T10:52:14Z
2016-05-30T10:52:14Z
2016-05-11
Sharipov, D.K., Agibayeva, A.G., Malimbaev, S.T. 2016. Using multi-omics technologies in innovative medicine. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1524.
http://nur.nu.edu.kz/handle/123456789/1524
Medicine of the XXI century is inextricably linked and increasingly uses data of OMICS technologies for the diagnosis and treatment of various diseases.
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multi-omics technologies
metallome
essential elements
Using multi-omics technologies in innovative medicine
Abstract
oai:nur.nu.edu.kz:123456789/15252018-08-15T03:49:59Zcom_123456789_1487com_123456789_106col_123456789_1491
Alimbetov, D.
Idrissova, D.
Davis, T.
Kipling, D.
2016-05-30T10:59:50Z
2016-05-30T10:59:50Z
2016-05
D. Alimbetov, D. Idrissova, T. Davis, and D. Kipling. 2016. Establishment of small cell lung cancer cell lines and validation of their growth characteristics. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1525
http://nur.nu.edu.kz/handle/123456789/1525
Rapidly metastasizing lung cancer is the top killer in the United States and
many other countries. In 2014, there were nearly 224 210 new cases of lung cancer and 159 260
predicted mortality from the disease in the US and approximately 44 488 new registered cases
of lung cancer in 2012 with 80% mortality and 5 % survival rate within 10 years of diagnosis in
the UK. Lung cancer is the most prevalent type of cancer in Kazakhstan accounting for nearly
22.1 % of all cancer cases. Small cell lung cancers (SCLCs) derived from the hormonal cells of
the lung and classified as one of the most dedifferentiated cancers representing 10 - 15% of
all lung cancers however showing extremely aggressive and rapid dissemination into various
parts of the body. In this work we established SCLC cell line and characterised their growth for
upcoming research purposes.
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Lung cancer
small cell lung cancer
NCI-H69
p53
Establishment of small cell lung cancer cell lines and validation of their growth characteristics
Abstract
oai:nur.nu.edu.kz:123456789/15262018-08-15T03:49:54Zcom_123456789_1487com_123456789_106col_123456789_1491
Kim, Y.
Zhiyenbay, Y.
Baltabekova, A.
Shagyrova, Zh.
Aksambayeva, A.
Voikov, M.
Shustov, A.
2016-05-30T11:13:02Z
2016-05-30T11:13:02Z
2016-05-11
Kim, Y., Zhiyenbay, Y., Baltabekova, A., Shagyrova, Zh., Aksambayeva, A., Voikov, M., Shustov, A. 2016. Using of alphavirus capsid mutant as a vector for the production of recombinant proteins. Abstract book. 4 th International Scientific Conference. “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1526.
http://nur.nu.edu.kz/handle/123456789/1526
Recombinant DNA technology is used in various ways in a healthcare. By the genetic engineering techniques recombinant protein with pharmaceutical activity aka biopharmaceuticals are produced. The most of approved drugs are produced by mammalian cells. Because, in order to function properly in human organism, recombinant proteins have to pass through glycosilation which can be performed in mammalian cells. In this research we investigated alphaviral vector based on Venezuelan encephalitis virus (VEEV) as possible gene delivery system for mammalian cells transduction.
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alphavirus capsid
recombinant proteins
Using of alphavirus capsid mutant as a vector for the production of recombinant proteins
Abstract
oai:nur.nu.edu.kz:123456789/15272018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Sekenova, A.
Kumasheva, V.
Li, Ye.
Baidosova, Sh.
Ogay, V.
2016-05-30T11:32:37Z
2016-05-30T11:32:37Z
2016-05
A. Sekenova, V. Kumasheva, Ye. Li, Sh. Baidosova, and V. Ogay. 2016. Generation of hepatocyte-like cells from human pluripotent stem cells. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University.
http://nur.nu.edu.kz/handle/123456789/1527
The demand for donor livers in transplantation medicine continues to increase
every year with the difficulties in finding compatible human hepatocytes. Therefore, generation
of patient specific human hepatocytes from pluripotent stem cells (PSCs) possess the possibility
for cell-based therapeutics, bioengineering and modeling of fetal liver development. In this
regard, the aim of this study was to generate of human hepatocyte-like cells from human PSCs
under xeno-free and feeder-independent conditions.
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pluripotent stem cells
differentiation
hepatocyte-like cells
liver development
Generation of hepatocyte-like cells from human pluripotent stem cells
Abstract
oai:nur.nu.edu.kz:123456789/15282018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Riethmacher, D.
2016-05-30T11:42:44Z
2016-05-30T11:42:44Z
2016-05
D. Riethmacher. 2016. Glial cells and their molecules in nerve regeneration. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1528
http://nur.nu.edu.kz/handle/123456789/1528
Peripheral nerve injury has many causes ranging from traumatic damage to metabolic
disturbances (e.g.in diabetes mellitus). The primary pathology can affect axons (nerve
transection) or Schwann cells, and their interdependence means that injury to one will ultimately
affect the other. Fortunately, the PNS has a significant capacity for repair, and axons are able to
regenerate over long distances and are also capable of remyelination.
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nerve regeneration
Glial cells and their molecules in nerve regeneration
Abstract
oai:nur.nu.edu.kz:123456789/15292018-08-15T03:49:59Zcom_123456789_1487com_123456789_106col_123456789_1491
Shuinshkalieva, Zh.
Turganbekova, A.
Akparova, A.
2016-05-31T02:52:34Z
2016-05-31T02:52:34Z
2016-05
Zh. Shuinshkalieva, A. Turganbekova, A. Akparova. 2016. HLA-B27 subtypes distribution among the healthy population in Kazakhstan. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1529
http://nur.nu.edu.kz/handle/123456789/1529
Human leukocyte antigen B27 (HLA-B27) is a molecule of class I major
histocompatibility complex. Numerous studies showed an association of the antigen with
various types of spondyloarthropathies. The strength of this association varied considerably
among racial and ethnic groups.
The aim of this study was to determine the frequency of occurrence of polymorphic variants
of HLA-B27 gene in individuals residing in the Republic of Kazakhstan.
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MHC-I
HLA-B27
HLA-B27 subtypes distribution among the healthy population in Kazakhstan
Abstract
oai:nur.nu.edu.kz:123456789/15302018-08-15T03:49:54Zcom_123456789_1487com_123456789_106col_123456789_1491
Jaganathan, S. K.
2016-05-31T03:00:35Z
2016-05-31T03:00:35Z
2016-05
Jaganathan S. K. 2016. Honey and papaya extract loaded polyurethane based bio-nanofibrous scafford for skin regeneration. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1530
http://nur.nu.edu.kz/handle/123456789/1530
Skin regeneration is vital for chronic or acute wounds healing. Honey and
Carica papaya fruit extract are rich source of various proteins, amino acids, vitamins and
essential minerals. These naturally available biomolecules have proven antioxidant, antimicrobial,
anti-inflammatory, anti-scarring and healing properties. The advent of electrospinning
technique has provided a platform for the synthesis of various advanced scaffolds with natural
substances for effective skin regeneration.
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Honey
papaya
skin regeneration
electrospinning
Honey and papaya extract loaded polyurethane based bio-nanofibrous scafford for skin regeneration
Abstract
oai:nur.nu.edu.kz:123456789/15312018-08-15T03:49:56Zcom_123456789_1487com_123456789_106col_123456789_1491
Francipane, M. G.
Bulanin, D.
Lagasse, E.
2016-05-31T03:13:47Z
2016-05-31T03:13:47Z
2016-05
M. G. Francipane, D. Bulanin, and E. Lagasse. 2016. Identification of therapeutic targets for chemotherapy-resistant colon cancer stem cells. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1531
http://nur.nu.edu.kz/handle/123456789/1531
Current first-line chemotherapy generally consists of cytotoxic agents. While these agents
may initially control disease by effectively debulking tumors, the tumors invariably recur due to
the ability of cancer stem cells (CSCs) to survive and repopulate the tumor mass. To identify
potential molecular targets in 5-fluorouracil (5-FU) refractory colon CSCs, we developed
5-FU resistant cell lines over a period of a year. Here we show that 5-FU maintains colon
CSCs in an undifferentiated state in vitro.
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cancer stem cells
cancer
Identification of therapeutic targets for chemotherapy-resistant colon cancer stem cells
Abstract
oai:nur.nu.edu.kz:123456789/15322018-08-15T03:49:58Zcom_123456789_1487com_123456789_106col_123456789_1491
Imanbay, A.
Turbekova, Sh.
Akparova, A.Yu.
Abishev, M.T.
Bersimbaev, R. I.
2016-05-31T03:21:28Z
2016-05-31T03:21:28Z
2016-05
A. Imanbay, Sh. Turbekova, A.Yu. Akparova, M.T. Abishev, and R. I. Bersimbaev. 2016. IL-10-1082 A/G pomoter polimorphism is associated with copd. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University.
http://nur.nu.edu.kz/handle/123456789/1532
Interleukin-10 is an important immunoregulatory cytokine produced by many
cell populations. It inhibits the production of proinflammatory cytokines by macrophages and
thus has immunosuppressive effects on T cells, monocytes and macrophages. IL-10 has a
protective effect against airway hyperresponsiveness and inflammation. It is a candidate gene
in the pathophysiological mechanisms of inflammatory and autoimmune diseases. According to
research, the most important functional polymorphism is the replacement of A —> G in position
-1082 (rs 1800896). This SNP localized in the binding site of the transcription factor, resulting in
a change in IL-10 production and secretion.
Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow
obstruction associated with chronic lung inflammatory process, which is caused by action of
pathogenic particles and gases. Many of inflammatory cells, enzymes and mediators, that
enhance the pathological changes and cause structural alteration, are involved in the formation
of the inflammatory process.
The aim of our study was to determine the distribution of polymorphic gene variants IL10 in
COPD patients.
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chronic obstructive pulmonary disease
gene polymorphism
interleukin-10
IL-10-1082 A/G pomoter polimorphism is associated with copd
Abstract
oai:nur.nu.edu.kz:123456789/15332018-08-15T03:50:26Zcom_123456789_1487com_123456789_106col_123456789_1491
Zhalbinova, M.
Rakhimova, S.
Bekbosynova, M.
Myrzakhmetova, Sh.
Akilzhanova, A.
2016-05-31T03:37:55Z
2016-05-31T03:37:55Z
2016-05
M. Zhalbinova, S. Rakhimova, M. Bekbosynova, Sh. Myrzakhmetova, and A. Akilzhanova. 2016. Influence of Gamma-glutamyl carboxylage (GGCX) on warfarin dose. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1533
http://nur.nu.edu.kz/handle/123456789/1533
Warfarin is an oral anticoagulant which is popular in cardiology for the prevention
and treatment of thromboembolic events in patients with deep vein thrombosis. Patients usually
treated according to the clinical data. However, incorrect dose of the treatment can be followed
with side effects such as excessive bleeding and thrombosis. To avoid these side effects
patients need genetic tests for specific genes which are responsible for the sensitivity of patient
to warfarin. GGCX is one of the genes which have a role in dose of the warfarin
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warfarin
GGCX
anticoagulant
Influence of Gamma-glutamyl carboxylage (GGCX) on warfarin dose
Abstract
oai:nur.nu.edu.kz:123456789/15342018-08-15T03:49:54Zcom_123456789_1487com_123456789_106col_123456789_1491
Салимбаева, Д.Н.
2016-05-31T03:44:58Z
2016-05-31T03:44:58Z
2016-05-11
Салимбаева, Д.Н. 2016. Анализ мутаций гена РАН у больных фенилкетонурией казахов и уйгур в Казахстане. Книга абстрактов. 4 Международная научная конференция. “Regenerative medicine & healthy aging”. National Laboratory Astana, Назарбаев Университет. http://nur.nu.edu.kz/handle/123456789/1534.
http://nur.nu.edu.kz/handle/123456789/1534
Фенилкетонурия (ФКУ) - наследственная аминоацидопатия, этиологическим фактором которой являются мутации в гене фенилаланингидроксилазы (РАН). Описано более 500 мутаций, частота и спектр которых характеризуются гетерогенностью и межпопуляционными различиями.
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фенилкетонурия
ФКУ
ген РАН
Анализ мутаций гена РАН у больных фенилкетонурией казахов и уйгур в Казахстане
Abstract
oai:nur.nu.edu.kz:123456789/15352018-08-15T03:49:55Zcom_123456789_1487com_123456789_106col_123456789_1491
Baidosova, S.
Kumasheva, V.
Kerimbayev, T.
Aleynikov, V.
Aldiyarova, N.
Ogay, Vyacheslav
2016-05-31T03:53:09Z
2016-05-31T03:53:09Z
2016-05
S. Baidosova, V. Kumasheva, T. Kerimbayev, V. Aleynikov, N. Aldiyarova, and Vyacheslav Ogay. 2016. Isolation and enrichment of rat bone marrow mesenchymal stem cells. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1535
http://nur.nu.edu.kz/handle/123456789/1535
Mesenchymal stem cells (MSCs) are a promising tool for cell therapy, because
of their specific characteristics, which mimic partially those of embryonic stem cells, but with
some advantages in terms of availability, expandability, transplantability and ethical implications.
These cells can be isolated from the bone marrow and enriched with two mesenchymal surface
markers CD54 and CD90 by immunomagnetic separation. In this regard, the purpose of this
study was to isolate and enrich rat MSCs from bone marrow.
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Mesenchymal stem cells
rat
bone marrow
immunomagnetic separation
Isolation and enrichment of rat bone marrow mesenchymal stem cells
Abstract
oai:nur.nu.edu.kz:123456789/15362018-08-15T03:49:59Zcom_123456789_1487com_123456789_106col_123456789_1491
Surumbayeva, A.
Ogay, Vyacheslav
2016-05-31T04:01:22Z
2016-05-31T04:01:22Z
2016-05
A. Surumbayeva, V. Ogay. 2016. Isolation and characterization of rabbit periosteum-derived mesenchymal stem cells. Abstract book. 4 th International Scientific Conference “Regenerative medicine & healthy aging”. National Laboratory Astana, Nazarbayev University. http://nur.nu.edu.kz/handle/123456789/1536
http://nur.nu.edu.kz/handle/123456789/1536
Periosteum represents a good source for mesenchymal stem cells (MSCs).
They have been regarded as a promising therapeutic tool for muscoskeletal regeneration.
Periosteum-derived MSCs have higher osteogenic potential in vitro than MSCs from other
tissues and organs. The aim of this study was to isolate and characterize rabbit periosteumderived
MSCs for further their application for bone tissue engineering
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periosteum
mesenchymal stem cells
regenerative medicine
rabbit
Isolation and characterization of rabbit periosteum-derived mesenchymal stem cells
Abstract
oai:nur.nu.edu.kz:123456789/15372018-08-15T03:49:57Zcom_123456789_1487com_123456789_106col_123456789_1491
Коркан, А.И.
Лактионова, М.В.
Сармулдаева, Ш.К.
2016-05-31T04:06:25Z
2016-05-31T04:06:25Z
2016-05-11
Коркан, А.И., Лактионова, М.В., Сармулдаева, Ш.К. 2016. Анализ эффективности сочетания хирургических методов в лечении пролапса тазовых органов. Книга абстрактов. 4 Международная научная конференция. “Regenerative medicine & healthy aging”. National Laboratory Astana, Назарбаев Университет. http://nur.nu.edu.kz/handle/123456789/1537.
http://nur.nu.edu.kz/handle/123456789/1537
Пролапс тазовых органов занимает 3-е место в структуре гинекологических заболеваний (28%). В связи с этим, до 15% всех «больших» гинекологических операций производится по этому поводу (Краснопольский В.И., 2005). На сегодняшний день основным способом лечения пролапса тазовых органов является хирургический метод. Результаты крупных исследований доказывают актуальность и эффективность замещения тазовой фасции сетчатыми протезами в лечении пролапса гениталий, а также сочетание различных оперативных приемов для одномоментного устранения функциональных нарушений органов малого таза.
ru
http://creativecommons.org/licenses/by-nc-sa/3.0/us/
Attribution-NonCommercial-ShareAlike 3.0 United States
анализ
пролапс тазовых органов
Анализ эффективности сочетания хирургических методов в лечении пролапса тазовых органов
Abstract
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