2024-03-29T02:05:47Zhttp://nur.nu.edu.kz/oai/requestoai:nur.nu.edu.kz:123456789/4122018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Construction of large scale boolean logic based pathways of colorectal cancer stem cells
Abetov, D.A.
Mustapova, Z.N.
Begimbetova, D.A.
Bulanin, D.
biological interactions
colorectal cancer stem cells
pathway diagram
CCSC biology
Despite advances in the post-genomic era, which allowed for generation of an impressive
amount of biological data, representing the whole network of biological interactions, gene regulating
networks and signaling pathways in a unified temple and coherent way is still a challenging task. Here
we performed analysis of upregulated molecular networks found in colorectal cancer stem cells (CCSC).
2015-10-21T05:33:31Z
2015-10-21T05:33:31Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/412
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4132018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Gene expression and methylation profiles as a biomarker for human radiation exposure
Abilmazhinova, A.
Zhabagin, M.
Rakhimova, S.
Bakhtin, M.
Kazymbet, P.
Akilzhanova, A.
Zhumadilov, Z.
gene expression
global methylation
hydroxymethylation
human radiation
biomarker
Taking into account the fact that Kazakhstan is one of the world's leaders in uranium mining, and given the extent of the damage suffered as a result of the work on the Semipalatinsk nuclear test site, the general background radiation in some regions came under the influence of additional effects of chronic exposure to low doses of radiation, the study and search for new methods of dosimetry, as an integral part of the radiological protection of the population, is a priority for the state. The purpose of this study is the search for and development of potential biomarkers by assessing the impact if ionising radiation on gene expression and quantification of global methylation and hydroxymethylation of uranium industry workers.
2015-10-21T06:30:19Z
2015-10-21T06:30:19Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/413
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4142018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Genetic homongeneity and major histocompatibility complex haplotyping of white mice
Sydykova, K.
Sadykov, M.
Zhailauova, A.
Adilbayeva, A.
Myngbay, A.
Adarichev, V. A.
genetic homogeneity
histocompatibility complex
haplotype
DNA product
Inbred murine strains are generated to insure genetic homogeneity and uniqueness
and define immune characteristics, like major histocompatibility complex (MHC) haplotype, of the
experimental model. Maintaining of the perfect inbred stock leads to increased level of homozygosity
and sometimes encounters a problem of inbreeding depression and consequently deviation from
strict inbreeding protocol. Our goals are (i) study genetic homogeneity of mice in the colony, and (ii)
haplotyping of H-2 complex (MHC in mice) in this strain.
2015-10-21T09:08:58Z
2015-10-21T09:08:58Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/414
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4152018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Molecular mimicry of brucella melitensis epitopes in mouse and human arthritis
Bexeitov, Y. K.
Ramez, M
Forde, T. S.
Adarichev, V. A.
brucellosis
osteomyelitis
arthritis
spondyloarthritis
cytotoxic T cells
Brucellosis is one of the most frequent zoonosis worldwide. Infection is transferable
to humans, where brucellosis is associated with high incidence of osteoarticular disease including
osteomyelitis, arthritis and spondyloarthritis. Peripheral arthritis and sacroiliitis often develop in patients
with no or low count of live Brucella. Recently, we demonstrated that mice develop spontaneous arthritis
several weeks after acute infection when bacteria are already eradicated. We aim to decipher immune
mechanism of the brucellosis-associated delayed arthritis that has not been elucidated so far.
2015-10-21T09:26:49Z
2015-10-21T09:26:49Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/415
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4162018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
New arthritic pannus-specific protein promotes fibroblast motility and polarization
Adilbayeva, A.
Myngbay, A.
Adarichev, V. A.
fibroblast motility
protein
cell morphology
cell movement velocity
cell polarization
Rheumatoid arthritis (RA) is chronic inflammatory disease characterized by the
development of hypercellular pannus tissue in the affected joints of patients. Pannus invasiveness and
activation correlates with stronger tissue destruction and worse clinical prognosis. Using murine arthritis
model, we recently discovered that synovial concentration of Collagen Triple Helix Repeat-containing
1 (CTHRC1) message and protein is directly correlated with arthritis severity. In carcinogenesis,
overexpression of CTHRC1 is associated with enhanced metastatic potential of solid tumors and increased
cell motility. Our goal is to investigate the mechanism of synovial cell motility and invasiveness and the
role of non-canonical WNT signaling in pannus development.
2015-10-21T09:42:29Z
2015-10-21T09:42:29Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/416
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4172018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
New serum biomarker for rheumatoid arthritis
Myngbay, A.
Adilbayeva, A.
Adarichev, V. A.
serum
biomarker
rheumatoid arthritis
protein
blood plasma
Development of hypercellular invasive pannus tissue within synovial joints is a hallmark
of Rheumatoid Arthritis (RA). Pannus produces proteases that damage bone and cartilage. Non-invasive
monitoring of pannus activity is important for clinical assessment of patients as well as for control of
the efficacy of therapeutic interventions. Available biomarkers are not satisfactory in terms of pannus
specificity and sensitivity for monitoring local inflammation and bone erosion. Our goal is collecting
clinical samples of synovial fluid and plasma from patients with RA and/or osteoarthritis (OA) to study
the role of WNT signaling in pannus formation and developing set of serum biomarkers to monitor
pannus activity.
2015-10-22T10:05:37Z
2015-10-22T10:05:37Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/417
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4182018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Protective effect of peptide vaccination in murine infection with influenza virus
Myngbay, A.
Adilbayeva, A.
Sadykov, M.
Zhailauova, A.
Adarichev, V. A.
Alibek, K.
vaccination
immunobiology
clinical evaluations
influenza vaccine
Vaccination is a major tool to protect people from seasonal infections of different
strains of influenza virus that presently infects millions of individuals worldwide. Virus genome is
highly polymorphic, and universal vaccine that protects against permanently changing virus is still
under development. Despite notable differences between humans and rodents in the disease course,
immunobiology and clinical evaluations, murine infectious models remain one of the major tools to test
approaches for influenza vaccine development.
2015-10-22T10:23:30Z
2015-10-22T10:23:30Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/418
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4192018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Beijing genotype is the most dominant genotype among clinical isolates of m.tuberculosis in Kazakhstan
Akhmetova, А.
Kozhamkulov, U.
Bismilda, V.
Chingissova, L.
Akilzhanova, A.
genotype
Beijing genotype
isolates of M. tuberculosis
MIRU-VNTR analysis
Methods of genotyping of M. tuberculosis play important role in tuberculosis (TB)
infection control. These techniques are used to detect or exclude laboratory errors, control recurrent
cases and determine ways of TB transmission. Today, there are more than 10 methods of genotyping,
MIRU-VNTR being one of the most widely used methods in the world.
2015-10-22T10:45:11Z
2015-10-22T10:45:11Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/419
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4202018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Screening mutation in RYR2 gene in a Kazakhstani idiopathic ventricular tachycardia study cohort: two novel mutations
Akilzhanova, A.
Guelly, C.
Abilova, Z. M.
Rakhimova, S.
Nuralinov, O. M.
Abdrakhmanov, A. C.
Bekbosynova, M. S.
ventricular tachycardia
ventricular arrhythmia
RYR2 gene
The human ryanodine receptor 2 (RYR2) is one of the key players tightly regulating
calcium efflux from the sarcoplasmic reticulum to the cytosol and found frequently mutated (<60%) in
context of catecholaminergic polymorphic ventricular tachycardia (CPVT1) [1].
2015-10-22T10:57:00Z
2015-10-22T10:57:00Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/420
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4212018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Regulation of asymmetric neurogenesis in c. elegans
Aldabergenova, A.
Poole, R.
asymmetric
neuronal
non-neuronal
C. elegans
proneural gene
embryos
Neural specification is further complicated when we consider that it needs to be
coordinated across the left-right (L/R) axis. Disruptions in the bilaterally symmetric organization of
the human brain are frequently observed in patients with neurological disorders. Furthermore, certain
neurological disorders such as schizophrenia and Parkinson's disease present or progress asymmetrically,
suggesting the possibility of underlying asymmetric genetic causes. The question of how early neural
specification is regulated to produce both bilaterally symmetric and L/R asymmetric structures has been
largely unexplored.
2015-10-22T11:21:04Z
2015-10-22T11:21:04Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/421
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4222018-08-15T03:49:33Zcom_123456789_409com_123456789_129col_123456789_411
Human movement learning with dynamic movement primitives combined with mixture models
Alizadeh, T.
Calinon, S.
dynamical movement primitives
human motions
mixture models
The proposed research is to provide a probabilistic approach to learn human movements.
Dynamical Movement Primitives (DMP) have been extensively used in robotics in order to learn human
motions [1]. The DMP modulates a virtual spring with a learned non-linear force profile /(x), perturbing
the system to make it follow a desired trajectory.
2015-10-22T11:30:36Z
2015-10-22T11:30:36Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/422
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4232018-08-15T03:49:33Zcom_123456789_409com_123456789_129col_123456789_411
Development and testing of new force fields for molecular dynamics simulations
Balabaev, N. K.
Finkelstein, A. V.
Galzitskaya, O. V.
Garbuzynskiy, S. O.
Glyakina, A. V.
Lobanov, M. Yu.
Matkarimov, B.
molecular dynamics
3D structures
molecular crystals
thermodynamics characteristics
Recent progress in modeling of protein folding in Dr. Shaw laboratory has been
achieved only after some improvements of potentials of covalent forces, taken from the standard AMBER
force field; and still, the force field used is not quite satisfactory to reproduce folded structures of some
larger proteins, having significant, about 5A, RMS deviation between the computed and experimentally
determined 3D structures. The objective of this research is to develop and test new polarizable atomic
force fields (FFs) for "in-vacuum" and "in-water" non-bonded interactions based on AMBER ff99SBILDN
force fields, improved by inclusion of new terms. FFs parameter optimization will be done using
our set of molecular crystals with crystallographic data from the Cambridge Structural Database and
sublimation/solvation thermodynamics characteristics from various sources.
2015-10-22T11:40:33Z
2015-10-22T11:40:33Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/423
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4242018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Split core technology allows efficient production of virus-like particles presenting a receptor-contacting epitope of human IgE
Baltabekova, A. Zh.
Shagyrova, Zh. S.
Voykov, M.
Ramanculov, E. M.
Shustov, A. V.
immunoglobulin E
human IgE
immunodominant region
split core technology
Immunoglobulin E (IgE) plays a central role in type I hypersensitivity including allergy
and asthma. Novel treatment strategy envisages development of a therapeutic vaccine designed to elicit
autologous blocking antibodies against the IgE. We sought to develop an IgE-epitope antigen that induces
antibodies against a receptor-contacting epitope on human IgE molecule.
2015-10-22T11:53:03Z
2015-10-22T11:53:03Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/424
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4252018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Prediction of blood damage within biomedical blood-wetted devices due to mechanical action
Zhanshayeva, L.
Zhussupbekov, M.
Rojas-Solorzano, L.
CFD model
biomedical blood-wetted
blood rheology
The goal of this project is to develop a CFD model of blood to predict hemolysis due to
mechanical action in biomedical blood-wetted devices. Most of the current models approximate blood as
a Newtonian fluid at high shear rates. Our work is based on numerical model developed in [1] that
modeled blood as a multiphase fluid with constant viscosity. Although successful in capturing phase
segregation (Fahraeus-Lindqvist effect), it still did not reach acceptable agreement with experimental
data in terms of damage. Gijsen et al. [2] reported significant differences between flow fields obtained by
Newtonian and non-Newtonian models of blood. The goal of this study is to introduce non-Newtonian
blood rheology to the base model and validate it with existing experimental data.
2015-10-22T12:03:29Z
2015-10-22T12:03:29Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/425
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4262018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Mathematical modeling and big data analytics in biomedicine
Brusic, V.
biomedical data
mathematical modeling
data formats
T-cell immunome
big data analysis
The World's total data is doubling every two years. Data expansion includes growth in quantity,
complexity, and types of data. The enormous rate of generation and on-line access to data is profoundly
changing the way how business is conducted. Biomedical data include research and development data,
clinical data, activity and cost data, patient behavior data, basic science data, and standards and ontologies,
among others. Furthermore, Big Data approaches are increasingly needed for utilization of results
from various Omics studies. Specific applications include predictive and content analytics that support
drug discovery and optimization, the development of new diagnostic methods, and personalization of
medicine. Biomedical data vary in granularity, quality, and complexity. There is a variety of sources and
data formats - web pages, publications, technical reports, and databases. The challenge is to make the
transition from data to actionable knowledge.
2015-10-22T12:13:34Z
2015-10-22T12:13:34Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/426
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4272018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Subnanomolar detection of tuberculosis biomarker MPT64 in sandwich sers immunoassay on novel low -cost substrate
Ralchenko, Y.
Khamkhash, L.
Bukasov, R.
subnanomolar detection
tuberculosis biomarker
antibodies
molecule
The use of SERS for detection, analysis and imaging has attracted great interest in the
past decade owing to its high sensitivity and molecular fingerprint specificity. There is an increasing
interest in scientific community to SERS as it becomes a versatile method for early medical diagnostics
and reliable detection of major health threats to humans (e.g. cancer, tuberculosis, etc) and animals [1].
The key component of our SERS-based immunoassay include:1) a capture substrate to specifically adsorb
antigens from solution; (2) Extrinsic Raman Labels (ERLs): surface functionalized gold nanoparticles
(AuNPs) to bind to captured antigens selectively and generate intense SERS signals, which contain both
capture antigen and SERS active readout molecule (4-nitrobenzenethiol (4-NBT)).
2015-10-22T12:24:26Z
2015-10-22T12:24:26Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/427
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4282018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Cardiovascular diseases and health:patient perspectives
Craig, B. J.
Karabayeva, A.
cardiovascular diseases
health
patient perspectives
One of the greatest challenges to public health in Kazakhstan is the increasing prevalence
of cardiovascular diseases (CVDs). Perceptions of responsibility in health vary across populations [1],
and research in Kazakhstan has revealed that patients tend to place the responsibility for their health
on doctors rather than on their own individual health choices [2]. Due to the relationship between
lifestyle and many CVDs, this presents a problem for the future health of Kazakhstan's public. This study
examined the perspectives of patients being treated for CVDs regarding their care and lifestyles in order
to be able to inform patient education and behavior change efforts as well as improve larger public health
promotion.
2015-10-22T12:34:03Z
2015-10-22T12:34:03Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/428
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4292018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
New nucleic dyes for pico-and nanoplankton cytometric analysis
Dashkova, V.
Segev, E.
Khromov, V.
Kolter, R.
Vorobjev, I.
Barteneva, N. S.
nuclear dyes
propidium iodide
eosin
cytometric systems
phytoplankton populations
Flow cytometry (FCM) is a promising tool in the field of aquatic phytoplankton
ecology because it allows for multi-parameter assessment of the physiological state of individual cells in
an algal population. It can help to elucidate major questions such as phytoplankton taxa identification,
the evaluation of cell quantity and viability, and the measuring of phytoplankton and general microbial
metabolic activities. Traditionally, microalgal characterization is performed by microscopic analysis using
UV-excited nuclear dyes (e.g. Hoechst and DAPI) or dyes that are excited in the blue-green part of the
spectrum such as propidium iodide and eosin. The development of multi-laser cytometric systems has
widened the possibilities for multi-parametric analysis and cell sorting of phytoplankton populations.
Notwithstanding, significant algae autofluorescence originating from different types of chlorophyll and
accessory pigments may overlap with propidium iodide and/or eosin staining and affect the resolution
of algae clusters and cell sorting.
2015-10-22T12:43:20Z
2015-10-22T12:43:20Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/429
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4302018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Listening to reporter proteins: how loud does the message need to be?
Dauyey, K.
Morgan, F. J.
Bohndiek, S. E.
colorectal adenocarcinoma
fluorescent spectral
spheroids
molecules
tissue
ultrasound
Optical imaging as non-invasive modality has tremendous research applications in the
area of biomedical sciences such as characterization of cancerous cells. However, this imaging modality
is limited by depth of light penetration of around 1 mm in living tissues obscuring visualization in vivo.
Optoacoustic imaging is a potential solution of this problem based on detection of ultrasound produced
by light-absorbing molecules exposed to laser radiation resulting in a tissue contrast. The image contrast
relies on absorption of laser emission, however providing ultrasound resolution in living tissues. This
study characterized properties of colorectal adenocarcinoma cells expressing Near-infrared Fluorescent
proteins (iRFPs) for detection and visualization in Multispectral Optoacoustic Tomography (MSOT)
settings in both tissue-mimicking phantoms and mice. We estimated variables affecting MSOT imaging of
3D multicellular tissue spheroids such as size, expression of iRFP in vitro. We tested MSOT for detection
of subcutaneously implanted tumours expressing iRFPs in BALB/C nude mice in vivo.
2015-10-23T04:35:32Z
2015-10-23T04:35:32Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/430
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4312018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Development of a technology for expression of recombinant human erythropoietin in cultured mammalian cells using alphavirus expression system
Evtyhova, E. B.
Voykov, M.
Ramanculov, E. M.
Shustov, A. V.
recombinant
human erythropoietin
mammalian cells
synthetic gene
oligonucleotides
polyprotein
protein
Currently there are no industrial eukaryotic expression systems other than transient
expression from plasmids or expression from genes integrated into host genome. Both approaches (use
of eukaryotic plasmids or chromosomal integration) suffer from poor scalability and often from poor
yields. Although, in laboratory settings, effective means for transducing of cultured cells to express
foreign proteins and for high-level transient expression were developed based on viral genomes. We
thought to develop a scalable and suitable for industrial application technology for the production of
recombinant human erythropoietin (EPO) in mammalian cell cultures using an expression vector based
on the genome of RNA virus.
2015-10-23T04:52:02Z
2015-10-23T04:52:02Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/431
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4322018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Design methodology for haptic interfaces and rehabilitation systems
Folgheraiter, M.
robot
haptic interface
rehabilitation system
design
dynamic model
Designing the actuation system for a robot is a crucial step during the machine
development. This phase is even more critical if the robotic system is represented by a haptic interface
or a rehabilitation system that are meant to operate in near contact with the human body. Generally, the
design process takes into account a realistic model of the limb interacting with the interface [1,2] and
includes as set of simulations intended to study the coupled interface-limb system. The result of these
simulations allows fixing important requirements necessary to design the interface. Among them the
number of Degrees of Freedom (DOF), the joints type and configuration, and the links dimensions.
When the kinematic of the interface is ready a proper dynamic model [3] needs to be formalized and
computed. This is demanded to find out other important design elements like the optimal actuators
displacement and dimensioning.
2015-10-23T05:11:31Z
2015-10-23T05:11:31Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/432
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4332018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Role of HSC70 protein in maintenance of endoplasmic reticulum CA2+ homeostasis
Khamzina, Y.
Nauryzbayeva, A.
Gilman, C.
intracellular
calcium
homeostasis
neuronal
brain
endoplasmic
reticulum
injuries
apoptosis
Intracellular calcium homeostasis is disrupted in many neuronal diseases and traumatic
brain injuries resulting in endoplasmic reticulum (ER) stress [1]. ER stress and intracellular calcium
homeostasis is a hub of signaling mechanisms that determine whether injured neurons will live or die.
With survivable injuries neurons seek to restore normal function by several mechanisms including the
upregulation of chaperones [2]. Hsc70 (aka Hsp73 and HSPA8) is one of such proteins, which is found
to be highly concentrated in neurons. Unlike other chaperones in the HSP family Hsc70 is constitutively
expressed and interacts with both cell cycle and apoptosis regulating proteins [3]. Therefore, we tested
the hypothesis that Hsc70 regulates neural stem cell fate in response to changes intracellular calcium
homeostasis. Currently little is known about the function of this novel chaperone or about the role of ER
calcium homeostasis in neural stem cell fate determination and this work is the first to investigate this
topic.
2015-10-23T05:29:00Z
2015-10-23T05:29:00Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/433
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4362018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Research on the bio-distribution of interferon gamma-containing pharmacocytes
Ibrasheva, D.
Idrissova, D.
Umbayev, B.
Masoud, A.
Askarova, Sholpan
treatment
erythrocytic pharmacocytes
blood
immune system
phagocytes
bio-distribution
plasma
Viral hepatitis B and C- is a widespread infectious disease of the liver and is a potential
threat to human life. Treatment of HCV and HBV requires prolonged (parenteral or oral) administration
of antiviral and immune-stimulating agents, which often have serious side effects that lead to abrupt
termination of the therapy and the development of viral resistance. Targeted delivery of drugs directly
to the affected organ is one of the most promising areas that seek to improve the outcome of treatment
of patients with chronic diseases. Among the various drug delivery systems, erythrocytic pharmacocytes
are of special interest. They are a shade of red blood cells, that could be loaded with antiviral drugs and
drugs that boost the immune system. Owing to the fact that erythrocytes are destroyed by mononuclear
phagocytes in the liver, it is assumable that the EP serve as a promising and direct means of delivering
antiviral drugs and immune-modulators into the liver parenchyma to treat viral hepatitis.
2015-10-23T08:38:04Z
2015-10-23T08:38:04Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/436
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4372018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Age-realted dementia in Kazahstan: adaptation of the 10/66 dementia research group population -based study protocol
Kaiyrlykyzy, A.
Adambekov, Sh.
Alimbetov, D.
Askarova, Sholpan
dementia diagnosis
subtypes
mental disorders
physical health
anthropometry
demographics
care arrangements
Background. The prevalence of dementia is increasing worldwide as the population ages and affects
10 % of the population over 65 years old and 40 % of people over the age of 80.[1] In Kazakhstan, as well
as in other countries around the world, the population of aged people has been increasing over the past
decades. According to available statistics, by the end of 2013, the percentage of people aged 65 and older
in Kazakhstan was 6.7% [2]. Given the fact that Kazakhstan's current population is about 17,221 million
people [2], and based on data from the global statistics, it can be assumed that at least 115,000 elderly
people could be suffering from age-related dementia. Nevertheless, such pathology is currently may not
being diagnosed in Kazakhstan; consequently giving no accurate statistical data on the number of people
suffering from this age-related pathology. Thus, the aim of this study is to estimate true prevalence of
dementia and assess the risk factors associated with the disease.
2015-10-23T09:16:19Z
2015-10-23T09:16:19Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/437
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4382018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
Development of a recombinant foot -and-mouth disease vaccine
Kalieva, M. Zh.
Shagyrova, Zh. S.
Voykov, M.
Ramanculov, E. M.
Shustov, A. V.
foot-and-mouth disease
vaccine
recombinant vaccine
inactivation of virus
animals
immunogenicity
Foot-and-mouth disease (FMD) is important disease of cloven-foot animals including
cows and swine. Although annual vaccination against the FMD is mandated in regions of South
Kazakhstan, outbreaks of the disease are registered every year. These outbreaks result in huge economic
losses because international rules require culling of all the diseased and contacted animals and all
products from these animals must be destroyed. Currently available anti-FMD vaccines are all produced
using the original technology of inactivation of virus (foot-and-mouth disease virus, FMDV) grown in
cell cultures. Recombinant anti-FMD vaccine is a long anticipated development in the industry because
the recombinant vaccine is safe and compatible with diagnostic tests for discrimination of diseased and
vaccinated animals (DIVA).
2015-10-23T09:28:18Z
2015-10-23T09:28:18Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/438
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4502018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
The multidimensional analysis of cell behaviour
Kauanova, S.
Kakpenova, A.
Balabiyev, A.
Vorobjev, I.
cell
microtubule
mechanism
nocodazole
taxol
vinorelbine
The cell motility assays became an important step for trial of new developed anti-tumor
drugs and compounds [1, 2]. Set of experiments was performed with microtubule affecting drugs on a
model population of 3T3 cells. This study is focused on the complex analysis of cell population behavior
that can be further used to develop method for evaluation of drugs in preclinical trials.
2015-10-26T05:32:05Z
2015-10-26T05:32:05Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/450
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4512018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Correlation between ocular elasticity and intraocular pressure on optic nerve damages
Ko, M. W. L.
Ali, Md. H.
Lam, D. C. C.
optic
glaucoma
ocular elasticity
lamina cribrosa
cornea
sclera
intraocular pressure
Optic neuropathy in glaucoma
causes visual field loss and blindness [1]. The optic
nerve damage in the lamina cribrosa (LC) of the
sclera, the primary site of glaucoma, is correlated
with the intraocular pressure (IOP) [2]. Literature
shows that the optic nerves are sheared at high
IOP and the scleral biomechanical properties
play an important role in the development and
progression of glaucomatous damage to the LC
and ganglion cell axons with the optic nerve head
(ONH). The aim of this study is to determine and
characterize the correlation between the corneal,
scleral and ONH elasticity, and intraocular
pressure on the optic nerve damages.
2015-10-26T05:47:15Z
2015-10-26T05:47:15Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/451
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4522018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
PIPK1a regulates RAC1 and akt activation to promote cell migration and proliferation
Merzhakupova, D.
Adilgozhina, G.
Kim, A.
Chao, W. T.
Kunz, J.
rac1
cell
osteosarcoma
breast cancer
biochemical
plasma membrane
Rac1 activity is concentrated at the front of migrating cells where it initiates signaling
processes necessary for cell migration in normal and pathological situations. The signaling pathways
downstream of Rac1 are well characterized. However, how Rac1 activation is regulated to confer cell
movement is incompletely understood.
2015-10-26T05:59:43Z
2015-10-26T05:59:43Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/452
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4532018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
PIPK1b regulates integrin endocytosis for focal adhesion disassembly by modulating the recruitment of the endocytic machinery to focal adhesions
Beisekenova, S.
Ospanova, B.
Kabdullayeva, T.
Chao, W. T.
Kunz, J.
PIPK1b
alpha5beta1
endocytosis
phosphatidylinositol
4-phosphate
phosphatidylinositol-4
5-kinase beta PIPK1P
via synthesis of PI4,5P2
Cell migration and tissue invasion during tumor metastasis require the regulated
disassembly of focal adhesions, but the underlying mechanisms remain poorly defined. We previously
showed that the turnover of focal adhesions occurs through odpha5Peta1 integrin endocytosis from focal
adhesions (1). We further discovered that only integrins in their active conformation are internalized
during focal adhesion disassembly and we set out to define the molecular machinery responsible for
integrin transport (1,2). These studies revealed that the pathway required for the trafficking of active
integrins involves different components than the pathway required for the trafficking of inactive integrins
(1,2). Significantly, only by inhibiting the endocytosis of activated integrins was cell migration inhibited
(2). Hence, the further identification of key components of the focal adhesion disassembly pathway is
likely to expose novel avenues to inhibit tumor cell invasion and metastasis.
2015-10-26T06:24:31Z
2015-10-26T06:24:31Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/453
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4552018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
SNX 9 interacts with dynamin 2 and N-wasp to regulate focal adhesion disassembly and cell migration
Zhubanchaliyev, A.
Chao, W. T.
Kunz, J.
cell migration
Snx9 regulation
cell biological
biochemical
The turnover of focal adhesions is essential for normal cell migration and tumor
invasion, but the underlying mechanisms are poorly understood. We have previously shown that the
disassembly of focal adhesions occurs by endocytosis of activated integrins from adhesion sites (1). We
have further identified new components that mediate integrin endocytosis. Here, we provide the initial
characterization of one of these components, sorting nexin 9 (Snx9), an endocytic adaptor protein not
previously implicated in cell adhesion and migration.
2015-10-26T08:01:25Z
2015-10-26T08:01:25Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/455
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4562018-08-15T03:49:34Zcom_123456789_409com_123456789_129col_123456789_411
PI4,5P2 regulates the polarized trafficking of integrins through EXO70 for directional cell migration
Jaguparov, A.
Tursynbay, Y.
Kim, A.
Chao, W. T.
Kunz, J.
PI4,5P2
Exo70
PIPK1P protein
cell migration
cell polarity
The polarized delivery of integrin adhesion molecules to the leading edge is required
for cell migration and has been linked to cancer cell invasion, cancer aggressiveness, and poor patient
outcome (1,2). Thus, regulators of integrin traffic may represent new molecular targets to inhibit tumor
progression. However, identifying the regulatory networks that control integrin traffic has posed a big
challenge, because, in contrast to the internalization of other cargoes, integrins take diverse routes,
depending on their specific ligand, activation state, type of adhesion structure and cell type assayed.
2015-10-26T08:18:13Z
2015-10-26T08:18:13Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/456
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4582018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
PIPK1b regulates E-cadherin endocytosis in polarized breast cancer cells and promotes a switch to a migratory phenotype
Azhunussova, A.
Shayakhmetov, Y.
Chao, W. T.
Kunz, J.
endocytosis
degradation
cadherins
dynamic regulation
pathological conditions
migratory phenotype
The endocytosis, degradation, and recycling of cadherins is crucial for the dynamic
regulation of adherens junctions and the control of cell-cell adhesion during tissue formation and in
many pathological conditions. In order to allow for dynamic changes in intercellular adhesion, adherens
junctions assemble and disassemble in a continuous fashion. A key mechanism for modulating adhesion
strength is the adjustment of the cell surface levels of E-cadherin, the major component of adherens
junctions. E-cadherin endocytosis, often accompanied by its degradation, has been observed in many
developmental and disease processes and accounts for more rapid changes in adhesion strength that can
occur independently of the transcriptional regulation of E-cadherin. However, the molecular mechanisms
underlying E-cadherin endocytosis and recycling remain incompletely understood.
2015-10-26T08:30:24Z
2015-10-26T08:30:24Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/458
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4602018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Genetic factors of hypertension in individuals with different rates of Na-Li counter -transport
Masoud, A.
Kravtsova, O. A.
Biktagirova, E.
DNA extraction
polymerase chain reaction (PCR)
restriction analysis
separation of the amplified products
analysis of statistical data
hypertension
Na-Li counter-transport
Currently, hypertension is recognized as one of the most common cardio-vascular
diseases. Recent studies indicate the multifactorial nature of this disease, in which much emphasis is given
to genetic factors for their role in the development of this disease. With, results based on the identification
of genetic markers associated with the risk of developing hypertension vary vastly and remain highly
controversial, primarily due to the ethno-genetic and geographical features of the populations under
study, there is an urgent need to identify a phenotypic trait that would allow analysis of associations with
the risk of developing hypertension irrespective of an individual's ethnic background or geographical
location. One such a prospective trait is the rate of Na-Li counter-transport, which remains unchanged
for most of an individual's lifetime, with rare exceptions. Hence this study is aimed at identifying the
contribution of gene polymorphisms of the renin-angiotensin system in the formation of genetic
predisposition to hypertension in individuals with different rates of erythrocyte Na-Li counter-transport.
2015-10-26T08:50:00Z
2015-10-26T08:50:00Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/460
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4622018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Protein's conformational structure prediction via pattern recognition and constraint satisfaction methods
Matkarimov, B.
Takhanov, R.
biology
biophysics
biochemistry
biomacromolecules
bioinformatics software
computer science
The prediction of protein's native structure given its amino acid sequence is one of
the central problems in modern computational biology/biophysics/biochemistry and computer science.
Today there are more than 80000 3D structures of various biomacromolecules at the open access, e.g. in
Protein Data Bank (PDB), and these databases have exponential growth rate. Project goal is to design
and implement computing experiments related to biomacromolecular folding problem. This includes the
development of high performance bioinformatics software.
2015-10-26T09:16:33Z
2015-10-26T09:16:33Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/462
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4642018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Whole genome sequencing of mycobacterium tuberculosis in Kazakhstan: first sequence results of two clinical isolates
Molkenov, A.
Kairov, U.
Kozhamkulov, U.
Rakhimova, S.
Askapuli, A.
Zhabagin, M.
Abilova, Zh.
Akhmetova, A.
Yerezhepov, D.
Abilmazhinova, A.
Bismilda, V.
Chingisova, L.
Zhumadilov, Zh.
Akilzhanova, A.
genome sequences
tuberculosis
genetic markers
strains
The project is aimed to create the prerequisites for a personalized approach to the diagnosis
and treatment of tuberculosis (TB) by identifying and comparing the whole genome sequences of
M.tuberculosis strains isolated in Kazakhstan. Analysis for whole genome sequences obtained using the
next generation sequencing technology will clarify the factors cause of the formation of highly virulent
strains of M.tuberculosis, the evolution of local strains, and genetic markers of drug resistance.
2015-10-26T09:44:22Z
2015-10-26T09:44:22Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/464
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4662018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Epigenetic reprogramming of cancer cells under embryonic microenvironment
Mu, X.
Sultankulov, B.
Agarwal, R.
Mahjoub, A.
Schott, T.
Greco, N.
Huard, J.
Weiss, K.
epigenetic reprogramming
embryonic microenvironment
osteosarcoma cells
cell apoptosis
genes
The idea of epigenetic reprogramming of cancer cells by an embryonic microenvironment
possesses potential interest from the prospect of both basic science and potential therapeutic strategies.
Chick embryo extract (CEE) has been used for the successful expansion of many specific stem cells
and has demonstrated the ability to facilitate DNA demethylation. The current study was conducted to
compare the status of DNA methylation in highly metastatic and less metastatic osteosarcoma cells and
to investigate whether CEE may affect the epigenetic regulation of tumor suppressor genes and thus
change the metastatic phenotypes of highly metastatic osteosarcoma cells.
2015-10-26T10:03:44Z
2015-10-26T10:03:44Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/466
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4672018-08-15T03:50:24Zcom_123456789_409com_123456789_129col_123456789_411
Pre-clinical evaluation of an adult extracorporeal carbon dioxide removal system for pediatric application
Mussin, Y.
Jeffries, R.
Bulanin, D.
Zhumadilov, Zh.
Olzhayev, F.
Federspiel, W.
adult extracorporeal
carbon dioxide
blood
hypercapnic respiratory
anesthesia
pulmonary artery
Adult extracorporeal carbon dioxide removal (ECCO2R) systems and pediatric ECMO
share the common objectives of having a low blood flow rate and low priming volume while safely
maintaining sufficient respiratory support. The Hemolung is a highly simplified adult ECCO2R system
intended for partial respiratory support in adult patients with acute hypercapnic respiratory failure.
2015-10-26T10:16:00Z
2015-10-26T10:16:00Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/467
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4692018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Evaluation of extracorporeal gas exchange device hemolung for potential application in pediatric practice
Mussin, Y.
Bulanin, D.
Jeffries, R.
Zhumadilov, Zh.
Olzhayev, F.
Federspiel, W.
gas exchange
blood
hydrodynamic pressure
hemolung
The main purpose of this work is to evaluate the Hemolung pumping ability and gas exchange
effectiveness while using the catheters of smaller diameter and blood flow rates applied in pediatrics.
2015-10-26T10:29:01Z
2015-10-26T10:29:01Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/469
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4722022-02-02T09:39:14Zcom_123456789_409com_123456789_129col_123456789_411
E.Coli derived camelid antibodies as a sensor for P53 in saliva
Niyazmetova, L.
Zhailauova, A.
Sadykov, M.
Muradova, Z.
Ospanova, B.
Pak, A.
Abdirakhmanova, Altynay
Stambekova, D.
Bayakhmetov, S.
Tsyba, N.
cell carcinoma
saliva
protein
camelid antibodies
Oral squamous cell carcinoma (OSCC) is a malignant tumor with 640,000 new cases
annually in the world [1]. Saliva testing is non-invasive procedure that is capable to detect potential
biomarkers for OSCC. It was shown that elevated level of p53 protein was identified in OSCC patients
at different stages of the disease (ibid). Camelid antibodies containing only variable regions, nanobodies
(VHH) and single-chain variable regions (scFv) with VH and VL, are becoming popular in many
biological studies including diagnostic applications. It was identified that VL region alone showed higher
affinity to p53 than VHH, and dimerization of VL region with another one increases the affinity up
to 10 folds [2]. Camelid antibodies have similar affinity to its substrate as human antibodies and can
be conjugated to other proteins without functional lose. They can be expressed and secreted in many
organisms including E.Coli in high amount, which reduces the cost of antibodies production. Thus, the
aim of this project is to design a biosensor, based on available sequence of antibodies, to detect p53 in
saliva samples for OSCC diagnosis.
2015-10-27T04:16:43Z
2015-10-27T04:16:43Z
2014
Abstract
http://nur.nu.edu.kz/handle/123456789/472
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4862018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Genetic dissection of the biochemical activities of human DNA repair protein, APE1
Redrejo-Rodriguez, M.
Mursalimov, A.
Koshenov, Z.
Zhakupova, K.
Saparbaev, M. K.
Ishchenko, A. A.
Matkarimov, B.
DNA repair
APE1 protein
endonucleases
glycosylases
amino acid
biochemical
Human apurinic/apyrimidinic endonuclease 1 (APE1) is a key DNA repair enzyme
involved in both base excision repair (BER) and nucleotide incision repair (NIR) pathways. In the BER
pathway, APE1 cleaves DNA at AP sites and 3'-blocking moieties generated by DNA glycosylases. In the
NIR pathway, APE1 incises DNA 5' to a number of oxidatively damaged bases. Here we propose to identify
and characterize critical amino acids of APE1 involved in either BER and/or NIR functions by using
the alignment of the known three-dimensional (or tertiary) structures of Xth family AP endonucleases
including the Methanothermobacter thermautotrophicus Mth212, Bacillus subtilis ExoA (1), E. coli Xth
and human APE1 proteins (2).
2015-10-27T04:40:45Z
2015-10-27T04:40:45Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/486
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4932018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
An integrated review program for the preparation for the United States medical license examination (USMLE)
Rogers, P.
Niyazmetova, L.
Abdiyeva, K.
USMLE review programs
medical license
program
integration
project
educational
The primary objective of the present educational research program is to improve upon existing
commercially available USMLE review programs. With the clear shortage of both residency slots,
the medical student's performance (score), on the USMLE assumes a new and critical importance.
Furthermore, there is a global need for 4.3 million new doctors and nurses. This shortage is particularly
evident in Central and Southeast Asia. Many of the needed new doctors will most probably be required
to pass the USMLE.
2015-10-27T04:56:02Z
2015-10-27T04:56:02Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/493
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/4952018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Toxicity studies of combination of silver nanoparticles and cryogels
Saliev, T.
Illsley, M.
Akhmetova, A.
Nurgozhin, T.
Mikhalovsky, S. V.
cryogel
nanoparticles
silver
polyacrylamide cryogel
human fibroblasts
The combination "cryogel + nanoparticles" allows developing a new type of wound
dressing, where antimicrobial properties of silver nanoparticles made have been utilized. Previous reports
have shown that the production of shaped nanoparticles and the incorporation onto cryogels is feasible
[1-2]. This study investigates the toxicity of these constructs to primary human dermal fibroblast cells in
context of possible clinical application.
2015-10-27T05:15:34Z
2015-10-27T05:15:34Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/495
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5022018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
The future of translational biomedical research at Nazarbayev University
Saparov, A.
Alibek, K.
Brusic, V.
Pignatelli, M.
biomedical research
molecules
cells
tissues
organs
diagnosis
patient
clinical practice
health
gene
transcriptomics
proteomics
metabolomics
biomedical informatics
The ultimate goal of fundamental biomedical research is to decipher mechanisms underlying the
impairment of molecules, cells, tissues, and organs and subsequent dysfunction of the whole human body.
Knowledge of these mechanisms helps discover and develop new approaches in the diagnosis, prevention
and treatment of various diseases. Translational biomedical research enables the application of basic
scientific discoveries to diagnostics, patient care and clinical practice. Thus, translational biomedical
research is a link between fundamental research, clinical research and clinical practice. Transfer of
discoveries from the bench to the bedside is a very complex and time consuming process that includes
pre-clinical studies and several phases of clinical trials, along with the development of clinical guidelines
and protocols, and the eventual implementation of best clinical practices.
2015-10-27T05:35:29Z
2015-10-27T05:35:29Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/502
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5032018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Z-DNA forming regions in the human genome
Fujimoto, Y.
Schonbach, C.
Z-DNA
human genome
gene ontology
chromosomes
Z-DNA is the left-handed helical structure of the usually right-handed B-DNA double
helix structure. Z-DNA conformations have been found to cause mutagenesis and genetic instability [1].
In this study, human genome sequences potentially forming Z-DNA regions (ZDRs) were extracted and
analysed for functional implications.
2015-10-27T05:44:36Z
2015-10-27T05:44:36Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/503
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5052018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_411
Preparation of anti-idiotypic antibodies for the diagnosis of bovine leukemia
Shramko, A.
Kiyan, V.
Borovikov, S. N.
antigens
antibodies
diagnosis
bovine leukemia
anti-idiotypic
The basic components of the diagnostic test systems are antigens and specific antibodies.
The main objective of developing express tests for the diagnosis of bovine leukemia virus (BLV) is to
obtain a virus antigen drug, which is very time-consuming to prepare. This problem can be solved by
producing anti-idiotype antibodies that have a chemical structure identical to that of the viral antigen
and does not require large expenditures to manufacture [1, 2].
2015-10-27T05:53:29Z
2015-10-27T05:53:29Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/505
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5072018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Development of technology and study of optimized secreted products of stem cells for collaterogenesis
Sultankulov, B.
Mektepbayeva, D.
Zhiyenbay, Y.
Seralin, A.
Alibek, K.
cell
implanted cells
cell therapy
cytokines
polymer
nanoparticles
angiogenesis
tissue
allogeneic transplantations
clinical application
Cell therapy using stem cells is a promising strategy for the treatment of ischemic
diseases, nevertheless low viability of implanted cells, is one of the main problems limiting stem cell
therapy. In addition, there is a risk of proliferation of the transformed cells in mesenchymal stem cells
carrying properties of cancer stem cells. Using conditioned media from stem cells instead of stem cell
themselves avoids the risks that may arise with the direct use of stem cells. Conditioned media from
various stem cells contains a different number of cytokines and growth factors, necessary for the natural
process of new vessel formation.
2015-10-27T06:04:33Z
2015-10-27T06:04:33Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/507
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5232018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Multiplexed detection of cancer biomarkers using an optical biosensor
Sypabekova, M. D.
Bekniyazov, I. S.
Bekmurzayeva, A. K.
Myrkhiyeva, Zh. M.
Chinybayeva, A. K.
Ashikbayeva, Zh. A.
Ayupova, T. Zh.
Mustafina, K. B.
Kanayeva, D.
biomarkers
protein
spectrometer
analyze
magnetic nanoparticles
aptamers
biological fluids
Early detection of cancer is important in administering timely treatment and increasing
cancer survival rates. For early cancer detection one can use biomarkers, which are characteristics that
can be objectively measured or evaluated as indicators of normal or pathogenic processes. In our study we
study three protein biomarkers: carcinoembryonic antigen (CEA), interleukin-6 (IL-6) and extracellular
protein kinase A (ECPKA), which have been implicated in various types of human cancer. The main
objective of this project is to develop a biosensor for detection of multiple cancer biomarkers. To detect
these protein biomarkers high affinity ssDNA aptamers are being selected. Aptamers are short single
stranded DNAs with an ability to bind to various targets with high affinity and specificity which selected
by SELEX (Systemic Evolution of Ligands through Exponential enrichment) [2]. Ultimately, aptamers
against each of the biomarker will be conjugated to magnetic nanoparticles to capture biomarkers from
biological fluids. Another aptamer is proposed to be conjugated to quantum dots for quantitation of
biomarkers when analyzed on spectrometer.
2015-10-27T08:18:16Z
2015-10-27T08:18:16Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/523
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5252017-11-01T04:33:08Zcom_123456789_409com_123456789_129col_123456789_411oai:nur.nu.edu.kz:123456789/5352018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Altered NR2A/NR2B ratio in hippocampus of spatial learning-impaired aged rats
Tokay, T.
Rehberg, M.
Kirschstein, T.
Rohde, M.
Mueller, L.
Askarova, Sholpan
Kohling, R.
Zhumadilov, Z.
hippocampus
aged animals
NR2B/NR2A ratio
synaptic plasticity
The activation of the N-methyl-D-aspartate receptor (NMDAR) is critical for the
induction of synaptic plasticity in the hippocampus. Aging can alter glutamatergic synaptic transmission
in the hippocampus, and cognitive impairments in aged animals are accompanied by reduced NMDARmediated
plasticity at Schaffer collateral—CA1 synapses. However, the specific contribution of NMDAR
subunits to NMDAR-mediated synaptic responses in aged tissue has not yet been fully understood. The
main purpose of present study was to examine whether there is an impact of aging on NMDAR subunit
expression and whether synaptic plasticity may depend on NMDAR subunit composition in the aged
hippocampus.
2015-10-27T09:17:29Z
2015-10-27T09:17:29Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/535
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5372018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Role of ROS in AB42 mediated cell surface P-selectin expression and actin polymerization
Tsoy, A.
Askarova, Sholpan
Shalakhmetova, T.
Umbayev, B.
Adambekov, S.
Zhumadilov, Z.
blood-brain
leukocytes
cytoplasmic
endothelial cells
physiological trigger
actin polymerization
blood
Blood-brain barrier dysfunction plays an important role in the onset and progression
of Alzheimer's disease (AD). In the AD brains an increased deposition of A(3 in the cerebral vasculature
has been found to correlate with increased transmigration of blood-born inflammatory cells and
neurovascular inflammation [1]. Transmigration of leukocytes into brain parenchyma is a sequential
process starting with primary capture to the endothelium and rolling adhesion mediated by tethering
on selectins and selectin ligands. P-selectin is a type I transmembrane cell adhesion molecule which is
stored in cytoplasmic Weibel-Palade bodies (WPb) and can be mobilized on the endothelial cell surface
within minutes upon exposure to different pro-inflammatory agents; then it's rapidly cleared through
endocytosis in 30 min. It has become evident that A(3 activates cerebral endothelial cells (CECs) and
induces mobilization of P-selectin to the cell surface [2]. However, expression mechanisms of this receptor
on the surface of brain endothelial cells under administration with A(342 remain unclear. Since P-selectin
is stored in WPb, and there is an evidence of active role of ROS (reactive oxygen species) and actin
filaments in the different stages of WPb exocytosis, in this study we examined the dynamic of P-selectin
expression on the endothelial cell surface activated by A(342 in relation to ROS and actin polymerization.
2015-10-27T10:20:56Z
2015-10-27T10:20:56Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/537
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5392018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Differentiation of mesenchymal stem cells into hepatocytes
Ualiyeva, S.
Umbayev, B.
Masoud, A.
Askarova, Sholpan
acute
chronic
liver
cell
organ
transplantation
mesenchymal stem cells
hepatocytes
Acute and chronic liver diseases are common in Kazakhstan and other countries. These
diseases are known to cause significant disability and death. In many cases, liver transplantation is the
last resort for patients with end stage liver disease, but it is an extremely expensive procedure and is
associated with many risks. The most important among them is an immune rejection. Autologous cell
transplantation is a potential therapeutic approach for liver regeneration and could become an alternative
to organ transplantation. In this regard, mesenchymal stem cells (MSCs) are a very attractive source for
differentiation into hepatocytes. These cells can be isolated from bone marrow and adipose tissue of the
patient and exponentially expanded in vitro. Transplantation of hepatocytes differentiated from MSCs
could become a new promising approach in treatment of the patients with chronic liver conditions.
2015-10-27T10:47:44Z
2015-10-27T10:47:44Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/539
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5402018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Isolation of primary human hepatocytes from cirrhotic liver
Ualiyeva, S.
Umbayev, B.
Donbay, A.
Askarova, Sholpan
chronic degenerative liver
epidemiological health
pathology
orthotopic liver
liver
hepatocyte
cirrhosis
Chronic degenerative liver diseases are among most complex social, clinical and
epidemiological health problems worldwide. This is due to the steady increase in the incidence and
mortality of patients with this pathology. Orthotopic liver transplantation is the only way to save the
lives of patients with decompensated diffuse and focal lesions of the liver. One-year survival after liver
transplantation reaches 60-80%, but more than half of the patients on the waiting list do not survive until
operation. In this regard, hepatocyte transplantation could be an option for the patients who are on the
waiting list for organ transplantation.
2015-10-27T10:58:27Z
2015-10-27T10:58:27Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/540
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5472018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Combating CVD in Kazakhstan through workplace interventions
Wheeler, C. G.
Felten, M. K.
Yengsep, K.
CVD
workplace
combating
social marketing
methodology
The project designs and tests a multifaceted worksite intervention protocol that includes
smoking cessation, dietary instruction, and exercise regimens to lower the prevalence of CVD morbidity
and mortality in Kazakhstan. Kazakhstan has among the highest CVD morbidity and mortality rates in
the world. Development of an effective worksite intervention model that targets and improves the health
behaviors and health status of high-risk middle age working males can be extended to the Republic's
crucial and expanding workplace environment.
2015-10-28T06:25:44Z
2015-10-28T06:25:44Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/547
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5502018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Association of vitamin D receptor (FOKI, TAQI, APAI & BSMI) and IF-y genes' polymorphisms with risk of developing pulmonary TB (PTB) among Kazakhstani population
Yerezhepov, D.
Zhabagin, M.
Abilova, Zh.
Askapuli, A.
Abilmazhinova, A.
Rakhimova, S.
Kairov, U.
Molkenov, A.
Akhmetova, A.
Akilzhanova, A.
vitamin D
FokI
TaqI
ApaI
BsmI
IF-y genes
polymorphisms
pulmonary
healthy
Almost one third of the world's population is infected with Mycobacterium tuberculosis
(MTB) and only 10% of them will develop any active form of the disease. TB is second (1s t is HIV/AIDS)
greatest killer worldwide due to a single infectious agent. In 2012, 8.6 million people developed active TB
and 1.3 million died. Over 95% of TB deaths occur in developing countries. In 2012, an estimated more
than half million children became ill with TB and 74 000 of them died. The TB cases are declining annually,
but very slowly. Multi-drug resistant TB (MDR-TB) and extensively drug-resistant tuberculosis (XDRTB)
is present in almost all surveyed countries. Kazakhstan is not highly burdened by TB. Kazakhstan is
the list of MDR-TB and XDR-TB burden countries. Our aim is to investigate an association of Vitamin D
receptor (FokI, TaqI, ApaI & BsmI) and IF-y genes" polymorphisms with risk of developing pulmonary
TB (PTB) among Kazakhstani population.
2015-10-28T08:28:34Z
2015-10-28T08:28:34Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/550
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5512018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Hyperglycemia induced epigenetic changes and cell migration
Zhalmagambetov, B.
Orakov, A.
Gilman, C.
diabetes
hyperglycemia
glioblastoma cells
epigenetic changes
immunofluorescence
cell migration
chemotherapy
cell
Cancer is responsible for millions of deaths annually1. Especially, cancer in overweight people
becoming to pose a threat as some cancers are becoming resistant to chemotherapy 2 , 3 . In addition,
most overweight people have a diabetes or hyperglycemia. Although it was shown that hyperglycemia
can trigger epigenetic changes in many cancer cells, there is no data how hyperglycemia would affects
migration through epigenetic alterations. We aim to study abovementioned by assessing the cell migration
under hyperglycemic conditions on glioblastoma cells and the specific epigenetic changes associated with
hyperglycemia. We will use immunofluorescence, bisulfate conversion sequencing to assess epigenetic
status and do scratch assay to study cell migration. Our results can shed light on the effect of epigenetic
changes to cell migration under hyperglycemic conditions.
2015-10-28T08:38:36Z
2015-10-28T08:38:36Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/551
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5532018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Analysis of protector mechanism of probiotics using DNA comet assay
Zhulamanova, A.
Shakhabayeva, G.
Saduakhasova, S.
Kozhakhmetov, S.
Kushugulova, A.
ecology
human organism
DNA
comet assay
eukaryotic cells
biomonitoring
genotoxicology
gel electrophoresis
electrophoresis
fluorescent light
probiotics
Ecology affects human organism by causing breaks in DNA and, therefore, induce
mutations and malignant cell formation. Comet assay is a quantitative method that allows to measure
DNA damage in eukaryotic cells (Liao, McNutt, & Zhu, 2009). This method is widely used in areas,
such as human biomonitoring, genotoxicology, and ecology. Comet assay is also called a single-cell gel
electrophoresis. Thus, the products of electrophoresis are analyzed under the fluorescent light, which
makes it similar to comets. DNA strand breaks are detected by comparing the intensity of the comet
tail relative to the head (Collins, 2004). Probiotics containing Lactobacillus rhamnosus were used, as
Lactobacilli probiotics were found to be safe and effective against urogenital diseases, food hypersensitivity,
and dental caries (Lebeer, Vanderleyden, & De Keersmaeckler, 2008). The aim of the research was to
study DNA protector mechanism for three probiotic products, containing L. rhamnosus.
2015-10-28T08:50:26Z
2015-10-28T08:50:26Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/553
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5552018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Extract of limonium gmelinii attenuates AB-and H2O2-induced oxidative response in cerebral endothelial cells
Shayakhmetov, Y.
Jaguparov, A.
Tsoy, A.
limoniun gmelinii
polyphenols
neuron
hypertrophy
astrocytes
pathology
blood brain barrier
Alzheimer's disease (AD) is a chronic neurodegenerative disorder which affects
approximately 10% of the population at age 65 and 40% of people over the age 80. Clinically, AD pathology
is characterized by an increased deposition of amyloid-(3 peptide (A(3) in the brain, and a progressive
impairment of cognition and memory of affected individuals. Blood Brain Barrier (BBB) dysfunction is
observed in all of the stages of AD, and may even precede neuron degeneration in AD brains. During the
early stages of AD, microvasculature deficiencies and hypertrophy of astrocytes are commonly observed.
Numerous in vivo and in vitro studies have demonstrated that the vascular deposition of A(3 induces
oxidative stress in cerebral endothelial cells (CECs). A(3-induced oxidative stress in cells, in turn, initiates
a cascade of redox reactions leading to apoptosis and neurovascular inflammation. Consequently,
antioxidants are considered as therapeutic agents in A(3-induced CECs damage.
2015-10-28T09:02:16Z
2015-10-28T09:02:16Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/555
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5572018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
A new generalization of the normal distribution: the gamma-normal distribution and its applications
Alzaatreh, A.
Famoye, F.
Lee, C.
phenomena
generalization
normal distribution
statistical properties
gamma-normal distribution
Statistical distributions are commonly applied to describe real world phenomena. Due to the usefulness
of statistical distributions, their theory is widely studied and new distributions are developed. The
interest in developing more flexible statistical distributions remains strong in statistics profession. Many
generalized classes of distributions have been developed and applied to describe various phenomena.
Recently, Alzaatreh et al. (2014) developed a new method to generate family of distributions and called it
the gamma-X family of distributions.
2015-10-28T09:12:58Z
2015-10-28T09:12:58Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/557
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5592018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Analysis of pollutant dispersion in a street canyon of Astana
Akhatova, A.
Kassymov, A.
Kazmaganbetova, M.
Rojas-Solorzano, L.
atmospheric
air
pollution
vehicle
analyze
conditions
Due to the steadily rising number of vehicles, atmospheric air pollution has become
one of the evident problems in main cities around the world. Astana, the capital city of Kazakhstan,
is not an exception with it current expansion and economic growth. In order to avoid the hazardous
consequences of automobile and industry pollution onto the residents' health of Astana, it is important
to analyze and monitor the conditions of atmospheric air in the city. The main objective of this research
project is to simulate and analyze the dispersion of vehicle pollutants (CO) at the crossroad of Zhenis
and Bogenbay streets using Computational Fluid Dynamics (CFD) tools based on SolidWorks-EFD
numerical platform. This particular place for the study is selected because of its relatively heavy traffic
load and its close location to many residential buildings.
2015-10-28T09:35:01Z
2015-10-28T09:35:01Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/559
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5612018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Optimal current quality of a single-phase multilevel inverter with a staircase modulation
Aldabergenov, M.
Familiant, Y. L.
Ruderman, A.
optimal
current
quality
single-phase
multilevel inverter
staircase modulation
The authors address the problem of optimal current quality for a single-phase
multilevel inverter with a staircase modulation (Fig.1). The current quality is characterized by current
ripple Normalized Mean Square (NMSc). The goal is to find theoretically optimal switching angles and
respective minimal NMSc values. The previous research didn't provide comprehensive solutions for
arbitrary modulation indices and level counts.
2015-10-28T10:00:16Z
2015-10-28T10:00:16Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/561
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5622018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Development of novel highly productive track etch membranes for forward osmosis process
Arkhangelsky, E.
Zdorovets, M.
osmosis
energy
development
membranes
generation
irradiation
polymer
physical
chemical
treatment
ions
Forward osmosis (FO) process has gained vast popularity in recent years. FO has the
potential advantages of low energy demand, insignificant membrane fouling, and as result rare membrane
cleaning is required [1]. Despite that nowadays different research groups from around the world [2]
working on development of highly productive membranes for direct osmosis process, water flux of FO
membranes is far away from water flux of reverse osmosis membranes. With reference to that it can be
claimed that development of the new generation of forward osmosis membrane is of high importance.
2015-10-28T10:08:25Z
2015-10-28T10:08:25Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/562
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5642018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Modelling of electricity sector of Kazakhstan
Bakdolotov, A.
Assembayeva, M.
Akhmetbekov, Y.
modeling
electricity sector
energy system
technical
economic
analysis
energy storage
power plants
The project's main objective is the modeling of the electricity sector in Kazakhstan. The
demand growth in the last years could be compensated so far by reactivation and retrofit of existing old
reserve capacities from the Soviet era. Translated into choices for system development the decisions are
on technologies of new capacity, availability and costs of resources, and the transmission network. All
these aspects can be addressed with the detailed electricity sector model.
2015-10-28T10:21:36Z
2015-10-28T10:21:36Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/564
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5662018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
CFD study of an oil catch can
Abilgaziyev, A.
Nogerbek, N.
Rojas-Solorzano, L.
oil
analyze
platform
mass conservation
energy conservation
model
Oil catch cans are devices used in some internal combustion engines to prevent oil
droplets from entering into the exhaust manifold of the engine. The main purpose of this paper is to study
the design of a typical oil catch can used in regular vehicles and analyze the effects caused by varying the
length of its inner tube and the relative position of the outlet: either radial or tangential to the can body.
2015-10-28T10:30:49Z
2015-10-28T10:30:49Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/566
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5672018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_411
Heavy-metal binding affinity in metalloproteins: a computational approach
Balanay, M. P.
biological
organism
heavy-metal
pre-treatment
wastewaters
bacillus
chryseomonas
cadmium
protein
The use of biological organisms for removal of
heavy-metal in situ brings down the production cost due to the lesser
pre-treatment steps in the removal process. Initial assessments of
the heavy-metal binding bacteria from wastewaters, indicates that
Bacillus and Chryseomonas sp. exhibited positive growth response
behavior when exposed to lead and cadmium [1]. This incorporation
of the heavy-metal species leads to the increase in the molecular
mass of the protein as shown in the SDS-PAGE result (Figure 1).
In this research, two metal-binding proteins of B. subtilis 1C7I and
1P3J were analyzed and optimized using DFT method to look into
the possibility of replacement of heavy metals (Cd, Cr, Hg, and Pb)
in its metal active sites.
2015-10-28T10:53:49Z
2015-10-28T10:53:49Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/567
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5682018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Triphenylamine dyes having symmetric double D-TI-A configuration for dye-sensitized solar cells
Balanay, M. P.
Lee, S. H.
Kim, D. H.
photovoltaic
synthesis
configuration
chromophores
electrolyte
photophysical
electrochemical
The conformation of the dye on the semiconductor is an important factor for the
improvement of charge injection and minimization of the back electron transfer process. In addition, the
dye should be able to suppress aggregation by introducing bulky alkyl groups, addition of co-adsorbents,
or designing a dye with a п-bridge between two chromophores forming a spiro-like configuration [1,2].
This study presents the synthesis of two compounds having double D-TT-A configurations namely, KS-11
and KS-13 and comparing their photovoltaic properties with the rod-like configuration, herein labelled
as KS-10.
2015-10-28T11:02:09Z
2015-10-28T11:02:09Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/568
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5722018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Representation of algebraic convex geometries
Adaricheva, K.
convex geometries
system
modelling
automatic
algebraic
Convex geometry is a set system generated by the closure operator with the antiexchange
axiom. These systems model the concept of convexity in various settings. They are also closely
connected to anti-matroids, which are set systems with the property of accessibility. In particular, the
latter were used in modelling the states of human learners and found practical applications in designing
the automatic tutoring systems. In current work we develop the theoretical foundations of infinite convex
geometries in case their closure operator satisfies the finitary property: closure of any subset is a union of
closures of its finite subsets. In such case, the convex geometry is called algebraic.
2015-10-29T06:07:28Z
2015-10-29T06:07:28Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/572
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5742018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
New particle or dark matter decay discovery studying cosmic ray showers
Beznosko, D.
Batykhanov, A.
Beremkulov, T.
Duspayev, A.
Tailakov, A.
Yessenov, M.
cosmic ray
energy
prototype system
HorizonT
system
In the field of High Energy Physics today there are several open topics that are left. The
Higgs boson has been recently discovered, neutrino oscillations are being studied, and some hints of the
dark matter have been detected as well. The large remaining mystery is the origin and the nature of the
Ultra-high energy Cosmic Rays (UCR).
2015-10-29T06:18:26Z
2015-10-29T06:18:26Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/574
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5762018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Preliminary land use classification of Burabay state national nature park
Baiglaiyeva, M.
Nessipbekov, G.
Yapiyev, V.
Abudanash, D.
Kassymbekova, A.
Kabiyeva, M.
Malgazhdar, D.
Zhumabayev, D.
Burabay
watersheds
Shortan
Ulken Shabakty
Kishi Shabakty
Tekekol
land
The main objective of the given project is to study land use distribution within five
watersheds located in Burabay National Park: Shortan, Ulken Shabakty, Kishi Shabakty, Burabay and
Tekekol. The overall strategy consists of the following tasks: creation of unified map regarding land use
distribution; identification of current land cover trends; estimation of land use impact on water resources.
2015-10-29T06:27:21Z
2015-10-29T06:27:21Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/576
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5772018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Development of energy system model of the Caspian region
Miglio, R. De.
Akhmetbekov, Y.
Baigarin, K.
Bakdolotov, A.
Tosato, G.
Central Asia
Caspian region
develop
project
model
energy system
hydrocarbons
cooperation
The main objective of the project is to develop and to use the model of energy system
of Central Asia and Caspian region (CAC): Azerbaijan (AZJ), Kazakhstan (KZK), Turkmenistan (TKM)
and Uzbekistan (UZB) - TIMES-CAC-4R and to assess quantitatively the direct economic benefits of
cooperation in export of hydrocarbons among CAC countries.
2015-10-29T06:35:14Z
2015-10-29T06:35:14Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/577
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5792018-08-15T03:49:38Zcom_123456789_409com_123456789_129col_123456789_411
Intrinsic photoluminescence stokes shift in thin-film cadmium sulfide
Bhowmick, M.
Ullrich, B.
X i, H.
Flores, D. A.
photoluminescence
energy
phenomenon
project
semiconductor
cadmium sulfide
Exciting a semiconductor through light absorption produces photoluminescence (PL).
In general, the emitted energy is lower than the energy absorbed. The phenomenon, first discovered
in the nineteenth century, is known as Stokes shift energy [1]. The change in energy (AS t o k e s), crucial
for the information about the phonon relaxation in the material and with importance in light emitting
devices, has not been investigated experimentally very systematically [2]. In this project, we present the
observation of the intrinsic photoluminescence Stokes shift in a semiconductor.
2015-10-29T08:01:45Z
2015-10-29T08:01:45Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/579
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5802018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Estimation of carrier life time from intrinsic photoluminescence of ZnO
Bhowmick, M.
Ullrich, B.
X i, H.
Flores, D.A.
photoluminescence
ZnO
electron concentration
spectroscopy
Raman modes
Comprehensive knowledge of the optical properties, particularly of the room
temperature (RT) photoluminescence (PL), of ZnO is essential for the future employment of this wideband
gap (~3.3 eV at 300 K) II-VI compound semiconductor in photonic and optoelectronic device
structures [1]. Hence, vigorous research activities on ZnO thin films, epilayers, and crystals took place
during the last two decades, encompassing a vast variety of effects and phenomena such as birefringence,
photocurrent, PL including sub-band gap emission, reflectance, transmittance, excitonic properties,
Raman modes, and absorption edge steepness [1-4]. However, despite that large body of knowledge and
its essential importance for light emitting processes, a discussion of the ZnO PL lineshape is not found
in the literature [5].
2015-10-29T08:30:58Z
2015-10-29T08:30:58Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/580
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5812018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Design and synthesis of organic nonlinear optical materials
Zhanabergenova, M.
Baptayev, B.
Tauanov, Z.
Zhakiyeva, Z.
Yergeshbayeva, S.
Berillo, D.
Adilov, S.
nonlinear optical
organic
trans-porphyrins
porphyrins
nitrophenyl
analyz
molecules
Following the development of the idea of octupolar molecules as nonlinear optical
materials a variety of compounds have been reported. Trans-porphyrins have a great potential to selforder
into octupolar symmetry. Nonlinear optical properties can be tuned by using strong donor-acceptor
groups in porphyrins as well as extension of conjugation. Here we report the syntheses of trans-A2D2-
porphyrins and their dimerization into cubic octupoles by organic bidentate ligands.
2015-10-29T08:52:50Z
2015-10-29T08:52:50Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/581
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5822018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
High sensitivity detection of NBT on novel SERS substrate
Khamkhash, L.
Ralchenko, Y.
Bukasov, R.
biological analysis
chemical analysis
nanoparticles
metals
molecule
spectroscopy
model Raman
shape
Surface-enhanced Raman scattering (SERS) is rapidly evolving as a useful analytical
tool in chemical and biological analysis. The most critical aspect of SERS is the research of efficient SERSactive
substrates, such as nanostructured surface or nanoparticles of noble metals with suitable physical
parameters such as their material, size, shape, and spacing [1]. Generally, Ag and Au substrates are
regarded as one of the best candidates for SERS. Nevertheless, fabrication of SERS substrates with both
high sensitivity and high reproducibility remains difficult, and it is costly for routine SERS detection.
We report the novel combined substrate for highly sensitive Surface Enhanced Raman spectroscopy
(SERS) are capable of detecting 4-nitrobenzenethiol (NBT), as a model Raman active molecule, at very
low concentration.
2015-10-29T09:05:44Z
2015-10-29T09:05:44Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/582
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5832018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Developing an asset management framework for water resource management in Kazakhstan
Bradshaw, R. A.
Mashtayeva, S.
Khairaliyev, S
James, A.
Kho, Y. H.
Rojas-Solorzano, L.
development
asset management
framework
water resource management
water
The project's main objective is the development and application of an asset management
framework that institutionalizes and operationalizes infrastructure management and decision making
(investment, operation, maintenance) in the context of achieving Integrated Water Resource Management
(IWRM) objectives [1,2].
2015-10-29T09:39:56Z
2015-10-29T09:39:56Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/583
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5842018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Asset management in the water sector: measurement and improvement of organizational capability and performance
Bradshaw, R. A.
Kaskina, D.
Kabiyeva, M.
asset management
processes
water sector
organization
physical assets
Asset management and its processes can be defined as the "systematic and coordinated
activities and practices through which an organization optimally manages its physical assets, and their
associated performance, risks and expenditures over their lifecycle for the purpose of achieving its
organizational strategic plan".
2015-10-29T09:46:44Z
2015-10-29T09:46:44Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/584
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5872018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Quantum dynamics in molecules and nanostructures in strong fields
Bubin, S.
quantum
dynamics
photochemistry
molecular
electron
nanoscale
structure
With the advance of time-dependent probes the investigation of the dynamical behavior
of matter at the nanoscale has become a very important research direction. Laser-assisted steering
of the electron motion in molecules and manipulation of their structure and composition has been
dreamt about since the very emergence of coherent light sources. Realizing new possibilities in selective
photochemistry of complex molecular systems, however, requires good understanding of underlying
quantum dynamics. First-principles quantum-mechanical simulations can be of great help in assisting
experiments, understanding the complex quantum dynamics, and interpreting the experimental data.
2015-10-30T03:00:09Z
2015-10-30T03:00:09Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/587
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5882018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Stability of small positronic atoms in ground and excited states
Bubin, S.
energy
stability
positronic atom
beams
positron molecule
positronic beryllium
positronic boron
Studying the dynamical stability of positron-atom and positron-molecule complexes
provides an insight into the physics and chemistry of low energy positrons and their interaction with matter.
Beams of low energy positrons have applications in medical imaging (positron emission tomography) and
materials science (positron annihilation spectroscopy). The first theoretical confirmation of the stability
of a positronic atom (e+Li) was obtained back in 1997 [1]. However, many facts remain undiscovered. In
particular, this concerns the existence of excited states.
2015-10-30T03:08:16Z
2015-10-30T03:08:16Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/588
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5912018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Quantifying impact of the low-cost SERS substrate on SERS signal
Beishanova, M.
Issayeva, D.
Yerbulekova, A.
Kamzabek, D.
Bukasov, R.
molecules
metal
SERS
low-cost
aluminum foil
food safety
medical diagnostics
Surface-Enhanced Raman Spectroscopy (SERS) allows structural detection of molecules
absorbed on rough noble metal surfaces by amplifying a normally weak Raman signal. It can be applied
in forensic science, biosensing, food safety, and medical diagnostics [1]. Although costly gold and silver
films are used as SERS substrates, AuNPs (gold nanoparticles) on aluminum foil can become a low-cost
alternative.
2015-10-30T03:22:07Z
2015-10-30T03:22:07Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/591
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5922018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Practical large scale antenna systems for 5G cellular communications
Rowell, C.
Han, S.
cellular
cellular communications
radio
scale antenna systems
beamforming
project
In order to increase capacity and reduce power consumption for future cellular
networks, new cellular architectures and radio access schemes will be required. Two important
technologies for future 5G networks include Cloud-Radio Access Networks (C-RAN) [1] and Large Scale
Antenna Systems (LSAS) with hundred's of low power radios to increase the cell capacity with multi-user
MIMO multiplexing and beamforming. Although LSAS in theory [2] promises large capacity gains at the
fraction of the power consumed by the current macro-basestations; there are many practical challenges
that need to be overcome before LSAS can be successfully integrated into current and future cellular
networks including: 1) low-power beamforming algorithms and 2) irregular array beamforming. This
project examines each challenge and proposes possible solutions.
2015-10-30T03:33:06Z
2015-10-30T03:33:06Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/592
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5932018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Transverse free vibration of rotating non-uniform euler-bernoulli beams using the adomian modified decomposition method
Adair, D.
dynamic
beams
since
gas
elastic beam
The dynamic behavior of non-uniform rotating beams is of practical interest since it is
widely used in many engineering applications such as helicopter rotor blades, spinning space structures
and gas turbine blades.
2015-10-30T03:42:17Z
2015-10-30T03:42:17Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/593
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5952018-08-15T03:49:35Zcom_123456789_409com_123456789_129col_123456789_411
Thermal management of LI-ION battery packs
Adair, D.
Ismailov, K.
Bakenov, Zhumabay
lithium-ion battery
electric
battery
management
thermal management
A design for the thermal management of Lithium-ion battery packing as used in hybrid
and electric vehicles has been developed. The design satisfies all thermal and physical issues relating
to the battery packs used in vehicles including operating temperature range and volume, and, should
increase battery cycle life, and, charge and discharge performances. Particular attention was devoted to
the thermal management of batteries operating in extreme temperature conditions.
2015-10-30T03:48:24Z
2015-10-30T03:48:24Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/595
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5982018-08-15T03:49:36Zcom_123456789_409com_123456789_129col_123456789_411
Developing monitoring system for long-distance pipeline leakage incorporating fusion of conflicting evidences
Adair, D.
Emara-Shabaik, H. E.
Jaeger, M.
petroleum products
economy
hydraulic model
developing
monitoring system
evidences
theory
When transporting petroleum products, the use of long-distance pipelines have become
commonplace, due to their inherent efficiency and economy. However, such pipe systems often leak due
to corrosion, natural destruction, and, natural aging and weathering, causing harm to the environment,
fire etc. The ability to detect leakage with certainty and quickly is therefore very important. In this work,
leakage is detected using a combination of a hydraulic method and Dezert-Smarandache theory.
2015-10-30T04:05:21Z
2015-10-30T04:05:21Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/598
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/5992018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_411
Development of a reinforced concrete foundation system for renewable energy storage using compressed air technology
Zhang, D.
Kim, J.
Nguyen, M.
Lee, S-R.
Kim, D-S.
Zhu, A.
Zhang, Y.
renewable energy
energy generation
energy storage
economic
energy transportation
methods
reinforced concrete
The utilization of renewable
energy leads to challenges of efficient energy
generation, reliable energy storage and
economic energy transportation. One of them is
caused by the intermittent nature of renewable
energy, which requires efficient methods for
energy storage matching the generation of
renewable energy with customer demands.
Thus this project is to develop a reliable, safe
and economic renewable energy storage media
utilizing one of building structural components:
a reinforced concrete (RC) foundation system.
The proposed RC foundation system, in addition
used for transferring structure loads into soils or
rocks underground, will be configured to store
renewable energy generated from solar panels
or wind mills attached to building structures
through compressed air energy storage (CAES)
technology.
2015-10-30T04:14:13Z
2015-10-30T04:14:13Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/599
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6022018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_411
Development of a fidelity structural model based on a shake table test for an innovative seismic resisting system
Zhang, D.
Fleischman, R.
structural model
seismic resisting system
project
3D model
system
table test
The research project is to produce a fidelity
three-dimensional (3D) structural model based on a shake table
test, which is used to demonstrate performances of an
innovative seismic resisting system for reducing damages to
building structures under earthquakes.
2015-10-30T04:24:22Z
2015-10-30T04:24:22Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/602
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6032018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_411
Brain inspired computing networks for smart building monitoring
Dorzhigulov, A. Z.
Bakir, D. S.
James, A. P.
brain
monitoring
project
manner
network
building space
services
information
The intelligent sensor systems capable of measuring a wide range of building conditions
remotely, and in a real-time manner can reveal useful information on the overall quality of services
offered in the maintenance and reliability of building space.
2015-10-30T04:31:16Z
2015-10-30T04:31:16Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/603
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6042018-08-15T03:49:37Zcom_123456789_409com_123456789_129col_123456789_411
Development and characterization of compatible cellulose and cellulose blended with soy protein membranes using a novel solvent system
Douglass, E. F.
Kotek, R.
cellulose
cellulose blend membranes
membranes
solvents
environmental concerns
solvent dissolution system
A new environmentally friendly solvent system has been developed to make cellulose
and cellulose blend membranes. Current industrial methods for making cellulose membranes are relatively
expensive, use toxic or dangerous solvents, and have environmental concerns regarding hazardous waste
production.
2015-10-30T04:40:20Z
2015-10-30T04:40:20Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/604
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6062018-08-15T03:49:41Zcom_123456789_409com_123456789_129col_123456789_411
High rate continuous synthesis of nanocrystalline materials in a colliding vapor stream of microdroplets
Ould-Ely, T.
Reing, L. K.
Morse, D. E.
nanotechnology
synthesis
nanomaterials
laboratories
practical nanofabrication
high rate
inorganic nanomaterials
microdroplets
Progress in nanotechnology is driving the need of large scale synthesis of functional
nanomaterials. The lack of a workforce trained on process control and scale-up of nanomaterials
manufacturing, the gap between laboratories and economically practical nanofabrication and the
funding strain on the survivability of startup companies all contribute to the difficulties in scaling up
nanotechnologies and their commercialization [1,2]. We report here a high rate continuous synthesis of
functional inorganic nanomaterials using colliding vapor stream of reagents microdroplets.
2015-10-30T04:47:33Z
2015-10-30T04:47:33Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/606
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6082018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_411
All-at-once multilevel interation for BI-harmonic system
Erlangga, Y.
multilevel
BI-harmonic system
method
multigrid
multilevel iteration
The iterative method converges at a rate that is independent of the mesh size. The rate of
convergence is comparable to that of multigrid, but is achieved with simpler components.
2015-10-30T04:58:47Z
2015-10-30T04:58:47Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/608
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6112018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Study of aggregation of the 2', 7'-dichlorofluorescein dye caused by the intermolecular hydrogen bond
Balanay, M.
Fan-Hagenstein, H.
aggregation
study
2',7'-dichlorofluorescein
molecule
intermolecular
hydrogen
chromophores
The project's main objective is to study the aggregation of the 2',7'-dichlorofluorescein
dye molecule through intermolecular hydrogen bonding in various solvents. With two chromophores
perpendicular to each other, 2',7'-dichlorofluorescein likely demonstrate J-aggregate and H-aggregate
simultaneously. The present project is expected to provide some insights in the knowledge-based
molecular design to improve device performance for optoelectronic applications.
2015-10-30T05:08:17Z
2015-10-30T05:08:17Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/611
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6122018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Numerical modelling of compound channel flow
Filonovich, M. S.
Leal, J. B.
Rojas-Solorzano, L.
numerical modelling
channel flow
structures
anisotropic models
Most natural rivers have compound cross-section. Compound channel flow is
characterized by complicated three-dimensional flow structures. These structures are called secondary
flows and have been classified into two categories by Prandtl (1952). He distinguished the secondary
flows of the first kind and of the second kind. The secondary flows of the the second type are typically
about 2-3% of the maximum streamwise velocity (Nezu and Rodi, 1985), however, they have a major
impact on the mean flow and turbulence structures.
2015-10-30T05:16:39Z
2015-10-30T05:16:39Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/612
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6132019-02-04T03:55:42Zcom_123456789_409com_123456789_129col_123456789_411
Energy saving technologies of advanced membranes for water desalination
Insepov, Z.
Tynyshtykbayev, K.
Imanbayev, G.
Ainabayev, A.
Berdenova, B.
Dybyspayeva, K.
Ramazanova, Z.
Kuzembayeva, N.
Bulekbayeva, G.
energy saving
technologies
advanced membranes
water desalination
nanoscopic
analysis
Actuation of fluid flow in nanochannels by surface and volume acoustic wave (SAW,
VAW) propagation were studied. Increase of infiltration rate of fluid flow through porous media,
fabrication of Labs-on-a-Chip (LOC), fast analysis of environmental pollution in field conditions using
micro- or even nanoscopic amount of samples, in pumping gases and liquids through the channels with
diameters as small as 1-10 nm and 1-10 цш were addressed.
2015-10-30T05:25:01Z
2015-10-30T05:25:01Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/613
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6142018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_411
Numerical simulation of slurry flows in heterogeneous and saltation regimes in horizontal pipelines
Gonzalez, J.
Rojas-Solorzano, L.
Sabirgalieva, N.
numerical simulation
slurry flows
heterogeneous
horizontal pipelines
fluid flows
CFD models
model
In this work, the simulation of a two-phase liquid-particles flow is performed using an Eulerian-
Eulerian model to predict the complex flow behavior where both particle concentration and particle velocity
profile are shown and compared with experimental data. One of the main concerns during implementation of
pipeline transportation of multiphase mixtures the is assurance of the flow, where the formation of particle fixed
beds should be strongly avoided due to its disadvantageous and damaging effects on the flow, which mostly occur
at the bottom sides of the pipeline walls.
2015-10-30T05:53:22Z
2015-10-30T05:53:22Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/614
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6162018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
On particle production, negative energy flux and acceleration horizons
Good, M. R. R.
Akhmetzhanova, G.
energy flux
model
quantum inequalities
thermodynamics
acceleration horizons
In the moving mirror model, removal of acceleration horizons gives rise to negative
energy flux. The total emitted energy is positive and finite, in agreement with quantum inequalities and
the second law of thermodynamics [1]. Exact solutions to the moving mirror model have been found
which demonstrate this rare effect.
2015-10-30T06:03:15Z
2015-10-30T06:03:15Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/616
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6182018-08-15T03:49:39Zcom_123456789_409com_123456789_129col_123456789_411
Intelligent robotic rehabilitation system for treatment of disabilities subsequent to injuries or neurological disorders
Jamwal, P. K.
injuries
neurological trauma
paraplegia
hemiplegia
muscle
therapy
articulating
rehabilitation system
health
Injuries or neurological trauma, such as stroke, complete and incomplete spinal cord
injuries result in paraplegia and hemiplegia, which is the leading cause of disabilities world over. Survivors
have muscle coordination discrepancies resulting in impaired joint motions and inability to perform
activities of daily living (ADL). Neurological trauma falls in top 15 risk factors for Kazakhstan people and
their health conditions. Urgent steps are required to be initiated as the current rate of such disorders is
predicted to increase by three times over the next 30 years. Robot assisted physical therapy has shown
some preliminary signs of improvement in subjects and therefore active orthosis have been developed to
impart repetitive, prolonged and systematic therapy. Existing robots are normally inspired by the
industrial robots and thus provide constrained motion to the articulating joints in an uncomfortable and
unsafe manner. There is a need to develop human friendly, safe and intelligent robots in order to carry
out physical therapy. We aim at developing an intelligent rehabilitation system (IRS) using wearable
robots equipped with state of the art sensors and actuators, optimization routines (to identify
musculoskeletal functions at the affected limb) and development of advanced controllers. Physical
therapy is expected to be evidence based, objective and human friendly.
2015-10-30T07:53:50Z
2015-10-30T07:53:50Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/618
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6192018-08-15T03:50:25Zcom_123456789_409com_123456789_129col_123456789_411
Implementing and optimizing the operation of membrane bioreactors for petroleum wastewater treatment
Inglezakis, V.
Fatone, F.
Loizidou, M.
Omirkhan, A.
Seidakhmetov, T.
Nauruzbayeva, J.
Maktayeva, Zh.
oil
gas
technology
water management
wastewater treatment
chemical processes
membrane
treatment
cyanides
bioreactor
In the recent Kazakhstan Upstream Oil and Gas Technology and R&D Roadmap,
water management has been recognized one of the fifteen main challenges that must be dealt with. This
roadmap mentions that chemical processes are increasingly used for wastewater treatment; however it is
recognized that "the preferred, longer term solution is likely to be membrane technology, which present
a local R&D opportunity since further development is needed. This could lead to local opportunities
for design, installation and maintenance of membrane separation equipment"[1]. In line with the above
requirements the proposed project develops and optimizes a membrane based treatment scheme for the
treating & recycling of the water within the industry. Another objective is to investigate several biological
processes within the membrane bioreactor (MBR) including nitrification/denitrification and biological
removal of cyanides.
2015-10-30T08:05:30Z
2015-10-30T08:05:30Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/619
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6212019-02-04T03:40:24Zcom_123456789_409com_123456789_129col_123456789_411
Vacuum breakdown mitigation
Insepov, Z.
Tynyshtykbayev, K.
Imanbayev, G.
Ainabayev, A.
Berdenova, B.
Dybyspayeva, K.
Ramazanova, Z.
Kuzembayeva, N.
Bulekbayeva, G.
specifically technology
breakdown mitigation
accelerators
thermonuclear synthesis
vacuum
plasma heating
atomic layer deposition
irradiation
gas
Understanding the breakdown voltage process in vacuum, specifically technology of
breakdown mitigation, is important for applications such as accelerators and thermonuclear synthesis. In
our work, we present simulation results and our conclusions about crater formation on a material surface
due to vacuum arc and plasma heating. Atomic layer deposition (ALD) and irradiation by gas cluster ion
beam (GCIB) can be applied to smoothen electrode surfaces; thus reducing the risks of a breakdown.
2015-10-30T08:14:21Z
2015-10-30T08:14:21Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/621
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6222018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Zeolite development from fly ASH and utilization in lignite mine-water treatment
Itskos, G.
Koutsianos, A.
Koukouzas, N.
Vasilatos, C.
fly ash
lignite-fed power
synthesize
zeolitic materials
adsorption capacity
siliceous
temperature
microstructure
chemical
mineralogical
The synthetic zeolitic materials were tested comparatively, showing that the more
intense the zeolitic presence in the synthetic materials, the greater the uptake rates for certain groups of
trace elements.
2015-10-30T08:23:09Z
2015-10-30T08:23:09Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/622
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6242018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Stand -alone net zero energy container houses as temporary offsite working/living
Kim, J. R.
Bakhtiyarov, D.
Saliyev, D.
Zhumabekov, G.
Sailauova, N.
analyze
standalone
net zero energy
energy transformation
technologies
project
This paper is aimed to investigate and briefly analyze the conditions in Kazakhstan to
predict the effectiveness of operation of standalone net zero energy container house. The description of
Kazakhstani weather conditions as well as container house's characteristics is provided. The comparison
was done between the specifications of solar, wind energy transformation technologies with the data
collected in all regions of the country to check the feasibility of the project. Additionally, the brief
description of stand-alone net zero energy container houses, including both interior-exterior design and
energy control system, are provided.
2015-10-30T08:40:17Z
2015-10-30T08:40:17Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/624
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6252018-08-15T03:49:40Zcom_123456789_409com_123456789_129col_123456789_411
Innovative wireless sensor framework for enhanced characterization of oil and gas reserves in Kazakhstan
Kim, J. R.
Spencer, B. F.
James, A.
Park, J. W.
Zhang, D.
Zhumabekov, G.
wireless
technologies
seismic surveys
oil
gas
hypothesis
sensor networks
system
This research will develop a broad foundation in support of innovative wireless smart
sensing strategies and technologies that can provide high-resolution subsurface seismic surveys to
enable more effective exploration of the oil and gas reserves in Kazakhstan. The hypothesis is that next
generation wireless smart sensor networks, coupled with UAV (Unmanned Aerial Vehicle) technologies,
can create an autonomous seismic survey system that is scalable to large geographical regions and
terrains of interest. The UAV will be employed as an airborne base station to provide cooperative wireless
transmission for sensor nodes and data harvesting. Digital mapping of the exploration area will take
advantage of the UAV's mobility, onboard computational power, and image processing capabilities. A key
benefit of the proposed solution is its ability to scale to mega-node networks, yielding an unprecedented
level of resolution for seismic surveys.
2015-10-30T08:49:39Z
2015-10-30T08:49:39Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/625
en
Nazarbayev University
oai:nur.nu.edu.kz:123456789/6272018-08-15T03:49:41Zcom_123456789_409com_123456789_129col_123456789_411
Modeling and optimazation of energetic system in a hybrid smart house
Kaishubayeva, N.
Kazmaganbetova, M.
Mukhanov, N.
Rojas-Solorzano, L.
Ko, M. W. L.
Khakimova, A.
model
electricity
hybrid smart house
energetic system
The project objectives are to model the energetic configuration of a Smart House in a
numerical platform (e.g., HOMER Energy™ software), to validate the numerical predictions of technical
performance with experimental facilities at NU-Technopark and to predict the optimal energetic
configuration of the Smart House. This case study will be implemented particularly in Astana, but once
the model is validated, configurations can be obtained for other cities with a small extra modeling effort.
2015-10-30T09:00:38Z
2015-10-30T09:00:38Z
2014
Abstract
9786018046728
http://nur.nu.edu.kz/handle/123456789/627
en
Nazarbayev University
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