Isolation of primary human hepatocytes from cirrhotic liver

Abstract

Chronic degenerative liver diseases are among most complex social, clinical and epidemiological health problems worldwide. This is due to the steady increase in the incidence and mortality of patients with this pathology. Orthotopic liver transplantation is the only way to save the lives of patients with decompensated diffuse and focal lesions of the liver. One-year survival after liver transplantation reaches 60-80%, but more than half of the patients on the waiting list do not survive until operation. In this regard, hepatocyte transplantation could be an option for the patients who are on the waiting list for organ transplantation.