Аннотация:
The turnover of focal adhesions is essential for normal cell migration and tumor
invasion, but the underlying mechanisms are poorly understood. We have previously shown that the
disassembly of focal adhesions occurs by endocytosis of activated integrins from adhesion sites (1). We
have further identified new components that mediate integrin endocytosis. Here, we provide the initial
characterization of one of these components, sorting nexin 9 (Snx9), an endocytic adaptor protein not
previously implicated in cell adhesion and migration.