Abstract:
Foot-and-mouth disease (FMD) is important disease of cloven-foot animals including
cows and swine. Although annual vaccination against the FMD is mandated in regions of South
Kazakhstan, outbreaks of the disease are registered every year. These outbreaks result in huge economic
losses because international rules require culling of all the diseased and contacted animals and all
products from these animals must be destroyed. Currently available anti-FMD vaccines are all produced
using the original technology of inactivation of virus (foot-and-mouth disease virus, FMDV) grown in
cell cultures. Recombinant anti-FMD vaccine is a long anticipated development in the industry because
the recombinant vaccine is safe and compatible with diagnostic tests for discrimination of diseased and
vaccinated animals (DIVA).