• INVOLVEMENT OF 3′,5′-CYCLIC INOSINE MONOPHOSPHATE IN CYSTATHIONINE Γ-LYASE-DEPENDENT REGULATION OF THE VASCULAR TONE 

  Mitidieri, Emma; Vellecco, Valentina; Brancaleone, Vincenzo; Vanacore, Domenico; Manzo, Onorina L.; Martin, Emil; Sharina, Iraida; Krutsenko, Yekaterina; Monti, Maria Chiara; Morretta, Elva; Papapetropoulos, Andreas; Caliendo, Giuseppe; Frecentese, Francesco; Cirino, Giuseppe; Sorrentino, Raffaella; Bianca, Roberta d'Emmanuele di Villa; Bucci, Mariarosaria (British Journal of Pharmacology, 2021-04-30)

  l-cysteine or hydrogen sulfide (H2S) donors induce a biphasic effect on precontracted isolated vessels. The contractile effect occurs within a concentration range of 10 nM to 3 μM followed by vasodilatation at 30–100 μM. ...
• GIW and InCoB, two premier bioinformatics conferences in Asia with a combined 40 years of history 

  Schönbach, Christian; Horton, Paul; Yiu, Siu Ming; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2015)

  Knowledge discovery in bioinformatics thrives on joint and inclusive efforts of stakeholders. Similarly, knowledge dissemination is expected to be more effective and scalable through joint efforts. Therefore, the International ...
• InCoB2014: Mining Biological Data From Genomics for Transforming Industry and Health 

  Schönbach, Christian; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2014)

  The 13th International Conference on Bioinformatics (InCoB2014) was held for the first time in Australia, at Sydney, July 31-2 August, 2014. InCoB is the annual scientific gathering of the Asia-Pacific Bioinformatics Network ...
• InCoB2013 introduces Systems Biology as a major conference theme 

  Schönbach, Christian; Shen, Bairong; Tan, Tin Wee; Ranganathan, Shoba (BMC, 2013-09)

  The Asia-Pacific Bioinformatics Network (APBioNet) held the first International Conference on Bioinformatics (InCoB) in Bangkok in 2002 to promote North-South networking. Commencing as a forum for Asia-Pacific researchers ...
• Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori 

  Turgimbayeva, Aigerim; Abeldenov, Sailau; Zharkov, Dmitry O.; Ishchenko, Alexander A.; Ramankulov, Yerlan; Saparbaev, Murat; Khassenov, Bekbolat (PLoS ONE, 2018-08-15)

  Apurinic/apyrimidinic (AP) endonucleases play critical roles in the repair of abasic sites and strand breaks in DNA. Complete genome sequences of Helicobacter pylori reveal that this bacterial specie has a single AP ...
• Genetic Diversity of Brucella melitensis in Kazakhstan in Relation to World-Wide Diversity 

  Shevtsova, Elena; Vergnaud, Gilles; Shevtsov, Alexandr; Shustov, Alexandr; Berdimuratova, Kalysh; Mukanov, Kasim; Syzdykov, Marat; Kuznetsov, Andrey; Lukhnova, Larissa; Izbanova, Uinkul; Filipenko, Maxim; Ramankulov, Yerlan (FRONTIERS MEDIA SA, 2019-08-13)

  We describe the genetic diversity of 1327 Brucella strains from human patients in Kazakhstan using multiple-locus variable-number tandem repeat (VNTR) analysis (MLVA). All strains were assigned to the Brucella melitensis ...
• Autoantibodies to tissue transglutaminase target epitopes dependent on residues in the N-terminal domain 

  Kozhakhmetova, A; Wyatt, R; Elvers, K; Emery, D; Williams, C; Annis, P; Lampasona, V; Gillespie, K; Williams, A (Coeliac UK's Research Conference, 2017-03-24)

  INTRODUCTION: Tissue transglutaminase (tTG), is the main autoantigen of coeliac disease (CD). Specific tTG epitopes, including N-and C-terminal sites as well as the catalytic triad, have been reported to be targeted by ...
• Type 1 Diabetes: Current Perspectives 

  Kozhakhmetova, A; Gillespie, KM (Methods in Molecular Biology, 2016)

  Type 1 diabetes, resulting from the autoimmune destruction of insulin producing islet beta cells is caused by genetic and environmental determinants. Recent studies agree that counterintuitively, the major genetic ...
• A quarter of patients with type 1 diabetes have co-existing non-islet autoimmunity: the findings of a UK population-based family study. 

  Kozhakhmetova, A; Wyatt, RC; Caygill, C; Williams, C; Long, AE; Chandler, K; Aitken, RJ; Wenzlau, JM; Davidson, HW; Gillespie, KM; Williams, AJK (Clinical and Experimental Immunology, 2018-03-24)

  Individuals with type 1 diabetes (T1D) are at increased risk of coeliac disease (CD), autoimmune thyroiditis and autoimmune gastritis, but the absolute risks are unclear. The aim of this study was to investigate the ...
• A Scorpion Defensin BmKDfsin4 Inhibits Hepatitis B Virus Replication in Vitro 

  Zeng, Zhengyang; Zhang, Qian; Hong, Wei; Xie, Yingqiu; Liu, Yun; Li, Wenxin; Wu, Yingliang; Cao, Zhijian (MDPI, 2016-04-27)

  Hepatitis B virus (HBV) infection is a major worldwide health problem which can cause acute and chronic hepatitis and can significantly increase the risk of liver cirrhosis and primary hepatocellular carcinoma (HCC). ...
• CFD Modeling of Chamber Filling in a Micro- Biosensor for Protein Detection 

  Islamov, Meiirbek; Sypabekova, Marzhan; Kanayeva, Damira; Rojas-Solórzano, Luis (Biosensors, 2017-10)

  Tuberculosis (TB) remains one of the main causes of human death around the globe. The mortality rate for patients infected with active TB goes beyond 50% when not diagnosed. Rapid and accurate diagnostics coupled with ...
• Discovery and Characterization of an Endogenous CXCR4 Antagonist 

  O., Zirafi; K-A., Kim; L., Ständker; K. B., Mohr; D., Sauter; A., Heigele; S. F., Kluge; E., Wiercinska; D., Chudziak; R., Richter; B., Moepps; P., Gierschik; V., Vas; H., Geiger; M., Lamla; T., Weil; T., Burster; A., Zgraja; F., Daubeuf; N., Frossard; Timo, Burster (Cell Reports, 2015-05-05)

  CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a ...
• Immune phenotypes predict survival in patients with glioblastoma multiforme 

  Mostafa, Haouraa; Pala, Andrej; Högel, Josef; Hlavac, Michal; Dietrich, Elvira; Westhoff, M. Andrew; Nonnenmacher, Lisa; Burster, Timo; Georgieff, Michael; Wirtz, C. Rainer; Schneider, E. Marion (Journal of Hematology and Oncology, 2016-09-01)

  Background: Glioblastoma multiforme (GBM), a common primary malignant brain tumor, rarely disseminates beyond the central nervous system and has a very bad prognosis. The current study aimed at the analysis of ...
• CK1δ in lymphoma: gene expression and mutation analyses and validation of CK1δ kinase activity for therapeutic application 

  Winkler, B.Sophia; Oltmer, Franziska; Richter, Julia; Bischof, Joachim; Xu, Pengfei; Burster, Timo; Leithäuser, Frank; Knippschild, Uwe (Frontiers in Cell and Developmental Biology, 2015-02-20)

  The prognosis of lymphoid neoplasms has improved considerably during the last decades. However, treatment response for some lymphoid neoplasms is still poor, indicating the need for new therapeutic approaches. One promising ...
• Lactoferrin Is an Allosteric Enhancer of the Proteolytic Activity of Cathepsin G 

  Eipper, Steffen; Steiner, Robin; Lesner, Adam; Sienczyk, Marcin; Palesch, David; Halatsch, Marc- Eric; Zaczynska, Ewa; Heim, Christopher; Hartmann, Marcus D.; Zimecki, Michal; Rainer Wirtz, Christian; Burster, Timo (PLOS ONE, 2016-03-17)

  Protease-mediated degradation of proteins is critical in a plethora of physiological processes. Neutrophils secrete serine proteases including cathepsin G (CatG), neutrophile elastase (NE), and proteinase 3 (PR3) together ...
• Characterization of Legumain 

  Schwarz, Gerold; Brandenburg, Jens; Reich, Michael; Burster, Timo; Driessen, Christoph; Kalbacher, Hubert (Biological Chemistry, 2002-11)

  The mammalian legumain, also called asparaginyl endopeptidase (AEP), is critically involved in the processing of bacterial antigens for MHC class II presentation. In order to investigate the substrate specificity of ...
• Exogenous cathepsin G upregulates cell surface MHC class I molecules on immune and glioblastoma cells 

  Giese, Madleen; Turiello, Nadine; Molenda, Nicole; Palesch, David; Meid, Annika; Schroeder, Roman; Basilico, Paola; Benarafa, Charaf; Halatsch, Marc-Eric; Zimecki, Michal; Westhoff, Mike-Andrew; Rainer Wirtz, Christian; Burster, Timo (Oncotarget, 2016-10-28)

  Major histocompatibility complex (MHC) class I molecules present antigenic peptides to cytotoxic T cells. During an adaptive immune response, MHC molecules are regulated by several mechanisms including lipopolysaccharide ...
• Regulation of Cathepsin G Reduces the Activation of Proinsulin-Reactive T Cells from Type 1 Diabetes Patients 

  Zou, Fang; Schafer, Nadja; Palesch, David; Brucken, Ruth; Beck, Alexander; Sienczyk, Marcin; Kalbacher, Hubert; Sun, ZiLin; Boehm, Bernhard O.; Burster, Timo (PLoS ONE, 2011-08-05)

  Autoantigenic peptides resulting from self-proteins such as proinsulin are important players in the development of type 1 diabetes mellitus (T1D). Self-proteins can be processed by cathepsins (Cats) within endocytic ...
• Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation 

  Sun, Xiaoming; Shi, Yi; Akahoshi, Tomohiro; Fujiwara, Mamoru; Gatanaga, Hiroyuki; Schönbach, Christian; Kuse, Nozomi; Appay, Victor; Gao, George F.; Oka, Shinichi; Takiguchi, Masafumi (Cell Reports, 2016-06-07)

  Summary The mechanistic basis for the progressive accumulation of Y135F Nef mutant viruses in the HIV-1-infected population remains poorly understood. Y135F viruses carry the 2F mutation within RW8 and RF10, which are two ...
• Extracellular vesicles in gastrointestinal cancer in conjunction with microbiota: On the border of Kingdoms 

  Barteneva, Natasha S.; Baiken, Yeldar; Fasler-Kan, Elizaveta; Alibek, Kenneth; Wang, Sheng; Maltsev, Natalia; Ponomarev, Eugene D.; Sautbayeva, Zarina; Kauanova, Sholpan; Moore, Anna; Beglinger, Christoph; Vorobjev, Ivan A. (Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2017-12-01)

  Abstract Extracellular vesicle (EV) production is a universal feature of metazoan cells as well as prokaryotes (bMVs - bacterial microvesicles). They are small vesicles with phospholipid membrane carrying proteins, DNA and ...

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