Abstract:
Neural specification is further complicated when we consider that it needs to be
coordinated across the left-right (L/R) axis. Disruptions in the bilaterally symmetric organization of
the human brain are frequently observed in patients with neurological disorders. Furthermore, certain
neurological disorders such as schizophrenia and Parkinson's disease present or progress asymmetrically,
suggesting the possibility of underlying asymmetric genetic causes. The question of how early neural
specification is regulated to produce both bilaterally symmetric and L/R asymmetric structures has been
largely unexplored.
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