Transcriptome profiling by next - generation sequencing and pathway analysis of esophageal squamous cell carcinoma in Kazakhstan

Abstract

Esophageal cancer is the eighth most common cancer in the world and the highest in Eastern Asia. The incidence rate in Kazakhstan is 10.1: 100 000. Esophageal squamous cell carcinoma (ESCC) is the dominant histological type (> 90%) of esophageal cancer cases. Usage of NGS technologies allows determining effective diagnostic markers and therapeutic approaches for to increase the longevity of the patients. The aim of the project is to identify genetic basis of ESCC by performing whole transcriptome sequencing in Kazakhstani patients.