Аннотация:
Dyslipidemia is an important risk factor for cardiovascular disease due to the
significant influence of cholesterol on atherosclerosis. Several genetic variants in genes related
with triglyceride (TG) metabolism has been described, including LPL, apolipoprotein A5 and
apolipoprotein E (Apo E) are associated with dyslipidemia by involvement to lipid metabolism. The
combined analysis of these polymorphisms could produce clinically meaningful complementary
information. Changes in TG levels are now considered an independent cardiovascular risk
factor; hence, the study of combined variants in genes involved in TG metabolism may help
explain part of the risk for CVD. The most informative polymorphisms within the Apo E gene are
the Arg158Cys (rs7412) and Cys112Arg (rs429358) which define Apo E gene alleles, epsilon2,
3 and 4 (£2, £3 and £4).