Аннотации:
C-kit/SCF signaling play a key role in regulating NK cell homeostasis,
maturation, proliferation and cytotoxicity. C-kit-deficiency in NK results in significant reduction of
their, suggesting imperative role fore-kit signaling in NKcell immunobiology. We have recently
showed that human NK cells express not only c-kit-receptor, but also both membrane-bound
and soluble forms of c-kit ligand - Stem cell factor. The goal of this study was to characterize the
c-kit/SCF autocrine loop in peripheral blood NK cells obtained from patients with cancer.