Center for Life Sciences: Recent submissions

Now showing items 1-20 of 126

ONE HEALTH PROBIOTICS AS BIOCONTROL AGENTS: ONE HEALTH TOMATO PROBIOTICS

Harutyunyan, Natalya; Kushugulova, Almagul; Hovhannisyan, Narine; Pepoyan, Astghik (Plants, 2022)

Tomato (Lycopersicon esculentum) is one of the most popular and valuable vegetables in the world. The most common products of its industrial processing in the food industry are juice, tomato paste, various sauces, canned ...
MESENCHYMAL STEM CELLS COATED WITH SYNTHETIC BONE-TARGETING POLYMERS ENHANCE OSTEOPOROTIC BONE FRACTURE REGENERATION

Safarova, Yuliya; Olzhayev, Farkhad; Umbayev, Bauyrzhan; Tsoy, Andrey; Hortelano, Gonzalo; Tokay, Tursonjan; Murata, Hironobu; Russell, Alan; Askarova, Sholpan (MDPI AG, 2020-10-12)

Osteoporosis is a progressive skeletal disease characterized by reduced bone density leading to bone fragility and an elevated risk of bone fractures. In osteoporotic conditions, decrease in bone density happens due to the ...
SCREENING OF ANTIMICROBIAL AND ADHESIVE ACTIVITY OF LACTOBACILLI ISOLATED FROM THE NATIONAL FOOD PRODUCTS FROM DIFFERENT DISTRICTS OF THE KARAGANDA REGION (KAZAKHSTAN)

Amirkhanova, Zhanerke; Akhmetova, Saule; Kozhakhmetov, Samat; Kushugulova, Almagul; Bodeeva, Rahat; Issina, Zauresh; Tusbayev, Marat (Scientific Foundation SPIROSKI, 2021-09-14)

BACKGROUND: It is a national priority to look for new probiotic bacteria with highly active biological properties to create a new generation of probiotics, ferments, therapeutic, and prophylactic fermented milk products, ...
EPIDEMIOLOGY SURVEY OF MEASLES IN KAZAKHSTAN

Zhuzzhasarova, Aygerim; Baesheva, Dinagul; Turdalina, Bayan; Seidullaeva, Aliya; Altynbekova, Alena; Nurgaziev, Madiyar; Abdullaev, Bakhytzhan; Kushugulova, Almagul (Scientific Foundation SPIROSKI, 2021-07-21)

BACKGROUND: Measles (rubella) is a highly contagious disease that is caused by a virus in the Paramyxoviridae family. The measles virus is directly responsible for more than 100,000 deaths each year. Epidemiological studies ...
PLANT EXTRACT OF LIMONIUM GMELINII ATTENUATES OXIDATIVE RESPONSES IN NEURONS, ASTROCYTES, AND CEREBRAL ENDOTHELIAL CELLS IN VITRO AND IMPROVES MOTOR FUNCTIONS OF RATS AFTER MIDDLE CEREBRAL ARTERY OCCLUSION

Nurkenov, Tulendy; Tsoy, Andrey; Olzhayev, Farkhad; Abzhanova, Elvira; Turgambayeva, Anel; Zhussupova, Aizhan; Avula, Bharathi; Ross, Samir; Aituarova, Aigerim; Kassymova, Dariya; Zhusupova, Galiya; Shalakhmetova, Tamara; Tokay, Tursonjan; Lee, James C.; Askarova, Sholpan (MDPI, 2021-11-15)

There are numerous publications demonstrating that plant polyphenols can reduce oxidative stress and inflammatory processes in the brain. In the present study we have investigated the neuroprotective effect of plant extract ...
WHOLE-GENOME SEQUENCING DATA OF KAZAKH INDIVIDUALS

Kairov, Ulykbek; Molkenov, Askhat; Rakhimova, Saule; Kozhamkulov, Ulan; Sharip, Aigul; Karabayev, Daniyar; Daniyarov, Asset; H.Lee, Joseph; D.Terwilliger, Joseph D.; Akilzhanova, Ainur; Zhumadilov, Zhaxybay (BMC Res Notes, 2021-02-04)

Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today is the ...
DYNAMIC CHANGES IN MICROBIOME COMPOSITION FOLLOWING MARE’S MILK INTAKE FOR PREVENTION OF COLLATERAL ANTIBIOTIC EFFECT

Kushugulova, Almagul R.; Löber, Ulrike; Akpanova, Saniya; Rysbekov, Kairat; Kozhakhmetov, Samat S.; Khassenbekova, Zhanagul R.; Essex, Morgan; Nurgozhina, Ayaulym; Nurgaziyev, Madiyar; Babenko, Dmitriy; Marko, Lajos; Forslund, Sofia K. (Frontiers Media S.A., 2021-04-21)

Introduction: Probiotics and prebiotics are widely used for recovery of the human gut microbiome after antibiotic treatment. High antibiotic usage is especially common in children with developing microbiome. We hypothesized ...
RE-SEARCHER: GUI-BASED BIOINFORMATICS TOOL FOR SIMPLIFIED GENOMICS DATA MINING OF VCF FILES

Karabayev, Daniyar; Molkenov, Askhat; Yerulanuly, Kaiyrgali; Kabimoldayev, Ilyas; Daniyarov, Asset; Sharip, Aigul; Seisenova, Ainur; Zhumadilov, Zhaxybay; Kairov, Ulykbek (PeerJ Inc., 2021-05-03)

Background. High-throughput sequencing platforms generate a massive amount of high-dimensional genomic datasets that are available for analysis. Modern and user-friendly bioinformatics tools for analysis and interpretation ...
ANALYSIS OF BACTEROIDES FRAGILIS CLINICAL STRAINS ISOLATED IN KAZAKHSTAN

Zholdybayeva, Elena V.; Kozhahmetova, Saniya; Tarlykov, Pavel; Atavliyeva, Sabina; Mukhtarova, Kymbat; Syzdykov, Tleuli; Khasenov, Ruslan; Shevtsov, Alexsandr; Amirgazin, Asylulan; Daniyarov, Asset; Ramankulov, Yerlan (Microbiology Resource Announcements, 2021-02-04)

Our aim was to study the nucleotide sequences of 9 previously undescribed strains of B. fragilis collected from patients with intra-abdominal diseases at city hospitals in Nur-Sultan, Kazakhstan.
TRENDS OF COLORECTAL CANCER PREVALENCE IN KAZAKHSTAN RELATED TO SCREENING

Zhylkaidarova, Alma; Kaidarova, Dilyara; Batyrbekov, Kanat; Shatkovskaya, Oxana; Begimbetova, Dinara (Clinical Endoscopy, 2020-05)

Colorectal cancer (CRC) is one of the global health problems and is the third leading cause of morbidity and second leading cause of mortality from cancer worldwide [1,2]. In the United States and European countries, the ...
PALINDROMIC SEQUENCE-TARGETED (PST) PCR, VERSION 2: AN ADVANCED METHOD FOR HIGH-THROUGHPUT TARGETED GENE CHARACTERIZATION AND TRANSPOSON DISPLAY

Kalendar, Ruslan; Shustov, Alexandr V.; Schulman, Alan H. (Frontiers Media S.A., 2021-06-22)

Genome walking (GW), a strategy for capturing previously unsequenced DNA fragments that are in proximity to a known sequence tag, is currently predominantly based on PCR. Recently developed PCR-based methods allow for ...
GUT MODULATION OF DYSBIOSIS INDUCED BY DEXTRAN SULFATE SODIUM

Kozhakhmetov, Samat S.; Babenko, Dmitriy; Kozhakhmetova, Saniya; Tuyakova, Altynay; Nurgaziyev, Madiyar; Nurgozhina, Ayaulym; Muhanbetganov, Nurislam; Chulenbayeva, Laura; Sergazy, Shynggys; Gulyayev, Alexander; Tanabayev, Baimakhan; Saliev, Timur; Kushugulova, Almagul R. (Elsevier Ltd, 2021-06-08)

Inflammatory bowel disease is one of the serious burdens of clinical medicine and healthcare. This study investigated the potential of a biological product based on mare's milk and metabolites of symbiotic microflora for ...
WHOLE-GENOME SEQUENCING DATA OF KAZAKH INDIVIDUALS

Kairov, Ulykbek; Molkenov, Askhat; Rakhimova, Saule; Kozhamkulov, Ulan; Sharip, Aigul; Karabayev, Daniyar; Daniyarov, Asset; Lee, Joseph H.; Terwilliger, Joseph D.; Akilzhanova, Ainur; Zhumadilov, Zhaxybay (BioMed Central Ltd, 2021-02-04)

Objectives: Kazakhstan is a Central Asian crossroad of European and Asian populations situated along the way of the Great Silk Way. The territory of Kazakhstan has historically been inhabited by nomadic tribes and today ...
GALACTOSE-INDUCED SKIN AGING: THE ROLE OF OXIDATIVE STRESS

Umbayev, Bauyrzhan; Askarova, Sholpan; Almabayeva, Aigul; Saliev, Timur; Masoud, Abdul-Razak; Bulanin, Denis (Hindawi, 2020-06-17)

Skin aging has been associated with a higher dietary intake of carbohydrates, particularly glucose and galactose. In fact, the carbohydrates are capable of damaging the skin’s vital components through nonenzymatic glycation, ...
IMPROVEMENT OF NEUROLOGICAL FUNCTION IN RATS WITH ISCHEMIC STROKE BY ADIPOSEDERIVED PERICYTES

Ogay, Vyacheslav; Kumasheva, Venera; Li, Yelena; Mukhlis, Sholpan; Sekenova, Aliya; Olzhayev, Farkhad; Tsoy, Andrey; Umbayev, Baurzhan; Askarova, Sholpan; Shpekov, Azat; Kaliyev, Assylbek; Zhetpisbayev, Berik; Makhambetov, Yerbol; Akshulakov, Serik; Saparov, Arman; Ramankulov, Yerlan (SAGE Publications, 2020-09-04)

Pericytes possess high multipotent features and cell plasticity, and produce angiogenic and neurotrophic factors that indicate their high regenerative potential. The aim of this study was to investigate whether transplantation ...
THE MAJOR SATELLITE DNA FAMILIES OF THE DIPLOID CHENOPODIUM ALBUM AGGREGATE SPECIES: ARGUMENTS FOR AND AGAINST THE “LIBRARY HYPOTHESIS”

Belyayev, Alexander; Jandova, Michaela; Josefiova, Jiřina; Kalendar, Ruslan; Mahelka, Va´clav; Manda´k, Bohumil; Krak, Karol (Public Library of Science, 2020-10-27)

Satellite DNA (satDNA) is one of the major fractions of the eukaryotic nuclear genome. Highly variable satDNA is involved in various genome functions, and a clear link between satellites and phenotypes exists in a wide ...
THE ARABIDOPSIS THALIANA POLY(ADP-RIBOSE) POLYMERASES 1 AND 2 MODIFY DNA BY ADP-RIBOSYLATING TERMINAL PHOSPHATE RESIDUES

Taipakova, Sabira; Kuanbay, Aigerim; Saint-Pierre, Christine; Gasparutto, Didier; Baiken, Yeldar; Groisman, Regina; Ishchenko, Alexander A.; Saparbaev, Murat; Bissenbaev, Amangeldy K. (Frontiers Media, 2020-11-26)

Proteins from the poly(ADP-ribose) polymerase (PARP) family, such as PARP1 and PARP2, use NAD+ as a substrate to catalyze the synthesis of polymeric chains consisting of ADP-ribose units covalently attached to an acceptor ...
IN SILICO ESTIMATION OF THE ABUNDANCE AND PHYLOGENETIC SIGNIFICANCE OF THE COMPOSITE OCT4-SOX2 BINDING MOTIFS WITHIN A WIDE RANGE OF SPECIES

Kulyyassov, Arman; Kalendar, Ruslan (MDPI, 2020-11-29)

High-throughput sequencing technologies have greatly accelerated the progress of genomics, transcriptomics, and metagenomics. Currently, a large amount of genomic data from various organisms is being generated, the volume ...
A NEW INSIGHT ON THE RADIOPROTECTIVE POTENTIAL OF EPSILON-AMINOCAPROIC ACID

Takagi, Satoshi; Oyama, Takuto; Jimi, Shiro; Saparov, Arman; Ohjimi, Hiroyuki (MDPI, 2020-11-25)

Negative pressure wound therapy (NPWT) has been commonly used over the years for a wide range of chronic/refractory lesions. Alternatively, autologous micrografting technology is recently becoming a powerful modality for ...
WHOLE GENOME SEQUENCE DATA OF MYCOBACTERIUM TUBERCULOSIS XDR STRAIN, ISOLATED FROM PATIENT IN KAZAKHSTAN

Daniyarov, Asset; Molkenov, Askhat; Rakhimova, Saule; Akhmetova, Ainur; Nurkina, Zhannur; Yerezhepov, Dauren; Chingissova, Lyailya; Bismilda, Venera; Toxanbaeva, Bekzat; Akilzhanova, Ainur; Kozhamkulov, Ulan; Kairov, Ulykbek (Elsevier, 2020-12)

Drug-resistant tuberculosis (TB) is a major public health problem. Clinical Mycobacterium tuberculosis (MTB) isolate with Extensively drug-resistant tuberculosis (MTB-XDR) profile was subjected to whole-genome sequencing ...