NU Research Week: abstractshttp://nur.nu.edu.kz:80/handle/123456789/4092024-03-28T16:43:02Z2024-03-28T16:43:02ZPeriostin in Inflammatory Bowel Disease (IBD) development and synergistic effects mediated via CCL5Riethmacher, EvaVangelista, LucaMukanova, SaidaRiethmacher, Dieterhttp://nur.nu.edu.kz:80/handle/123456789/35812018-11-01T21:00:52Z2018-10-18T00:00:00ZPeriostin in Inflammatory Bowel Disease (IBD) development and synergistic effects mediated via CCL5
Riethmacher, Eva; Vangelista, Luca; Mukanova, Saida; Riethmacher, Dieter
The incidence of IBD is rising all over the world and is affecting 1 in
4000 people in Europe and 1 in 16.000 in Asia. [1] Welldocumented,
reliable numbers for Kazakhstan are currently not
available but observations from local physicians (personal
communication) suggest that numbers might be significantly higher
than suggested by the literature. The matricellular protein Periostin
has recently been shown to be involved in IBD [2] (and our own
unpublished data). In a chemically induced murine model (dextrane
sulfate sodium DSS) it mediates intestinal inflammation through the
activation of NF-κB signaling, which suggests that periostin is a
potential therapeutic target for inflammatory bowel disease [2].
CCL5, also know as RANTES, is a chemokine shown to be
interacting with the G protein-coupled receptors CCR1, CCR3 and
CCR5 [3]. In a recent study it could be shown that CCR5 expression
correlates with the infiltration of inflammatory cells into the lamina
propria of IBD patients [4].
Periostin is a matricellular protein originally isolated from
osteoblasts and found to be preferentially expressed in the
periosteum [5, 6]. Periostin contains an N-terminal secretory signal
peptide, followed by a cysteine-rich domain, four internal
homologous repeats, and a C-terminal hydrophilic domain. The four
internal repeats exhibit homology to the axon guidance protein
fasciclin I that is involved in the development of nervous system in
invertebrates and were thus named fasciclin domains.
2018-10-18T00:00:00ZAssessment of unmet needs and barriers to end-of-life care provision in KazakhstanToleubekova, LyazzatCrape, ByronDauyey, KaisarArgandykov, DiasBekenova, AigerimMadikenova, Meruyerthttp://nur.nu.edu.kz:80/handle/123456789/35802018-11-01T21:00:50Z2018-10-18T00:00:00ZAssessment of unmet needs and barriers to end-of-life care provision in Kazakhstan
Toleubekova, Lyazzat; Crape, Byron; Dauyey, Kaisar; Argandykov, Dias; Bekenova, Aigerim; Madikenova, Meruyert
Palliative care, a holistic multidisciplinary approach for those persons with
terminal diseases, providing relief for physical, emotional, psychosocial and
spiritual suffering of both the patients and their families and to support
the dignity of all involved in the process of dying¹.
Palliative care has developed recently, and an understanding of unmet
needs and barriers, especially in Kazakhstan, can be addressed through
innovative rigorous qualitative research methods covering all the
stakeholders involved. Palliative care is an integral Nazarbayev University’s
commitment to improving health services in Kazakhstan. The published
literature shows a lack of palliative care providers in Kazakhstan and the
few existing services are underdeveloped2,3.
Our current will substantially characterize more in-depth and more broadly
on opportunities and barriers for national expansion of quality palliative
care in Kazakhstan.
2018-10-18T00:00:00ZInfluence of CYP2C9 and VKORC1 gene variants on warfarin response in Kazakhstani patients with left ventricular assist devicesAkilzhanova, А.Rakhimova, S.Andosova, S.Kalkamanova, InkarTokanova, AruzhanZhumadilov, Zh.Bekbossynova, M.http://nur.nu.edu.kz:80/handle/123456789/35792018-11-01T21:00:48Z2018-10-18T00:00:00ZInfluence of CYP2C9 and VKORC1 gene variants on warfarin response in Kazakhstani patients with left ventricular assist devices
Akilzhanova, А.; Rakhimova, S.; Andosova, S.; Kalkamanova, Inkar; Tokanova, Aruzhan; Zhumadilov, Zh.; Bekbossynova, M.
Heart failure is a worldwide epidemic affecting approximately 23 million people globally and is a major burden for the healthcare system [1,2]. Despite advances in medical therapy, the disease is progressive and a significant proportion of patients will need advanced heart replacement therapy.
Left ventricular assist devices (LVAD) are an invaluable part of the therapeutic measures for patients suffering from advanced heart failure. When used either as a bridge to transplant, to promote myocardial recovery, or as lifetime use, LVADs have proven to prolong survival and improve quality of life [1-3]. In spite of their success in improving mortality and quality of life, thrombotic and bleeding events remain significant complications [1]. Achieving therapeutic anticoagulation efficiently with warfarin is important to reduce thrombotic and bleeding risks and is influenced by genotype.
Warfarin has a narrow therapeutic index and displays marked person-to-person variation in dose requirement. Functional polymorphisms at candidate genes can therefore offer utility as biomarkers to individualize warfarin treatment.
2018-10-18T00:00:00ZWhole genome sequencing of m. Tuberculosis strains in kazakhstan reveal genomic variants in genes coding pe/ppe protein family specific for mdr/xdr isolatesKozhamkulov, U.Kairov, U.Molkenov, A.Steins, M.Akhmetova, А.Akilzhanova, Ahttp://nur.nu.edu.kz:80/handle/123456789/35782018-11-01T21:00:47Z2018-10-18T00:00:00ZWhole genome sequencing of m. Tuberculosis strains in kazakhstan reveal genomic variants in genes coding pe/ppe protein family specific for mdr/xdr isolates
Kozhamkulov, U.; Kairov, U.; Molkenov, A.; Steins, M.; Akhmetova, А.; Akilzhanova, A
Worldwide in 2016, around 10.4 million people were diagnosed with TB among which 1.7 million died [1]. Despite the progress in decreasing the global incidence of drug-susceptible TB, multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in the past decade led to decreased efficiency of chemotherapy. However, the rate of drug-resistant TB increases annually, especially multidrug-resistant TB (MDR TB) [1].
2018-10-18T00:00:00ZDe Novo Assembly And Bioinformatics Analysis Of M.Tuberculosis Mdr Strains Sequenced On Next-Generation Sequencing PlatformDaniyarov, A.Kairov, U.Molkenov, A.Kozhamkulov, U.Akhmetova, A.Akilzhanova, AZhumadilov, Zh.http://nur.nu.edu.kz:80/handle/123456789/35772018-11-01T21:00:45Z2018-10-18T00:00:00ZDe Novo Assembly And Bioinformatics Analysis Of M.Tuberculosis Mdr Strains Sequenced On Next-Generation Sequencing Platform
Daniyarov, A.; Kairov, U.; Molkenov, A.; Kozhamkulov, U.; Akhmetova, A.; Akilzhanova, A; Zhumadilov, Zh.
Tuberculosis remains one of the major problems
in public health (1). During the last 10 years the
tuberculosis incidence and mortality rate in
Kazakhstan decreased by 2.4 times and 6 times,
respectively. Despite the decreasing rate of
incidences in Kazakhstan last years, the rate of
multidrug-resistant (MDR) forms is increasing.
2018-10-18T00:00:00ZGenotyping Of M. Tuberculosis Clinical Isolates From New Cases Of Tuberculosis In KazakhstanAkhmetova, А.Akilzhanova, A.Assatova, B.Moldakhmetova, N.Toksanbaeva, B.Bismilda, V.Chingissova, L.Kozhamkulov, U.http://nur.nu.edu.kz:80/handle/123456789/35762018-10-31T21:00:58Z2018-10-18T00:00:00ZGenotyping Of M. Tuberculosis Clinical Isolates From New Cases Of Tuberculosis In Kazakhstan
Akhmetova, А.; Akilzhanova, A.; Assatova, B.; Moldakhmetova, N.; Toksanbaeva, B.; Bismilda, V.; Chingissova, L.; Kozhamkulov, U.
Tuberculosis (TB) remains a major health
problem in Kazakhstan. Despite of that the
rates of TB disease and mortality decreased
from 58,5/100000 and 4,1/100000 in 2015 to
52,7/100000 and 3,4/100000 in 2016
respectively, the rate of multidrug-resistant
TB (MDR-TB) increased from 12,2/100000
in 2014 to 13,5/100000 in 2015 [1];
MDR strains associated with resistance to
the main two first line anti-TB drugs –
isoniazid and rifampicin are the most
dangerous. 27 countries relate to high
MDR-TB burden countries, 15 of them in
the European region, including
Kazakhstan [2];
Methods of genotyping of M. tuberculosis
play important role in TB infection control.
There are more than 10 methods of
genotyping, MIRU-VNTR is one of the widely
used method in the world.
2018-10-18T00:00:00Z