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Browsing by Subject "gene expression"

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Deletion of HP1γ in cardiac myocytes afects H4K20me3 levels but does not impact cardiac growth

El‑Nachef, Danny; Fang, Chen; Kajimoto, Hidemi; Brown, Jeremy P.; Singh, Prim B.; MacLellan, W. Robb (Epigenetics Chromatin, 2018-04-18)

Heterochromatin, which is formed when tri-methyl lysine 9 of histone H3 (H3K9me3) is bound by heterochromatin 1 proteins (HP1s), plays an important role in differentiation and senescence by silencing cell cycle genes. ...
Gene expression and methylation profiles as a biomarker for human radiation exposure

Abilmazhinova, A.; Zhabagin, M.; Rakhimova, S.; Bakhtin, M.; Kazymbet, P.; Akilzhanova, A.; Zhumadilov, Z. (Nazarbayev University, 2014)

Taking into account the fact that Kazakhstan is one of the world's leaders in uranium mining, and given the extent of the damage suffered as a result of the work on the Semipalatinsk nuclear test site, the general background ...
Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes

Yeo, Adeline; Azhar, Nur Atiqah; Yeow, Wanyi; Talbot Jr., C. Conover; Asif Khan, Mohammad; Shankar, Esaki M.; Rathakrishnan, Anusyah; Azizan, Azliyati; Wang, Seok Mui; Kim Lee, Siew; Yik Fong, Mun Yik; Manikam, Rishya; Devi Sekaran, Shamala (PLOS ONE:Open Access journal, 2014-04)

Dengue represents one of the most serious life-threatening vector-borne infectious diseases that afflicts approximately 50 million people across the globe annually. Whilst symptomatic infections are frequently reported, ...
The p90 Ribosomal S6 Kinase (RSK) Is a Mediator of Smooth Muscle Contractility

Artamonov, Mykhaylo; Momotani, Ko; Utepbergenov, Darkhan; Franke, Aaron; Khromov, Alexander; Derewenda, Zygmunt S.; Somlyo, Avril V. (2013)

In the canonical model of smooth muscle (SM) contraction, the contractile force is generated by phosphorylation of the myosin regulatory light chain (RLC20) by the myosin light chain kinase (MLCK). Moreover, phosphorylation ...
Tumor antigens as proteogenomic biomarkers in invasive ductal carcinomas

Olsen, Lars Rønn; Campos, Benito; Winther, Ole; Sgroi, Dennis C.; Karger, Barry L.; Brusic, Vladimir (BMC Medical Genomics, 2014-12-08)

Background: The majority of genetic biomarkers for human cancers are defined by statistical screening of high-throughput genomics data. While a large number of genetic biomarkers have been proposed for diagnostic and ...